World Journal of Acupuncture-Moxibustion最新文献

{"title":"Efficacy of warm needling in patients with persistent allergic rhinitis: A multicenter randomized controlled trial","authors":"Wen-bin NIE (聂文彬) ,&nbsp;Qi FAN (范琦) ,&nbsp;Yi-xuan FENG (丰逸轩) ,&nbsp;Yu-xiu SUN (孙玉秀) ,&nbsp;Shi-xi HUANG (黄石玺) ,&nbsp;Yong-ming YE (叶永铭) ,&nbsp;Ming-juan HAN (韩明娟) ,&nbsp;Wen-jing BAI (白文静) ,&nbsp;Hong ZHAO (赵宏)","doi":"10.1016/j.wjam.2025.09.009","DOIUrl":"10.1016/j.wjam.2025.09.009","url":null,"abstract":"<div><h3>Objective</h3><div>Although there is evidence to support the therapeutic effect of acupuncture on allergic rhinitis (AR), it is not clear whether acupuncture can achieve an efficacy comparable to that of pharmacological therapy. This multicenter, non-inferiority, single-blinded randomized controlled trial aimed to compare the differences in efficacy between warm needling (WN) therapy and loratadine (LO) in improving AR symptoms and quality of life.</div></div><div><h3>Methods</h3><div>A total of 98 patients with persistent AR (PAR) were randomly divided into two groups in a 1:1 ratio: treatment group receiving WN therapy at Dazhui (GV14) and normal acupuncture at other acupoints for 12 sessions in 4 weeks and control group receiving LO at a dosage of 10 mg/day for oral administration. The study duration was 28 weeks (4-week treatment period with a 24-week follow-up). The primary outcome was the mean change in the Total Nasal Symptom Score (TNSS) from baseline to week 28, and the secondary outcomes included the Total Non-Nasal Symptom Score (TNNSS) and the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score. Statistical analyses were conducted using SPSS22.0. Both intention-to-treat and treatment compliance analyses were performed to analyze all outcomes.</div></div><div><h3>Results</h3><div>After intervention, TNSS scores improved from baseline to week 28 by 5.18 (95 % confidence interval [CI]: 3.91, 6.45; <em>P</em> &lt; 0.001) in the WN group and 4.59 (95 % CI 3.28, 5.89; <em>P</em> &lt; 0.001) in the LO group, but the changes did not differ between the groups (<em>P</em> = 0.515). The margin by 95 % CI (−1.20, 2.38) was not reached, indicating non-inferiority. WN therapy resulted in clinical improvements in TNNSS, with a significant difference compared with LO treatment (<em>f</em> = 5.466, <em>P</em> = 0.021). WN therapy also resulted in clinical improvements in RQLQ scores, with a significant difference compared with LO (<em>f</em> = 9.222, <em>P</em> = 0.003).</div></div><div><h3>Conclusions</h3><div>WN therapy demonstrated comparable efficacy to oral LO in improving nasal symptoms of PAR. However, it showed superior effects in alleviating concomitant nasal symptoms and enhancing patients’ quality of life.</div><div>Clinical Trial Registration: <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Identifier NCT02339714.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 349-356"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence map of systematic reviews on acupuncture and moxibustion for prevention and management of cancer-related conditions","authors":"Xiao-yan LYU (吕笑颜) ,&nbsp;Xin-ru YUAN (袁馨如) ,&nbsp;Zi-yang FAN (樊紫阳) ,&nbsp;Jia-ni MA (马佳妮) ,&nbsp;Chang-qi LI (李昌奇) ,&nbsp;Xin-yang LI (李昕洋) ,&nbsp;Hui ZHANG (张慧) ,&nbsp;Li-yuan FU (傅丽媛) ,&nbsp;Bin-xu SUN (孙彬栩) ,&nbsp;Dan LI (李丹) ,&nbsp;Xiao-hua WEN (温小华) ,&nbsp;Tian-yi ZHAO (赵天易) ,&nbsp;Mei-dan ZHAO (赵美丹) ,&nbsp;Yi-nan GONG (公一囡) ,&nbsp;Bin WANG (王斌) ,&nbsp;Ao-xiang CHEN (陈翱翔) ,&nbsp;Yi GUO (郭义) ,&nbsp;Shi-yan YAN (闫世艳) ,&nbsp;Bo CHEN (陈波)","doi":"10.1016/j.wjam.2025.09.007","DOIUrl":"10.1016/j.wjam.2025.09.007","url":null,"abstract":"<div><h3>Objective</h3><div>In this study, we evaluated the methodological quality of systematic reviews on acupuncture and moxibustion for the prevention and management of cancer-related conditions, aiming to provide evidence-based support and establish levels of evidence for clinical application.</div></div><div><h3>Method</h3><div>A comprehensive search was conducted to identify systematic reviews on acupuncture and moxibustion for the prevention and management of cancer-related conditions, covering databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Databases, China Science and Technology Journal Database, and Wanfang Data, from their inception to August 1, 2024. The methodological quality of the included systematic reviews was assessed by using AMSTAR 2, and bubble plots were employed to visualize the evidence.</div></div><div><h3>Results</h3><div>Overall, 137 systematic reviews were included, with China being the most prolific country, with 117 reviews. These reviews addressed 21 cancer-related conditions, with the three most frequently studied being cancer-related fatigue (25 reviews), nausea and vomiting (20 reviews), and cancer pain (19 reviews). The three most commonly used acupuncture modalities were manual acupuncture (81 reviews), electroacupuncture (55 reviews), and moxibustion (39 reviews). Quality assessment revealed that one systematic review was rated as ``high quality,” eight as ``low quality,” and 128 as ``critically low quality,” primarily due to the absence of protocol registration and lists of excluded studies.</div></div><div><h3>Conclusion</h3><div>Acupuncture and moxibustion have shown potential efficacy in alleviating cancer-related conditions and treatment-related adverse effects, and their clinical use has been widely reported. However, the overall methodological quality of the included systematic reviews was low, limiting the reliability and the strength of the evidence. Future high-quality studies are needed to improve the quality of evidence and support the standardized application and broader promotion of acupuncture and moxibustion clinical practice.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 290-302"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of tumor growth inhibition by electroacupuncture in breast cancer-bearing mice","authors":"Xue-chao HUANG (黄学超) ,&nbsp;Jing-xuan LIU (刘敬萱) ,&nbsp;Tian-yu LI (李天玉) ,&nbsp;Rui ZHANG (张锐) ,&nbsp;Qian MO (默倩) ,&nbsp;Guo-wu LEI (雷国伍) ,&nbsp;Ran-ran LIU (刘冉冉) ,&nbsp;Chun-sheng JIA (贾春生) ,&nbsp;Li-Jia PAN (潘丽佳)","doi":"10.1016/j.wjam.2025.07.001","DOIUrl":"10.1016/j.wjam.2025.07.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To explore the mechanism of electroacupuncture (EA) on inhibiting tumor growth in breast cancer-bearing mice.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Thirty Bagg Albino (c) (BALB/c) mice were randomly divided into a sham-operation group, a tumor group, a chemotherapy group, and an acupuncture group, and an EA group, with six mice in each one. Except in the sham-operation group, 4T1 cells were injected into the fourth mammary fat pad on the right side of each mouse in the rest groups to develop breast-cancer bearing models. In the sham-operation group, the sham operation was underwent by injecting normal saline with the same volume as 4T1 cell suspension. After successful modeling, the intraperitoneal injection of doxorubicin solution was delivered in the chemotherapy group. In the acupuncture group, needles was inserted at “Zusanli” (ST36) and “Sanyinjiao” (SP6) perpendicularly, without manipulation, once daily and needles were retained for 15 min. In the EA group, on the basis of the operation as the acupuncture group, electric stimulation was attached to “ST36” (positive electrode) and “SP6” (negative electrode), once daily, 15 min each time. Starting on Day 1 of intervention, the changes of tumor volume was observed once every two days in each group photographed. The sample was collected on Day 21 of intervention. The tumors were photographed and weighed. Hematoxylin-eosin (HE) staining was used to observe the pathological changes of tumor tissue. Western blot, fluorescence quantitative polymerase chain reaction (FQ-PCR), and immunohistochemistry (IHC) were adopted to detect the protein expression, mRNA expression, and positive expression of CYLD, BCL-3, and P50 in tumor tissue, respectively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;(1) The tumor volume in the tumor group, chemotherapy group, acupuncture group, and EA group was (815.67 ± 275.61) mm&lt;sup&gt;3&lt;/sup&gt;, (197.50 ± 66.11) mm&lt;sup&gt;3&lt;/sup&gt;, (412.62 ± 58.96) mm³, and (327.51 ± 125.46) mm&lt;sup&gt;3&lt;/sup&gt;, respectively, and the tumor mass was (1.21 ± 0.39) g, (0.39 ± 0.05) g, (0.66 ± 0.06) g, and (0.55 ± 0.11) g on Day 21 of intervention, respectively. Compared with the tumor group, the tumor volume and mass were lower in the chemotherapy group, acupuncture group, and EA group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). (2) Respectively, in the tumor group, chemotherapy group, acupuncture group, and EA group, the mRNA expression of CYLD in tumor tissue was 1.01 ± 0.19, 2.90 ± 0.24, 2.55 ± 0.03, and 4.01 ± 0.32; the protein expression was 1.00 ± 0.00, 1.88 ± 0.16, 1.64 ± 0.11, and 2.30 ± 0.29; and the positive expression was 0.06 ± 0.01, 0.11 ± 0.01, 0.11 ± 0.004, and 0.14 ± 0.003. Compared with the tumor group, the mRNA expression, protein expression, and positive expression of CYLD were higher in the intervention groups (&lt;em&gt;P&lt;/em&gt; &lt; 0.05), and each expression in the EA group was higher in comparison with the chemotherapy and acupuncture groups (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). (3) The mRNA expression ","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 367-375"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for the treatment of temporomandibular disorders: A systematic review and meta-analysis","authors":"Quan MIAO (苗荃),&nbsp;Qiu-yi CHEN (陈秋怡),&nbsp;Sheng-xian LI (李晟贤),&nbsp;Wo-yu WANG (王握瑜),&nbsp;Li-min NIE (聂利敏),&nbsp;Shu-ting LI (郦淑婷),&nbsp;Ying LIN (林颖),&nbsp;Yu-han LIU (刘昱含),&nbsp;Lu LIU (刘璐),&nbsp;Bin LI (李彬)","doi":"10.1016/j.wjam.2025.09.002","DOIUrl":"10.1016/j.wjam.2025.09.002","url":null,"abstract":"<div><h3>Background</h3><div>Temporomandibular disorders (TMD) are the leading cause of chronic orofacial pain, which significantly affects patients’ quality of life. However, the efficacy of acupuncture in the management of TMD remains unclear.</div></div><div><h3>Objective</h3><div>This systematic review aimed to conduct a PRISMA-compliant review to critically assess the therapeutic efficacy of acupuncture as an intervention for patients with TMD.</div></div><div><h3>Methods</h3><div>We searched nine electronic databases for randomized controlled trials on acupuncture for TMD published up to February 4, 2025. Eligible studies included adults diagnosed with TMD and compared acupuncture (manual, electroacupuncture, warm, auricular, thread-embedding, or laser) with conservative treatment (positive control) or sham acupuncture (negative control). Outcomes included pain intensity, mouth opening, pressure pain threshold, and adverse events. Risk of bias was assessed using ROB 2, and certainty of evidence was evaluated using GRADE. All outcome data were analyzed using RevMan 5.4 software. Low heterogeneity was defined as <em>I</em>² ≤ 50% and <em>P</em> ≥ 0.1, in which case a fixed-effects model was applied. High heterogeneity (<em>I</em>² &gt; 50% or <em>P</em> &lt; 0.1) prompted further analysis to identify its source. After excluding the influence of evident heterogeneity, a random-effects model was used for the meta-analysis.</div></div><div><h3>Results</h3><div>Of the 2664 screened records, 14 randomized controlled trials involving 476 participants met the inclusion criteria. Acupuncture significantly reduced pain intensity compared with that of negative controls (MD = −1.75, 95% confidence interval [CI] −2.47 to −1.03; <em>P</em> &lt; 0.00001; I² = 60%) but showed no difference compared with that of positive controls (MD = −0.06, 95% CI −0.62 to 0.50; <em>P</em> = 0.83; I² = 0%). No significant differences were observed in pain-free jaw opening, whereas acupuncture improved maximum mouth opening relative to negative controls (MD = 1.80, 95% CI 1.62 to 1.97; <em>P</em> &lt; 0.00001; I² = 0%). For pressure pain threshold, two small studies suggested greater increases with acupuncture. Safety data were limited, with only one trial reporting mild adverse events in the acupuncture group.</div></div><div><h3>Conclusion</h3><div>Based on limited evidence, acupuncture appears superior to negative controls in relieving pain associated with TMD but shows no significant advantage over positive controls. The certainty of the evidence for all outcomes, as assessed by GRADE, was low or very low. Therefore, these findings should be interpreted with caution. Future high-quality randomized controlled trials are warranted to further evaluate the role of acupuncture in the management of patients with TMD.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 320-330"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture treatment for Bartholin’s abscesst: A case report and literature review","authors":"Xiao-xuan GENG (耿晓萱),&nbsp;Sheng CHEN (陈晟),&nbsp;Wen-yi YANG (杨文夷),&nbsp;Mei-lun HUANG (黄美伦),&nbsp;Jia-le KANG (康家乐)","doi":"10.1016/j.wjam.2025.09.005","DOIUrl":"10.1016/j.wjam.2025.09.005","url":null,"abstract":"<div><div>A 30-year-old female patient with Bartholin’s abscess was treated by acupuncture. Before visit, she had taken <em>wuwei xiaodu yin</em> for 4 consecutive days, but the symptoms were not alleviated markedly and pain was worsening. According to the conditions of tongue and pulse, and physical signs, the case was differentiated as pathogenic heat invading blood phase; and the injury of <em>qi</em> and <em>yin</em> by the herbal decoction the patient took before. In treatment with acupuncture, the treatment principle focused on benefiting <em>qi</em>, nourishing <em>yin</em>, expelling pus from the interior and draining toxin, and promoting the circulations of meridians to stop pain. <em>He</em>-sea points were selected to clear heat and resolve damp, and replenish the liver and kidney; and the acupoints of bladder meridian were combined under the guidance of “<em>taiyang</em> dominating the openings,” aiming at elevating <em>qi</em> and expelling toxin from the interior. Acupuncture was given once daily. After treated for 4 days, abscess was ruptured, pain disappeared, and no recurrence was presented and no sequelae happened during over 2 years of follow-up. This case shows that acupuncture is effective on Bartholin’s abscess. By reviewing this case, it is put forward that there may by the signs before the onset of Bartholin’s abscess, and the treatment should focus on opening a way for eliminating pathogens. Moreover, the clinical trial is required to verify acupuncture effect on this disease.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 384-387"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenergic agonist therapy and emerging acupuncture targets in asthma: A review of mechanisms and therapeutic implications","authors":"Jin LU (卢进) ,&nbsp;Jun-tao FENG (冯俊涛) ,&nbsp;Lei-miao YIN (尹磊淼) ,&nbsp;Yong-qing YANG (杨永清)","doi":"10.1016/j.wjam.2025.08.002","DOIUrl":"10.1016/j.wjam.2025.08.002","url":null,"abstract":"<div><div>The development of adrenergic agonists (AAs) for asthma has provided important mechanistic insights into acupuncture-based target discovery and treatment strategies. This review describes the historical evolution of AA therapy, including the precise optimization of nonselective to β₂-selective agonists, improvement from short-acting to ultra-long-acting agents, shift from targeted monotherapy to combination regimens, and alterations in drug formulation. Additionally, this review summarizes recent advances in acupuncture treatment for asthma, including the development of novel targeted therapies, application of acupuncture-based combination regimens, and optimization of the mode of administration. Taken together, this article discusses key insights from research on AA that inform acupuncture approaches, with a focus on: (1) precision targeting: identifying acupuncture-specific targets to improve efficacy; (2) synergistic treatment: employing multi-target combination regimens to enhance therapeutic outcomes; (3) formulation innovation: advancing acupuncture delivery methods to improve patient compliance; and (4) evidence-based development: strengthening clinical research to generate high-quality evidence to inform the discovery of novel targets and treatment strategies for asthma.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 269-275"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of motion style acupuncture treatment in rehabilitation medicine","authors":"Ye-tong CHEN (陈烨彤) ,&nbsp;Feng-lin ZHU (朱凤林) ,&nbsp;Yang ZHU (朱洋) ,&nbsp;Yu-cheng DUAN (段玉丞) ,&nbsp;Zhen-min BAI (白震民)","doi":"10.1016/j.wjam.2025.08.004","DOIUrl":"10.1016/j.wjam.2025.08.004","url":null,"abstract":"<div><div>This review summarizes the clinical applications and mechanisms of action of motion-style acupuncture (MSAT) in rehabilitation medicine. Patients are required to perform active or passive movements while the acupuncture needles are inserted. Owing to its effectiveness, MSAT is progressively applied in clinical settings, including musculoskeletal and neurological diseases. Acupuncture and exercise generate synergistic effects through interactive mechanisms. From the perspective of the Traditional Chinese Medicine (TCM) theory, needling with movement can trigger the propagation of the needling sensation, thereby enhancing its efficacy in dredging meridians and regulating <em>qi</em>-blood circulation. In modern medicine, these mechanisms include neural inhibition, ischemia/reperfusion, and fascial stimulation propagation. Although the clinical applications and mechanism research of MSAT in rehabilitation medicine have advanced, the mechanisms of MSAT in treating various diseases and the scope of applicable diseases warrant deeper exploration. This will provide novel therapeutic strategies for clinical applications, thereby advancing the integration and application of TCM therapies with exercise-based interventions.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 303-311"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroplasticicity mechanism of acupuncture for pain-induced emotions: From function to structure","authors":"Hong-yu LU (卢宏玉),&nbsp;Bao-jin WANG (王宝金),&nbsp;Cui MA (马翠),&nbsp;An-guo LIU (刘安国),&nbsp;Xing-ke YAN (严兴科)","doi":"10.1016/j.wjam.2025.07.003","DOIUrl":"10.1016/j.wjam.2025.07.003","url":null,"abstract":"<div><div>Pain-induced emotions are the negative moods caused by pain, such as depression and anxiety. Acupuncture can effectively relieve pain-induced emotions, and its mechanism is closely related to the regulation of neuroplasticity. Neuroplasticity is composed of two types, functional neuroplasticity and structural neuroplasticity. (1) Acupuncture improves functional neuroplasticity by inhibiting the activation of microglia and astrocytes, regulating the expression of neurotransmitters and receptors, modulating cellular signal transduction pathways, and optimizing synaptic transmission efficiency. (2) Acupuncture improves structural neuroplasticity by modulating neuronal synaptic plasticity, inhibiting neuronal apoptosis, and up-regulating the expression of the BDNF/TrKB/CREB signaling pathway. Additionally, acupuncture up-regulates the expression of brain-derived neurotrophic factors to improve both the functional and structural neuroplasticity, thus relieves pain-induced emotions. The above discovery provides an approach to the mechanism research of acupuncture for pain-induced emotions.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 276-282"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inheritance and development of Lian ZHU’s acupuncture academic thought in the construction of Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences","authors":"Yu ZHOU (周宇),&nbsp;Zhong-chao WU (吴中朝),&nbsp;Peng WU (吴鹏)","doi":"10.1016/j.wjam.2025.08.001","DOIUrl":"10.1016/j.wjam.2025.08.001","url":null,"abstract":"<div><div>This paper exhibits the construction and development of Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences (CACMS), based on Lian ZHU’s acupuncture academic thought, focusing on the practice of the hospital development during the past 74 years, from 1951 to 2025, and by analyzing the development trajectory and elaborating the four-dimensional collaborative development mode guided by Lian ZHU’s thought, grounded in clinical evidence, driven by scientific innovation, guided by international standards, and rooted in educational inheritance. (1) After more than 70 years of development, Acupuncture and Moxibustion Hospital of CACMS has developed into the typical small-scaled general hospital of traditional Chinese medicine (TCM) with acupuncture-moxibustion as the main intervention, and has obtained a fruitful achievement in academic research. (2) The Hospital has led and participated in the formulation of a number of clinical practice guidelines of China Association of Acupuncture and Moxibustion, is entitled as the World Health Organization Collaborating Centre for traditional medicine, and has been ranked among the top in the outpatient visits of acupuncture-moxibustion department of TCM hospitals in Beijing for years. (3) There is a well-known professional team of acupuncture-moxibustion of TCM in the Hospital, and with the characteristic modes of acupuncture-moxibustion diagnosis and treatment delivered, the remarkable curative effects have been obtained in treatment of diseases in neurological, gynecological diseases, orthopedic departments, as well as pain disorders, allergic diseases. (4) In the future, facing the opportunities and challenges in the development of global healthcare, it is necessary to deepen the research on “intelligent acupuncture and moxibustion”, integrating modern technologies such as artificial intelligence and big data, exploring the potential value of acupuncture and moxibustion, discovering and innovating theoretical research on acupuncture and moxibustion, establishing scientific methods, standardizing clinical operation techniques, and driving the creative transformation of TCM. (5) The hospital lays the great consideration to the cultivation of acupuncture-moxibustion talents by means of multiple approaches, in order to deeply grasp the essence of TCM and improve the comprehensive quality of talents. (6) The hospital keeps on the leading role of international communication, advancing the international exchange and cooperation of acupuncture and moxibustion, and contributes more eastern wisdom to global health governance, and promote acupuncture and moxibustion of TCM, the treasure of the Chinese nation to display its importance in the world.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 388-392"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential mechanism of acupuncture on overeating and the significance in preventing and treating adiposity-based chronic disease: A new perspective based on the addiction model","authors":"Pei-ming ZHANG (张培铭) ,&nbsp;Dan-chun LAN (蓝丹纯) ,&nbsp;Ting-ting GU (谷婷婷) ,&nbsp;Jia-hua WU (吴佳华) ,&nbsp;Rui-rui TAO (陶睿睿) ,&nbsp;Chun-zhi TANG (唐纯志) ,&nbsp;Zi-yong LI (李子勇) ,&nbsp;Li-ming LU (陆丽明)","doi":"10.1016/j.wjam.2025.09.001","DOIUrl":"10.1016/j.wjam.2025.09.001","url":null,"abstract":"<div><div>Overeating is a risk factor and a management challenge in adiposity-based chronic disease (ABCD). Acupuncture has shown high safety and reliable clinical evidence in addressing overeating, and it is the promising potential non-pharmacological intervention. However, the mechanism underlying its effects has not been sufficiently summarized. The addiction model offers a framework to elucidate the mechanism of this aberrant eating behavior and provides novel perspectives and breakthrough points for optimizing clinical acupuncture strategies in ABCD management. In the paper, through analyzing domestic and international relevant findings, the characteristics of overeating based on food addiction, the relationship between overeating and ABCD, and the potential effect mechanisms of acupuncture for FA have been reviewed and summarized. Including adaptive balance of transmitters and hormones, functional networks, periphery-central connection, and cross-system interaction. In future studies, the maturely-developed addiction research methods should be adopted to deepen the exploration on the mechanism of acupuncture effect, addiction medicine should be leveraged to shatter the cognitive barriers surrounding acupuncture's role in mind-body regulation for ABCD treatment, and the prevention and treatment of overeating via acupuncture should be organically integrated into multidisciplinary management strategies.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 312-319"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}