A contemporary insight into the sero-epidemiology of Toxoplasma gondii infection in the foot-hills of Himalayas: A cross-sectional study from a tertiary care center in Northern India.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-03-31 eCollection Date: 2021-03-01 DOI:10.3126/nje.v11i1.34228

Sangeeta Deka, Deepjyoti Kalita, Pratima Gupta, Yogendra Pratap Mathuria

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引用次数: 2

Abstract

Background: Toxoplasma gondii infects 30-50% of the world's population with high diversity in the geo-epidemiology and seroprevalence. The burden of toxoplasmosis and its determinants from remote and vulnerable regions of India is unknown. Therefore, this study aim to evaluate the prevalence of toxoplasma antibodies and factors associated with seropositivity among individuals from Uttarakhand and adjoining areas.

Methods: Serum samples from 442 cases were tested for anti-Toxoplasma IgG and IgM antibodies by Enzyme-linked Immunosorbent Assay. Association of seropositivity of toxoplasmosis with age, gender, place of residence, dietary habits, and comorbidities were analyzed using binary logistic regression analysis.

Results: The overall Toxoplasma seropositivity was found to be 36.88% [95% Confidence Interval (CI)=30.40-39.28]. While anti-T. gondii IgG was present in 34.84% [95% CI=30.40-39.28], anti-IgM was detected in 6.33% [95% CI=4.06-8.61]. The overall and IgG seroprevalence increased with age in both the genders and there was a sharp increase in the seropositivity after the age of 40 years [adjusted Odds Ratio (aOR)=2.98, p-value=0.030]. The seropositivity rate was significantly higher in individuals from Uttarakhand in both the hilly region (aOR=5.61; 95%CI:[2.14-14.68]) and plains (aOR=5.14; 95%CI:[2.2-12.02]). Multivariable logistic regression analysis also showed that being rural residents (aOR=3.23; 95%CI:[1.67-6.23]) and presence of comorbidities (aOR=8.64; 95%CI:[4.62-16.18]) were potential risk factors of Toxoplasmosis. On the other hand, consumption of vegetarian diet was found to have a protective effect (aOR=0.46; 95%CI:[0.28-0.75]).

Conclusion: Seroprevalence of T. gondii antibodies was relatively high in Uttarakhand, particularly in rural and hilly terrain, indicating a necessity for the implementation of integrated public health strategies to prevent and control toxoplasmosis in this region.

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喜马拉雅山麓刚地弓形虫感染血清流行病学的当代见解:来自印度北部三级保健中心的横断面研究。

背景:刚地弓形虫感染了世界30-50%的人口，在地理流行病学和血清流行率方面具有很高的多样性。来自印度偏远和脆弱地区的弓形虫病负担及其决定因素尚不清楚。因此，本研究旨在评估北阿坎德邦及邻近地区个体中弓形虫抗体的流行情况及其血清阳性相关因素。方法:采用酶联免疫吸附法对442例患者血清进行弓形虫IgG和IgM抗体检测。采用二元logistic回归分析弓形虫病血清阳性与年龄、性别、居住地、饮食习惯、合并症的相关性。结果:弓形虫血清总阳性率为36.88%[95%置信区间(CI)=30.40 ~ 39.28]。而anti-T。阳性率为34.84% [95% CI=30.40 ~ 39.28]，抗igm阳性率为6.33% [95% CI=4.06 ~ 8.61]。男女血清总阳性率和IgG阳性率均随年龄增长而升高，40岁后阳性率急剧上升[校正优势比(aOR)=2.98, p值=0.030]。北阿坎德邦丘陵地区的血清阳性率明显高于其他地区(aOR=5.61;95%CI:[2.14-14.68])和平原(aOR=5.14;95%置信区间:[2.2 - -12.02])。多变量logistic回归分析也显示为农村居民(aOR=3.23;95%CI:[1.67-6.23])和合并症的存在(aOR=8.64;95%CI:[4.62 ~ 16.18])是弓形虫病的潜在危险因素。另一方面，食用素食被发现有保护作用(aOR=0.46;95%置信区间:[0.28 - -0.75])。结论:北阿坎德邦弓形虫抗体血清阳性率较高，特别是农村和丘陵地区，有必要实施综合公共卫生策略，预防和控制该地区弓形虫病。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.