NUCLEAR MEDICINE REVIEW最新文献

{"title":"SPECT-CT Imaging with [99mTc]PSMA-T4 in patients with Recurrent Prostate Cancer.","authors":"Sonya Sergieva,&nbsp;Radoslav Mangaldgiev,&nbsp;Milena Dimcheva,&nbsp;Kamen Nedev,&nbsp;Zahary Zahariev,&nbsp;Bozhil Robev","doi":"10.5603/NMR.2021.0018","DOIUrl":"https://doi.org/10.5603/NMR.2021.0018","url":null,"abstract":"<p><strong>Background: </strong>Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein with a large extracellular domain with overexpression of the prostatic tumour cells. Several small molecules of PSMA ligands of inhibitors binding to the active site of PSMA were developed. [99mTc]Tc-PSMA-T4 is a new radiopharmaceutical (Polatom) for imaging loco-regional metastases and/or local relapse in patients with prostate cancer. The purpose of this work was to evaluate the clinical application of SPECT-CT imaging with [99mTc]Tc-PSMA-T4 in patients with recurrent prostate cancer.</p><p><strong>Material and methods: </strong>Thirty-six patients with prostate cancer, aged 60-80 years with biochemical relapse of PSA (ranged from 0.1 to 73 ng/mL) were included. Three patients were studied after tru-cut biopsy, hormonal and cytoreductive radiotherapy and 33 patients out of 36 - after radical treatment (total prostatectomy or definitive radiotherapy of the tumour). All of them underwent whole-body imaging examinations with subsequent target SPECT-CT studies of the pelvis, abdomen and/or chest, 1-3 hrs post i.v. administration of [99mTc]Tc-PSMA-T4. The average activity dose was 6.3 MBq/kg in a man of 70 kg. A Dual-head SPECT-CT gamma camera with a low dose CT scan (Symbia T2, Siemens) was used. The images were interpreted based on all other clinical and radiological data. Follow-up could be conducted in 11/36 patients during that period.</p><p><strong>Results: </strong>Normal biodistribution of the radiopharmaceutical with high activity background was observed in the liver, spleen, kidneys, lacrimal and salivary glands, bowels and urinary bladder. Positive imaging for local relapse in the prostate bad was imaged in 21 patients, lymph node metastases - in 16 cases, bone lesions - in 10 cases, pulmonary metastases - in 2 cases, hepatic lesions were visualised in one of them and in another - adrenal suprarenal metastasis with intensive tracer uptake significant for overexpression of PSMA. There was a suspicion for local recurrences in 4 patients with negative MRT studies who were followed up. In 3 cases, previously treated bone metastases were partially negative without tracer uptake, only some progressive bone lesions were positive. Five patients were with negative results. Sensitivity was 84.37% (27/32), specificity - 100% (4/4) and accuracy - 86.11% (31/36).</p><p><strong>Conclusions: </strong>In conclusion SPECT-CT imaging with [99mTc]Tc-PSMA-T4 could be applied in patients with prostate cancer for the diagnosis of recurrent disease to determine personalized treatment for each patient. Specific uptake of this tracer, depicted by SPECT-CT images has clinical importance of identifying and assessing PSMA expression before consideration of Radio Ligand Therapy (RLT) with [¹⁷⁷Lu]Lu-PSMA. SPECT-CT imaging with [99mTc]PSMA is promising and reliable nuclear medicine approach to monitoring therapeutic effect after treatment and for restaging of the di","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39303509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"False-positive radioiodine uptake in breasts in a female haemodialysis patient.","authors":"Aleksandra Ledwon,&nbsp;Przemysław Soczomski,&nbsp;Ewa Paliczka-Cieslik,&nbsp;Aleksandra Blewąska,&nbsp;Daria Handkiewicz-Junak","doi":"10.5603/NMR.2021.0030","DOIUrl":"https://doi.org/10.5603/NMR.2021.0030","url":null,"abstract":"The Na+/Isymporter (NIS) is an intrinsic plasma membrane glycoprotein that mediates the active uptake of Iin the thyroid and other tissues such as salivary glands, gastric mucosa and lactating mammary gland. Physiologically, NIS is expressed in the breast exclusively during gestation and lactation. In vitro and in vivo studies confirmed that lactogenic hormones, including prolactin, can induce functional NIS expression in mammary tissue. Hyperprolactinemia is common in patients with end-stage renal disease (ESRD).","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39303848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung perfusion SPECT/CT images associated with COVID-19 - a case series.","authors":"Sara Kurkowska,&nbsp;Hanna Piwowarska-Bilska,&nbsp;Jacek Iwanowski,&nbsp;Bozena Birkenfeld","doi":"10.5603/NMR.2021.0009","DOIUrl":"https://doi.org/10.5603/NMR.2021.0009","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) most often presents with mild symptoms, but it can also present with viral pneumonia and acute respiratory distress syndrome, which predispose to thromboembolic disease. There is an increasing number of case studies which report the significance of ventilation/perfusion scintigraphy in the diagnosis of pulmonary embolism in COVID-19 patients [1, 2]. Since most of the patients in Poland were managed in an outpatient setting, this population has been excluded from many studies and its characteristics are not well-documented. Dhawan et al. [3] emphasize the importance of the evaluation of the prevalence and extent of perfusion abnormalities in survivors of COVID-19 through the whole spectrum of illness, from non-hospitalised patients to those in the intensive care unit (ICU). We report a case series of three patients after recovery from COVID-19, who underwent lung perfusion SPECT/CT. Scintigraphic examinations were performed after administration of 99mTc-Makro-Albumon with an activity of about 2 MBq/kg of patient’s body weight. All patients were examined using Symbia Intevo Bold with a protocol including SPECT/CT acquisition with the following parameters: LEHR collimator, 360 degrees, 120 projections, time per projection 15 sec, matrix 128x128; low-dose CT protocol. The examinations were performed to assess lung lesions in these patients. All patients were diagnosed through RT-PCR for SARS-CoV2 and were presenting mild-to-moderate symptoms. Treatment was symptomatic, including paracetamol and ibuprofen in all patients and additional azithromycin in case of Patient 1. None of them required hospitalization. Data and perfusion SPECT/CT findings of the patients are presented in the Table 1 below. Figure 1 and 2 show SPECT/CT findings of Patients 1 and 3, respectively.","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25364678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memoriam - Prof. Anna Celler.","authors":"Bozena Birkenfeld,&nbsp;Renata Mikolajczak","doi":"10.5603/NMR.2021.0011","DOIUrl":"https://doi.org/10.5603/NMR.2021.0011","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25364679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical quantities useful for quality control of quantitative SPECT/CT imaging.","authors":"Sara Kurkowska,&nbsp;Bożena Birkenfeld,&nbsp;Hanna Piwowarska-Bilska","doi":"10.5603/NMR.2021.0020","DOIUrl":"https://doi.org/10.5603/NMR.2021.0020","url":null,"abstract":"<p><p>SPECT/CT imaging is transitioning from solely qualitative applications to quantitative analysis. Quantitative SPECT/CT systems require proper calibration, optimization and quality control. Various types of modern SPECT/CT scanners have different software for calibration and quality control (QC). There is still no standardization in this regard for quantitative SPECT/CT. This issue hinders the exchange of obtained results across centers and stunts the development of repeatable and reproducible measurements. The unification and standardization of calibration and quality control techniques for quantitative SPECT/CT systems is currently a pressing need for nuclear medicine departments. The present study presents three selected physical quantities characterizing the quality of quantitative SPECT/CT system and seven quantities, currently used in the literature, to assess the quality of quantitative SPECT/CT images. The measurement of these parameters requires the use of standard gamma camera software for QC, external programs for quantitative analysis of recorded data and clinical software. The authors hope this will help physicists who are willing to perform quantitative SPECT/CT in their departments.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39303512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation of genital tuberculosis detected on FDG PET/CT scan resembling a primary gynecologic tumor and metastases.","authors":"Inci Uslu Biner,&nbsp;Ebru Tatci,&nbsp;Ozlem Ozmen,&nbsp;Mujgan Güler,&nbsp;Fatma Benli","doi":"10.5603/NMR.2021.0022","DOIUrl":"https://doi.org/10.5603/NMR.2021.0022","url":null,"abstract":"<p><p>Gastric cancer (GC) is a common cause of cancer-related deaths in the world. In addition to the patient's clinical history and clinical examination, nuclear medicine tools are required for diagnosis. [¹⁸F]FDG PET/CT has been commonly used for cancer patients for staging, restaging, evaluation of treatment response. This study aimed to review the current literature on the role of [¹⁸F]FDG PET/CT for GC management.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39303514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentinel lymph node biopsy in upper tract urothelial cancers: an experience with intraoperative radiotracer injection.","authors":"Leili Zarifmahmoudi,&nbsp;Hamidreza Ghorbani,&nbsp;Ramin Sadeghi,&nbsp;Salman Soltani,&nbsp;Kayvan Sadri,&nbsp;Mahmoud Tavakkoli,&nbsp;Maliheh Keshvari","doi":"10.5603/NMR.2021.0013","DOIUrl":"https://doi.org/10.5603/NMR.2021.0013","url":null,"abstract":"<p><strong>Background: </strong>The feasibility of the sentinel node mapping in upper tract urothelial cancers (UTUC) was evaluated, using a radiotracer as the mapping material.</p><p><strong>Material and methods: </strong>To identify the sentinel lymph nodes, 37 MBq of [99mTc] phytate was injected in five patients with the renal pelvis or ureter cancer, who were candidates for ureterectomy and lymphadenectomy. The radiotracer was injected in a peritumoral fashion following the surgical exposure of the tumour. The sentinel lymph nodes were detected using a handheld gamma probe.</p><p><strong>Results: </strong>By intraoperatively injecting the radiotracer immediately after surgical exposure of the tumour, at least one sentinel lymph node could be detected in each patient, and the detection rate was 100%. The location of sentinel nodes was in the paracaval, renal hill, retro-aortic, para-aortic, common iliac, and external iliac areas, which was dependent on the tumour location. No false-negative case was identified.</p><p><strong>Conclusions: </strong>Sentinel node mapping is feasible in UTUC. Injection technique (intra-vesical approach vs peri-tumoral injection after exposure of the tumour) and location of the tumour (proximal vs distal) may affect the technique's feasibility.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39303545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholethorax with biliopleural communication detected on [99mTc]mebrofenin hepatobiliary scintigraphy.","authors":"Georgios Meristoudis,&nbsp;Ioannis Ilias,&nbsp;Evangelia Zaromytidou,&nbsp;Emmanouil Alevroudis,&nbsp;Athanasios Notopoulos","doi":"10.5603/NMR.2021.0031","DOIUrl":"https://doi.org/10.5603/NMR.2021.0031","url":null,"abstract":"<p><p>Bilious pleural effusion or cholethorax is a rare type of exudative pleural effusion. Here is presented a case of right-sided cholethorax, in which the direct communication between the pleural effusion with the biliary duct was visible only on the posteriori images of dynamic hepatobiliary scintigraphy with [99mTc]mebrofenin.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39313950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial.","authors":"Grzegorz Kamiński","doi":"10.5603/NMR.2021.0010","DOIUrl":"https://doi.org/10.5603/NMR.2021.0010","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25364670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the usefulness of positron emission tomography with [18F]fluorodeoxylglucose performed to detect non-radioiodine avid recurrence and/or metastasis of differentiated thyroid cancer - a preliminary study.","authors":"Maciej Kolodziej,&nbsp;Marek Saracyn,&nbsp;Arkadiusz Lubas,&nbsp;Dorota Brodowska-Kania,&nbsp;Andrzej Mazurek,&nbsp;Mirosław Dziuk,&nbsp;Jolanta Dymus,&nbsp;Grzegorz Kaminski","doi":"10.5603/NMR.2021.0017","DOIUrl":"https://doi.org/10.5603/NMR.2021.0017","url":null,"abstract":"<p><strong>Background: </strong>About 30% of patients with disseminated differentiated thyroid cancer (DTC) may experience a loss of iodine uptake. It is associated with higher aggressiveness of the tumour and a reduced 10-year survival rate. The diagnosis of non-radioiodine avid DTC metastases remains a diagnostic challenge. A helpful technique for this diagnosis is positron emission tomography with 2-[¹⁸F]fluoro-2-deoxy-D-glucose (PET/CT with [¹⁸F]FDG). On the other hand, there are still discussions about the clinical value of using exogenous thyroid-stimulating hormone (TSH) stimulation before PET/CT with [¹⁸F]FDG. The aim of the study was the assessment of the usefulness of PET/CT with [¹⁸F]FDG under TSH suppression and stimulation of TSH performed in the detection of non-radioiodine avid DTC metastases, as well as determination of the thyroglobulin concentration under suppression and stimulation of TSH, which influences the result of PET/CT with [¹⁸F]FDG in patients with non-radioiodine avid DTC.</p><p><strong>Material and methods: </strong>Retrospective analysis of 37 PET/CT with [¹⁸F]FDG performed in patients with DTC diagnosed and treated at the Department of Endocrinology and Isotope Therapy of the Military Institute of Medicine from January 2018 to July 2020. Of these, PET/CT with [¹⁸F]FDG under exogenous rhTSH stimulation was performed in 22 patients and PET/CT with [¹⁸F]FDG under TSH suppression in 15 was performed. In all analyzed patients, the result of diagnostic whole-body scintigraphy (WBS) using 80 MBq ¹³¹I under rhTSH stimulation was negative, and the concentration of thyroglobulin after stimulation (sTg) was greater than 1.0 ng/mL.</p><p><strong>Results: </strong>In the group of patients examined under TSH suppression, non-radioiodine avid in PET/CT with [¹⁸F]FDG were found in 6 out of 15 patients (40%) and in the group of patients examined under rhTSH stimulation in 10 out of 22 patients (45%). The differences between the groups were not statistically significant. The analysis of the receiver operating characteristic (ROC) curves allowed to determine the cut-off point for the positive result of PET/CT performed under TSH suppression with sTg concentration of 11.03 ng/mL. In the group of studies performed under rhTSH stimulation, the cut-off point for sTg was 6.3 ng/mL. There was no statistically significant difference between the baseline thyroglobulin (natTg) and sTg levels and the positive PET/CT result. The administration of rhTSH before the PET/CT examination also had no statistically significant effect on the maximum standard uptake value (SUVmax) of the dominant lesion identified in the PET/CT.</p><p><strong>Conclusions: </strong>1) PET/CT with [¹⁸F]FDG is a useful tool for detection of non-radioiodine avid recurrence and/or metastases of DTC. 2) The concentration of natTg and sTg is highly correlated with a positive result of PET/CT with [¹⁸F]FDG. 3) The concentration of natTg is comparable with sTg in predicting a pos","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39303508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}