NUCLEAR MEDICINE REVIEW最新文献

{"title":"Incidental finding of a dermoid cyst in a whole-body iodine scan: importance of using [131I]SPECT/CT in the differentiated thyroid carcinoma.","authors":"Hadis Mohammadzadeh Kosari,&nbsp;Seyed Rasoul Zakavi,&nbsp;Somayeh Barashki,&nbsp;Hesamoddin Roustaei Firouzabad,&nbsp;Saeedeh Ataei Nakhaei,&nbsp;Kamran Aryana","doi":"10.5603/NMR.2021.0023","DOIUrl":"https://doi.org/10.5603/NMR.2021.0023","url":null,"abstract":"<p><p>A 33-year-old female with a history of total thyroidectomy for papillary thyroid carcinoma was referred to the nuclear medicine department for ablative radioiodine therapy. Post ablation scan showed an area of intense iodine uptake on the left side of the pelvic region, corresponding to the large well-defined heterogeneous mass in the left ovary in the SPECT/CT images. The radiologic features of this lesion were compatible with a dermoid cyst, previously unrecognized. Eventually, the lesion was laparoscopically removed, and a typical dermoid cyst was confirmed through histopathologic assessment.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"24 2","pages":"106-107"},"PeriodicalIF":0.9,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39313943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary skeletal muscle lymphoma with unusual soft tissue metastases in the stomach and pancreas detected by 18F-FDG PET/CT.","authors":"Fatemeh Farahmandfar,&nbsp;Sara Shakeri,&nbsp;Sadegh Moradian,&nbsp;Shirin Shahlaei,&nbsp;Ramin Sadeghi","doi":"10.5603/NMR.2020.0021","DOIUrl":"https://doi.org/10.5603/NMR.2020.0021","url":null,"abstract":"<p><p>A 69 y/o woman with a history of primary diffuse large B cell lymphoma in the right thigh muscle was referred for recurrence evaluation with 18F-FDG PET/CT. After routine courses of chemoradiation, MRI was done in order to evaluate treatment response with inconclusive findings. 18FDG PET/CT revealed abnormal uptake in the primary site of the disease as well as secondary involvement of stomach, pancreas, pelvic lymph nodes, and both tibiae. Our case showed the importance of 18F-FDG PET/CT in the detection of unusual soft tissue extension of lymphoma.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"108-109"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can inflammatory markers and clinical indices serve as useful referral criteria for leukocyte scan with inflammatory bowel disease?","authors":"Tihana Klarica Gembić,&nbsp;Domagoj Kustić,&nbsp;Josipa Vukšić,&nbsp;Dražen Huić","doi":"10.5603/NMR.a2020.0002","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0002","url":null,"abstract":"<p><strong>Background: </strong>In the follow-up of patients with inflammatory bowel disease (IBD), Tc-99m-HMPAO labelled leukocytes scintigraphy (leukocyte scan; LS) has long been established as a valuable diagnostic tool. The aim of this study was to estimate the relationship between scintigraphic results, inflammatory markers (IM) (including white blood cells (WBCs) and C-reactive protein (CRP)), clinical parameters and clinical indices of the disease activity (CI), in order to determine clinical settings in which LS is indicated.</p><p><strong>Materials and methods: </strong>A total of 147 patients who underwent LS, (79 males, 68 females, median age 36), were examined from April 2010 until December 2017 at the University Hospital Centre Zagreb, Croatia. Among these, 126 (86%) had Crohn's disease (CD) and 21 (14%) had ulcerative colitis (UC). Either increased IM (either WBCs ≥10x109/L and/or CRP ≥7.4 mg/L) and/or CI, Crohn's disease activity index (CDAI) score ≥220 points, Harvey-Bradshaw index (HBI) score ≥8 points, and severe colitis defined according to Truelove and Witts' criteria (TWC) for UC, respectively, were considered consistent with active disease.</p><p><strong>Results: </strong>Eighty-two patients (56%) had negative scans, while in 65 (44%) the scans were positive. Positive correlations were found between LS and all of the 3 parameters, WBCs, CRP and CI. When combined, the 3 parameters demonstrated even stronger positive correlation with the LS results with the correlation coefficient 0.76 (p<0.0001, 95% CI [0.68-0.82]). Using endoscopy and histological study findings of the obtained specimens as a composite reference standard, the overall sensitivity, specificity, positive predictive value and negative predictive value of IM and CI for LS were determined, being 91%, 85%, 83%, and 92%, respectively. IM and CI were both negative in 76 (52%) out of the total subjects. Of these, 70 had negative LS as well.</p><p><strong>Conclusion: </strong>In the presence of normal IM with CI pointing to no active or mildly active disease, LS is not necessarily indicated.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"15-20"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referral to radioisotope examination as a source of additional radiation exposure for staff.","authors":"Pawel Gadzicki,&nbsp;Wiesław Tryniszewski,&nbsp;Michał Świeczewski","doi":"10.5603/NMR.a2020.0003","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0003","url":null,"abstract":"<p><strong>Background: </strong>Every exposure of human to ionizing radiation increases the likelihood of deterministic sequelae. At the same time, it is associated with the risk of stochastic effects. Consequently, this can lead to cancer, mainly of the hematopoietic system. Organs or tissues show a different affinity for gamma radiation. There are many technical and organizational measures which minimize the impact of this radiation on people and especially on the staff of the nuclear medicine laboratory.</p><p><strong>Materials and methods: </strong>The study was based on 208 referrals to the scintigraphic laboratory, which were executed between 26.09.2018 and 13.11.2018 in the Department of Nuclear Medicine of Military Medical Academy Memorial Teaching Hospital of the Medical University of Lodz - Central Veterans` Hospital. Referrals concerned scintigraphic tests of bones, salivary glands, parathyroid glands, myocardial perfusion, somatostatin receptor analogues, renoscintigraphic and lymphoscintigraphic tests. In case of each referral, radiation power was measured at a distance of approx. 10 cm with the use of a calibrated Geiger-Muller detector. Measurements were performed immediately after the end of the last examination each day. Daily measurement of the background radiation dose was also a standard procedure. For calculations, this value was averaged to 0.18µSv/h. Based on the above measurements, a statistical analysis of all data was performed. Obtained data was also analysed after it was ascribed to the person complexing radiopharmaceuticals on a given day. The annual dose for a radiopharmacist is 0.12 mSv, for a technician 0.35 mSv and for a doctor 0.45 mSv.</p><p><strong>Results: </strong>The average radiation dose received every working day by the staff was 11.49 µSv/h. After considering the average distance from the potential source of exposure (50 cm), this power decreased to 0.46µSv/h. In order to calculate the quarterly and annual radiation dose, it was assumed that the employee worked 250 days a year.</p><p><strong>Conclusions: </strong>Medical records may pose an additional personnel exposure to ionizing radiation. Physicians are the most vulnerable group of employees. The way of radiopharmacists work contributes to the contamination of medical records.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"21-24"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental double neurinoma detected by 18F-choline PET/CT scan in a prostate cancer patient.","authors":"Francesco Dondi, Domenico Albano, Francesca Prandini, Francesco Bertagna, Raffaele Giubbini","doi":"10.5603/NMR.2020.0006","DOIUrl":"10.5603/NMR.2020.0006","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"40-41"},"PeriodicalIF":0.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter malposition during a direct radionuclide cystography - case report.","authors":"Shirin Shahlaei,&nbsp;Farnaz Nesari Javan,&nbsp;Atena Aghaee,&nbsp;Ramin Sadeghi","doi":"10.5603/NMR.2020.0020","DOIUrl":"https://doi.org/10.5603/NMR.2020.0020","url":null,"abstract":"<p><p>We reported a 15-year-old girl with a history of mild left vesicoureteral reflux who underwent direct radionuclide cystography in our department. Bladder catheterization was mistakenly placed in the vagina. The filling phase showed vagina and uterine cavity which was similar to vesicoureteral reflux. The procedure was repeated with correct catheterization of the bladder and no vesicoureteral reflux was noted.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"103-104"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value of dual-phase SPECT/CT scintigraphy based on transport kinetics of 99mTc-sestamibi confirmed with histopathological findings in patients with secondary hyperparathyroidism - practical consideration.","authors":"Maria H Listewnik,&nbsp;Hanna Piwowarska-Bilska,&nbsp;Krzysztof Safranow,&nbsp;Marek Ostrowski,&nbsp;Jacek Iwanowski,&nbsp;Maria Chosia,&nbsp;Bozena Birkenfeld","doi":"10.5603/NMR.a2020.0017","DOIUrl":"https://doi.org/10.5603/NMR.a2020.0017","url":null,"abstract":"<p><strong>Background: </strong>Dual phase 99mTc-sestamibi SPECT/CT preoperative parathyroid scintigraphy (PPS) is seldom discussed in terms of the transport kinetics of the tracer.</p><p><strong>Objectives: </strong>To assess the relationship between the characteristic type of tracer transport in particular PPS and histopathological findings in patients with secondary hyperparathyroidism (sHPT).</p><p><strong>Material and methods: </strong>The study comprised 27 patients (13 females and 14 males) with sHPT. Based on tracer accumulation in early phase (EP) and delayed phase (DP), the following types of accumulation for PPS(+) lesions were identified: EP(-)/ DP(+) (type I), EP(+)/DP(+) (type II), EP(+)/DP(-) (type III). EP(-)/DP(-) (type IV) lesions constituted PPS(-) group invisible in SPECT/CT. Overall, 69 lesions 59 PPS(+) and 10 PPS(-) were evaluated histopathologically.</p><p><strong>Results: </strong>Among SPECT/CT PPS(+), types I, II and III occurred in 9 (15%), 49 (83%), and 1 (2%) lesions, respectively. The frequency of histopathological diagnosis of normal and abnormal (APG - adenoma or hyperplasia) parathyroid gland, as well as non-parathyroid (thyroid, lymph nodes, or fat) lesions differed significantly between type I, II, and III lesions (p = 0.036). APG histopathological diagnosis was significantly more frequent in lesions with type II uptake than in lesions with type I uptake (76% vs. 33%, p = 0.0197). Type II lesions had significantly higher odds for histopathological diagnosis of APG or NPG than type IV, PPS(-) lesions [odds ratio = 13.1 (95% CI: 2.75 to 63.27)].</p><p><strong>Conclusions: </strong>For SHP patients evaluated with SPECT/CT PPS accumulation type I is a weak premise for surgeon to find parathyroid pathology. Only persistent 99mTc-sestamibi accumulation in both phases - equivocal with accumulation type II - effectively differentiates parathyroid and non-parathyroid lesions as well as indicates with high probability the presence of adenoma or hyperplasia. Type III consistent with washout pattern is rare in sHPT.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"71-77"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38542570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Efficiency Index - quantitative parameter of a dynamic renal scintigraphy. I. Theory and preliminary verification.","authors":"Krzysztof Grzegorz Filipczak,&nbsp;Pawel Cichocki,&nbsp;Jacek Kusmierek,&nbsp;Anna Plachcinska","doi":"10.5603/NMR.2020.0025","DOIUrl":"https://doi.org/10.5603/NMR.2020.0025","url":null,"abstract":"<p><strong>Background: </strong>One of the basic clinical indications for dynamic renal scintigraphy (DRS) is a diagnosis of obstructive uropathy and/or nephropathy. Currently, a basic quantitative criterion for diagnosing nephropathy is the percentage of individual kidney's contribution in the global uptake of a radiopharmaceutical from the blood (so-called Split Function - SF). From a clinical point of view, a parameter evaluating a radiopharmaceutical uptake and reflecting the efficiency of a specific kidney, determined independently of the total uptake of both kidneys, would be much more useful. Based on a Rutland theory, a kidney uptake constant K proportional to a radiotracer uptake by individual kidney was introduced and applied to DRS with 99mTc-ethylene-1-dicysteine (99mTc-EC). In addition, a kidney efficiency index (KEi) was also worked out as a new parameter obtained by dividing the uptake constant K by the surface of the ROI of a given kidney, which can be interpreted as the average \"efficiency\" of clearance of a kidney.</p><p><strong>Material and methods: </strong>K and KEi values were verified in 72 studies selected retrospectively from patients referred routinely for DRS, with available current level of blood creatinine, used for calculation of estimated GFR (eGFR) according to a CKD-EPI formula. After splitting of eGFR values into individual kidneys according to SF, single kidney eGFR values (SKeGFR) were obtained and then used as a verification method for SF, K and KEi values.</p><p><strong>Results: </strong>Correlation between SF and SKeGFR values, rsp = 0.64, was significantly weaker (p < 0.0022) than the correlation of SKeGFR values with K uptake constants and KEi indices: 0.90 and 0.84, respectively.</p><p><strong>Conclusions: </strong>Uptake constant K and KEi, as quantitative parameters, give the opportunity to analyze a function of each kidney separately and in an absolute way. KEi also allows for a reliable assessment of kidneys of atypical sizes (larger or smaller than average). It also gives the opportunity to create normative values for this parameter and may be useful in a number of clinical situations where the diagnostic effectiveness of such a relative parameter as SF, is severely limited, e.g. in assessing a large kidney with hydronephrosis or while differing a cirrhotic from hypoplastic (i.e. a small but properly functioning) kidney.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"78-83"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38542571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technetium pertechnetate uptake in parathyroid adenoma.","authors":"Ali Sellem, Wassim Elajmi, Hatem Hammami","doi":"10.5603/NMR.2020.0023","DOIUrl":"10.5603/NMR.2020.0023","url":null,"abstract":"","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 2","pages":"112"},"PeriodicalIF":0.6,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38445510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99mTc-DMSA Scintigraphy Revealed A Unilateral Multicystic Anomaly In A Horseshoe Kidney.","authors":"Sara Shakeri,&nbsp;Fatemeh Farahmandfar,&nbsp;Sadegh Moradian,&nbsp;Ramin Sadeghi","doi":"10.5603/NMR.2020.0009","DOIUrl":"https://doi.org/10.5603/NMR.2020.0009","url":null,"abstract":"<p><p>The multicystic dysplastic pattern in a half of a horseshoe kidney is a very uncommon presentation. We present a 6-month-old male infant with a history of antenatally unilateral cystic abnormality in the right kidney which was reevaluated after birth by ultrasonography (US) and 99m Tc-DMSA scintigraphy. The US showed a horseshoe kidney with the multicystic dysplastic area on the right side, which proved to be non-functional on 99m Tc-DMSA scintigraphy.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"23 1","pages":"47-48"},"PeriodicalIF":0.9,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}