Immunometabolism in atherosclerosis: a new understanding of an old disease

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2024-09-01 DOI:10.1016/j.tibs.2024.06.003

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Abstract

Atherosclerosis, a chronic inflammatory condition, remains a leading cause of death globally, necessitating innovative approaches to target pro-atherogenic pathways. Recent advancements in the field of immunometabolism have highlighted the crucial interplay between metabolic pathways and immune cell function in atherogenic milieus. Macrophages and T cells undergo dynamic metabolic reprogramming to meet the demands of activation and differentiation, influencing plaque progression. Furthermore, metabolic intermediates intricately regulate immune cell responses and atherosclerosis development. Understanding the metabolic control of immune responses in atherosclerosis, known as athero-immunometabolism, offers new avenues for preventive and therapeutic interventions. This review elucidates the emerging intricate interplay between metabolism and immunity in atherosclerosis, underscoring the significance of metabolic enzymes and metabolites as key regulators of disease pathogenesis and therapeutic targets.

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动脉粥样硬化中的免疫代谢：对一种古老疾病的新认识。

动脉粥样硬化是一种慢性炎症，仍然是全球死亡的主要原因，因此有必要采用创新方法来靶向促动脉粥样硬化的途径。免疫代谢领域的最新进展突显了致动脉粥样硬化环境中代谢途径与免疫细胞功能之间的重要相互作用。巨噬细胞和 T 细胞会进行动态代谢重编程，以满足活化和分化的需求，从而影响斑块的进展。此外，代谢中间产物对免疫细胞反应和动脉粥样硬化的发展有着错综复杂的调节作用。了解动脉粥样硬化中免疫反应的代谢控制（即动脉粥样硬化免疫代谢）为预防和治疗干预提供了新途径。这篇综述阐明了动脉粥样硬化中代谢与免疫之间新出现的错综复杂的相互作用，强调了代谢酶和代谢物作为疾病发病机制和治疗靶点的关键调控因子的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.