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Programmed cell death: NINJ1 and mechanisms of plasma membrane rupture 程序性细胞死亡：NINJ1 和质膜破裂机制
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.05.007
{"title":"Programmed cell death: NINJ1 and mechanisms of plasma membrane rupture","authors":"","doi":"10.1016/j.tibs.2024.05.007","DOIUrl":"10.1016/j.tibs.2024.05.007","url":null,"abstract":"<div><p>Lytic cell death culminates in cell swelling and plasma membrane rupture (PMR). The cellular contents released, including proteins, metabolites, and nucleic acids, can act as danger signals and induce inflammation. During regulated cell death (RCD), lysis is actively initiated and can be preceded by an initial loss of membrane integrity caused by pore-forming proteins, allowing small molecules and cytokines to exit the cell. A recent seminal discovery showed that ninjurin1 (NINJ1) is the common executioner of PMR downstream of RCD, resulting in the release of large proinflammatory molecules and representing a novel target of cell death-associated lysis. We summarize recent developments in understanding membrane integrity and rupture of the plasma membrane with a focus on NINJ1.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 717-728"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein lipoylation: mitochondria, cuproptosis, and beyond 蛋白质脂酰化：线粒体、杯突症及其他。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.04.002
{"title":"Protein lipoylation: mitochondria, cuproptosis, and beyond","authors":"","doi":"10.1016/j.tibs.2024.04.002","DOIUrl":"10.1016/j.tibs.2024.04.002","url":null,"abstract":"<div><p>Protein lipoylation, a crucial post-translational modification (PTM), plays a pivotal role in mitochondrial function and emerges as a key player in cell death through cuproptosis. This novel copper-driven cell death pathway is activated by excessive copper ions binding to lipoylated mitochondrial proteins, disrupting energy production and causing lethal protein aggregation and cell death. The intricate relationship among protein lipoylation, cellular energy metabolism, and cuproptosis offers a promising avenue for regulating essential cellular functions. This review focuses on the mechanisms of lipoylation and its significant impact on cell metabolism and cuproptosis, emphasizing the key genes involved and their implications for human diseases. It offers valuable insights into targeting dysregulated cellular metabolism for therapeutic purposes.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 729-744"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of the ‘double diamond’ design framework to nurture creativity in life sciences research 利用 "双钻石 "设计框架培养生命科学研究的创造力。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.04.008
{"title":"Use of the ‘double diamond’ design framework to nurture creativity in life sciences research","authors":"","doi":"10.1016/j.tibs.2024.04.008","DOIUrl":"10.1016/j.tibs.2024.04.008","url":null,"abstract":"<div><p>Designers' work processes are shaped by a four-phase ‘discover, define, develop, and deliver’ model that alternates between divergent and convergent thinking. We suggest consideration of this conceptual scaffold in ‘design sprint’ workshops for graduate students in the life sciences and in design to promote creativity, interdisciplinary collaboration, and knowledge cocreation.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 654-657"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sharing is caring: TMEM165 a Golgi calcium importer used by the lysosome 分享就是关爱TMEM165 溶酶体使用的高尔基体钙离子输入器
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.05.006
{"title":"Sharing is caring: TMEM165 a Golgi calcium importer used by the lysosome","authors":"","doi":"10.1016/j.tibs.2024.05.006","DOIUrl":"10.1016/j.tibs.2024.05.006","url":null,"abstract":"<div><p><span>Calcium is a crucial second messenger in the cell that is stored in organelles including lysosomes. Proteins that facilitate calcium entry to the lysosome were unknown. A recent report by </span><span><span>Zajac <em>et al.</em></span><svg><path></path></svg></span><span> identified TMEM165 as a proton-activated calcium importer on the lysosome, thus discovering a key player in subcellular calcium homeostasis.</span></p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 658-659"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/S0968-0004(24)00170-1
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(24)00170-1","DOIUrl":"10.1016/S0968-0004(24)00170-1","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Page e1"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re-evaluating TRP channel mechanosensitivity 重新评估 TRP 通道机械敏感性
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.05.004
{"title":"Re-evaluating TRP channel mechanosensitivity","authors":"","doi":"10.1016/j.tibs.2024.05.004","DOIUrl":"10.1016/j.tibs.2024.05.004","url":null,"abstract":"<div><p>Transient receptor potential (TRP) channels are implicated in a wide array of mechanotransduction processes. However, a question remains whether TRP channels directly sense mechanical force, thus acting as primary mechanotransducers. We use several recent examples to demonstrate the difficulty in definitively ascribing mechanosensitivity to TRP channel subfamilies. Ultimately, despite being implicated in an ever-growing list of mechanosignalling events in most cases limited robust or reproducible evidence supports the contention that TRP channels act as primary transducers of mechanical forces. They either (i) possess unique and as yet unspecified structural or local requirements for mechanosensitivity; or (ii) act as mechanoamplifiers responding downstream of the activation of a primary mechanotransducer that could include Ca<sup>2+</sup>-permeable mechanosensitive (MS) channels or other potentially unidentified mechanosensors.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 693-702"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001142/pdfft?md5=09b13a76b3c80b1fc631d78be848548c&pid=1-s2.0-S0968000424001142-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141292983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fine-tuning phosphatidic acid production for optimal plant stress responses 微调磷脂酸生产，优化植物胁迫反应。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.05.008
{"title":"Fine-tuning phosphatidic acid production for optimal plant stress responses","authors":"","doi":"10.1016/j.tibs.2024.05.008","DOIUrl":"10.1016/j.tibs.2024.05.008","url":null,"abstract":"<div><p>Phosphatidic acid<span> (PA) is involved in biotic and abiotic stress<span><span> responses in plants. Here, we summarize quantitative lipidomics and real-time imaging used in PA studies and highlight recent studies of diacylglycerol (DAG) kinase (DGK) 5, an </span>enzyme<span> involved in PA biosynthesis, facilitating fine-tuning PA production for optimal stress responses in plants.</span></span></span></p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 663-666"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141439973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A team of chaperones play to win in the bacterial periplasm 在细菌的外质中，一队陪护人员玩得不亦乐乎。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.03.015
{"title":"A team of chaperones play to win in the bacterial periplasm","authors":"","doi":"10.1016/j.tibs.2024.03.015","DOIUrl":"10.1016/j.tibs.2024.03.015","url":null,"abstract":"<div><p>The survival and virulence of Gram-negative bacteria require proper biogenesis and maintenance of the outer membrane (OM), which is densely packed with β-barrel OM proteins (OMPs). Before reaching the OM, precursor unfolded OMPs (uOMPs) must cross the whole cell envelope. A network of periplasmic chaperones and proteases maintains unfolded but folding-competent conformations of these membrane proteins in the aqueous periplasm while simultaneously preventing off-pathway aggregation. These periplasmic proteins utilize different strategies, including conformational heterogeneity, oligomerization, multivalency, and kinetic partitioning, to perform and regulate their functions. Redundant and unique characteristics of the individual periplasmic players synergize to create a protein quality control team capable responding to changing environmental stresses.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 667-680"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway 组装河马：动物发育信号通路的进化过程。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.04.005
{"title":"Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway","authors":"","doi":"10.1016/j.tibs.2024.04.005","DOIUrl":"10.1016/j.tibs.2024.04.005","url":null,"abstract":"<div><p>Decades of work in developmental genetics has given us a deep mechanistic understanding of the fundamental signaling pathways underlying animal development. However, little is known about how these pathways emerged and changed over evolutionary time. Here, we review our current understanding of the evolutionary emergence of the Hippo pathway, a conserved signaling pathway that regulates tissue size in animals. This pathway has deep evolutionary roots, emerging piece by piece in the unicellular ancestors of animals, with a complete core pathway predating the origin of animals. Recent functional studies in close unicellular relatives of animals and early-branching animals suggest an ancestral function of the Hippo pathway in cytoskeletal regulation, which was subsequently co-opted to regulate proliferation and animal tissue size.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 681-692"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140903559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The YTHDF proteins display distinct cellular functions on m6A-modified RNA YTHDF 蛋白在 m6A 修饰的 RNA 上显示出不同的细胞功能。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-07-01 DOI: 10.1016/j.tibs.2024.04.001
Zhongyu Zou , Chuan He
{"title":"The YTHDF proteins display distinct cellular functions on m6A-modified RNA","authors":"Zhongyu Zou ,&nbsp;Chuan He","doi":"10.1016/j.tibs.2024.04.001","DOIUrl":"10.1016/j.tibs.2024.04.001","url":null,"abstract":"<div><p>YTHDF proteins are main cytoplasmic ‘reader’ proteins of RNA <em>N</em><sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation in mammals. They are largely responsible for m<sup>6</sup>A-mediated regulation in the cell cytosol by controlling both mRNA translation and degradation. Recent functional and mechanistic investigations of the YTHDF proteins revealed that these proteins have different functions to enable versatile regulation of the epitranscriptome. Their divergent functions largely originate from their different amino acid sequences in the low-complexity N termini. Consequently, they have different phase separation propensities and possess distinct post-translational modifications (PTMs). Different PTMs, subcellular localizations, and competition among partner proteins have emerged as three major mechanisms that control the functions of these YTHDF proteins. We also summarize recent progress on critical roles of these YTHDF proteins in anticancer immunity and the potential for targeting these proteins for developing new anticancer therapies.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 7","pages":"Pages 611-621"},"PeriodicalIF":11.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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