World Journal of Acupuncture-Moxibustion最新文献

{"title":"Prospects for the development of acupuncture analgesia from an international perspective","authors":"Yi（梁宜） LIANG , Jie(周杰) ZHOU , Jun-ying(杜俊英) DU , Xiao-mei(邵晓梅) SHAO , Jian-qiao(方剑乔) FANG","doi":"10.1016/j.wjam.2022.11.002","DOIUrl":"10.1016/j.wjam.2022.11.002","url":null,"abstract":"","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 6-8"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48410016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocircuit of chronic pain and pain-induced negative emotions and regulatory mechanisms of electroacupuncture 慢性疼痛及其诱发负面情绪的神经环路及电针调节机制","authors":"Zi-yue ZHANG (张子月),&nbsp;Wen-xin ZHONG (钟文欣),&nbsp;Kai-ling ZHANG (张楷苓),&nbsp;Man LI (李熳)","doi":"10.1016/j.wjam.2022.09.003","DOIUrl":"https://doi.org/10.1016/j.wjam.2022.09.003","url":null,"abstract":"<div><p><span><span><span>Chronic pain is a common clinical condition that is frequently linked to negative emotions such as anxiety and depression. Electroacupuncture<span><span> (EA) has been shown to have beneficial therapeutic effects in analgesia and the reduction of pain-induced negative emotions, and promising results have been obtained in the study of its neural circuit mechanism. Optogenetics, chemogenetics, neurocircuit tracing, functional magnetic resonance imaging (fMRI), and conditional </span>gene knockdown<span> experiments have shown that EA activates parvalbumin (PV) </span></span></span>interneurons<span> in the anterior cingulate cortex<span> (ACC), inhibits Protein kinase<span><span> Mzeta-glutamate receptor (PKMzeta-GluR1) signaling pathway in ACC, and upregulates the expression of the neuropeptide S/neuropeptide S receptor (NPS/NPSR) system in ACC to alleviate pain and pain-induced anxiety. EA activates </span>endogenous cannabinoid receptors 1(CB1Rs), inhibits γ-aminobutyric acid (GABA)-ergic neurons and activates glutamatergic neurons in the </span></span></span></span>ventrolateral periaqueductal gray<span><span> (vlPAG) to exert an analgesic effect, while EA exerts an anxiolytic effect by downregulating CB1R in GABAergic neurons in the </span>ventral hippocampus (vHPC). EA relieves only pain-induced anxiety but not pain through inhibiting the rostral anterior cingulate cortex (rACC)</span></span>^Glu<span>-thalamus circuit. By inhibiting the medial prefrontal cortex (mPFC)</span>^Glu-vlPAG^GABA<span> circuit, EA relieves only pain but not pain-induced anxiety. EA activated dopamine receptor D1<span><span> (DRD1) or inhibited dopamine receptor D2 (DRD2) in the </span>basolateral amygdala<span> (BLA) to alleviate anxiety-like behaviors. Taken together, these findings would offer a novel theoretical framework for a thorough investigation of theoretical studies and clinical promotion of EA analgesic mechanisms.</span></span></span></p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 20-27"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on mechanisms of acupuncture analgesia - The most impressive field of acupuncture medicine 针刺镇痛机制研究-针灸学最引人注目的领域","authors":"Jun-ling Liu (刘俊岭)","doi":"10.1016/j.wjam.2022.11.004","DOIUrl":"10.1016/j.wjam.2022.11.004","url":null,"abstract":"","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 3-5"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41913503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for the relief of chronic pain: Regulating negative emotions and reward/motivation circuits based on the theory of “spirit-regulation with acupuncture”☆ 针灸改善慢性疼痛的新视角:“针灸治神”调控负性情绪及奖赏/动机环路","authors":"Xia-li WEI (魏夏利) ,&nbsp;Jun TIAN (田峻) ,&nbsp;Shao-hui JIA (贾绍辉) ,&nbsp;Qing SHU (舒晴)","doi":"10.1016/j.wjam.2022.10.001","DOIUrl":"10.1016/j.wjam.2022.10.001","url":null,"abstract":"<div><p><span>Chronic pain is often accompanied by negative emotions, and the progression of negative emotions may further impede pain relief. Both chronic pain and negative emotions are closely associated with reward/motivation circuits. Treatment<span> with acupuncture<span> is effective for the relief of pain and emotional disorders, although the acupoint combinations vary. Thus, this study aimed to elucidate the relationship of chronic pain and emotional disorders with the reward/motivation circuits. In association with the theory on “seven emotional factors that cause pain” in </span></span></span>traditional Chinese medicine, the potential effect mechanism of “spirit-regulation with acupuncture” for the relief of chronic pain and negative emotions was explored. The findings suggest that chronic pain and its related negative emotions may be effectively relieved with acupuncture after optimizing its acupoint combination based on “spirit-regulation”. However, the role of reward/motivation circuits for negative emotions in the relief of chronic pain with acupuncture needs to be demonstrated.</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 28-33"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47269599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of mángzhēn huīcì (relaxing needling with sharp long needle) for iliotibial band friction syndrome: A randomized clinical trial 芒针恢刺治疗髂胫束摩擦综合征-随机临床试验","authors":"Shi-sheng LI (李石胜),&nbsp;Yao-chi WU (吴耀持)","doi":"10.1016/j.wjam.2022.09.004","DOIUrl":"https://doi.org/10.1016/j.wjam.2022.09.004","url":null,"abstract":"<div><h3>Objective</h3><p><span>to observe the clinical effect of acupuncture by </span><em>mángzhēn huīcì (</em><span>relaxing needling with sharp long needle) on iliotibial band friction syndrome (ITBS).</span></p></div><div><h3>Design</h3><p>this was a two-arm randomized controlled trial with blinding of participants, outcome assessment and statistician.</p></div><div><h3>Setting</h3><p>acupuncture-Moxibustion, Tuina<span> and Orthopedics Department and the Orthopedics Department of Shanghai the Sixth People's Hospital, June 2018 to January 2021.</span></p></div><div><h3>Participants</h3><p>a total of 64 patients with iliotibial band friction syndrome (ITBS).</p></div><div><h3>Interventions</h3><p>with a 1:1 ratio the patients were randomly assigned to either the conventional acupuncture group (CA, n=32) or the Relaxing Needling with Sharp Long Needle group (RNSLN, n=32). The CA group was treated by applying acupuncture at Jūliáo (居髎GB 29), Fēngshì (风市GB 31), Liángqiū (梁丘ST 34), Yánglíngquán (阳陵泉GB 34), and <em>Ashi</em> points (阿是穴) of the affected side, and the RNSLN group was treated by applying relaxing needling with sharp long needle at Jūliáo (居髎GB 29), Liángqiū (梁丘ST 34), and <em>Ashi</em><span> points of the affected side. Both groups were treated once every other day, 10 times as one course of treatment.</span></p></div><div><h3>Outcome measures</h3><p>the treatment effect was evaluated after one course of treatment by comparing their KSS<span> scores and VAS scores, as well as overall response rate.</span></p></div><div><h3>Results</h3><p>Sixty-four patients were included in the final data analysis. There was no difference in KSS and VAS scores between the two groups before treatment (<em>P</em>&gt;0.05). After treatment, the KSS score of the two groups was higher than that before treatment, the VAS score of the two groups was lower than that before treatment (<em>P</em>&lt;0.05). The KSS score of the RNSLN group was higher than that of the CA group, and the VAS score of the RNSLN group was lower than that of the CA group (<em>P</em>&lt;0.05). The overall response rate of the RNSLN group was 93.75%, higher than 75% of the control group (<em>P</em>&lt;0.05). Each group has 1 case of subcutaneous bleeding as adverse event.</p></div><div><h3>Conclusion</h3><p>Relaxing Needling with Sharp Long Needle could be more beneficial for iliotibial band friction syndrome (ITBS) compared with conventional acupuncture, and more evidence is required for its effectiveness before introducing the approach widely to clinical practice.</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 58-63"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The “Special issue on acupuncture Analgesia”","authors":"Jian-qiao FANG（方剑乔）","doi":"10.1016/j.wjam.2022.11.003","DOIUrl":"https://doi.org/10.1016/j.wjam.2022.11.003","url":null,"abstract":"","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 1-2"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49789981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention mechanism of electroacupuncture on the EP1-TRPV1 pathway in the dorsal root ganglion of rats in the transition from acute to chronic pain","authors":"Hai-ju SUN (孙海榉),&nbsp;Xiao-yu LI (李晓宇),&nbsp;Si-si WANG (王思思),&nbsp;Xiao-mei SHAO (邵晓梅),&nbsp;Jun-ying DU (杜俊英),&nbsp;Jian-qiao FANG (方剑乔),&nbsp;Jun-fan FANG (房军帆)","doi":"10.1016/j.wjam.2022.11.005","DOIUrl":"10.1016/j.wjam.2022.11.005","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;To observe the law of changes in mechanical paw-withdrawal threshold (MPWT) and thermal paw-withdrawal latency (TPWL) on the modeled side of rats with pain transition (hyperalgesic priming [HP]), and the expression of prostaglandin E receptor 1&lt;span&gt;&lt;span&gt;&lt;span&gt; (EP1) and transient receptor potential vanilloid type 1 (TRPV1) in the &lt;/span&gt;dorsal root&lt;span&gt; ganglion (DRG) of the affected side of rats. To observe the effects of &lt;/span&gt;&lt;/span&gt;electroacupuncture (EA) on the TPWL on the modeled side of rats with pain transition and regulation of EP1 and TRPV1 expression in DRG.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;Part 1: Eighteen SD rats were randomly divided into control, sham HP, and HP groups, with 6 rats in each group. The modeling comprised two injections. The rats in the HP group were subcutaneously injected with 1% carrageenan&lt;span&gt;&lt;span&gt; (100 µL) into the left hind paw&lt;span&gt;&lt;span&gt; in the first injection (those in the control and sham HP groups were injected with saline).The second injection was administered 8 days later by injecting prostaglandin E2 (PGE2) (100 ng/25 µL) into the dorsum of the paw (the rats in the control group were administered with saline and those in the sham HP group PGE2), thereby developing a pain transition model. TPWL and MPWT were measured before rat modeling, 4 h, and 1, 2, 3, and 7 days after the first injection, and 1, 4, 24, and 48 h after the second injection (8 days after the first injection). The expression rates of EP1- and TRPV1-positive cells in the affected DRG were measured by immunofluorescence(IF). Part 2: Eighteen SD rats were randomly divided into sham HP (6 rats), and HP groups (12 rats), then the rats in HP group were randomly divided into HP (6 rats) and HP + EP1 antagonist (6 rats) groups for the detection of TPWL. Rats in the EP1 antagonist group were injected with EP1 antagonist 5 min before PGE2 injection. The expression rate of TRPV1-positive cells in the affected DRG 48 h after PGE2 injection was detected using the &lt;/span&gt;IF method. Part 3: Twenty-four SD rats were randomly divided into sham HP (6 rats), and HP groups (18 rats), then the rats in HP group were randomly divided into HP (6 rats), sham EA (6 rats) and EA (6 rats) groups for the detection of TPWL. Following the injection of carrageenan, rats in the EA group were intervened at “Zúsānlĭ (足三里 ST36)” and “Kūnlún(昆仑 BL60)” &lt;/span&gt;&lt;/span&gt;acupoints bilaterally, once a day. The expression rate of EP1- and TRPV1-positive cells in the affected DRG was detected by the IF method.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Part 1: 1. Compared with the control and sham HP groups, the MPWT of the affected paw of the rats in the HP group was significantly reduced at 4, 24, 48, and 72 h after carrageenan injection, and at 4, 24, and 48 h after PGE2 injection (all &lt;em&gt;P&lt;/em&gt; &lt; 0.01). 2. Compared with the control group, the TPWL of the affected paw was significantly decreased in the HP group at 4, 24, 48, and 72 h after ","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 34-43"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49543252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The dose-effect relationship of electroacupuncture analgesia and its stimulus parameters: Progress in the last 3 decades 电针镇痛及其与刺激参数的量效关系研究:近三十年研究新进展","authors":"Yi LIANG (梁宜) ,&nbsp;Jie ZHOU (周杰) ,&nbsp;Jing SUN (孙晶) ,&nbsp;Xin-zheng FAN (范新政) ,&nbsp;Si-yi ZHENG (郑思懿) ,&nbsp;Jun-fan FANG (房军帆) ,&nbsp;Jian-qiao FANG (方剑乔)","doi":"10.1016/j.wjam.2022.12.001","DOIUrl":"10.1016/j.wjam.2022.12.001","url":null,"abstract":"<div><p><span>In this review, we explored the dose-effect relationship of electroacupuncture<span><span> (EA) analgesia and its stimulus parameters by searching articles on clinical and experimental research of EA analgesia in the past 30 years. The impacts on the analgesic effects are discussed in terms of the pulse waveform, frequency, amplitude, wave width, and time effect, as well as parameter combinations, and the optimization of the EA parameters are summarized for the </span>treatment of neuropathic, inflammatory, and cancer pains. It was initially discovered that the distant-dense (D-D) wave (2/15 Hz or 2/100 Hz) and stimulus for 30−45 min were appropriate in the treatment of </span></span>chronic inflammatory pain<span>, the strong stimulus was applicable to the acute stage of pain (twice a week), while the weak stimulus was for the stable stage (once weekly). The continuous (2 Hz)/D-D wave (2/100 Hz) and moderate/low intensity of stimulus for 30−45 min are preferred in the treatment of neuropathic pain with EA, once daily or every 2 days. Regarding the treatment of cancer pain, EA with continuous (2 Hz or 100 Hz) or D-D wave (2/100 Hz), moderate and low intensity of stimulus for 30−45 min is adopted, once every 2 days. There is a certain rule for the correlation of each parameter and the combination of parameters to ensure an analgesic effect of EA, which should be further explored in future studies.</span></p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 12-19"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47948570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture-moxibustion for lung cancer patient-reported outcomes: A systematic review and meta-analysis protocol","authors":"Zi-qi XI (奚紫琦) ,&nbsp;Xu-qiang WEI (魏绪强) ,&nbsp;Zi YE (叶子) ,&nbsp;Ke WANG (王珂),&nbsp;Jia ZHOU (周嘉)","doi":"10.1016/j.wjam.2022.07.004","DOIUrl":"https://doi.org/10.1016/j.wjam.2022.07.004","url":null,"abstract":"<div><h3>Background</h3><p><span>Lung cancer is one of the most common cancers globally with high incidence and mortality rate. Acupuncture<span> and moxibustion have been used as adjuvant therapies to relieve the symptoms and complications of lung cancer. At present, acupuncture and moxibustion can partially improve the </span></span>quality of life<span><span> (QOL) of cancer patients. However, the evidence that acupuncture and moxibustion can improve patient-reported outcomes (PROs) in patients with lung cancer is still insufficient. We aimed to conduct a </span>systematic review<span> and meta-analysis of published randomized controlled trials (RCTs) to determine whether acupuncture and moxibustion can improve PROs among patients with lung cancer, providing a support basis for acupuncture and moxibustion inclusion in relevant guidelines.</span></span></p></div><div><h3>Methods</h3><p>We will search the following electronic databases: PubMed, Embase, Cochrane Library, Web of Science, CNKI, CQVIP, Wanfang Data, Sinomed, and gray literature including the ClinicalTrials.gov Database (clinicaltrials.gov) and Chinese Clinical Trial<span><span> Register (chictr.org.cn). All English and Chinese articles will be searched until July 1, 2021. Two researchers independently extracted data. Any disagreement was resolved by discussion until consensus was reached or by consulting a third researcher. The primary outcomes mainly included the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), functional assessment of cancer therapy-lung (FACT-L), and </span>Karnofsky Performance Status (KPS). The secondary outcomes included improvement of individual lung cancer-related symptoms and the safety of acupuncture intervention.</span></p></div><div><h3>Discussion</h3><p>Our study is the first to focus on the PROs of acupuncture and moxibustion for lung cancer treatment. The results will contribute to a deeper understanding of the evidence distribution of acupuncture and moxibustion in PROs, which may support the use of acupuncture and moxibustion in lung cancer patients.</p></div><div><h3>Clinical trial registration number</h3><p>CRD42021274122.</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"32 4","pages":"Pages 271-276"},"PeriodicalIF":0.7,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137218733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of taking acupuncture at the acupoints based on \"four seas theory\" for post-stroke cognitive impairment 基于“四海理论”组穴针刺治疗脑卒中后认知障碍的临床观察","authors":"Jin-hua YANG (杨金华),&nbsp;Yong-lei ZHU (朱永磊),&nbsp;Bing HAN (韩冰),&nbsp;Long YANG (杨龙)","doi":"10.1016/j.wjam.2022.05.004","DOIUrl":"10.1016/j.wjam.2022.05.004","url":null,"abstract":"<div><h3>Objective</h3><p><span>To observe the clinical effect on post-stroke cognitive impairment (PSCI) treated by </span>acupuncture<span> at the acupoints composed in accordance with the \"four seas theory\".</span></p></div><div><h3>Methods</h3><p><span>A total of 70 patients with PSCI were randomly divided into a treatment group (</span><em>n</em> = 35) and a control group (<em>n</em><span> = 35). In the control group, conventional basic treatment and rehabilitation training were adopted, while in the treatment group, on the base of the treatment as the control group, acupuncture was applied at the acupoints composed in accordance with \"four seas theory\", lasting 8 weeks. The scores of mini-mental state examination (MMSE) and the instantaneous memory, the scores of Montreal cognitive assessment<span> (MoCA) and the delayed memory, the score of kidney essence insufficiency in syndrome differentiation scale of vascular dementia (SDSVD), event-related potentials (ERP) P300 and clinical therapeutic effect were compared in the patients between two groups before and after treatment separately.</span></span></p></div><div><h3>Results</h3><p><span>After treatment, MMSE score and the score of instantaneous memory were higher than the results before treatment in either group respectively (all </span><em>P</em> &lt; 0.05), in which, MMSE score in the treatment group was higher than that in the control group (<em>P</em> &lt; 0.05). After treatment, MoCA score and the score of delay recall were higher than the results before treatment in either group (all <em>P</em> &lt; 0.05), in which, MoCA score in the treatment group was higher than that of the control group (<em>P</em> &lt; 0.05). After treatment, the score of SDSVD was lower than that before treatment in either group (both <em>P</em> &lt; 0.05), in which SDSVD score in the treatment group were lower than the control group (<em>P</em> &lt; 0.05). There were no statistical changes in P300 latency and wave amplitude in the patients of the control group after treatment (both <em>P</em> &gt; 0.05). However, in the treatment group, P300 latency was reduced and the wave amplitude was increased after treatment (both <em>P</em> &lt; 0.05). The total effective rate was 88.57% in the treatment group, higher than 71.43% in the control group (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>Acupuncture at the acupoints composed on the base of the \"four seas theory” effectively improves the cognitive function and traditional Chinese medicine syndrome scores in PSCI patients. This therapy is of great value in clinic in the future.</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"32 4","pages":"Pages 324-328"},"PeriodicalIF":0.7,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42612265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}