Trends in Food Science & Technology最新文献

{"title":"Self-assembly of bioactive peptides: A novel perspective for digestive adaptation and functional food design","authors":"Rongbo Pan ,&nbsp;Kailin Li ,&nbsp;Jiakai Xu ,&nbsp;Kuncheng Lin ,&nbsp;Xianliang Luo ,&nbsp;Baodong Zheng","doi":"10.1016/j.tifs.2026.105533","DOIUrl":"10.1016/j.tifs.2026.105533","url":null,"abstract":"<div><h3>Background</h3><div>Self-assembly behavior of bioactive peptides has emerged as a research hotspot, offering novel approaches to enhance digestive stability and develop functional foods.</div></div><div><h3>Scope and approach</h3><div>This study systematically elucidated the molecular mechanisms of peptide self-assembly and its crucial role in enhancing peptide structural stability and digestive resistance.</div></div><div><h3>Key findings and conclusion</h3><div>By adjusting environmental factors (such as temperature and pH), and by designing peptide sequences enriched with aromatic amino acids, bioactive peptides can undergo molecular self-assembly to form highly ordered nanostructures, including through molecular self-assembly, including nanofibers, micelles, and hydrogels. This self-assembling structure can markedly enhance the digestive stability of bioactive peptides in the gastrointestinal environment, thereby improving their bioavailability and delivery efficiency. Bioactive peptides rich in proline also exhibit excellent anti-digestive activity. These self-assembling peptides exhibit multifunctional biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Self-assembly enables improved encapsulation efficiency, controlled and targeted release, enhanced bioavailability, and optimized sensory properties, supporting the development of functional foods and nutritional supplements for precision nutrition. However, clinical translation remains constrained by challenges in structural stability, <em>in vivo</em> absorption, and safety. Notably, the self-assembly behavior of bioactive peptides under physiological conditions is still poorly understood. This study reviewed the molecular basis of peptide self-assembly in regulating digestive stability and provides a theoretical framework for designing efficient delivery systems and functional foods.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105533"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress in microbial synthesis of D-allulose using metabolically engineered microbes","authors":"Junchi Zhu ,&nbsp;Like Fan ,&nbsp;Jiajun Chen ,&nbsp;Wei Xu ,&nbsp;Azis Boing Sitanggang ,&nbsp;Fina Amreta Laksmi ,&nbsp;Junmei Ding ,&nbsp;Wanmeng Mu","doi":"10.1016/j.tifs.2026.105551","DOIUrl":"10.1016/j.tifs.2026.105551","url":null,"abstract":"<div><h3>Background</h3><div>D-Allulose is a functional low-calorie sugar with a huge market potential. Industrial production of D-allulose mainly relies on the reversible enzymatic epimerization of D-fructose by D-allulose 3-epimerase (DAEase). Recently, various microbes have been engineered to produce D-allulose efficiently through microbial fermentation.</div></div><div><h3>Scope and approach</h3><div>Four typical types of microbial of D-allulose synthesis are reviewed, including DAEase-based, epimerization/hydrogenation/dehydrogenation-based, aldol reaction/dephosphorylation-based, and phosphorylation/epimerization/dephosphorylation-based biosynthesis.</div></div><div><h3>Key findings and conclusions</h3><div>Introduction of DAEase and deletion of D-fructose catabolism pathway easily achieves the D-allulose production from D-fructose, but it does not change the reversibility of epimerization. The introduction of specific hydrogenation and dehydrogenation enzymes can drive D-allulose synthesis using allitol as an intermediate. A programmable bidirectional dynamic switch has been designed to highly-efficiently produce D-allulose from D-fructose. Aldol reaction and dephosphorylation modules can be introduced into microbes to produce D-allulose from glycerol; however, a considerable amount of D-sorbose is generated as a byproduct. Phosphorylation/epimerization/dephosphorylation pathway can be introduced into microbes to produce D-allulose from D-fructose, D-glucose, D-xylose, glycerol, or sucrose. The pathways of various carbon sources toward D-fructose-6-phosphate are respectively designed and epimerization-dephosphorylation is introduced to thermodynamically driven production of D-allulose from D-fructose-6-phosphate.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105551"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances on aroma-food ingredient interactions: A review","authors":"Ruijie Ni ,&nbsp;Ping Zhan ,&nbsp;Honglei Tian ,&nbsp;Aheidamu Abudalimu ,&nbsp;Peng Wang ,&nbsp;Wanying He ,&nbsp;Runguang Zhang","doi":"10.1016/j.tifs.2026.105550","DOIUrl":"10.1016/j.tifs.2026.105550","url":null,"abstract":"<div><h3>Background</h3><div>Aroma-food ingredient interactions fundamentally govern aroma release, stability, and perception; however, current understanding remains fragmented due to the lack of a unified conceptual framework that integrates molecular mechanisms with predictive modeling and real-food complexity. Existing research is heavily reliant on simplified binary systems, limiting the ability to interpret synergistic or competitive behaviors in multi-component matrices.</div></div><div><h3>Scope and approach</h3><div>This review systematically elucidates the mechanisms underlying aroma-food ingredient interactions, including non-covalent interactions, covalent binding, and mass transfer effects. A multi-scale, integrative framework is proposed that links the characterization of volatile and non-volatile compounds with sensory-based theoretical modeling (threshold method, <em>S</em>-curve, σ-τ plot, and U-model), molecular docking and molecular dynamics simulation to elucidate interaction mechanisms, and multi-spectroscopic validation to support mechanistic interpretation and strengthen predictive, mechanism-driven models. Within this framework, interactions between aroma compounds and major food ingredients (proteins, lipids, carbohydrates, and polyphenols) are critically synthesized, providing mechanistic insights and design principles for targeted flavor modulation.</div></div><div><h3>Key findings and conclusions</h3><div>Recent advances in multi-scale analytical tools and computational techniques have substantially enhanced mechanistic understanding and predictive capability, enabling more precise aroma modulation. However, most studies rely on simplified model systems, insufficiently reflecting real food complexity, interfacial effects, and oral processing. Future research should focus on multi-component and structurally realistic matrices, address these experimental challenges, and integrate multi-omics, sensory science, predictive modeling, machine learning, molecular simulation, and neuroimaging techniques to guide the rational design of foods with optimized flavor performance.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105550"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate metabolism in meat: from postmortem changes to emerging regulatory mechanisms","authors":"Xiangfei Liu,&nbsp;Chengli Hou,&nbsp;Xin Li,&nbsp;Dequan Zhang","doi":"10.1016/j.tifs.2026.105532","DOIUrl":"10.1016/j.tifs.2026.105532","url":null,"abstract":"<div><h3>Background</h3><div>Once regarded solely as a metabolic end-product of anaerobic glycolysis, lactate is now recognized as a multifunctional signaling molecule involved in regulating diverse physiological processes. Historically, meat science research primarily focused on the accumulation of lactic acid as a driver of postmortem pH decline, while recognizing that lactate contributes to key quality traits such as color stability and water-holding capacity. However, recent biochemical insights reveal that lactate also exerts significant regulatory effects through protein lactylation, a novel post-translational modification (PTM).</div></div><div><h3>Scope and approach</h3><div>This review provides a systematic overview of the historical trajectory of lactate research, highlighting the shift from its early characterization as a mere metabolic end-product to its current recognition as a multifaceted signaling molecule. Particular attention is given to the emergence of protein lactylation, including its functional significance and potential regulatory roles. The review also assesses the current understanding of lactate-associated mechanisms in the field of meat science and proposes promising avenues for future research.</div></div><div><h3>Key findings and conclusions</h3><div>Lactylation profoundly impacts protein function, enzyme activity, and cell signaling pathways, and extends its implications far beyond traditional metabolic boundaries. Despite these groundbreaking discoveries, lactate's regulatory role and lactylation mechanisms remain understudied in meat science. Advancing investigations into lactate metabolism is essential for fostering innovation in meat processing technologies, improving quality control systems, and potentially reshaping the conceptual framework of meat quality evaluation.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105532"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hen egg white lysozyme as a functional building block: structural features, assembly behavior, and emerging food applications","authors":"Lijuan Hou ,&nbsp;Xiaozheng Liu ,&nbsp;Zhenyu Wang ,&nbsp;Ruili Pan ,&nbsp;Guangrong Huang ,&nbsp;Xianjun Dai","doi":"10.1016/j.tifs.2025.105521","DOIUrl":"10.1016/j.tifs.2025.105521","url":null,"abstract":"<div><h3>Background</h3><div>Hen egg white lysozyme (HEWL) is a natural, small globular protein renowned for potent antimicrobial activity and exceptional physicochemical stability. Beside traditional applications in food preservation for degrading bacterial cell walls, HEWL has recently attracted growing attention for a broader functional potential in food science and technology.</div></div><div><h3>Scope and approach</h3><div>This review provides a comprehensive overview of HEWL's molecular structure and functional attributes, with a focus on the physicochemical principles that govern the assembly into a wide range of nanostructures, including amyloid fibrils/nanotubes, microbubbles, hydrogels, micro/nanoparticles, emulsions, and films. The review also surveys recent advances in applying these HEWL–based structures to various domains such as food formulation, active compound delivery, food preservation, and biosensing.</div></div><div><h3>Key findings and conclusions</h3><div>HEWL exhibits exceptional structural adaptability, enabling the formation of multifunctional assemblies tailored for diverse food–related applications. These properties position HEWL as a promising, sustainable building block for innovative food system design. However, challenges such as the heterogeneity of assembled architectures, the allergenic potential of egg–derived proteins, and uncertainties surrounding long–term biocompatibility remain. Future research should focus on overcoming these barriers to fully unlock HEWL's potential in safe, sustainable, and multifunctional food applications.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105521"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging application of electrochemical sensors in detection of honey adulteration","authors":"S.R. Priyadharshini ,&nbsp;S. Sujith ,&nbsp;Arunkumar Anandharaj,&nbsp;S. Shanmugasundaram,&nbsp;Ashish Rawson","doi":"10.1016/j.tifs.2025.105519","DOIUrl":"10.1016/j.tifs.2025.105519","url":null,"abstract":"<div><h3>Background</h3><div>Honey is naturally occurring highly viscous liquid, rich in nutrients, antioxidants and having antibacterial properties etc. Adulteration in honey diminishes its nutritional and therapeutic potential and creates economic and public health implications.</div></div><div><h3>Scope and approach</h3><div>In this review, we discuss the use of electrochemical sensors (ES) as a modern analytical tool for detecting honey adulterants including direct adulteration such as addition of sugar syrups, artificial additives, and indirect adulteration such as feeding honey bees with sugars. Compared to other methods, electrochemical sensors are simple to use, portable, cost-effective, and provide real time quantification.</div></div><div><h3>Key findings and conclusions</h3><div>This work emphasizes several strategies for sensor development including amperometric, voltametric, impedimetric, and potentiometric sensors. It also describes new opportunities for novel electrode development using nanomaterials, polymers, enzyme &amp; antibody modification, surface functionalization techniques and molecularly imprinted polymers. It provides examples of smart electrochemical platforms with artificial intelligence (AI), internet of things (IoT) and deep learning for possible on-field and accurate honey authenticity screening. Highlighting the current challenges, emerging directions, and a roadmap for potential future investigations with the goal of establishing reliable, scalable electrochemical solutions for monitoring honey quality.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105519"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-assisted recovery of lycopene from tomato waste: a systematic review supported by generative artificial intelligence","authors":"Cristina Arroqui,&nbsp;Maria N. Berradre,&nbsp;Idoya Fernandez-Pan,&nbsp;María José Beriain,&nbsp;Francisco C. Ibañez,&nbsp;Paloma Virseda","doi":"10.1016/j.tifs.2025.105518","DOIUrl":"10.1016/j.tifs.2025.105518","url":null,"abstract":"<div><h3>Background</h3><div>The processing parameters and analytical conditions for the recovery of lycopene from tomato waste using ultrasound-assisted extraction (UAE) have been found to be inconsistent. This hinders the capacity to draw comparisons between results and to design experiments with the objective of optimizing recovery.</div></div><div><h3>Scope and approach</h3><div>A systematic review in accordance with the PRISMA statement was conducted to identify the specifics of the variables involved in extracting lycopene from tomato waste by UAE. Scopus and Web of Science databases were used to retrieve documents. The screening and data extraction of the identified articles were carried out using GenAI-assisted workflow (Elicit) and traditional human-driven systematic review.</div></div><div><h3>Key findings and conclusions</h3><div>GenAI speeded up the screening, and the extraction of experimental parameters from the selected documents. In addition, this tool also expedited the summarization of the information obtained. However, the research review tool used is subject to certain limitations and needed to resort to critical human intelligence (CritHI) throughout most of the process. The paper provides a reproducible model for incorporating GenAI into systematic literature reviews in food science and related fields. Based on the conducted PRISMA systematic review, the most appropriate experimental conditions for recovering lycopene from tomato waste via UAE are as follows: <em>i</em>) ethanol as suitable solvent, <em>ii</em>) times less than 20 min, temperatures not exceeding 40 °C, and by-product:solvent ratios of 1:10 to 1:80 as processing parameters, and <em>iii</em>) 350 W, 24 kHz, and amplitudes of 65–100 % as sonication conditions.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105518"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future-proof frameworks for allergenicity assessment of novel foods: Bridging immunology and bioengineering","authors":"Tianliang Bai ,&nbsp;Chuang Chen ,&nbsp;Chao Zhang ,&nbsp;Huming Shao ,&nbsp;Zhongliang Wang ,&nbsp;Jun Lu ,&nbsp;Xuanyi Meng ,&nbsp;Yong Wu ,&nbsp;Hongbing Chen ,&nbsp;Xin Li","doi":"10.1016/j.tifs.2026.105529","DOIUrl":"10.1016/j.tifs.2026.105529","url":null,"abstract":"<div><h3>Background</h3><div>The transition to sustainable proteins such as plant-based foods, edible insects, cultured meat, algae, and fungi broadens food diversity but raises allergenic concerns. Novel proteins from new sources, processing and cultivation technologies may carry distinct epitopes, modified structures, or cross-reactive motifs beyond known allergens, complicating risk prediction. Given the multifactorial nature of IgE-mediated allergy, these challenges highlight the need for dynamic, integrative, mechanism-based assessment frameworks more accurately evaluate allergenic potential and support evidence-based regulation and dietary guidance.</div></div><div><h3>Scope and approach</h3><div>We conducted literature searches using the keywords novel food, novel protein, allergen, allergenicity, cross-reactivity, and allergenicity assessment across the Web of Science and PubMed databases. Studies published between 2000 and 2025 were prioritized, and the reference lists of key articles were also screened. We synthesize current evidence to propose a multi-layered allergenicity assessment framework encompassing <em>in silico</em> screening, <em>in vitro</em> IgE-binding and digestion assays, cell-based activation tests, and <em>in vivo</em> mouse models. In addition, emerging and forward-looking technological platforms are highlighted that aim to improve both the efficiency and physiological relevance of allergenicity assessment, including artificial intelligence and machine learning–based prediction tools, microfluidic detection systems, integrated basophil activation test–on-chip platforms, and human organoid and organ-on-chip platforms.</div></div><div><h3>Key findings and conclusion</h3><div>Integrated multi-tier approaches indicate that advanced technologies may can improve the prediction of de novo allergenicity, increase the throughput of allergen testing, enable timely diagnosis, and enhance physiological relevance, thereby facilitating more reliable risk assessment. Nevertheless, challenges such as the lack of standardization, limited scalability remain, and alongside regulatory gaps. We propose integrating immunological insights with data-driven analytics and novel bioengineering methods to establish a comprehensive and forward-looking framework for evaluating the allergenicity of novel foods.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105529"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145923382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Camellia sinensis-polyphenols as functional modulators of carbohydrate-based packaging: Mechanistic insights, functional properties, and industrial translation","authors":"Muhammad Aaqil ,&nbsp;Jingchuan Zheng ,&nbsp;Taixia Chen ,&nbsp;Feng Zhang ,&nbsp;Muhammad Kamil ,&nbsp;Yuwei Guo ,&nbsp;Taufiq Nawaz ,&nbsp;Cunchao Zhao ,&nbsp;Yang Tian","doi":"10.1016/j.tifs.2026.105564","DOIUrl":"10.1016/j.tifs.2026.105564","url":null,"abstract":"<div><h3>Background</h3><div>Sustainable active packaging is urgently needed to reduce reliance on synthetic preservatives and plastic waste. Biopolymer films enhanced with plant polyphenols show strong potential, with <em>Camellia sinensis</em>-derived tea polyphenols (TPs) standing out for their antioxidant, antimicrobial, and UV-protective roles in carbohydrate matrices. Yet findings remain fragmented, with outcomes varying by compound type, dosage, matrix compatibility, and processing conditions, further complicated by non-standard testing and limited retention data.</div></div><div><h3>Scope and approach</h3><div>This study consolidates 2020–2025 studies on TPs in carbohydrate-based food packaging and provides a unified synthesis that integrates formulation and processing strategies, functional properties, structure–interaction mechanisms, and industrial translation across starch, chitosan, alginate, pectin, and cellulose matrices. Unlike earlier studies that treated polyphenols broadly or focused on single matrices, this synthesis is the first to systematically integrate TPs across carbohydrate biopolymer systems, mapping their mechanistic roles to functional and translational outcomes. It critically evaluates recent advances and outlines a forward-looking 4S agenda to guide commercial translation: Standardization, Stability, Scale, and Sustainability.</div></div><div><h3>Key findings and conclusions</h3><div>TPs act as context-dependent regulators, enhancing barriers and bioactive functions at moderate loadings but causing aggregation, darkening, or embrittlement at higher levels. Processing strongly dictates retention: casting preserves activity, while extrusion requires stabilization strategies. The review emphasizes stabilization techniques and cross-process comparisons as prerequisites for scale-up. To advance commercial viability, standardized methods, stability-enhancing designs, and techno-economic assessments are essential. This synthesis provides researchers and industry stakeholders with a roadmap to translate TPs–based packaging into scalable, regulator-ready, and sustainable solutions.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105564"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health challenges and frontier solutions for the post-80s and post-90s generation","authors":"Qing Xia ,&nbsp;Kang Zou","doi":"10.1016/j.tifs.2026.105563","DOIUrl":"10.1016/j.tifs.2026.105563","url":null,"abstract":"<div><h3>Background</h3><div>Individuals born between 1980 and 1999 represent the first cohort to fully experience digital transformation, rapid industrialization, and medical advancements, yet they face unprecedented health paradoxes, including potential longevity gains overshadowed by novel environmental and lifestyle-related risks. These challenges encompass neurological, metabolic, reproductive, and multi-system disruptions driven by modern exposures.</div></div><div><h3>Objective</h3><div>This review systematically examines the distinctive health risks, underlying pathophysiological mechanisms, and innovative medical technologies poised to mitigate these issues over the next 1-2 decades.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted across databases including PubMed, Web of Science, Scopus, and CNKI, using keywords such as \"post-80s generation,\" \"circadian disruption,\" \"ultra-processed foods,\" \"microplastics,\" and \"stem cell therapy,\" published from 2000 to 2025. Inclusion criteria focused on peer-reviewed studies providing empirical evidence on risks or interventions, with screening yielding 199 articles after de-duplication and quality appraisal.</div></div><div><h3>Results</h3><div>This generation confronts chronic neurological dysfunction from digital-induced circadian disruption, metabolic dysregulation and reproductive decline from ultra-processed foods and additive overload, and environmental toxins like microplastics. Emerging technologies show promise, including stem cell therapy, organoid platforms for personalized modeling, gut microbiome modulation for metabolic restoration, precision-targeted therapeutics for disease-specific interventions, modernized phytomedicine for natural anti-inflammatory effects, and exosome-based therapies for non-invasive delivery. Integration with multi-omics monitoring enables early detection and proactive management.</div></div><div><h3>Conclusions</h3><div>Systematic adoption of these technologies and comprehensive health monitoring frameworks could enable sustained healthy longevity for this generation. This synthesis catalyzes a shift from reactive disease management to proactive optimization, offering actionable insights for individuals, clinicians, and policymakers.</div></div>","PeriodicalId":441,"journal":{"name":"Trends in Food Science & Technology","volume":"169 ","pages":"Article 105563"},"PeriodicalIF":15.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}