World Journal of Acupuncture-Moxibustion最新文献

{"title":"Optimization and principles of acupoint selection and coordination in the treatment of adult abdominal obesity using acupuncture and moxibustion over the past decade: A data mining","authors":"Jia-xin SHEN (沈佳欣) ,&nbsp;Tian-yun HUANG (黄天韵) ,&nbsp;Zhou HAO (郝舟) ,&nbsp;Guang-bin PENG (彭广彬) ,&nbsp;Yue-ying MA (马玥樱) ,&nbsp;Huan-gan WU (吴焕淦) ,&nbsp;Chun-hui BAO (包春辉)","doi":"10.1016/j.wjam.2025.06.008","DOIUrl":"10.1016/j.wjam.2025.06.008","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the optimization and principles of acupoint selection and coordination in the treatment of adult abdominal obesity using acupuncture and moxibustion over the past decade using data mining.</div></div><div><h3>Methods</h3><div>Clinical studies of abdominal obesity treated with acupuncture and moxibustion, collected in the past 10 years, were searched from China Biology Medicine disc(CBMdisc), China National knowledge infrastructure (CNKI), Wanfang, China Science and Technology Journal Database(VIP), Pubmed, Embase, Google Scholar, Web of Science, (The Cumulative Index to Nursing and Allied Health Literature)CINAHL, Psyclnfo and Scopus, dated from March 1, 2013 to March 31, 2023. Using IBM SPSS Modeler 18.0 and other software, the frequency analysis, association-rules analysis and cluster analysis were conducted on interventions, traditional Chinese medicine(TCM) patterns, use frequency of acupoint, meridian attribution of acupoint, acupoint location, etc.</div></div><div><h3>Results</h3><div>A total of 55 articles were included, with 102 prescriptions and 71 acupoints involved. The top 3 interventions were acupoint embedding method, simple electroacupuncture and simple filiform needling. Seventeen patterns/syndromes of TCM differentiation were collected, dominated by spleen deficiency and damp blockage, spleen and kidney <em>yang</em> deficiency and heat accumulation in stomach and intestines. The acupoints in clinical practice were mostly at the foot-<em>yangming</em> stomach meridian, the conception vessel and the foot-<em>taiyin</em> spleen meridian, and located at the abdominal region. The top 5 acupoints of high frequency were Tianshu (ST25), Zhongwan (CV12), Daheng (SP15), Zusanli (ST36), Huaroumen (ST24) and Daimai (GB26). The specific points of the high frequency were the crossing points and front-<em>mu</em> points, of which, ST25 and CV12 were the most prominent. After association-rules analysis on the high-frequency acupoints, 20 groups of associated acupoints were obtained, in which, the core acupoints included ST25, CV12, SP15 and ST36.</div></div><div><h3>Conclusion</h3><div>In recent 10 years, abdominal obesity is treated by the acupoints of foot-<em>yangming</em> stomach meridian, the conception vessel and the foot-<em>taiyin</em> spleen meridian. Compared with the regimen for simple obesity, the acupoints at the abdominal region are specially selected in treatment of abdominal obesity, such as ST25, CV12, SP15 and ST36. Supplementary acupoints are selected based on syndrome differentiation to simultaneously address both the disease manifestations and root causes.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 223-231"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological interventions for temporomandibular disorders: A systematic review and meta-analysis","authors":"Qiu-yi CHEN (陈秋怡),&nbsp;Quan MIAO (苗荃),&nbsp;Fei-yu FU (付飞羽),&nbsp;Ying LIN (林颖),&nbsp;Chen-xi ZENG (曾晨曦),&nbsp;Pei-yue PENG (彭佩玥),&nbsp;Yi-xin ZHANG (张艺馨),&nbsp;Lu LIU (刘璐),&nbsp;Bin LI (李彬)","doi":"10.1016/j.wjam.2025.05.002","DOIUrl":"10.1016/j.wjam.2025.05.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;A temporomandibular disorders (TMDs) is a musculoskeletal and neuromuscular condition that affects the temporomandibular joint, masticatory muscles, and associated tissues. Non-pharmacological interventions are currently considered as potential therapies for TMDs. However, high-quality systematic reviews and meta-analyses evaluating their clinical efficacy are lacking.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study aimed to evaluate the clinical efficacy of non-pharmacological interventions for TMDs, focusing on their impact on pain relief, jaw mobility, and functional improvement. Specifically, we aimed to compare the effectiveness of four non-pharmacological interventions, including acupuncture, exercise, occlusal splinting, and laser therapy, for treating TMDs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Comprehensive searches for randomized controlled trials (RCTs) were conducted in PubMed, Web of Science, Scopus, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, China Biomedical Literature Database (SinoMed), VIP, and Wanfang databases. The primary outcome was visual analog scale (VAS) score. The secondary outcomes included pain-free mouth opening, maximum assisted and unassisted mouth opening, and occurrence of adverse events. We used the Cochrane Risk of Bias tool and the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the risk of bias and the quality of evidence. The meta-analysis was performed using RevMan 5.4 software.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 22 RCTs involving 717 patients with TMDs were included. Non-pharmacological interventions significantly reduced VAS scores (n=19; mean difference [MD]= –1.86, 95 % confidence interval [CI] –2.40 to –1.31; &lt;em&gt;Z&lt;/em&gt;=6.68; &lt;em&gt;P&lt;/em&gt;&lt;0.05) and improved the pain-free mouth opening (n=6; MD=6.92, 95 % CI 4.91 to 8.94; &lt;em&gt;Z&lt;/em&gt;=6.73; &lt;em&gt;P&lt;/em&gt;&lt;0.05) and maximum unassisted mouth opening (n=10; MD=4.05, 95 % CI 2.08 to 6.02; &lt;em&gt;Z&lt;/em&gt;=4.04; &lt;em&gt;P&lt;/em&gt;&lt;0.05) in patients with TMDs. However, non-pharmacological interventions did not show a significant effect on maximum assisted mouth opening (n=2; MD=0.33, 95 % CI –4.16 to 4.82; &lt;em&gt;Z&lt;/em&gt;=0.15; &lt;em&gt;P&lt;/em&gt;=0.88). Only one RCT reported the occurrence of adverse events. Subgroup analysis showed that acupuncture (n=6; MD= –1.52, 95 % CI –2.86 to –0.18; &lt;em&gt;Z&lt;/em&gt;=2.22; &lt;em&gt;P&lt;/em&gt;=0.03), exercise (n=4; MD= –1.12, 95 % CI –1.94 to –0.31, &lt;em&gt;Z&lt;/em&gt;=2.70; &lt;em&gt;P&lt;/em&gt;&lt;0.05), occlusal splint (n=5; MD= –2.00, 95 % CI –2.67 to –1.33, &lt;em&gt;Z&lt;/em&gt;=5.88; &lt;em&gt;P&lt;/em&gt;&lt;0.05), and laser therapy (n=4; MD= –2.81, 95 % CI –3.89 to –1.73, &lt;em&gt;Z&lt;/em&gt;=5.10, &lt;em&gt;P&lt;/em&gt;&lt;0.05) were significantly superior to control treatments in reducing VAS scores. In addition, acupuncture (n=2; MD=6.50, 95 % CI 3.87 to 9.13; &lt;em&gt;Z&lt;/em&gt;=4.85; &lt;em&gt;P&lt;/em&gt;&lt;0.05), occlusal splint (n=2; MD=8.33, 95 % CI 4.41 to 12.24; &lt;em&gt;Z&lt;/em&gt;=4.17; &lt;em&gt;P&lt;/em&gt;&lt;0","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 182-196"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture-moxibustion for chemotherapy-induced peripheral neuropathy: A systematic review and network meta-analysis","authors":"Yan LI (李岩) ,&nbsp;Shuang LIU (刘双) ,&nbsp;Hai-fa QIAO (乔海法)","doi":"10.1016/j.wjam.2025.06.001","DOIUrl":"10.1016/j.wjam.2025.06.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Chemotherapy-induced peripheral neuropathy (CIPN) is a common neurotoxic reaction for patients undergoing anticancer regimens. More and more studies show that acupuncture-moxibustion plays a positive role in the management and prevention of CIPN.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To evaluate the clinical effect of acupuncture-moxibustion in patients with CIPN, with a focus on assessing its effectiveness on improving treatment response rates, alleviating pain, enhancing quality of life (QoL), and improving nerve conduction. Additionally, the study compares the differences in clinical effectiveness among various acupuncture therapies for CIPN management.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Six databases (PubMed, Embase, Cochrane Library, Web of Science, OVID, and China National knowledge infrastructure [CNKI]) were searched from earliest available dates to December 1, 2024, and only randomized controlled trials (RCTs) containing relevant search terms were included. Network meta-analysis of the RCT data were conducted to assess the effective rate of the treatment as the primary outcome. Nerve conduction, pain scores, and QoL were assessed as secondary outcomes. The version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) was used to examine methodological quality, and Stata 15.1 was used to take network meta-analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 34 RCTs involving 2039 participants and 9 acupuncture-moxibustion therapies were included. The network meta-analysis evaluated the effect of different acupuncture therapies across four outcomes: effective rate, pain scores, QoL, and nerve conduction. For effective rate, electroacupuncture combined with moxibustion ranked first with a surface under the cumulative ranking curve (SUCRA) value of 62.9 %, followed by acupoint application (56.9 %) and moxibustion (52.3 %). Electroacupuncture combined with moxibustion had the highest effective rate compared to standard of care treatments (odds ratio [OR] = 1.62, 95 % confidence interval [CI] −5.18 to 8.43). For alleviating pain, auricular acupressure had the highest SUCRA value (85.9 %), while electroacupuncture and electroacupuncture combined with three-edged needle ranked second (63.4 %) and third (51.0 %), respectively. Auricular acupressure significantly reduced pain (SMD= −1.73, 95 % CI −3.54 to 0.08). For QoL, warming needle ranked first (SUCRA= 92.0 %), followed by electroacupuncture (48.7 %) and filiform needle (43.0 %). Warming needle significantly improved QoL scores (SMD= −0.75, 95 % CI −1.66 to 0.15). For nerve conduction, electroacupuncture combined with three-edged needle had the highest SUCRA value (100 %), while moxibustion and filiform needle ranked second (65.3 %) and third (39.2 %), respectively. Electroacupuncture combined with three-edged had the best neuroprotective effect (SMD = 1.85, 95 % CI 1.23 to 2.47).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Network meta-analysis bas","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 197-207"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the mechanism of neural electrical information transmission in acupuncture intervention of depression","authors":"Shu-juan LI (李蜀娟) ,&nbsp;Min XIAO (肖敏) ,&nbsp;Chong-bing MA (马重兵) ,&nbsp;Xing-ke YAN (严兴科)","doi":"10.1016/j.wjam.2025.06.004","DOIUrl":"10.1016/j.wjam.2025.06.004","url":null,"abstract":"<div><div>Acupuncture has been proven effective in treating depressive disorders, and its neuroelectrophysiological mechanisms have drawn increasing scientific attention. This paper reviews recent neuroelectrophysiological studies on acupuncture in the treatment of depressive disorders. Studies have shown that acupuncture can modulate the Alpha and Theta wave frequencies and amplitudes of electroencephalograms; improve the latency and amplitude of event-related potential such as P300 and mismatch negativity (MMN); enhance the amplitude of motor-evoked potential and short-interval intracortical inhibition as measured by transcranial magnetic stimulation-electromyography (TMS-EMG); regulate both spontaneous and induced rhythmic activities; increase motor cortex excitability; and promote the electrical signal transmission in neuronal clusters. Acupuncture can enhance the long-term potentiation (LTP) detected by PCRT, repair the plasticity of synaptic functions, and promote the transmission of synaptic information; lower the action potential (AP) and population spike (PS) membrane voltage detected by PCRT, inhibit abnormal neuronal excitability, and restore electrical signal transmission across neuronal membranes. These findings, as summarized in this review, may reflect potential neuroelectrical signal transmission mechanisms involved in the acupuncture interventions for depressive disorders.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 167-172"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The analgesic effect and ATP release at acupuncture points in response to acupuncture with different parameters on arthritis rats","authors":"Jie LIN (林捷) ,&nbsp;Kai-yu CUI (崔凯宇) ,&nbsp;Yu-jia LI (李雨佳) ,&nbsp;Wei-min ZUO (左维敏) ,&nbsp;Jing-wen XU (徐靖雯) ,&nbsp;Xue-yong SHEN (沈雪勇) ,&nbsp;Guang-hong DING (丁光宏) ,&nbsp;Xiao-long TANG (汤晓龙) ,&nbsp;Li-na WANG (汪丽娜)","doi":"10.1016/j.wjam.2025.06.002","DOIUrl":"10.1016/j.wjam.2025.06.002","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies indicated a close correlation between manual acupuncture (MA) analgesia and the mobilization of extracellular adenosine triphosphate (ATP) at the acupoints. This study attempted to investigate whether this relationship is altered with the manipulation patterns of MA. Additionally, we further testified whether these two events parallelly varied with different frequencies of electroacupuncture (EA).</div></div><div><h3>Methods</h3><div>Male SD rats were randomly divided into four groups: blank group, model group, MA group, and EA group. MA group was further divided into four sub-groups: standard MA, sham MA, lifting-thrusting MA, and shallow MA. Similarly, EA group was categorized based on current frequency into 2 Hz, 2–100 Hz, 100 Hz, and ARL67156+100 Hz sub-groups. For the behavioral tests, each group comprised 4–8 rats; for extracellular ATP assessment, each group consisted of 3–6 rats. Complete Freund’s adjuvant (CFA) was injected into the left ankle joint cavity to create an acute adjuvant arthritis (AA) model. A 20-minute session of either MA at left Zusanli (ST36) or EA at bilateral ST36 was administered on AA rats. Thermal hyperalgesia of the hind paw was determined. Extracellular ATP in the interstitial space at ST36 (inters. ATP) was extracted using microdialysis and quantified via a luciferase-luciferin assay.</div></div><div><h3>Results</h3><div>Modeling induced tenderness at ST36 (<em>P</em> <em>&lt;</em> <em>0.001</em>) and higher ATP mobilization (<em>P</em> <em>&lt;</em> <em>0.05</em>) in response to MA. Both standard MA (<em>P</em> <em>&lt;</em> <em>0.001</em>) and lifting-thrusting manipulation (<em>P</em> <em>&lt;</em> <em>0.001</em>) exhibited a remarkable analgesic effect, which was not observed with sham MA, deep insertion plus retention. Verum MA (<em>P</em> <em>&lt;</em> <em>0.001</em>) rather than sham intervention, significantly elevated inters. ATP levels. Notably, shallow MA, penetrating the skin layer and needling with twirling-rotating, demonstrated analgesia and increasing inters. ATP level (<em>P</em> <em>&lt;</em> <em>0.05</em>). Regarding EA, treatments at frequencies of 2 Hz (<em>P</em> <em>&lt;</em> <em>0.01</em>), 2–100 Hz (<em>P</em> <em>&lt;</em> <em>0.05</em>), and 100 Hz (<em>P</em> <em>&lt;</em> <em>0.05</em>) significantly alleviated pain. Only the 2–100 Hz (<em>P</em> <em>&lt;</em> <em>0.05</em>) and 100 Hz (<em>P</em> <em>&lt;</em> <em>0.01</em>) interventions, particularly in the latter, potentiated ATP mobilization. Preventing ATP hydrolysis dampened the analgesic effects of the standard MA and 100 Hz EA.</div></div><div><h3>Conclusion</h3><div>There is a general correlation between ATP mobilization at the acupoint and the analgesic effect of MA and EA. However, the underlying mechanisms related to shallow MA and 2 Hz EA remain to be elucidated.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 254-261"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture attenuates retinal ischemia/reperfusion injury by protecting the outer blood-retina barrier via enkephalins activate delta opioid receptor","authors":"Ping CHEN (陈平) ,&nbsp;Xian-dan ZHU (朱娴丹) ,&nbsp;Run-jie GUO (郭润杰) ,&nbsp;Yong XIA (夏勇) ,&nbsp;Jing-ling JIN (金京玲) ,&nbsp;Nan-ge JIN (金南革) ,&nbsp;Ying-min GU (谷颖敏) ,&nbsp;Xue-song TIAN (田雪松)","doi":"10.1016/j.wjam.2025.05.001","DOIUrl":"10.1016/j.wjam.2025.05.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;Retinal ischemia-reperfusion (RIR) injury results in irreversible visual impairments. The disruption of the outer blood-retinal barrier (OBRB) is a major ocular pathogenic process that RIR injury affects. Current clinical strategies are limited. This study aimed to elucidate how electroacupuncture (EA) protects the OBRB against RIR injury.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Male Wistar rats (7 weeks old, 250 g to 280 g) were used in this study. Three independent experiments were conducted. First, Opioid peptide levels were quantified using enzyme-linked immunosorbent assay (ELISA). 42 rats were randomly divided into 7 groups (&lt;em&gt;n&lt;/em&gt; = 6/group): Control: No treatment; high intraocular pressure(HIOP): Acute intraocular pressure elevation-induced RIR injury; HIOP + SHAM EA: RIR injury + sham EA at Xinming (Extra acupoint) and Jingming (BL1) for 30 min (shallow needle insertion but without electric stimulation); HIOP + 2 Hz EA: RIR injury + 2 Hz EA at Xinming and BL1 for 30 min; HIOP +100 Hz: RIR injury + 100 Hz EA at Xinming and BL1 for 30 min; HIOP + 2/100 Hz EA: RIR injury + 2/100 Hz EA at Xinming and BL1 for 30 min; HIOP + 4/20 Hz EA: RIR injury + 4/20 Hz EA at Xinming and BL1 for 30 min. Second, retinal morphology was assessed by hematoxylin and eosin (HE) staining. 20 rats were randomly allocated into 4 groups (&lt;em&gt;n&lt;/em&gt; = 5/group): Control: No treatment; HIOP: Acute intraocular pressure elevation-induced RIR injury; HIOP + SHAM EA: RIR injury + sham EA at Xinming and BL1 for 30 min (shallow needle insertion but without electric stimulation); HIOP + 2 Hz EA: RIR injury + 2 Hz EA at Xinming and BL1 for 30 min. Third, the permeability of OBRB was evaluated using the fluorescein isothiocyanate(FITC)-dextran leakage assay. 15 rats were randomly divided into 5 groups (&lt;em&gt;n&lt;/em&gt; = 3/group): Control: No treatment; HIOP: Acute intraocular pressure elevation-induced RIR injury; HIOP + SHAM EA: RIR injury + sham EA at Xinming and BL1 for 30 min (shallow needle insertion but without electric stimulation); HIOP + 2 Hz EA: RIR injury + 2 Hz EA at Xinming and BL1 for 30 min; Nal + HIOP + 2 Hz EA: Intravitreal injection of δ-opioid receptor antagonist Naltridole (10µl, 100 nM) 30 min before RIR injury induction, followed by 2 Hz EA treatment at Xinming and BL1 for 30 min. In vitro studies examined enkephalins' effects on oxygen–glucose deprivation /reperfusion (OGD/R) induced injury in ARPE‐19 cells. Cell viability was evaluated by cell counting kit-8 (CCK-8) assay, and morphological changes were recorded by Molecular Devices. Apoptosis was detected by Annexin V-FITC flow cytometry. Delta opioid receptor (DOR) expression in total protein and membrane protein were analyzed by western blotting (WB). Immunofluorescence (IF) staining and WB assessed ZO-1 and Claudin-19. For cell-based assays, n indicates the number of biologically independent replicates.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;It was found that 2 Hz EA treatment ","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 238-253"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rules of acupoint and parameter selection for electrostimulation in treatment of functional dyspepsia based on bibliometrics","authors":"Dan WANG (王丹) ,&nbsp;Pei-jing RONG (荣培晶)","doi":"10.1016/j.wjam.2025.06.006","DOIUrl":"10.1016/j.wjam.2025.06.006","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the electrostimulation parameters and acupoint prescriptions for treatment of functional dyspepsia (FD) based on bibliometric methods.</div></div><div><h3>Methods</h3><div>The relevant papers were searched from PubMed, Web of Science, Embase, China National Knowledge Infrastructure(CNKI), Wanfang Data, China Science and Technology Journal Database(VIP) and China Biology Medicine disc(Sinomed), dated from January 1st, 2010 to May 31st, 2023. Inclusion criteria of studies: ① “functional dyspepsia” and electric stimulation involved in the title or abstract; and ② related to the assessment of electrostimulation therapy in clinical trials and experimental research for FD. Exclusion criteria of studies: ①duplication or failure to obtain full text; ② published in newspaper, presenting as research achievement, and review; ③nothing related to the acupoint selection; and ④nothing related to the parameters of electrostimulation. Using Excel 2019 and VOSviewer software, acupoint association and the parameters of electrostimulation were analyzed and graphed.</div></div><div><h3>Results</h3><div>A total of 181 eligible articles were screened. Statistical analysis revealed that the most frequently targeted acupoints for electrostimulation in functional dyspepsia (FD) were Zusanli (ST36), Taichong (LR3), and Neiguan (PC6), while the most commonly utilized auricular point was Erjia (CO, concha zone). The acupoint group demonstrating the strongest association consisted of ST36, LR3, Zhongwan (CV12), and PC6, which constituted the primary prescription for electrostimulation in FD. The optimal parameters for electrostimulation were identified as a disperse-dense wave, a frequency of 2/100 Hz, and an intensity of 1 mA. The acupoints ST36, LR3, and PC6 are the most prevalent for electrostimulation in FD, with CO being the most common auricular point. The optimal electrostimulation parameters are a disperse-dense wave, a frequency of 2/100 Hz, and an intensity of 1 mA.</div></div><div><h3>Conclusion</h3><div>The acupoints ST36, LR3, and PC6 are the most prevalent for electrostimulation in FD, with CO being the most common auricular point. The optimal electrostimulation parameters are a disperse-dense wave, a frequency of 2/100 Hz, and an intensity of 1 mA.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 232-237"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture for postoperative recovery of gastrointestinal function in patients with gastrointestinal cancers: A systematic review and meta-analysis","authors":"Xue-er YAN (严雪儿) ,&nbsp;Shu-sheng CUI (崔述生) ,&nbsp;Yan-rui WANG (王燕睿) ,&nbsp;Mao-yu DING (丁茂裕) ,&nbsp;Yi-qing CAI (蔡祎晴) ,&nbsp;Pak Hang LUK ,&nbsp;Ji-ping ZHAO (赵吉平) ,&nbsp;Chao YANG (杨超) ,&nbsp;Jia-jia ZHANG (张佳佳) ,&nbsp;Zi-chen WANG (王子辰) ,&nbsp;Si-yan CHEN (陈思言) ,&nbsp;Xiao-min ZANG (臧晓敏) ,&nbsp;Yu-hui HUANG (黄钰惠) ,&nbsp;Cheng TAN (谭程)","doi":"10.1016/j.wjam.2025.06.003","DOIUrl":"10.1016/j.wjam.2025.06.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of electroacupuncture (EA) for postoperative recovery in patients with gastrointestinal (GI) cancers.</div></div><div><h3>Methods</h3><div>We retrieved articles from PubMed, Embase, OVID, Cochrane Library, Web of Science, CINAHL, SinoMed, China National Knowledge Infrastructure (CNKI), Wanfang, and Technology Journal Database (VIP) from database inception to November 1, 2024. Randomized controlled trials (RCTs) that examine the use of EA to improve GI function, reduce pain, and promote ability ofself-care after GI cancer surgery were included. Based on the type of control interventions, separate meta-analyses were conducted for EA vs postoperative nursing (PN) and EA vs sham acupuncture (SA). The primary outcomes were the time to first flatus (TFF) and the time to first defecation (TFD). The secondary outcomes included the time to recovery of bowel sounds (TRBS), the time to tolerance of liquid diet (TTLD), the time to tolerance of semiliquid diet (TTSD), the time to independent walking (TIW), the length of hospitalization (LH), and visual analog scale (VAS) immediate resting pain scores measured on the first, second and third postoperative days (POD 1–3). Results are reported as mean differences (MDs) with 95 % confidence intervals (CIs). RevMan 5.3 was used for meta-analysis, StataSE 15.1 was used for sensitivity analyses and Egger’s tests. This study was registered on PROSPERO (CRD42022314754).</div></div><div><h3>Results</h3><div>A total of 19 RCTs involving 1902 participants were included, all of which were conducted in China between 2004 and 2023. When EA compared with PN, the meta-analysis showed EA significantly reduce TFF (<em>n</em> = 673, MD = -13.14, 95 % CI = [-18.97 to -7.31], <em>P</em> &lt; 0.00001), TFD (<em>n</em> = 598, MD = -19.86, 95 % CI = [-27.83 to -11.89], <em>P</em> &lt; 0.00001), TRBS (<em>n</em> = 216, MD = -12.44, 95 % CI = [-15.00 to -9.87], <em>P</em> &lt; 0.00001), TTLD (<em>n</em> = 268, MD = -18.14, 95 % CI = [-24.98 to -11.29], <em>P</em> &lt; 0.00001), TTSD (<em>n</em> = 141, MD = -20.44, 95 % CI = [-33.84 to -7.04], <em>P</em> = 0.003), VAS on POD 1 (<em>n</em> = 299, MD = -0.52, 95 % CI = [-0.92 to -0.11], <em>P</em> = 0.01), VAS on POD 2 (<em>n</em> = 256, MD = -0.91, 95 % CI = [-1.23 to -0.60], <em>P</em> &lt; 0.00001), VAS on POD 3 (<em>n</em> = 203, MD = -0.57, 95 % CI = [-0.80 to -0.34], <em>P</em> &lt; 0.00001), while no significantly decreasing in the LH (<em>n</em> = 322, MD = -1.16, 95 % CI = [-2.56 to 0.24], <em>P</em> = 0.10). As EA compared with SA, EA could significantly reduce TFF (<em>n</em> = 782, MD = -15.78, 95 % CI = [-24.96 to -6.60], <em>P</em> = 0.0008), TFD (<em>n</em> = 782, MD = -20.42, 95 % CI = [-36.14 to -4.70], <em>P</em> = 0.01), LH (<em>n</em> = 782, MD = -1.37, 95 % CI = [-2.69 to -0.05], <em>P</em> = 0.04), TIW (<em>n</em> = 743, MD = -0.33, 95 % CI = [-0.62 to -0.04], <em>P</em> = 0.03).13 studies reported that E","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 208-222"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of electroacupuncture on central insulin signal transduction-related proteins in insulin resistance model rats via the mTORC1/S6K1 pathway","authors":"Xiu-feng GU (顾秀锋) ,&nbsp;Jing-zhi WANG (王静芝) ,&nbsp;Ming KONG (孔茗) ,&nbsp;Li CHEN (陈丽) ,&nbsp;Jie SONG (宋杰) ,&nbsp;Tao QU (瞿涛)","doi":"10.1016/j.wjam.2025.06.007","DOIUrl":"10.1016/j.wjam.2025.06.007","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of electroacupuncture (EA) on the expression and phosphorylation of insulin signal transduction-related proteins in the hypothalamus of insulin resistance (IR) rats.</div></div><div><h3>Methods</h3><div>There were totally seventy-five Wistar rats. Ten rats were randomly assigned to the Normal group (N).The remaining 65 rats were fed a high-fat diet, fifty successfully modeled rats were randomly divided into the Model (M), EA, Sham EA (<em>S</em>+EA), <span>l</span>-leucine (L), and <span>l</span>-leucine + EA (<em>L</em>+EA) groups, with 10 rats in each group.EA was applied at acupoints “Guanyuan (CV 4)”, “Zhongwan (CV 12)”, “Zusanli (ST 36)”, and “Fenglong (ST 40)”, with each session lasting 10 min, three times per week for 8 weeks. The <em>S</em>+EA group received needle insertion to a depth of ≤2 mm without electrical stimulation, with the same treatment duration and same acupoint selection. Body weight, fasting blood glucose (FBG), and insulin sensitivity (glucose infusion rate, GIR) were measured. Western blot analysis was used to assess insulin receptor substrate-1(IRS-1) , (Protein kinase B)Akt, glycogen synthase kinase-3β(GSK-3β),mechanistic target of rapamycin complex 1(mTORC1), and Ribosomal S6 kinase 1(S6K1), along with their phosphorylated forms. PCR was used to evaluate mRNA expression of IRS-1, Akt, and GSK-3β. Immunofluorescence was used to detect hypothalamic Akt localization.</div></div><div><h3>Results</h3><div>(1) Compared to the N group, the M group exhibited increased body weight, FBG, and phosphorylation of GSK-3β, mTORC1, and S6K1, with decreased GIR, IRS-1, Akt phosphorylation, and mRNA expression (<em>P</em> &lt; 0.05, <em>P</em> &lt; 0.01). (2) Compared to the M group, the EA and <em>S</em>+EA groups showed reduced body weight, FBG, GSK-3β, mTORC1, and S6K1 phosphorylation, with increased GIR, IRS-1, Akt phosphorylation, and mRNA expression (<em>P</em> &lt; 0.05, <em>P</em> &lt; 0.01). (3) Compared to the EA group, the <em>S</em>+EA group had higher body weight, GSK-3β phosphorylation, and mRNA expression, with reduced p-IRS-1 and p-Akt expression (<em>P</em> &lt; 0.05); the L and <em>L</em>+EA groups showed increased GSK-3β, mTORC1, and S6K1 phosphorylation, with decreased GIR, IRS-1, and Akt mRNA expression (<em>P</em> &lt; 0.05). (4) Compared to the <em>L</em>+EA group, the L group exhibited higher GSK-3β, mTORC1, and S6K1 phosphorylation, with lower GIR, Akt mRNA, and p-Akt expression (<em>P</em> &lt; 0.05, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>EA positively influences body weight, glucose-lipid metabolism, and insulin sensitivity in IR rats, with regulatory effects on central insulin signal transduction-related proteins, potentially linked to its suppression of hypothalamic mTORC1/S6K1 pathway activity.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 262-268"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nosocomial infections after acupuncture and related therapies: A systematic review of case reports and case series","authors":"Chao-Yue ZHANG (张超月) ,&nbsp;Jun XU (徐俊) ,&nbsp;Xiao-Hong GU (顾晓红) ,&nbsp;Xuan YIN (殷萱) ,&nbsp;Shan-Shan LI (李珊珊) (李珊珊) ,&nbsp;Li-Xing LAO (劳力行) ,&nbsp;Shi-Fen XU (徐世芬) ,&nbsp;Yi-Qun MI (宓轶群)","doi":"10.1016/j.wjam.2025.06.005","DOIUrl":"10.1016/j.wjam.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>Acupuncture and its related therapies, as an important part of traditional Chinese medicine, have been widely accepted by the public and healthcare professionals all over the world. According to previous reviews, the department of acupuncture is a potential place where nosocomial infection might occur.</div></div><div><h3>Objectives</h3><div>To investigate the common pathogens and possible risk factors for nosocomial infection, figure out the measures and strategies for control and prevention, and provide general reporting guideline for future cases.</div></div><div><h3>Methods</h3><div>A systematic literature search of 6 libraries (EMBASE, CINAHL, PubMed, VIP, CNKI, SinoMed) was carried out on nosocomial infection (NIs) after acupuncture and its related therapies (e.g., moxibustion, cupping, massage, dry needling) published from January 1, 2012 to August 31, 2023. Studies providing primary data were included; reviews, comments, and non-primary data studies were excluded to prevent duplicate case analysis. Data on bibliographic details, study characteristics, and clinical information were extracted. Results were synthesized through tabulation and categorized by therapy type, country income level, symptoms/diagnoses, pathogens, risk factors, treatments, and outcomes.</div></div><div><h3>Conclusion</h3><div>Nosocomial infections after acupuncture and its related therapies are possible but preventable. Prevention measures can be carried out in terms of the risk factors listed above. Future case reports are suggested to provide specific details of infection, including the setting, qualification, treatment, disinfection, and causal evidence.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 173-181"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}