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Advisory Board and Contents 咨询委员会及内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-03-01 DOI: 10.1016/S0968-0004(25)00035-0
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引用次数: 0
Structured protein domains enter the spotlight: modulators of biomolecular condensate form and function 结构蛋白域进入聚光灯下：生物分子凝聚形式和功能的调节剂。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-03-01 DOI: 10.1016/j.tibs.2024.12.008
Nathaniel Hess , Jerelle A. Joseph
{"title":"Structured protein domains enter the spotlight: modulators of biomolecular condensate form and function","authors":"Nathaniel Hess ,&nbsp;Jerelle A. Joseph","doi":"10.1016/j.tibs.2024.12.008","DOIUrl":"10.1016/j.tibs.2024.12.008","url":null,"abstract":"<div><div>Biomolecular condensates are membraneless organelles that concentrate proteins and nucleic acids. One of the primary components of condensates is multidomain proteins, whose domains can be broadly classified as structured and disordered. While structured protein domains are ubiquitous within biomolecular condensates, the physical ramifications of their unique properties have been relatively underexplored. Therefore, this review synthesizes current literature pertaining to structured protein domains within the context of condensates. We examine how the propensity of structured domains for high interaction specificity and low conformational heterogeneity contributes to the formation, material properties, and functions of biomolecular condensates. Finally, we propose unanswered questions on the behavior of structured protein domains within condensates, the answers of which will contribute to a more complete understanding of condensate biophysics.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 3","pages":"Pages 206-223"},"PeriodicalIF":11.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-03-01 DOI: 10.1016/S0968-0004(25)00038-6
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(25)00038-6","DOIUrl":"10.1016/S0968-0004(25)00038-6","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 3","pages":"Page e1"},"PeriodicalIF":11.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein quality control machinery: regulators of condensate architecture and functionality 蛋白质质量控制机械：冷凝水结构和功能的调节器。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.tibs.2024.12.003
Anitha Rajendran , Carlos A. Castañeda
{"title":"Protein quality control machinery: regulators of condensate architecture and functionality","authors":"Anitha Rajendran ,&nbsp;Carlos A. Castañeda","doi":"10.1016/j.tibs.2024.12.003","DOIUrl":"10.1016/j.tibs.2024.12.003","url":null,"abstract":"<div><div>Protein quality control (PQC) mechanisms including the ubiquitin (Ub)-proteasome system (UPS), autophagy, and chaperone-mediated refolding are essential to maintain protein homeostasis in cells. Recent studies show that these PQC mechanisms are further modulated by biomolecular condensates that sequester PQC components and compartmentalize reactions. Accumulating evidence points towards the PQC machinery playing a pivotal role in regulating the assembly, disassembly, and viscoelastic properties of several condensates. Here, we discuss how the PQC machinery can form their own condensates and also be recruited to known condensates under physiological or stress-induced conditions. We present molecular insights into how the multivalent architecture of polyUb chains, Ub-binding adaptor proteins, and other PQC machinery contribute to condensate assembly, leading to the regulation of downstream PQC outcomes and therapeutic potential.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 2","pages":"Pages 106-120"},"PeriodicalIF":11.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical probes for imaging cellular compartmentalization 成像细胞区隔化的化学探针。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.tibs.2024.12.005
Margret H. Bülow , Johannes Broichhagen
{"title":"Chemical probes for imaging cellular compartmentalization","authors":"Margret H. Bülow ,&nbsp;Johannes Broichhagen","doi":"10.1016/j.tibs.2024.12.005","DOIUrl":"10.1016/j.tibs.2024.12.005","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 2","pages":"Pages 171-172"},"PeriodicalIF":11.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synaptoneurolipidomics: lipidomics in the study of synaptic function 突触神经脂组学：研究突触功能的脂组学。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.tibs.2024.12.004
Robert Ahrends , Shane R. Ellis , Steven H.L. Verhelst , Michael R. Kreutz
{"title":"Synaptoneurolipidomics: lipidomics in the study of synaptic function","authors":"Robert Ahrends ,&nbsp;Shane R. Ellis ,&nbsp;Steven H.L. Verhelst ,&nbsp;Michael R. Kreutz","doi":"10.1016/j.tibs.2024.12.004","DOIUrl":"10.1016/j.tibs.2024.12.004","url":null,"abstract":"<div><div>The brain is an exceptionally lipid-rich organ with a very complex lipid composition. Lipids are central in several neuronal processes, including membrane formation and fusion, myelin packing, and lipid-mediated signal transmission. Lipid diversity is associated with the evolution of higher cognitive abilities in primates, is affected by neuronal activity, and is instrumental for synaptic plasticity, illustrating that lipids are not static components of synaptic membranes. Several lines of evidence suggest that the lipid composition of synapses is unique and distinct from other neuronal subcompartments. Here, we delve into the nascent field of synaptoneurolipidomics, offering an overview of current knowledge on the lipid composition of synaptic junctions and technological advances that will allow us to study the impact on synaptic function.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 2","pages":"Pages 156-170"},"PeriodicalIF":11.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Textbook oxidative phosphorylation needs to be rewritten 教科书中的氧化磷酸化需要重写。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.tibs.2024.11.002
Alicia J. Kowaltowski , Fernando Abdulkader
{"title":"Textbook oxidative phosphorylation needs to be rewritten","authors":"Alicia J. Kowaltowski ,&nbsp;Fernando Abdulkader","doi":"10.1016/j.tibs.2024.11.002","DOIUrl":"10.1016/j.tibs.2024.11.002","url":null,"abstract":"<div><div>Oxidative phosphorylation (OxPhos) is the energy-transfer process that generates most of our ATP, fueled by proton and electrical gradients across the inner mitochondrial membrane. A new surprising finding by <span><span>Hernansanz-Agustín <em>et al</em>.</span><svg><path></path></svg></span> demonstrates that between one-third and half of this gradient is attributable to Na<sup>+</sup>, transported in exchange for protons within complex I.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 2","pages":"Pages 87-88"},"PeriodicalIF":11.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0968-0004(25)00014-3
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(25)00014-3","DOIUrl":"10.1016/S0968-0004(25)00014-3","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 2","pages":"Page e1"},"PeriodicalIF":11.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143312908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-02-01 DOI: 10.1016/S0968-0004(25)00011-8
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(25)00011-8","DOIUrl":"10.1016/S0968-0004(25)00011-8","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 2","pages":"Pages i-ii"},"PeriodicalIF":11.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143313389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins 羧酸夹紧四肽重复（CC-TPR）蛋白的伴侣依赖性和伴侣非依赖性功能。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-02-01 DOI: 10.1016/j.tibs.2024.11.004
Saugat Pokhrel , Shweta Devi , Jason E. Gestwicki
{"title":"Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins","authors":"Saugat Pokhrel ,&nbsp;Shweta Devi ,&nbsp;Jason E. Gestwicki","doi":"10.1016/j.tibs.2024.11.004","DOIUrl":"10.1016/j.tibs.2024.11.004","url":null,"abstract":"<div><div>The molecular chaperones HSP70 and HSP90 play key roles in proteostasis by acting as adapters; they bind to a 'client' protein, often with the assistance of cochaperones, and then recruit additional cochaperones that promote specific fates (e.g., folding or degradation). One family of cochaperones contains a region termed the tetratricopeptide repeat with carboxylate clamps (CC-TPRs) domain. These domains bind to an EEVD motif at the C-termini of cytoplasmic HSP70 and HSP90 proteins, bringing them into proximity to chaperone-bound clients. It has recently become clear that CC-TPR proteins also bind to 'EEVD-like' motifs in non-chaperone proteins, circumventing the need for HSP70s or HSP90s. We provide an overview of the chaperone-dependent and -independent roles of CC-TPR proteins and discuss how, together, they shape proteostasis.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 2","pages":"Pages 121-133"},"PeriodicalIF":11.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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