World Journal of Acupuncture-Moxibustion最新文献

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Construction of a pregnancy prediction model in acupuncture treatment for diminished ovarian reserve based on machine learning 基于机器学习的针灸治疗卵巢储备减退的妊娠预测模型构建
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2025-01-01 DOI: 10.1016/j.wjam.2025.01.001
Ming-hui GOU (勾明会) , Hui-sheng YANG (杨会生) , Yi-gong FANG (房繄恭)
{"title":"Construction of a pregnancy prediction model in acupuncture treatment for diminished ovarian reserve based on machine learning","authors":"Ming-hui GOU (勾明会) ,&nbsp;Hui-sheng YANG (杨会生) ,&nbsp;Yi-gong FANG (房繄恭)","doi":"10.1016/j.wjam.2025.01.001","DOIUrl":"10.1016/j.wjam.2025.01.001","url":null,"abstract":"<div><h3>Objective</h3><div>To construct a clinical prediction model of acupuncture treatment for diminished ovarian reserve (DOR) based on a machine learning algorithm to provide a clinical prediction of acupuncture for ameliorating pregnancy outcomes in DOR.</div></div><div><h3>Methods</h3><div>We enrolled 377 DOR patients treated with acupuncture and with records of pregnancy outcomes (139 cases of pregnancy and 238 cases failed) exported from the International Patient Registry Platform of Acupuncture-moxibustion (IPRPAM). The predictive variables were determined using Spearman's correlation analysis and feature engineering methods. The model was constructed by adopting logistic regression, naïve Bayes, random forest, support vector machine, extreme gradient boosting, the k-nearest neighbor algorithm, linear discriminant analysis, and neural network methods. The models were validated by the area under the curve (AUC), accuracy (ACC), and importance sequencing, and individual pregnancy prediction was conducted for the best-performing model.</div></div><div><h3>Results</h3><div>The key factors determining pregnancy after acupuncture in patients with DOR were age, luteinizing hormone (LH) level after treatment, follicle-stimulating hormone (FSH) level after treatment, the ratio of FSH to LH (FSH/LH) after treatment, and history of acupuncture treatment. Random forest model ACC was 0.95, Fβ was 0.93, Logloss was 0.30, Logloss value was the lowest, the model variables exhibited the highest accuracy and precision.</div></div><div><h3>Conclusion</h3><div>The random forest model for the effects of acupuncture on pregnancy outcomes in patients with DOR, constructed based on the IPRPAM, presents a favorable value for clinical application.</div></div><div><h3>Trial registration: Registration number in the Chinese Clinical Trial Registry Center</h3><div>ChiCTR2200062293.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 1","pages":"Pages 32-40"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpretation of SHARE: SHam Acupuncture REporting guidelines and a checklist in clinical trials SHARE:假针灸报告指南和临床试验核对表的解释
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2025-01-01 DOI: 10.1016/j.wjam.2024.12.001
Xiao-yu LIU (刘晓玉) , Pei-hong MA (马培宏) , Bao-yan LIU (刘保延) , Shi-yan YAN (闫世艳)
{"title":"Interpretation of SHARE: SHam Acupuncture REporting guidelines and a checklist in clinical trials","authors":"Xiao-yu LIU (刘晓玉) ,&nbsp;Pei-hong MA (马培宏) ,&nbsp;Bao-yan LIU (刘保延) ,&nbsp;Shi-yan YAN (闫世艳)","doi":"10.1016/j.wjam.2024.12.001","DOIUrl":"10.1016/j.wjam.2024.12.001","url":null,"abstract":"<div><div>Sham acupuncture, as a control intervention in acupuncture studies, has been widely conducted to evaluate the specific effect of acupuncture. However, there was no relevant particular reporting guideline, so the reporting quality of sham acupuncture was low, which could hinder the precise understanding and interpretation of details and implementation background of sham acupuncture by researchers. In order to standardize the reporting of sham acupuncture and improve its quality, <em>SHam Acupuncture REporting guidelines and a checklist in clinical trials (SHARE)</em> was developed by a research team from Beijing University of Chinese Medicine. The SAHRE standardizes the reporting of sham acupuncture from 10 categories, including brief name, rationales, details of sham acupuncture, treatment regimen of sham acupuncture, the information informed or explained to patients, practitioner information, modifications of protocol, communication between practitioner and patient, practitioner adherence and blinding. This article elaborates the development process and key content of SHARE in order to facilitate its application by researchers.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 1","pages":"Pages 27-31"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Holistic integrative medicine declaration 整体结合医学宣言
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2024-10-01 DOI: 10.1016/j.wjam.2024.09.002
Dai-ming FAN (樊代明)
{"title":"Holistic integrative medicine declaration","authors":"Dai-ming FAN (樊代明)","doi":"10.1016/j.wjam.2024.09.002","DOIUrl":"10.1016/j.wjam.2024.09.002","url":null,"abstract":"<div><div>Holistic integrative medicine, abbreviated as HIM, has been officially proposed since 2012. Its theoretical system has been continuously improved, and its practical methods have become increasingly diverse, becoming an inevitable choice and path for the medical development in the new era. This article demonstrates ten major propositions for HIM, elaborating on the connotation and extension of HIM from the perspectives of epistemology and methodology, in order to achieve the transformation and adaptive evolution of modern medicine.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 4","pages":"Pages 332-333"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis of the efficacy of acupuncture and moxibustion in the treatment of polycystic ovary syndrome 针灸治疗多囊卵巢综合征疗效的meta分析
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2024-10-01 DOI: 10.1016/j.wjam.2024.09.006
Dong-mei JIANG(江冬梅) , Hong LIN(林虹) , Zhi-feng YU(于志峰) , Meng WANG(王萌)
{"title":"Meta-analysis of the efficacy of acupuncture and moxibustion in the treatment of polycystic ovary syndrome","authors":"Dong-mei JIANG(江冬梅) ,&nbsp;Hong LIN(林虹) ,&nbsp;Zhi-feng YU(于志峰) ,&nbsp;Meng WANG(王萌)","doi":"10.1016/j.wjam.2024.09.006","DOIUrl":"10.1016/j.wjam.2024.09.006","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically evaluate the effectiveness of acupuncture and moxibustion as a complementary treatment for polycystic ovary syndrome(PCOS) and provide evidence for clinical treatment.</div></div><div><h3>Methods</h3><div>The following seven databases were searched from the date of database creation to October 29, 2023: PubMed, Embase, the Cochrane Library, China Biology Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang, and VIP. The literature was screened according to the inclusion and exclusion criteria, data were extracted, quality was evaluated using the Cochrane Risk of Bias Assessment Tool, and a meta-analysis of the outcomes was performed using Review Manager 5.4 software.</div></div><div><h3>Results</h3><div>A total of 20 researches were included and the test group was treated with modern medicine, acupuncture, electroacupuncture, warm needling, and thunder-fire moxibustion. The control group was treated with modern medicine, including clomiphene, Diane-35, letrozole, metformin, and progesterone. The meta-analysis showed that acupuncture and moxibustion as a complementary therapy for PCOS improved the ovulation and pregnancy rates and reduced the body mass index (BMI), luteinizing hormone (LH) levels, the LH/follicle-stimulating hormone (FSH) ratio, and ovarian volume; however, due to high heterogeneity, the differences regarding improvements in FSH, estradiol(E2), testosterone (T) and progesterone (P) levels could not draw a definite conclusion when compared with modern first-line drugs alone.</div></div><div><h3>Conclusion</h3><div>Acupuncture and moxibustion as a complementary treatment for PCOS has good clinical efficacy; however, because of the relatively low quality of the included studies, the results may be biased. More high-quality clinical studies are needed to verify the results. The Prospero Registration number is CRD42022368304.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 4","pages":"Pages 282-291"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on the mechanism of acupuncture in the treatment of secondary brain injury after intracerebral hemorrhage 针刺治疗脑出血后继发性脑损伤的机制研究进展
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2024-10-01 DOI: 10.1016/j.wjam.2024.09.001
Jing-wen TIAN (田静文) , Bo SUN (孙波) , Xiao-xiao ZHANG (张晓晓) , Ying KONG (孔莹)
{"title":"Research progress on the mechanism of acupuncture in the treatment of secondary brain injury after intracerebral hemorrhage","authors":"Jing-wen TIAN (田静文) ,&nbsp;Bo SUN (孙波) ,&nbsp;Xiao-xiao ZHANG (张晓晓) ,&nbsp;Ying KONG (孔莹)","doi":"10.1016/j.wjam.2024.09.001","DOIUrl":"10.1016/j.wjam.2024.09.001","url":null,"abstract":"<div><div>Intracerebral hemorrhage is a major cause of death in humans, with high morbidity, mortality, and disability rates. Secondary brain injury after intracerebral hemorrhage is a consequence of brain edema and neurological dysfunction. Acupuncture is markedly effective against secondary brain injury, and various mechanisms are involved in its action, such as inhibition of inflammatory cascades, inhibition of oxidative stress, attenuation of brain edema, inhibition of nerve cell death, and regulation of neural plasticity. This paper summarizes the mechanism underlying the effects of acupuncture on secondary brain injury after intracerebral hemorrhage in recent years to provide new ideas for subsequent research.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 4","pages":"Pages 277-281"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on the mechanism of acupuncture treatment for vascular dementia 针刺治疗血管性痴呆的机制研究进展
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2024-10-01 DOI: 10.1016/j.wjam.2024.06.001
Wei SUN (孙玮) , Ying-hua CHEN (陈英华) , Tong-yan LIU (刘同岩) , Xiao-qing SU (苏晓庆) , Rui-qi QIN (秦瑞琦)
{"title":"Research progress on the mechanism of acupuncture treatment for vascular dementia","authors":"Wei SUN (孙玮) ,&nbsp;Ying-hua CHEN (陈英华) ,&nbsp;Tong-yan LIU (刘同岩) ,&nbsp;Xiao-qing SU (苏晓庆) ,&nbsp;Rui-qi QIN (秦瑞琦)","doi":"10.1016/j.wjam.2024.06.001","DOIUrl":"10.1016/j.wjam.2024.06.001","url":null,"abstract":"<div><div>Acupuncture can intervene with and treat vascular dementia (VD) through multiple targets and pathways. The mechanisms of its action involve inhibiting central inflammatory responses, regulating neuronal synaptic plasticity, modulating oxidative stress, reducing neuronal apoptosis, and adjusting cellular autophagy. This paper summarizes researches on the mechanisms of acupuncture treatment for VD over the past decade, aiming to provide theoretical support for the clinical application of acupuncture in treating VD and offer a reference for future in-depth research in this field.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 4","pages":"Pages 270-276"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Scapular heat penetration” technique of acupuncture in treatment of scapulohumeral periarthritis: An exploratory research 针刺“肩胛骨热透”技术治疗肩周炎的探索性研究
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2024-10-01 DOI: 10.1016/j.wjam.2024.09.004
Shuo-quan RUAN (阮铄荃), Shu-ren MING (明树人), Chao-nan LI (李超楠), Jin-chuan RAN (冉津川), Bing-li CHEN (陈炳力), Wen SHU (舒文), Ting-ting DUAN (段婷婷), Wen-guang HOU (侯文光)
{"title":"“Scapular heat penetration” technique of acupuncture in treatment of scapulohumeral periarthritis: An exploratory research","authors":"Shuo-quan RUAN (阮铄荃),&nbsp;Shu-ren MING (明树人),&nbsp;Chao-nan LI (李超楠),&nbsp;Jin-chuan RAN (冉津川),&nbsp;Bing-li CHEN (陈炳力),&nbsp;Wen SHU (舒文),&nbsp;Ting-ting DUAN (段婷婷),&nbsp;Wen-guang HOU (侯文光)","doi":"10.1016/j.wjam.2024.09.004","DOIUrl":"10.1016/j.wjam.2024.09.004","url":null,"abstract":"<div><h3>Objective</h3><div>To observe the clinical effect of “scapular heat penetration” technique of acupuncture in treatment of scapulohumeral periarthritis.</div></div><div><h3>Design</h3><div>It was a single-central randomized controlled trial, the participants, outcome assessors and statisticians were blinded.</div></div><div><h3>Setting</h3><div>The trial was undertaken in Department of Acupuncture and Moxibustion, Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, from June 2021 to January 2022.</div></div><div><h3>Participants</h3><div>Sixty-seven patients with scalpulohumeral periarthritis were participated.</div></div><div><h3>Interventions</h3><div>In the control group, the routine acupuncture was given, while in the trial group, the “scapular heat penetration” technique of acupuncture was adopted. The intervention was delivered once every two days, 3 treatments a week; and one course included 9 treatments. Before the 1st treatment and after the 9th treatment, the symptoms and physical signs were observed and recorded in each group.</div></div><div><h3>Outcomes</h3><div>Primary outcome: the score of visual analogy scale (VAS) before treatment and after treatment completion. Secondary outcomes: the range of movement (ROM) of shoulder joint, the score of Japanese Orthopaedic Association (JOA) of shoulder joint and the infrared thermal imaging temperature around the shoulder.</div></div><div><h3>Results</h3><div>A total of 102 cases were collected, 72 cases of them were eligible and 5 cases were withdrawn. Sixty-seven cases were included in analysis. In the within-group comparison, VAS score, ROM and JOA score as well as the shoulder temperature were all ameliorated after 9 treatments in either the trial group or the control group, compared with those before treatment (<em>P</em> &lt; 0.05). In the comparison between two groups, after 9 treatments, VAS score in the trial group was lower than that of the control group (<em>P</em> &lt; 0.05); and the improvements in ROM and shoulder temperature in the trial group were better than those of the control group (<em>P</em> &lt; 0.05). No adverse reactions were found in the two groups.</div></div><div><h3>Conclusion</h3><div>Both the “scapular heat penetration” technique of acupuncture and the conventional acupuncture are effective on scapulohumeral periarthritis. But, regarding the improvements in pain, ROM of shoulder joint, the activity of daily life and shoulder temperature, the “scapular heat penetration” technique of acupuncture is superior to the conventional acupuncture.</div></div><div><h3>Registration number</h3><div>ChiCTR1900025505</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 4","pages":"Pages 306-311"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture for chronic nonspecific low back pain in middle-aged and older patients: A randomized controlled trial 针灸治疗中老年慢性非特异性腰痛:一项随机对照试验
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2024-10-01 DOI: 10.1016/j.wjam.2024.09.007
Fei XU (徐飞) , Kai-qiong JIAO (矫楷琼) , Lin-peng WANG (王麟鹏) , Fan ZHANG (张帆)
{"title":"Acupuncture for chronic nonspecific low back pain in middle-aged and older patients: A randomized controlled trial","authors":"Fei XU (徐飞) ,&nbsp;Kai-qiong JIAO (矫楷琼) ,&nbsp;Lin-peng WANG (王麟鹏) ,&nbsp;Fan ZHANG (张帆)","doi":"10.1016/j.wjam.2024.09.007","DOIUrl":"10.1016/j.wjam.2024.09.007","url":null,"abstract":"<div><h3>Objective</h3><div>To observe the specific effects of acupuncture in middle-aged and older patients with chronic nonspecific low back pain (CNSLBP).</div></div><div><h3>Methods</h3><div>Sixty-six patients with CNSLBP were randomized into the acupuncture or sham acupuncture groups (n = 33). In the acupuncture group, penetrating acupuncture with a long needle was delivered at <em>Ashi</em> points (painful/sensitive points), and the needles were manipulated by rotating technique after <em>deqi</em> till patients felt distending pain. The needles were retained in place for 30 min. Acupuncture was given three times per week for 4 weeks. In the sham acupuncture group, shallow needling was performed at non-meridian, non-acupoint, non-painful, and non-sensitive points. The needle retention and duration of treatment were the same as those of the acupuncture group before treatment, after the first intervention, after the whole treatment, and in follow-up visit (4 weeks after the whole treatment). The scores of the visual analog scale(VAS) for pain, range of movement (ROM) of the spine, and simplified Oswestry Dysfunction Index (ODI) were observed separately.</div></div><div><h3>Results</h3><div>Compared to the outcomes before treatment, the VAS score, spinal ROM, and simplified ODI score were lower after the first intervention, after treatment, and in follow-up visits in the acupuncture group, indicating the statistical significance (<em>P</em> &lt; 0.05). When compared with the sham acupuncture group, the VAS score, spinal ROM, and simplified ODI score were significantly lower in the acupuncture group after the first intervention, after treatment, and in follow-up visit (<em>P</em> &lt; 0.05). The total effective rate was 90.9% in the acupuncture group, which was significantly higher than that (75.76 %) in the sham acupuncture group (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Acupuncture has a specific effect on CNSLBP in middle-aged and older patients and a superior effect on immediate analgesia.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 4","pages":"Pages 300-305"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of acupuncture on iron metabolism in the hippocampus of the rats with cerebral ischemia-reperfusion injury based on the imbalance of iron homeostasis 基于铁稳态失衡针刺对脑缺血再灌注损伤大鼠海马铁代谢的影响
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2024-10-01 DOI: 10.1016/j.wjam.2024.09.003
Hong-Juan WANG (汪红娟), Hong TANG (唐红), Shan-Shan JIANG (江姗姗), Zhan-Fu LI (李展富), Hao-mei TIAN (田浩梅), Chu-Tao CHEN (陈楚淘)
{"title":"Effects of acupuncture on iron metabolism in the hippocampus of the rats with cerebral ischemia-reperfusion injury based on the imbalance of iron homeostasis","authors":"Hong-Juan WANG (汪红娟),&nbsp;Hong TANG (唐红),&nbsp;Shan-Shan JIANG (江姗姗),&nbsp;Zhan-Fu LI (李展富),&nbsp;Hao-mei TIAN (田浩梅),&nbsp;Chu-Tao CHEN (陈楚淘)","doi":"10.1016/j.wjam.2024.09.003","DOIUrl":"10.1016/j.wjam.2024.09.003","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;This study aimed to observe the effects of acupuncture on iron metabolism in the hippocampus of rats with cerebral ischemia-reperfusion injury (CIRI) and to explore the mechanism of acupuncture on neural repair in CIRI rats.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;After general feeding for 3 days, 16 of 48 healthy Sprague–Dawley rats were selected according to a random number table to form a sham-occlusion group, and the models were prepared in the remaining rats. After successful modeling, the rats were randomized into model and acupuncture groups, with 16 rats in each group. The CIRI models were prepared using the modified Zea Longa suture-occlusion method. In the acupuncture group, the rats were fixed and acupuncture was delivered at “Shuigou” (GV26), “Dazhui” (GV14), and “Baihui” (GV20), and the needles were manipulated once every 15 min. In the sham-occlusion and model groups, rats were fixed without acupuncture. The intervention was performed for 30 min in each group, once every 12 h, seven times. The degree of neurological impairment was assessed by using the modified Garcia score. Cerebral blood flow (CBF) was monitored using a laser speckle blood flow imaging system. The cerebral infarction area ratio was measured using triphenyltetrazolium chloride staining. Ferric ion aggregation in brain tissue was noted using Prussian blue staining. The ferric ion and glutathione (GSH) contents of the hippocampal tissue on the ischemic side were detected using ferric ion and GSH kits. The protein expression of transferrin receptor 1 (TFR1), iron regulatory protein 2 (IRP2), and ferroportin (FPN) was detected via western blotting.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;(1) Before intervention, compared with the sham-occlusion group, the Garcia neurological score was significantly reduced in the model and acupuncture groups (both &lt;em&gt;P &lt;&lt;/em&gt; 0.01). After the intervention, compared with the sham-occlusion group, the Garcia neurological score in the model group decreased significantly (&lt;em&gt;P &lt;&lt;/em&gt; 0.01), and the score in the acupuncture group was elevated compared with the model group (&lt;em&gt;P &lt;&lt;/em&gt; 0.05). Compared to before the intervention, the Garcia neurological score increased after the intervention in the acupuncture group (&lt;em&gt;P &lt;&lt;/em&gt; 0.05). (2) Compared with the sham-occlusion group, in the model group, CBF was reduced, the infarct area was significantly enlarged, ferric ion aggregation increased in the hippocampus, the content of ferric ion increased, and that of GSH decreased significantly (both &lt;em&gt;P &lt;&lt;/em&gt; 0.01), while the protein expression of TFR1 and IRP2 was upregulated and that of FPN was downregulated (both &lt;em&gt;P &lt;&lt;/em&gt; 0.05). When compared with the model group, in the acupuncture group, CBF was increased, the infarct area was reduced (&lt;em&gt;P &lt;&lt;/em&gt; 0.01), the ferric ion aggregation was reduced in the hippocampus, the content of ferric ion decreased, and that of GSH increased significantly (&lt;","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 4","pages":"Pages 292-299"},"PeriodicalIF":0.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professor Wei-bin GAO's experience in treatment of voiding dysfunction with electroacupuncture 高伟斌教授电针治疗排尿功能障碍的经验
IF 0.6 4区 医学
World Journal of Acupuncture-Moxibustion Pub Date : 2024-10-01 DOI: 10.1016/j.wjam.2024.09.009
Shao-peng LIU (刘少鹏) , Ming-yuan HAN (韩名媛) , Xin-yuan CAO (曹馨元) , Ying-ying ZHU (祝莹莹) , Jian-tao YIN (殷建涛) , Zhong-ren SUN (孙忠人) , Wei-bin GAO (高维滨) , Hong-na YIN (尹洪娜)
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