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Versatile JMJD proteins: juggling histones and much more 多用途 JMJD 蛋白：组蛋白和更多杂耍。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.06.009
{"title":"Versatile JMJD proteins: juggling histones and much more","authors":"","doi":"10.1016/j.tibs.2024.06.009","DOIUrl":"10.1016/j.tibs.2024.06.009","url":null,"abstract":"<div><p>Jumonji C domain-containing (JMJD) proteins are found in bacteria, fungi, animals, and plants. They belong to the 2-oxoglutarate-dependent oxygenase superfamily and are endowed with various enzymatic activities, including demethylation of histones and hydroxylation of non-histone proteins. Many JMJD proteins are involved in the epigenetic control of gene expression, yet they also modulate a myriad other cellular processes. In this review we focus on the 33 human JMJD proteins and their established and controversial catalytic properties, survey their epigenetic and non-epigenetic functions, emphasize their contribution to sex-specific disease differences, and highlight how they sense metabolic changes. All this underlines not only their key roles in development and homeostasis, but also that JMJD proteins are destined to become drug targets in multiple diseases.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 9","pages":"Pages 804-818"},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/S0968-0004(24)00197-X
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(24)00197-X","DOIUrl":"10.1016/S0968-0004(24)00197-X","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 9","pages":"Pages i-ii"},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S096800042400197X/pdfft?md5=4cf0e61b464c1e32c0d7234ffa2149e3&pid=1-s2.0-S096800042400197X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional implications of fumarate-induced cysteine succination 富马酸诱导半胱氨酸琥珀酸化的功能影响
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.05.003
{"title":"Functional implications of fumarate-induced cysteine succination","authors":"","doi":"10.1016/j.tibs.2024.05.003","DOIUrl":"10.1016/j.tibs.2024.05.003","url":null,"abstract":"<div><p>Mutations in metabolic enzymes are associated with hereditary and sporadic forms of cancer. For example, loss-of-function mutations affecting fumarate hydratase (FH), the tricarboxylic acid (TCA) cycle enzyme, result in the accumulation of millimolar levels of fumarate that cause an aggressive form of kidney cancer. A distinct feature of fumarate is its ability to spontaneously react with thiol groups of cysteines in a chemical reaction termed succination. Although succination of a few proteins has been causally implicated in the molecular features of FH-deficient cancers, the stoichiometry, wider functional consequences, and contribution of succination to disease development remain largely unexplored. We discuss the functional implications of fumarate-induced succination in FH-deficient cells, the available methodologies, and the current challenges in studying this post-translational modification.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 9","pages":"Pages 775-790"},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001130/pdfft?md5=df3dc6aac16d13e59cc8af993548abc8&pid=1-s2.0-S0968000424001130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141320369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orange carotenoid proteins: structural understanding of evolution and function 橙色类胡萝卜素蛋白：从结构上理解进化和功能。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.04.010
{"title":"Orange carotenoid proteins: structural understanding of evolution and function","authors":"","doi":"10.1016/j.tibs.2024.04.010","DOIUrl":"10.1016/j.tibs.2024.04.010","url":null,"abstract":"<div><p>Cyanobacteria uniquely contain a primitive water-soluble carotenoprotein, the orange carotenoid protein (OCP). Nearly all extant cyanobacterial genomes contain genes for the OCP or its homologs, implying an evolutionary constraint for cyanobacteria to conserve its function. Genes encoding the OCP and its two constituent structural domains, the N-terminal domain, helical carotenoid proteins (HCPs), and its C-terminal domain, are found in the most basal lineages of extant cyanobacteria. These three carotenoproteins exemplify the importance of the protein for carotenoid properties, including protein dynamics, in response to environmental changes in facilitating a photoresponse and energy quenching. Here, we review new structural insights for these carotenoproteins and situate the role of the protein in what is currently understood about their functions.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 9","pages":"Pages 819-828"},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141092751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunometabolism in atherosclerosis: a new understanding of an old disease 动脉粥样硬化中的免疫代谢：对一种古老疾病的新认识。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.06.003
{"title":"Immunometabolism in atherosclerosis: a new understanding of an old disease","authors":"","doi":"10.1016/j.tibs.2024.06.003","DOIUrl":"10.1016/j.tibs.2024.06.003","url":null,"abstract":"<div><p>Atherosclerosis, a chronic inflammatory condition, remains a leading cause of death globally, necessitating innovative approaches to target pro-atherogenic pathways. Recent advancements in the field of immunometabolism have highlighted the crucial interplay between metabolic pathways and immune cell function in atherogenic milieus. Macrophages and T cells undergo dynamic metabolic reprogramming to meet the demands of activation and differentiation, influencing plaque progression. Furthermore, metabolic intermediates intricately regulate immune cell responses and atherosclerosis development. Understanding the metabolic control of immune responses in atherosclerosis, known as athero-immunometabolism, offers new avenues for preventive and therapeutic interventions. This review elucidates the emerging intricate interplay between metabolism and immunity in atherosclerosis, underscoring the significance of metabolic enzymes and metabolites as key regulators of disease pathogenesis and therapeutic targets.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 9","pages":"Pages 791-803"},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001464/pdfft?md5=348df678388d4a0cc5c8ddb341c90fb2&pid=1-s2.0-S0968000424001464-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Back on the chain gang: polyphosphate modification of proteins 回到链式团伙：蛋白质的多磷酸修饰。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI: 10.1016/j.tibs.2024.06.010
{"title":"Back on the chain gang: polyphosphate modification of proteins","authors":"","doi":"10.1016/j.tibs.2024.06.010","DOIUrl":"10.1016/j.tibs.2024.06.010","url":null,"abstract":"<div><p>Polyphosphate<span><span> (polyP) mediates a plethora of biological functions<span>. Understanding the polyP-protein interactome<span> will help clarify the mechanisms underpinning these functions. Recent studies demonstrating a strong but noncovalent modification of lysine and histidine repeat proteins by polyP have provided new insights into polyP-protein </span></span></span>biochemistry with implications for research and therapeutics.</span></p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 9","pages":"Pages 757-760"},"PeriodicalIF":11.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IUBMB Emerging Leader Award and Africa Initiative 国际生物化学和分子生物学联合会（IUBMB）新兴领导人奖和非洲倡议。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.06.001
Alexandra Newton , Robert Adamu Shey
{"title":"IUBMB Emerging Leader Award and Africa Initiative","authors":"Alexandra Newton ,&nbsp;Robert Adamu Shey","doi":"10.1016/j.tibs.2024.06.001","DOIUrl":"10.1016/j.tibs.2024.06.001","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 651-653"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis 双重职责异构酶：异构化耦合酶催化案例研究。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.04.007
{"title":"Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis","authors":"","doi":"10.1016/j.tibs.2024.04.007","DOIUrl":"10.1016/j.tibs.2024.04.007","url":null,"abstract":"<div><p>Enzymes can usually be unambiguously assigned to one of seven classes specifying the basic chemistry of their catalyzed reactions. Less frequently, two or more reaction classes are catalyzed by a single enzyme within one active site. Two examples are an isomerohydrolase and an isomero-oxygenase that catalyze isomerization-coupled reactions crucial for production of vision-supporting 11-<em>cis</em>-retinoids. In these enzymes, isomerization is obligately paired and mechanistically intertwined with a second reaction class. A handful of other enzymes carrying out similarly coupled isomerization reactions have been described, some of which have been subjected to detailed structure–function analyses. Herein we review these rarefied enzymes, focusing on the mechanistic and structural basis of their reaction coupling with the goal of revealing catalytic commonalities.</p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 703-716"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001075/pdfft?md5=a620107d4e3bd5bffcb072370bae840f&pid=1-s2.0-S0968000424001075-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140954759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/S0968-0004(24)00167-1
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(24)00167-1","DOIUrl":"10.1016/S0968-0004(24)00167-1","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages i-ii"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0968000424001671/pdfft?md5=79268d7fa09f597c9b08430d8bdd78db&pid=1-s2.0-S0968000424001671-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141953067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design 祖先核糖核酸酶重新启动，以进化动力学为指导设计蛋白质。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-08-01 DOI: 10.1016/j.tibs.2024.06.005
{"title":"Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design","authors":"","doi":"10.1016/j.tibs.2024.06.005","DOIUrl":"10.1016/j.tibs.2024.06.005","url":null,"abstract":"<div><p>The dynamics behavior of a protein is essential for its functionality. Here, <span><span>Doucet <em>et al</em>.</span><svg><path></path></svg></span><span> demonstrate how the evolutionary analysis of conformational pathways within a protein family serves to identify common core scaffolds that accommodate branch-specific functional regions controlled by flexibility switches, offering a model for evolutionary-dynamics based protein design.</span></p></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 8","pages":"Pages 660-662"},"PeriodicalIF":11.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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