Nepal Journal of Epidemiology最新文献_第5页

The mortality burden of hematological malignancies in Ecuador. 厄瓜多尔恶性血液病的死亡率负担。

IF 3.9

Nepal Journal of Epidemiology Pub Date : 2021-06-30 eCollection Date: 2021-06-01 DOI: 10.3126/nje.v11i2.37057

David Garrido, Andrés Orquera, Johanna Rojas, Manuel Granja

{"title":"The mortality burden of hematological malignancies in Ecuador.","authors":"David Garrido, Andrés Orquera, Johanna Rojas, Manuel Granja","doi":"10.3126/nje.v11i2.37057","DOIUrl":"https://doi.org/10.3126/nje.v11i2.37057","url":null,"abstract":"Background: The Hematological neoplasms (HN) are a heterogeneous group of cancers that originated in the hematopoietic or lymphoid tissues. There is reduced information published regarding HN mortality in Ecuador. This study aims to present the crude and age-specific mortality rates for HN in the Ecuadorian population.Methods: We performed a cross-sectional study through the national database of defunctions published by the Ecuadorian National Institute of Statistics and Census, 2019. We used the ICD-10 codes to classify the HN.Results: During 2019, 1462 deaths were reported, 53.83% were males, 87.96% of mestizo ethnicity, and 78.32% residents in urban areas. The median age was 62 years, with an interquartile range of 34.The crude mortality rate obtained was 8.49 per 100000 inhabitants, and the higher age-specific mortality rates was 43.29 per 100000 inhabitants aged ≥ 60 years, contrasting with the 2.63 per 100000 inhabitants in people aged < 20 years. Considering each ICD-10 group, we found the following rates by 100000 inhabitants; C85 2.04, C91 1.92, C92 1.46, C90 1.11, C83 0.70, C95 0.48, C81 0.38, C84 0.16, C82 0.10, C96 0.05, C93 0.04, C86 and C94 0.02, and C88 0.01.Conclusion: In Ecuador, during 2019, approximately eight people died due to HN by 100000 inhabitants, affecting mainly people aged ≥ 60 years. The most frequent neoplasms were Non-Hodgkin lymphomas, similar to other reports globally. These results should be analyzed considering some deficiencies in the Ecuadorian health system and the national registry. Therefore, we suggest conducting more studies regarding HN.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":"11 2","pages":"1040-1048"},"PeriodicalIF":3.9,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39206808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19: Lockdown and its impact on medical students: A cross sectional study from a medical school in Mauritius. COVID-19：封锁及其对医学生的影响：毛里求斯一所医学院的横断面研究。

IF 1.7

Nepal Journal of Epidemiology Pub Date : 2021-06-30 eCollection Date: 2021-06-01 DOI: 10.3126/nje.v11i2.36951

Indrajit Banerjee, Jared Robinson, Poornasha Mohabeer, Abhishek Kashyap, Ananya Shukla, Brijesh Sathian

{"title":"COVID-19: Lockdown and its impact on medical students: A cross sectional study from a medical school in Mauritius.","authors":"Indrajit Banerjee, Jared Robinson, Poornasha Mohabeer, Abhishek Kashyap, Ananya Shukla, Brijesh Sathian","doi":"10.3126/nje.v11i2.36951","DOIUrl":"10.3126/nje.v11i2.36951","url":null,"abstract":"Background: The objectives of the study were to identify the psychological impacts of lockdown on medical students due to COVID-19 and to discover the educational perplexities being faced by these students during the lockdown.Methods: A cross-sectional study was conducted at Sir Seewoosagur Ramgoolam Medical College (SSRMC), Mauritius. Questions were designed after an extensive review of the literature, so as to ensure relevance to meet the objectives of the study.Results: Out of 700 undergraduate medical students, 663 participated, which equates to a response rate of 95%. 348 (52.5 %) of the students were stationed in their hometown and the remaining 315 (47.5 %) were stationed in Mauritius. 464(70%) of the students suffered from the psychological impacts of lockdown whereas 634(95.6%) of students suffered from the educational impact thereof. Mauritian students suffered a greater educational impact aOR4.236[1.606-11.173]. Psychological impacts aOR 1.280 [0.917-1.789] and educational impacts aOR 2.464 [1.076-5.647] were more prevalent in hometown-based students. Students pursuing their clinical studies had aOR1.219 [ 0.531-2.798] a greater educational impact as compared to preclinical studies.Conclusion: Lockdown triggered both educational and psychological impacts on medical students. On a psychological basis it was proven that the lockdown induced a feeling of guilt and had a greater psychological impact in pre-clinical students. The COVID-19 situation was simultaneously indicated to be a motivator in the majority of students; however, juxtaposed to this was the fact that various students felt as if they couldn't study at the same level that they were accustomed to due to the uncertainty of the situation.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":"11 2","pages":"1006-1022"},"PeriodicalIF":1.7,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8266400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39207334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 and mutations a threat level assessment. 新冠肺炎和突变的威胁水平评估。

IF 3.9

Nepal Journal of Epidemiology Pub Date : 2021-03-31 eCollection Date: 2021-03-01 DOI: 10.3126/nje.v11i1.35659

Jared Robinson, Indrajit Banerjee, Alexandra Leclézio, Brijesh Sathian

{"title":"COVID-19 and mutations a threat level assessment.","authors":"Jared Robinson, Indrajit Banerjee, Alexandra Leclézio, Brijesh Sathian","doi":"10.3126/nje.v11i1.35659","DOIUrl":"10.3126/nje.v11i1.35659","url":null,"abstract":"A mutation is defined as an alteration in the DNA or RNA sequences of a genome which may consequently confer a new phenotypic and or genotypic advantage both increasing the virulence as well as the survival of a virus or pathogen. At this current point in time there are 4 known major variants of the original SARS-CoV-2 virus, namely the English variant (B.1.1.7), the South African variant (B.1.351), Brazilian variants (VOC202101/02 (P.1) and VUI202101/01) and a variant similar to that of the South African variant found in North America (B.1.526), all of which have varying levels of resistance and infectivity. It is evident that the SARS-CoV-2 variants pose an international health risk, the mutations of E484K and N501Y are the two most implicated mutations. E484K being the most concerning as it aids in immune evasion and drastically causes the efficacy of the current vaccines to be reduced by large margins. The most worrisome variant is the South African or B.1.351 which harbors the above mutations. It is of the upmost importance that targeted vaccines are synthesized to ensure that immunized individuals have effective protection against these variants. Until these specific targeted vaccines are synthesized the current vaccines offer little long-term protection, however do confer a level of immunity to stop severe infections. It is thus advised that current vaccination programs should continue in earnest as a degree of protection is conferred.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":"11 1","pages":"983-987"},"PeriodicalIF":3.9,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10297052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A contemporary insight of metabolomics approach for COVID-19: Potential for novel therapeutic and diagnostic targets. 对 COVID-19 代谢组学方法的当代见解：新型治疗和诊断目标的潜力。

IF 3.9

Nepal Journal of Epidemiology Pub Date : 2020-12-31 eCollection Date: 2020-12-01 DOI: 10.3126/nje.v10i4.33964

Mohammad Asim, Brijesh Sathian, Indrajit Banerjee, Jared Robinson

{"title":"A contemporary insight of metabolomics approach for COVID-19: Potential for novel therapeutic and diagnostic targets.","authors":"Mohammad Asim, Brijesh Sathian, Indrajit Banerjee, Jared Robinson","doi":"10.3126/nje.v10i4.33964","DOIUrl":"10.3126/nje.v10i4.33964","url":null,"abstract":"The Coronavirus disease 2019 (COVID-19) pandemic is caused by rapidly spreading pathogenic virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that affects vast majority of population worldwide. Although, around 80% of the cases had mild infection but still remaining 20% had developed respiratory failure and dysfunction of other organs that necessitate urgent oxygen therapy or specific interventions. Therefore, it is imperative to establish novel prognostic approaches to screen patients at high-risk of developing severe complications. The primary focus of current research for COVID-19 is to discover safe and efficacious vaccine for prevention and effective treatment for better management of the patients to overcome the pandemic. To achieve this goal, it is imperative to have better understanding of the molecular pathways involved in the pathophysiology and progression of severe COVID-19. The surge for reliable diagnostics and therapeutics targets for COVID-19 highlighted the great potential of high-throughput approach like metabolomics which may enable the development of personalized medicine.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":"10 4","pages":"923-927"},"PeriodicalIF":3.9,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38860034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relevance of digital mental healthcare during COVID-19: Need for innovations. 2019冠状病毒病期间数字精神卫生保健的相关性:创新需求

IF 3.9

Nepal Journal of Epidemiology Pub Date : 2020-12-31 eCollection Date: 2020-12-01 DOI: 10.3126/nje.v10i4.32519

Sujita Kumar Kar, Shailendra K Saxena, Russell Kabir

引用次数: 6

Common Pitfalls in using Online Platforms for Data collection in COVID times and its implications. 新冠疫情期间使用在线数据收集平台的常见缺陷及其影响。

IF 3.9

Nepal Journal of Epidemiology Pub Date : 2020-12-31 eCollection Date: 2020-12-01 DOI: 10.3126/nje.v10i4.31614

Hariom Kumar Solanki, P Giridara Gopal, Rama Shankar Rath

引用次数: 0

COVID-19 and Artificial Intelligence: the pandemic pacifier. COVID-19 和人工智能：大流行病的安抚者。

IF 3.9

Nepal Journal of Epidemiology Pub Date : 2020-12-31 eCollection Date: 2020-12-01 DOI: 10.3126/nje.v10i4.33334

Indrajit Banerjee, Jared Robinson, Abhishek Kashyap, Poornasha Mohabeer, Brijesh Sathian

引用次数: 0

Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan. 不丹Samtse总医院肺结核病人的治疗结果。

IF 3.9

Nepal Journal of Epidemiology Pub Date : 2020-09-30 eCollection Date: 2020-09-01 DOI: 10.3126/nje.v10i3.28397

Thinley Dorji, Kinley Wangdi

{"title":"Treatment outcome of tuberculosis patient of Samtse General Hospital, Bhutan.","authors":"Thinley Dorji, Kinley Wangdi","doi":"10.3126/nje.v10i3.28397","DOIUrl":"https://doi.org/10.3126/nje.v10i3.28397","url":null,"abstract":"Background: Tuberculosis (TB) is one of the major public health problems in Bhutan. Evaluation of treatment outcomes of TB and identification of the risk factors are important components for the success of National TB control program. Therefore, this study was undertaken to assess the TB treatment outcome and factors associated with it in Samtse General Hospital.Methods: This was a retrospective, cross sectional study using the TB data from Samtse General Hospital from 2008-2019. A univariate and multiple logistic regression was used to check for associations between the outcome and other independent variables.Results: The study included a total of 634 TB patients. Of this, 44.0% (279) were smear positive TB (PTB+), 36.1% (229) were extra pulmonary TB (EPTB) and 19.9% (126) were smear negative TB (PTB-). During the study period, 56.2% (356) of them completed treatment, 33.3% (211) were declared cured, 0.2% (1) had defaulted, 5.1% (32) died and 5.4% (34) had treatment failure. The mean treatment success rate (TSR) was 89.4% (567). The TSR was highest for EPTB with 96.9% (222/229), followed by PTB- at 88.1% (111/126) and lowest for PTB+ with 83.9% (234/279). Successful treatment outcome was observed in EPTB patients (AOR: 7.3; 95% CI: 2.46-21.36), patients in age 15-28 years (AOR: 3.4; 95% CI: 1.59-7.46) and 29-42 years (AOR: 9.1; 95% CI: 2.44-33.61).Conclusion: The treatment outcome of TB in Samtse General Hospital is satisfactory and at par with the national level. Since, smear positive TB and elderly patients are prone to develop poor treatment outcome, they need to be monitored and followed up adequately.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":"10 3","pages":"888-896"},"PeriodicalIF":3.9,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/nje.v10i3.28397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38477199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Artificial Intelligence and Health in Nepal. 尼泊尔的人工智能与健康。

IF 1.7

Nepal Journal of Epidemiology Pub Date : 2020-09-30 eCollection Date: 2020-09-01 DOI: 10.3126/nje.v10i3.31649

Alexander van Teijlingen, Tell Tuttle, Hamid Bouchachia, Brijesh Sathian, Edwin van Teijlingen

引用次数: 0

South Africa and its COVID-19 prohibition predilection. 南非及其COVID-19禁止偏好。

IF 3.9

Nepal Journal of Epidemiology Pub Date : 2020-09-30 eCollection Date: 2020-09-01 DOI: 10.3126/nje.v10i3.31543

Indrajit Banerjee, Jared Robinson, Brijesh Sathian, Edwin R van Teijlingen

{"title":"South Africa and its COVID-19 prohibition predilection.","authors":"Indrajit Banerjee, Jared Robinson, Brijesh Sathian, Edwin R van Teijlingen","doi":"10.3126/nje.v10i3.31543","DOIUrl":"https://doi.org/10.3126/nje.v10i3.31543","url":null,"abstract":"The year 2020, will forever be marked by the Global pandemic, COVID-19. According to The Department of Health in South Africa until September 15, 2020 3,940,217 tests have been conducted. 651,521 positive cases have been identified, 583,126 recoveries have been reported and there has been a total of 15641 deaths. The South African government have introduced a range of parameters and laws in order to curb the spread of the virus whilst simultaneously endorsing programs to spearhead the preparedness of the healthcare system for the various waves of COVID-19 cases that have been forecast. In conjunction with the new laws and regulations, the South African Government has exercised lockdown and restriction of movement policies. South Africa’s unique, multifaceted and strategic method of combatting the coronavirus has proven to be effective in using existing resources and redirecting both manpower and personnel, thus being of great benefit to all stakeholders and citizens within the country. The prohibition of alcohol is a unique method employed by the government, the full extent to which this policy reform has benefitted the country, its government and its citizens is yet to be fully calculated and projected as South Africa’s Coronavirus cases are still increasing on a daily basis. This policy reform will likely find itself becoming a popular trend with crisis management protocols of other countries if the long-term benefits thereof are proven to be true.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":"10 3","pages":"874-877"},"PeriodicalIF":3.9,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3126/nje.v10i3.31543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38477196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10