Tetrahedron Letters最新文献

Halogenated Pyridine Derivatives from Cycloaddition / Cycloreversion of Oxazinone and Haloalkyne Precursors. 恶嗪酮和卤代炔前体环加成/环还原的卤代吡啶衍生物。

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-10-30 Epub Date: 2025-08-05 DOI: 10.1016/j.tetlet.2025.155765

Elizabeth A Davis, Megan S Hammett, Jonathan R Scheerer

引用次数: 0

Two novel fungal alkaloids were isolated from Arthrinium malaysianum and their bioactivities 从马来蓟马中分离到两种新的真菌生物碱及其生物活性

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-10-04 DOI: 10.1016/j.tetlet.2025.155841

Jie Zhen Shi , Yan Li Zhang , Jin Hua Yu , Da Mei Wang , Dong Gan , Zhong Tao Ding

{"title":"Two novel fungal alkaloids were isolated from Arthrinium malaysianum and their bioactivities","authors":"Jie Zhen Shi , Yan Li Zhang , Jin Hua Yu , Da Mei Wang , Dong Gan , Zhong Tao Ding","doi":"10.1016/j.tetlet.2025.155841","DOIUrl":"10.1016/j.tetlet.2025.155841","url":null,"abstract":"<div><div>Two new fungal alkaloids, arthriniumperazine A (<strong>1</strong>) and arthriniumperazine B (<strong>2</strong>), along with the known mycoediketopiperazine (<strong>3</strong>), were isolated from the endophytic fungus <em>Arthrinium</em> malaysianum DD-1. Notably, this class of fungal alkaloids is scarcely reported, with only compound <strong>3</strong> being previously documented in the literature. The planar structures of <strong>1</strong> and <strong>2</strong> were elucidated through comprehensive spectroscopic analyses, including <sup>1</sup>H/<sup>13</sup>C NMR and HR-ESI-MS. Their absolute configurations were unambiguously determined by comparative ECD calculations. In bioactivity assays, compound <strong>2</strong> exhibited weak α-glucosidase inhibitory activity (18.95 ± 3.77 %, <em>n</em> = 3). For antimicrobial evaluation, compound <strong>1</strong> showed broad-spectrum activity with consistent MICs of 26.60 μg/mL against <em>Bacillus subtilis</em>, <em>Staphylococcus aureus</em>, and <em>Escherichia coli</em>. Compound <strong>2</strong> exhibited selective inhibitory effects against <em>Escherichia coli</em> (26.60 μg/mL) and <em>Staphylococcus aureus</em> (26.60 μg/mL) in the broth microdilution assay, while displaying no significant inhibition against <em>Bacillus subtilis</em>.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"173 ","pages":"Article 155841"},"PeriodicalIF":1.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-catalyzed synthesis of pyrrolo[2,1-a]isoquinolines through condensation/cycloaddition/aromatization cascade 铜催化缩合/环加成/芳构化级联合成吡咯[2,1-a]异喹啉类化合物

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-10-02 DOI: 10.1016/j.tetlet.2025.155829

Man Jiang , Xue Sheng , Yu Luo, Hai-Lei Cui

引用次数: 0

Difluoromethylheteroarylation of unactivated alkenes through remote heteroaryl migration with bis(difluoroacetyl) peroxide 双（二氟乙酰基）过氧化物通过远端异芳基迁移对非活化烯烃的二氟甲基异芳基化

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-09-25 DOI: 10.1016/j.tetlet.2025.155842

Zhiqi Lei , Xiaoyu Wang , Siqi Li , Xia Zhao , Kui Lu

引用次数: 0

Electrochemical Di-functionalization: Oxidative Amination and Oxygenation of 4-Hydroxy-α-Benzopyrones under Ring Contraction 电化学双功能化：环收缩下4-羟基-α-苯并吡酮类化合物的氧化胺化和氧化

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-09-24 DOI: 10.1016/j.tetlet.2025.155839

Indrajit Karmakar

引用次数: 0

Transition metal free functionalization of nitrogen heterocycles, triggered and driven by electrophilic acetylenes 亲电乙炔引发和驱动的氮杂环过渡金属游离功能化

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-09-23 DOI: 10.1016/j.tetlet.2025.155837

Boris A. Trofimov, Kseniya V. Belyaeva

引用次数: 0

Synthesis of aza-polycyclic aromatic hydrocarbons as organic optoelectronic materials via the Povarov reaction Povarov反应合成氮杂-多环芳烃有机光电材料

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-09-22 DOI: 10.1016/j.tetlet.2025.155836

Yuanrong Shan , Takaki Kanbara , Junpei Kuwabara

{"title":"Synthesis of aza-polycyclic aromatic hydrocarbons as organic optoelectronic materials via the Povarov reaction","authors":"Yuanrong Shan , Takaki Kanbara , Junpei Kuwabara","doi":"10.1016/j.tetlet.2025.155836","DOIUrl":"10.1016/j.tetlet.2025.155836","url":null,"abstract":"<div><div>The Povarov reaction, a classical [4+2] cycloaddition of imines and unsaturated compounds, provides a versatile synthetic platform for the synthesis of nitrogen-doped π-conjugated molecules. This review highlights the recent advances in the application of the Povarov reaction in the synthesis of aza-polycyclic aromatic hydrocarbons (aza-PAHs), which are important components of emerging organic optical and electronic materials. The modularity, one-pot multicomponent compatibility, and broad catalyst scope of the Povarov reaction afford structurally diverse aza-PAHs. Representative examples spanning small molecules, conjugated polymers, covalent organic frameworks (COFs), and molecular cages are discussed, with particular emphasis on their functional properties, including photoluminescence, sensing, circularly polarized luminescence, hole-blocking, and electron transport properties in organic light-emitting diodes. Mechanistic insights into regioselectivity and π-extension are also reviewed to facilitate the future design of aza-PAHs. The Povarov reaction is a powerful synthetic tool for the development of advanced aza-PAH-based materials for optical and electronic applications.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"173 ","pages":"Article 155836"},"PeriodicalIF":1.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visible-Light-Induced Regioselective Benzylic CH Oxidation of Substituted 6-Aryl-7,8,9,10-tetrahydrobenzo[c]phenanthridine 可见光诱导取代6-芳基-7,8,9,10-四氢苯并[c]菲蒽啶的区域选择性苄基CH氧化

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-09-21 DOI: 10.1016/j.tetlet.2025.155828

Mukesh Kumar , Musfika Khatun , Simra Faraz , Satyajit Singh , Abu Taleb Khan

{"title":"Visible-Light-Induced Regioselective Benzylic CH Oxidation of Substituted 6-Aryl-7,8,9,10-tetrahydrobenzo[c]phenanthridine","authors":"Mukesh Kumar , Musfika Khatun , Simra Faraz , Satyajit Singh , Abu Taleb Khan","doi":"10.1016/j.tetlet.2025.155828","DOIUrl":"10.1016/j.tetlet.2025.155828","url":null,"abstract":"<div><div>A practical and sustainable protocol for the photocatalytic oxidation of benzylic C<img>H bonds, particularly within polycyclic heteroaromatic (PHA) frameworks, has been developed. In contrast to many previously reported systems, which often rely on long reaction times, narrow-spectrum LEDs, additives, or specialized photoreactors or setups, this method employs inexpensive eosin Y under white LED illumination with molecular oxygen supplied via a balloon. The transformation proceeds under mild conditions without the need for transition metals, hazardous oxidants, or auxiliary additives, and operates via a radical mechanism supported by inhibition studies. The broad substrate tolerance and operational simplicity of this protocol facilitate efficient access to benzylic ketones. Its utility is exemplified in the synthesis of a variety of 6-aryl-8,9-dihydrobenzo[<em>c</em>]phenanthridin-10(7<em>H</em>)-one derivatives, where the substituent at the 6-position plays a critical role in determining product outcome. This method represents one of the few reported examples of late-stage C<img>H functionalization in PHAs under photocatalytic conditions.</div></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":"171 ","pages":"Article 155828"},"PeriodicalIF":1.5,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver-catalyzed regioselective synthesis of benzo[2,7] naphthyridines using ortho-alkynyl quinoline carbaldehyde and anthranilic acid derivatives 银催化邻炔基喹啉乙醛和邻氨基苯甲酸衍生物的区域选择性合成苯并[2,7]萘啶

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-09-20 DOI: 10.1016/j.tetlet.2025.155835

Kapil Chahal , Ravikumar Badhavath , K. Velangini Sunidhi Reddy , Kirti Vashishtha , K. Rajender Reddy

引用次数: 0

Phosphoric acid-catalyzed regioselective amidation of para-quinone methides with acetonitrile 磷酸催化对醌与乙腈的区域选择性酰胺化

IF 1.5 4区化学

Tetrahedron Letters Pub Date : 2025-09-20 DOI: 10.1016/j.tetlet.2025.155834

Xiu Liu , Hongjun Chen , Chenzhong Jin , Longzhi Zhu , Biquan Xiong

引用次数: 0