教科书中的氧化磷酸化需要重写。

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-11-21 DOI:10.1016/j.tibs.2024.11.002

Alicia J Kowaltowski, Fernando Abdulkader

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引用次数: 0

摘要

氧化磷酸化（OxPhos）是产生大部分 ATP 的能量转移过程，其动力来自线粒体内膜上的质子和电梯度。埃尔南桑斯-阿古斯丁（Hernansanz-Agustín）等人的一项新的惊人发现表明，这种梯度的三分之一到一半可归因于Na+，它在复合体 I 中被输送以交换质子。

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Textbook oxidative phosphorylation needs to be rewritten.

Oxidative phosphorylation (OxPhos) is the energy-transfer process that generates most of our ATP, fueled by proton and electrical gradients across the inner mitochondrial membrane. A new surprising finding by Hernansanz-Agustín et al. demonstrates that between one-third and half of this gradient is attributable to Na⁺, transported in exchange for protons within complex I.

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.