World Journal of Acupuncture-Moxibustion最新文献

{"title":"Mechanism of the inhibitory effect of acupotomy on chondrocyte apoptosis in KOA rabbits explored via proteomics 运用蛋白质组学技术探讨针刀抗KOA兔软骨细胞凋亡的作用机制","authors":"Shuai XIA (夏帅) ,&nbsp;Xiao-shuang HUANG (黄小双) ,&nbsp;Xian WU (伍闲) ,&nbsp;Ze-yu SHE (佘泽宇) ,&nbsp;Man LU (卢曼) ,&nbsp;Qian CHEN (陈倩) ,&nbsp;Yong-hui YANG (杨永晖)","doi":"10.1016/j.wjam.2023.02.001","DOIUrl":"10.1016/j.wjam.2023.02.001","url":null,"abstract":"<div><h3>Objective</h3><p><span>To elucidate the mechanism underlying the inhibitory effect of acupotomy on chondrocyte<span> apoptosis in rabbits with </span></span>knee osteoarthritis<span> (KOA) through screening, analysis, and verification of apoptosis-related differentially expressed proteins via proteomics.</span></p></div><div><h3>Methods</h3><p><span><span>Thirty New Zealand white rabbits were randomly divided into the normal, model, and acupotomy groups, with 10 rabbits in each group. The Vidman method was used to prepare KOA models in the model and acupotomy groups. In the acupotomy group, acupotomy was performed at the midpoints of the patellar ligament and medial and lateral collateral ligaments on the left knees once a week for three weeks. Rabbit </span>articular cartilage<span> protein was quantified in each group, and the proteins with differential expression were profiled via proteomics. The apoptosis-related proteins were further screened, and differentially expressed proteins common among the normal, model, and acupotomy groups were collected for cluster analysis. Pathological changes in chondrocytes were observed via HE staining, and chondrocyte apoptosis was observed under an </span></span>electron microscope<span><span>. Quantitative real-time PCR (RT-PCR) and western blot were performed to determine the mRNA and </span>protein expression levels, respectively, of the common apoptosis-related proteins in the three groups.</span></p></div><div><h3>Results</h3><p><span>Western blot and RT-PCR showed that the protein and mRNA expression levels of TXN, CAP1 and FABP3 were lower (all </span><em>P</em><span> &lt; 0.05), whereas that of LTF, SCIN and IL-10 were higher (all </span><em>P</em> &lt; 0.01) in the acupotomy group than that in the model group.</p></div><div><h3>Conclusion</h3><p>The antiapoptotic effect of acupotomy on chondrocytes in KOA rabbits may be achieved by modulating the protein and mRNA expression of differentially expressed apoptosis-related proteins (TXN, CAP1, FABP3, LTS, SCIN, and IL-10).</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 2","pages":"Pages 126-134"},"PeriodicalIF":0.7,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44880403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture's effect on nerve remodeling among patients with dysphagia after cerebral infarction: a study based on diffusion tensor imaging","authors":"Chong ZHENG (郑冲) ,&nbsp;Wen-Bao WU (吴文宝) ,&nbsp;Dao-Feng FAN (范道丰) ,&nbsp;Qing-Qing LIAN (连清清) ,&nbsp;Fang GUO (郭芳) ,&nbsp;Lang-Lang TANG (汤琅琅)","doi":"10.1016/j.wjam.2022.12.003","DOIUrl":"10.1016/j.wjam.2022.12.003","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;&lt;span&gt;&lt;span&gt;To investigate the clinical effect of acupuncture among patients with &lt;/span&gt;dysphagia after &lt;/span&gt;cerebral infarction&lt;span&gt;, and the nerve remodeling of acupuncture using diffusion tensor imaging.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;One hundred and twenty patients with dysphagia after cerebral infarction were randomly assigned to either acupuncture group or sham-acupuncture group with a 1:1 ratio. All patients received usual care and swallowing function training of neurology&lt;span&gt; department. Additionally, acupuncture was applied at Sìshéncōng (四神聪EX-HN1), Băihuì (百会GV20), Tàiyáng (太阳EX-HN5), Fēngchí (风池GB20) and Shésānzhēn (舌三针three-tongue needling points, Extra) in acupuncture group. The needles were retained for 30 min each time, and five times a week for three weeks as a course of treatment. Two courses of treatments were required in total. In sham-acupuncture group, the blunt needles were put into the needle sleeve, and the top of needle was fixed on the skin. During treatment the blunt needle tip only had slight contact with the skin without any penetration. The blunt needle tips were placed on EX-HN1, GV20, EX-HN5, GB20 and three-tongue needling points, respectively. The duration of treatment in sham-acupuncture group was the same as that in acupuncture group. Before and after treatment, all patients underwent Kubota water swallowing test to evaluate the clinical effect. Using diffusion tensor image (DTI), the nerve remodeling was detected.&lt;/span&gt;&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;&lt;em&gt;Clinical effect:&lt;/em&gt; After treatment and assessed by water swallowing test, there were 38 cases of normal swallowing function in acupuncture group, higher than 15 cases in sham-acupuncture group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). Nerve remodeling: (1) apparent diffusion coefficient (ADC): before treatment, ADC in acupuncture group and sham acupuncture group were 1.76 ± 0.45 mm/s and 1.68 ± 0.51 mm/s, respectively. After treatment, ADC were 0.66 ± 0.15 mm/s and 0.74 ± 0.11 mm/s, respectively. The difference in ADC had no statistical significance between two groups after treatment (&lt;em&gt;P&lt;/em&gt;&lt;span&gt; &gt; 0.05); (2) fractional anisotropy (FA): after treatment, FA of acupuncture group was 0.57 ± 0.06, which was significantly higher than that of sham-acupuncture group (&lt;/span&gt;&lt;em&gt;P&lt;/em&gt;&lt;span&gt; &lt; 0.05); (3) observation of different infarct lesions: after treatment, ADC of temporal lobe infarction in acupuncture group was (0.57 ± 0.11) mm/s, lower than 0.82 ± 0.24 mm/s of sham acupuncture group, while FA in acupuncture group was 0.61 ± 0.07, higher than 0.45 ± 0.10 in sham-acupuncture group, both with statistical significance (both &lt;/span&gt;&lt;em&gt;P&lt;/em&gt; &lt; 0.05). Regarding the changes of FA maps for temporal lobe infarction before and after treatment, the transverse bundles of the white matter fibers increased remarkably in infarct lesions and on the healthy side of temporal lobe.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;Acupuncture could ","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 2","pages":"Pages 118-125"},"PeriodicalIF":0.7,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44245084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of a patient with cilioretinal artery occlusion treated by acupuncture and xuefu zhuyu tang","authors":"Fu-sheng DU (杜福生) ,&nbsp;Yan-ping DUAN (段燕萍) ,&nbsp;Jie-jie PING (平洁洁)","doi":"10.1016/j.wjam.2023.02.006","DOIUrl":"https://doi.org/10.1016/j.wjam.2023.02.006","url":null,"abstract":"<div><p><span><span><span>The report presented a case of cilioretinal artery occlusion. A 22-year-old woman, with a complain of reduced </span>visual acuity<span> of the right eye for 4 days, presented with blurred vision and inferior visual field defect at the time of visit. </span></span>Acupuncture combined with herbal medication of </span><span><em>Xuefu Zhuyu </em><em>Decoction</em></span><span> was applied for the patient. Main acupoints included Jingming (BL1), Qiuhou (EX-HN7), Sizhukong (TE23), Yuyao (EX-HN3), Sibai (ST2), Fengchi (GB20), Hegu (LI4), Guangming (GB37) and Taichong (LR3). The needles were remained for 30 min in each session, which was given once daily for 10 days. The modified </span><em>Xuefu Zhuyu Decoction</em> (<em>Semen Juglandis</em> [10 g], <em>Flos Carthami</em> [10 g], <span><em>Rhizoma Chuanxiong</em></span> [10 g], <span><em>Radix Paeoniae Rubra</em></span> [10 g], <span><em>Radix </em><em>Rehmanniae</em></span> [15 g], <span><em>Radix Angelicae</em><em> Sinensis</em></span> [10 g], <span><em>Radix Bupleuri</em></span> [10 g], <em>Fructus Aurantii</em> [5 g], <em>Radix et Rhizoma Glycyrrhizae Praeparata cum Melle</em> [6 g], <em>Fructus Crataegi</em> [20 g], <span><em>Endothelium Corneum</em><em> Gigeriae Galli</em></span> [10 g], Scorpio [5 g], <em>Herba Leonuri</em> [15 g], <span><em>Radix Astragali</em></span> [35 g] and <em>Ramulus Cinnamomi</em><span><span> [10 g]) was applied one dose daily for 7 days. After 7 days of treatment, the visual acuity of the patient was increased from 0.04 to 0.6 in the right eye with spectacles, the </span>retinal fundus<span> edema disappeared and the inferior vision field defect relieved. With acupuncture treatment<span> for another 10 days, it was observed that the visual acuity of the patient's right eye was improved and the inferior vision field defect reduced. There was no symptom recurrence and the visual acuities in both eyes of the patient were 1.0 with spectacles till the latest follow-up. This therapy provided a new idea and approach to treat cilioretinal artery occlusion.</span></span></span></p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 2","pages":"Pages 184-187"},"PeriodicalIF":0.7,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49789375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of xingnao kaiqiao acupuncture therapy for patient with acute ischemic stroke and the establishment of prediction model for prognosis","authors":"Xiao-Yan YANG (杨晓晏),&nbsp;Li-Li ZHU (朱利莉),&nbsp;Hua ZHONG (钟华),&nbsp;Qiu-Xia ZENG (曾秋霞),&nbsp;Xiao-Lin MA (马晓林),&nbsp;Xiang MAO (毛翔),&nbsp;Zheng-Peng FAN (范正鹏),&nbsp;Jiao-Lu LIAO (廖焦鲁),&nbsp;Fu-Qin ZHANG (张福琴)","doi":"10.1016/j.wjam.2023.02.004","DOIUrl":"https://doi.org/10.1016/j.wjam.2023.02.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;To explore the clinical effectiveness of &lt;em&gt;xingnao kaiqiao&lt;/em&gt; (regaining consciousness and opening orifice) acupuncture therapy for patients with acute ischemic stroke, and establish a prediction model for prognosis for the target population through Logistic regression analysis.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;Ninety-six patients with acute ischemic stroke were randomly assigned to either an ozone therapy group or an ozone therapy plus &lt;em&gt;xingnao kaiqiao&lt;/em&gt; acupuncture group (OA group) with a 1:1 ratio. The patients in the ozone group was treated with ozone therapy, and those in the OA group were treated with acupuncture at Nèiguān (内关PC6), Shuĭgōu (水沟GV26), Sānyīnjiāo (三阴交SP6), lower Jíquán (下极泉Extra, lower HT1), Wĕizhōng (委中BL40) and Chĭzé (尺泽LU5) on the basis of the treatment as the ozone therapy group. The treatment was given once daily for 7 days as a session and 3 consecutive sessions were required. Before treatment and 48 h after treatment, the serological indicators (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α] and hypersensitive C-reactive protein [hs-CRP]) were tested. Using the National Institute of Health stroke scale (NIHSS) score and Montreal cognitive assessment (MoCA) score, the neurological and cognitive functions of patients were assessed. The clinical efficacy was evaluated with the modified Rankin scale, and the incidence of adverse effects was analyzed statistically in two groups. The multivariate Logistic regression analysis was adopted to detect the risk factors of the prognosis in patients and the nomographic prediction model was established.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;(1) clinical therapeutic effect: after treatment, the levels of IL-6, TNF-α and Hs-CRP in the OA group were significantly lower than that in the ozone group (all &lt;em&gt;P&lt;/em&gt; &lt; 0.05). After treatment, compared with the ozone therapy group, NIHSS score was lower and the scores of BI and MoCA were significantly higher in the OA group (all &lt;em&gt;P&lt;/em&gt; &lt; 0.05). The total effective rate of the OA group was 91.67%, higher than that of the ozone therapy group (62.50%, &lt;em&gt;P&lt;/em&gt; &lt; 0.05). The incidence of adverse effects in the OA group was lower when compared with that in the ozone group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05); (2) establishment of prediction model for prognosis: age, history of diabetes, cardiogenic cerebral embolism, high density lipoprotein-cholesterol (HDL-C), white blood cell (WBC) and treatment methods were independent risk factors of the unfavorable prognosis for the patients with acute stroke. The established model had sound accuracy for prediction of prognosis.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;p&gt;&lt;em&gt;Xingnao kaiqiao&lt;/em&gt; acupuncture was effective on acute ischemic stroke, and the prognosis of this therapy was increased significantly when combined with the ozone therapy. The preventive measures should be set up for patients with risk factors, e.g. advanced age, diabetes, cardiogenic cerebral embolism, l","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 2","pages":"Pages 102-110"},"PeriodicalIF":0.7,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory study of acupuncture therapy using liver-soothing and mind-regulating method and well-timed auricular acupressure for patients with subthreshold depression","authors":"Li-Xia HUANG ,&nbsp;Jun-Ping ZHANG ,&nbsp;Yu-Ying ZHANG ,&nbsp;Qian LUO ,&nbsp;Dian-Hui YANG","doi":"10.1016/j.wjam.2023.01.002","DOIUrl":"https://doi.org/10.1016/j.wjam.2023.01.002","url":null,"abstract":"<div><h3>Objective</h3><p>To observe the clinical therapeutic effect on subthreshold depression<span> of liver stagnation and spleen deficiency treated with acupuncture therapy<span> for soothing the liver and regulating the mind combined with the well-timed auricular acupressure.</span></span></p></div><div><h3>Methods</h3><p><span>A total of 34 patients were treated with acupuncture therapy for soothing the liver and regulating the mind combined with well-timed auricular acupressure. In acupuncture therapy for soothing the liver and regulating the mind, main acupoints<span><span> included Baihui (BL20), Neiguan (PC6) and Taichong (LR3), and supplementary acupoints included Sishencong (EX-HN1), Shenting (GV24), Benshen (GB13), Zusanli<span> (ST36), Ganshu (BL18) and Pishu (BL20). Acupuncture was given three times a week as one course and 4 courses of treatment were required. In well-timed auricular acupressure, auricular points included Xin (CO15), Pizhixia (AT4), Shenmen (TF4), Gan (CO12) and Pi( CO13). Acupressure with herbal seeds at those auricular points was applied at three time divisions, i.e. 9: 00 to 11:00, 11:00 to 13:00 and 15:00 to 17:00 successively. The auricular acupressure with herbal seeds was given once every 3 days, the treatment for 1 week was 1 course and 4 courses were required. At the end of treatment and in 3 months of follow-up, the score of Hamilton depression scale-24 (HAMD-24), syndrome score of </span></span>traditional Chinese medicine (TCM), the score of Center for </span></span>epidemiologic studies depression scale (CES-D) and the score of Short-form 36 item health survey (SF-36) were adopted to evaluate clinical therapeutic effect.</p></div><div><h3>Results</h3><p>After treatment and in three months of follow-up, HAMD-24 score, TCM syndrome score and CES-D score were all reduced as compared with the scores before treatment (all <em>P</em> &lt; 0.05) and SF-36 score was higher than the score before treatment, respectively (both <em>P</em> &lt; 0.05). In comparison of the scores after treatment with those in 3 months of follow-up, differences were not statistically significant (all <em>P</em> &gt; 0.05). Of 34 patients with subthreshold depression, 8 cases were cured, 15 cases effective remarkably, 9 cases improved and 2 cases no effect. The total effective rate was 94.12%.</p></div><div><h3>Conclusion</h3><p>The combined treatment of acupuncture therapy for soothing the liver and regulating the mind with the well-timed auricular acupressure can be benefit for relieving the symptoms and improves the quality of life in the patients with subthreshold depression of liver stagnation and spleen deficiency.</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 2","pages":"Pages 164-167"},"PeriodicalIF":0.7,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49789376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress on acupuncture in relieving stroke induced limb spasticity by regulating neuroplasticity-related signals","authors":"Zi-an ZHOU (周子安) ,&nbsp;Si-rong WANG (王思蓉) ,&nbsp;Jing ZHANG (张静) ,&nbsp;Ru-hui GUO (郭茹绘) ,&nbsp;Bin GUO (郭斌)","doi":"10.1016/j.wjam.2023.02.005","DOIUrl":"https://doi.org/10.1016/j.wjam.2023.02.005","url":null,"abstract":"<div><p><span><span>Stroke may cause upper motor neurons lesions, and thus limb spasm may occur. </span>Brain plasticity refers to the brain's ability to change and adapt the environment and experience when the </span>nervous system<span><span><span> is damaged. Acupuncture<span> can relieve the relevant pathological status due to stroke by enhancing brain plasticity. Specifically, acupuncture may finally achieve the balance between excitatory and inhibitory neurotransmitters by inhibiting the expression of neurotransmitter </span></span>GABA, </span>neurotrophic factor<span> BDNF<span> and proteins related to synaptic plasticity. This article analyzed and summarized that taking advantage of nervous plasticity the acupuncture could regenerate nervous cells and restore the related regulation of the movement by upper motor neurons, so as to relieving limb spasticity. It also summarized the research and application of acupuncture in regulating related signals, providing a systematic thought for the future study on acupuncture in the treatment of stroke induced limb.</span></span></span></p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 2","pages":"Pages 65-71"},"PeriodicalIF":0.7,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49790133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing Declaration of Competing Interest and State of human and animal rights in previously published articles","authors":"","doi":"10.1016/j.wjam.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.wjam.2023.03.001","url":null,"abstract":"","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43110488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Edmonton Symptom Assessment system in daily cancer pain management by acupuncture: Retrospective analysis of data from an inpatient oncology department and a pilot prospective study☆ 埃德蒙顿症状评估量表在针灸治疗癌痛患者中的应用:基于肿瘤科住院患者的回顾性分析和一项前瞻性预试验","authors":"Geng-hang CHEN (陈耿杭) ,&nbsp;Mei-yu FAN (范美玉) ,&nbsp;Xue-song CHANG (常雪松) ,&nbsp;Ze-xia WU (吴泽霞) ,&nbsp;Hai-bo ZHANG (张海波) ,&nbsp;Xin-feng GUO (郭新峰) ,&nbsp;Yi-han HE (何怡瀚)","doi":"10.1016/j.wjam.2022.11.001","DOIUrl":"10.1016/j.wjam.2022.11.001","url":null,"abstract":"<div><h3>Background</h3><p>As pain is the most prominent clinical symptom for cancer patients and closely related to other symptoms, it is necessary to have a comprehensive assessment on promising intervention to improve pain management.</p></div><div><h3>Methods</h3><p><span>A retrospective study of 489 inpatient cancer patients (1081 visits) was conducted by querying the electronic medical record database to test the reliability and validity of the Edmonton Symptom Assessment System. Data from a pilot prospective randomized controlled study on </span>acupuncture<span> for cancer pain was analyzed to validate the Edmonton Symptom Assessment System (ESAS) as the primary outcome in the integrative oncology research.</span></p></div><div><h3>Results</h3><p><span>In the retrospective analysis, scores of the numerical rating scale (NRS) and the ESAS total score were significantly correlated (r=0.15, </span><em>P</em> = 0.02), and the correlation coefficient between NRS and pain sub-scale in ESAS was 0.47 (<em>P</em><span> &lt; 0.001). The pilot study showed the proportions of participants experiencing more than a 2-point reduction in NRS at the end of the treatment were 80% (</span><em>n</em> = 12/15) in the acupuncture group and 50% (<em>n</em> = 7/14) in the control group, without a significant difference between groups (<em>P</em> = 0.13). For the total scores of ESAS, more responders were found in the acupuncture group (<em>n</em> = 13/15) compared to that in the control group (<em>n</em> = 7/14), with no significant difference between groups (<em>P</em> = 0.05).</p></div><div><h3>Conclusions</h3><p>ESAS is suitable for the comprehensive assessment in patients with cancer pain and could be an appropriate outcome measurement in acupuncture research for cancer pain.</p></div><div><h3>Trial registration</h3><p>Registered on 09/07/2018 with ChiCTR1800017023 (<span>https://www.chictr.org.cn/edit.aspx?pid=28879&amp;htm=4</span><svg><path></path></svg>)</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 51-57"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43791103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of peptidergic neurons in modulating acupoint sensitization caused by neck acute inflammatory pain in rats 肽能神经元对颈部急性炎性痛模型大鼠穴位敏化的调节作用","authors":"Wei YUAN (袁伟) ,&nbsp;Jiang-xin YUE (岳江鑫) ,&nbsp;Qiang WANG (王强) ,&nbsp;Nan WU (吴楠) ,&nbsp;Yong-feng LI (李永丰) ,&nbsp;Xiao-hang YANG (杨晓航) ,&nbsp;Hai-fa QIAO (乔海法)","doi":"10.1016/j.wjam.2022.12.005","DOIUrl":"10.1016/j.wjam.2022.12.005","url":null,"abstract":"<div><h3>Objective</h3><p>Pain is a health problem<span> frequently reported in the clinical and general populations. Acupoint<span> therapy is one of the most effective ways to treat pain; however, its mechanism remains unclear. Therefore, this study aimed to explore the relationship between distal acupoints, dorsal root<span><span> ganglion (DRG) neurons, and </span>spinal cord dorsal horn<span> (SDH) neurons in neck acute inflammatory pain (NAIP).</span></span></span></span></p></div><div><h3>Methods</h3><p><span>NAIP model rats were used to explore the relationship between acupoint sensitization and pain. Out of fourteen rats, ten rats were grouped into control and NAIP groups, five rats in control and five rats in NAIP. Mustard oil was subcutaneously injected on one side between the C4 and C7 </span>vertebrae<span><span><span><span> of the neck to establish an NAIP model. Evans blue (EB) was injected through the </span>tail vein to detect sensitized acupoints after NAIP modeling. EB exudation in the body, Lieque (LU7), and Lingdao (HT4) were evaluated. An </span>immunofluorescence assay was conducted to detect the expression of calcitonin gene-related peptide (CGRP), </span>isolectin B4<span> (IB4), and c-Fos in the dorsal root ganglion (DRG) and spinal cord dorsal medullae spinalis<span> (CDMS). Four rats were used for the retrograde labeling of neurons of the LU7 region to the DRG and CDMS using CTB-488 and CTB-555 microinjection.</span></span></span></p></div><div><h3>Results</h3><p>NAIP was shown to lead to oozing and pain sensitization in the LU7 and HT4 and increased the proportion of c-Fos⁺/CGRP⁺ and c-Fos⁺/IB4⁺ cells in both the DRG and CDMS. CTB-488 and CTB-555 injected into the LU7 and sensitization point areas were observed in the DRG and CDMS regions of NAIP rats.</p></div><div><h3>Conclusions</h3><p>Our study revealed that NAIP could lead to oozing and pain sensitization in the LU7 and HT4 regions and that the pain point around LU7 might result from the transfer of peptidergic (CGRP-positive) and non-peptidergic (IB4-positive) neurons in the DRG and CDMS.</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 44-50"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45250980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating experimental research to clinical practice to optimize acupuncture protocol in pain management","authors":"Wei-Juan GANG,&nbsp;Xiang-Hong JING","doi":"10.1016/j.wjam.2022.12.002","DOIUrl":"10.1016/j.wjam.2022.12.002","url":null,"abstract":"","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"33 1","pages":"Pages 9-11"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41708946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}