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RNA imprinting by zinc-finger proteins 锌指蛋白的RNA印迹。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-05-20 DOI: 10.1016/j.tibs.2026.04.012
José E. Pérez-Ortín, Sebastián Chávez, Mordechai Choder
{"title":"RNA imprinting by zinc-finger proteins","authors":"José E. Pérez-Ortín,&nbsp;Sebastián Chávez,&nbsp;Mordechai Choder","doi":"10.1016/j.tibs.2026.04.012","DOIUrl":"10.1016/j.tibs.2026.04.012","url":null,"abstract":"<div><div>RNA imprinting refers to the co-transcriptional binding of (a) factor(s) that remain associated with the RNA as it enters the cytoplasm, where it/they regulate(s) post-transcriptional processes. Transcription factors (TFs), such as yeast Sfp1 and mammalian tristetraprolin, FUS, and Yin–Yang 1, exemplify RNA imprinting by zinc-binding proteins. These TFs contain large intrinsically disordered regions (IDRs) and have the capacity to bind both DNA and RNA. The most prevalent zinc-binding domains among TFs are zinc fingers (ZFs), which recognize nucleic acids through modular tandem arrangements. We hypothesize that the structural organization of ZFs enables switching between DNA and RNA during transcription. The IDRs of these TFs, together with the nascent RNA, contribute to transcription-related biomolecular condensates that may facilitate this switching, enabling their imprinting.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Pages 761-773"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147979907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of glycan modifications in health and disease 聚糖修饰在健康和疾病中的作用。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-06-24 DOI: 10.1016/j.tibs.2026.05.013
Madouc D. Bergers, Tessa A. Goté, Zachary Armstrong
{"title":"The role of glycan modifications in health and disease","authors":"Madouc D. Bergers,&nbsp;Tessa A. Goté,&nbsp;Zachary Armstrong","doi":"10.1016/j.tibs.2026.05.013","DOIUrl":"10.1016/j.tibs.2026.05.013","url":null,"abstract":"<div><div>Glycans are polymeric carbohydrate chains that often decorate proteins and lipids present on cell surfaces and in the extracellular space, thereby influencing cell interactions, immune responses, and host–microbiome relationships. Glycans are highly dynamic and can undergo a plethora of post-synthetic modifications, including <em>O</em>-acetylation, sulfation, and sulfamation. In this review, we examine how these glycan modifications are established and how they influence human health, from cell signaling to host–pathogen dynamics. We propose terming these glycan modifications, which give rise to a greater diversity of glycans, collectively as the epiglycome. Despite their biological importance, glycan modifications are considerably less well studied than the underlying glycans and proteins. However, advances in chemical and biochemical tools are enabling greater insights into their roles and translational potential.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Pages 787-800"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A unified mechanism of phosphate export across eukaryotes through EXS domain-containing proteins 磷酸盐通过含EXS结构域的蛋白在真核生物中输出的统一机制。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-07-06 DOI: 10.1016/j.tibs.2026.05.012
Ghazanfar Abbas Khan, Elycia Calvet, Jean-Luc Battini, Yves Poirier
{"title":"A unified mechanism of phosphate export across eukaryotes through EXS domain-containing proteins","authors":"Ghazanfar Abbas Khan,&nbsp;Elycia Calvet,&nbsp;Jean-Luc Battini,&nbsp;Yves Poirier","doi":"10.1016/j.tibs.2026.05.012","DOIUrl":"10.1016/j.tibs.2026.05.012","url":null,"abstract":"<div><div>Inorganic phosphate (Pi) is an essential macronutrient, and tight regulation of Pi import and export is required to maintain Pi homeostasis. Although Pi import mechanisms have been extensively characterized, the molecular basis of Pi export has only recently begun to emerge. <em>Arabidopsis</em> PHOSPHATE 1 (PHO1) and its homologue PHO1;H1 are prototypical members of the SPX [Syg1/PHO81/xenotropic and polytropic retrovirus receptor 1 (XPR1)]–EXS (ERD1/XPR1/SYG1) family of Pi exporters conserved throughout eukaryotes, including the metazoan orthologue XPR1 and fungal SYG1. We review recent structural studies redefining XPR1 and PHO1;H1 Pi transporters as channel-like proteins using a double-lock gating mechanism controlled by inositol pyrophosphates. This new knowledge enhances our ability to modulate the activity of SPX–EXS proteins involved in human diseases, such as cancer, as well as enhance phosphate-use efficiency in crops.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Pages 774-786"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CycloPepper learns cyclization sites in therapeutic peptides CycloPepper学习治疗肽中的环化位点。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-06-18 DOI: 10.1016/j.tibs.2026.05.008
Chengrui Hu (胡乘睿), Yourong Pan (潘有容), Chengxi Li (李承喜)
{"title":"CycloPepper learns cyclization sites in therapeutic peptides","authors":"Chengrui Hu (胡乘睿),&nbsp;Yourong Pan (潘有容),&nbsp;Chengxi Li (李承喜)","doi":"10.1016/j.tibs.2026.05.008","DOIUrl":"10.1016/j.tibs.2026.05.008","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Pages 844-845"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Musings of a lab janitor: Data analysis 实验室看门人的思考：数据分析。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-08-06 DOI: 10.1016/j.tibs.2026.06.006
Tamor A. Khan
{"title":"Musings of a lab janitor: Data analysis","authors":"Tamor A. Khan","doi":"10.1016/j.tibs.2026.06.006","DOIUrl":"10.1016/j.tibs.2026.06.006","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Page 846"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-type VI tactics: bacterial defenses against type VI secretion system attacks 抗VI型策略：细菌防御VI型分泌系统的攻击。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-03-31 DOI: 10.1016/j.tibs.2026.02.017
Nicolas Rivard, Julius Martinkus, Margot M. Dessartine, Jean-Philippe Côté, Eric Cascales
{"title":"Anti-type VI tactics: bacterial defenses against type VI secretion system attacks","authors":"Nicolas Rivard,&nbsp;Julius Martinkus,&nbsp;Margot M. Dessartine,&nbsp;Jean-Philippe Côté,&nbsp;Eric Cascales","doi":"10.1016/j.tibs.2026.02.017","DOIUrl":"10.1016/j.tibs.2026.02.017","url":null,"abstract":"<div><div>Survival of bacteria in dense and competitive microbial communities depends on their ability to access nutrients or outcompete neighboring cells. One of the key players in competition is the type VI secretion system (T6SS), a contractile nanomachine that injects a broad variety of effectors into competitors. However, target cells do not remain defenseless. Given the lethality of T6SS-mediated attacks, they have evolved countermeasures to detect, withstand, or resist such assaults: immunity proteins that neutralize effectors, activation of envelope stress pathways to mitigate damage, retaliatory responses to avoid recurrent attacks, physical barriers such as matrix polymers, or collective protection through aggregation. In this review article, we provide a comprehensive overview of these diverse strategies and emphasize the arms-race dynamics.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Pages 816-826"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-08-06 DOI: 10.1016/S0968-0004(26)00228-8
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(26)00228-8","DOIUrl":"10.1016/S0968-0004(26)00228-8","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Page e1"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148745748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cap in hand: giant viruses, stolen translation, and a road to endosymbiosis? 恭恭恭敬：巨型病毒，偷来的翻译，通往内共生之路？
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-06-17 DOI: 10.1016/j.tibs.2026.05.010
Nicholas W. Hubbard, Nels C. Elde
{"title":"Cap in hand: giant viruses, stolen translation, and a road to endosymbiosis?","authors":"Nicholas W. Hubbard,&nbsp;Nels C. Elde","doi":"10.1016/j.tibs.2026.05.010","DOIUrl":"10.1016/j.tibs.2026.05.010","url":null,"abstract":"<div><div><span><span>Fels <em>et al</em>.</span><svg><path></path></svg></span> (2026) report that the giant DNA virus mimivirus encodes a complete, functional translation initiation complex, termed vIF4F, which replaces the host’s own initiation machinery during infection, sustains viral protein synthesis under cellular stress, and points to a blurring of boundaries between viral and cellular life.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Pages 755-757"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148269820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycosphingolipids in cell identity: Biosynthesis, functions, and emerging tools 鞘糖脂在细胞身份：生物合成，功能和新兴工具。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-06-18 DOI: 10.1016/j.tibs.2026.05.009
Pavel Barahtjan, Nika Goršek, Jean Andrea Maillat, Giovanni D’Angelo
{"title":"Glycosphingolipids in cell identity: Biosynthesis, functions, and emerging tools","authors":"Pavel Barahtjan,&nbsp;Nika Goršek,&nbsp;Jean Andrea Maillat,&nbsp;Giovanni D’Angelo","doi":"10.1016/j.tibs.2026.05.009","DOIUrl":"10.1016/j.tibs.2026.05.009","url":null,"abstract":"<div><div>Cell fate is shaped by external cues and intrinsic cellular states. While supracellular signals, such as growth factors, provide instructive guidance, emerging evidence highlights the role of cell-autonomous properties in modulating these responses. Among these, lipid membrane composition, especially glycosphingolipids (GSLs), has gained attention as a contributor to cellular identity. GSL biophysical properties guide the formation of membrane nanodomains, which serve as platforms for receptor signaling and protein sorting, while their structural heterogeneity enables distinct interactions with signaling molecules and recognition factors. In this review, we discuss the biosynthesis and organization of GSLs, their biological roles, and emerging technologies for their analysis. Together, these studies support the view that GSLs contribute to cell-type-specific membrane properties and help shape cellular states and identity.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Pages 801-815"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148269846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-08-01 Epub Date: 2026-08-06 DOI: 10.1016/S0968-0004(26)00225-2
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(26)00225-2","DOIUrl":"10.1016/S0968-0004(26)00225-2","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 8","pages":"Pages i-ii"},"PeriodicalIF":14.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148745996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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