Difluoromethylheteroarylation of unactivated alkenes through remote heteroaryl migration with bis(difluoroacetyl) peroxide

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-09-25 DOI:10.1016/j.tetlet.2025.155842

Zhiqi Lei , Xiaoyu Wang , Siqi Li , Xia Zhao , Kui Lu

引用次数: 0

Abstract

We have developed a straightforward method for synthesizing distal difluoromethyl-substituted ketones bearing heteroaryl groups. This approach utilizes difluoromethylheteroarylation of unactivated alkenes through remote heteroaryl migration by employing bis(difluoroacetyl) peroxide (generated in situ from DFAA and urea·H₂O₂) as the difluoromethylating agent. Sunlight was proved to promote this transformation.

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双（二氟乙酰基）过氧化物通过远端异芳基迁移对非活化烯烃的二氟甲基异芳基化

我们已经开发了一种直接的方法来合成远端含杂芳基的二氟甲基取代酮。该方法利用双（二氟乙酰基）过氧化物（由DFAA和尿素·H₂O₂原位生成）作为二氟甲基化剂，通过远端异芳基迁移实现非活化烯烃的二氟甲基异芳基化。事实证明，阳光促进了这种转变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.