Nepal Journal of Epidemiology最新文献

{"title":"Acetaminophen poisonings in Chilean healthcare settings: a 20-year story that does not end.","authors":"Tamara Sanhueza-Aroca,&nbsp;Samuel Verdugo-Silva,&nbsp;Erwin Olate-Fica,&nbsp;Luisa Rivas,&nbsp;Claudio Müller-Ramírez","doi":"10.3126/nje.v11i4.38919","DOIUrl":"10.3126/nje.v11i4.38919","url":null,"abstract":"<p><strong>Background: </strong>Acetaminophen (Paracetamol) is one of the most used and prescribed anti-inflammatory and analgesic drugs worldwide. It has become one of the main drugs related to accidental and intentional overdoses in many countries, including Chile. The objective of this work was to characterize acetaminophen poisonings occurred in Chile between the years 2001 and 2020.</p><p><strong>Methods: </strong>A retrospective study of acetaminophen poisonings among patients who were hospitalized in Chilean public and private hospitals was carried out between the years 2001 and 2020. Data was obtained from the Medical Outcome Statistical Report database. Inclusion criteria were cases of patients who were admitted into either public or private healthcare settings with diagnosis of acetaminophen poisoning according to the WHO ICD-10. Statistical analyses were run to establish associations between variables selected in the study.</p><p><strong>Results: </strong>A total of 2,929 cases were included in the study. 77 % of the cases corresponded to female patients (p<0.05). Patients' age range went from 0 to 81 years old. Adolescents and young adults resulted more involved in reported cases during the 2001-2020 period (p<0.001). During the first period of the study, accidental poisonings were more commonly reported, however in the recent years intentional cases increased their occurrence, especially among female patients (p<0.05). A multivariate logistic regression model considered as statistically significant (p<0.05) the interaction between the variables age, gender and year of the event.</p><p><strong>Conclusion: </strong>The present study identified a large number of acetaminophen poisonings reported in Chile during the 2001-2020 period. Cases were characterized including patients' gender, age, and poisoning intent. Health authorities should consider these findings as an opportunity to improve public health associated with the use and misuse of over-the-counter drugs, including acetaminophen.</p>","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39714923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 pandemic and suicides in Nepal: Way forward for prevention.","authors":"Indrajit Banerjee,&nbsp;Jared Robinson,&nbsp;Brijesh Sathian,&nbsp;Indraneel Banerjee","doi":"10.3126/nje.v11i4.41116","DOIUrl":"https://doi.org/10.3126/nje.v11i4.41116","url":null,"abstract":"The SARS-CoV-2 pandemic has firmly rooted itself within our countries, communities, homes and now everyday lives. The impact of this global pandemic is immeasurable as it is catastrophic in nature and involves both a human and financial loss. Suicide and self-harm (SH) are both a serious public health and social issue. It is however preventable via the use of timely, evidence-based and many times low-cost interventions and therapies. The current situation depicted Nepal shows a true indicator of the mental health of the nation, as a precipitating factor (i.e., the extreme stress of COVID-19 and the lockdown) has exposed the submerged “ice-berg” phenomenon of disease.  \u0000It is evident that COVID-19 and the lockdown had a massively negative effect on the mental health of the population in Nepal. The increased rates of suicide and self-harm also simultaneously exposed the great pre-existing fragility of the mental health of the nation. It is therefore vital that both Nepal and other countries alike take cognizance of the fact that extra support and preventative measures need to be introduced during this difficult period and that further national programs must be employed to best aid the mental health of their fellow countrymen.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39714922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative clinical nursing care pathway for patients with mucormycosis: An experience from a tertiary care hospital in Rajasthan, India.","authors":"Nipin Kalal,&nbsp;Suresh K Sharma,&nbsp;Kapil Soni","doi":"10.3126/nje.v11i4.40498","DOIUrl":"https://doi.org/10.3126/nje.v11i4.40498","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic is a serious global health threat and it has numerous impacts on human life. India faced the problem of the second wave of COVID-19 and an unexpected new predicament in the form of mucormycosis has been added. The use of steroids drugs for long duration and comorbidity with COVID-19 infections are the risk factors of mucormycosis. It is important to understand the postoperative clinical pathway to assess and determine the policy and protocol, which help patients fasten their recovery, prevent further complications and readmission.</p><p><strong>Methods: </strong>A cross-sectional descriptive design was used to conduct the study. We adopted the validated Immediate Post-Operative Recovery Assessment (IPR-PA) Scale to assess the postoperative clinical nursing care pathway for patients with mucormycosis.</p><p><strong>Results: </strong>The current study shows that patients had highest score in the physiology clinical recovery domain (75.25%) and the lowest post-operative clinical recovery score in psycho-social domain (20.83%). There was a significant positive correlation was found between all the domains. The medication status domains found significantly associated with participants' age (P=.021) and physiological domains has shown significant association with received oxygen therapy during hospitalization (P=.046).</p><p><strong>Conclusion: </strong>Postoperative clinical nursing care pathway was effective to determine the progress of a patient. It helps us to know the parameter of different domains namely being physiological, physical, psycho-social and medication status. Patients required psycho-social support due to the epidemic and fear from disease.</p>","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39714924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiologic characteristics, clinical management, and public health implications of Coronavirus Disease 2019 (COVID-19) in pregnancy: A Systematic Review and Meta-analysis.","authors":"Brijesh Sathian, Indrajit Banerjee, Ahammed A Mekkodathil, Edwin R van Teijlingen, Ana Beatriz Pizarro, Mohammad Asim, Maraeh Angela Mancha, Russell Kabir, Padam Simkhada, Israel Júnior Borges do Nascimento, Hanadi Al Hamad","doi":"10.3126/nje.v11i4.41911","DOIUrl":"10.3126/nje.v11i4.41911","url":null,"abstract":"<p><strong>Background: </strong>The novel Coronavirus Disease 2019 (COVID-19) outbreak, caused by the pathogenic severe acute respiratory syndrome-2 (SARS-CoV-2) virus, is exponentially spreading across the globe.</p><p><strong>Methods: </strong>The current systematic review was performed utilising the following electronic databases PubMed, MEDLINE and EMBASE. We searched for the keywords \"COVID-19 AND \"pregnancy\" between January 1, 2020 until December 31, 2020.</p><p><strong>Results: </strong>Out of 4005 records which were identified, 36 original studies were included in this systematic review. Pooled prevalence of vertical transmission was 10%, 95% CI: 4-17%. Pooled prevalence of neonatal mortality was 7%, 95% CI: 0-21%.</p><p><strong>Conclusion: </strong>The contemporary evidence suggests that the incubation period of COVID-19 is 2-14 days, and this infection could be transmitted even from the infected asymptomatic individuals. It is found that the clinical presentation of pregnant women with COVID-19 infection is comparable with the infected non-pregnant females, and the frequent symptoms were fever, cough, myalgia, sore throat and malaise. Some cases have severe maternal morbidity and perinatal deaths secondary to COVID-19 infection. Under these circumstances, pregnant women should focus on maintaining personal hygiene, proper nutrition and extreme social distancing to reduce the risk of COVID-19. Therefore, systematic data reporting for evidence based clinical assessment, management and pregnancy outcomes is essential for preventing of COVID-19 infection among pregnant women.</p>","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39729721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Similarity, does it necessary mean plagiarism? Stop intentional and exaggerated paraphrasing.","authors":"Eslam Elsayed Ali Shohda","doi":"10.3126/nje.v11i4.41137","DOIUrl":"https://doi.org/10.3126/nje.v11i4.41137","url":null,"abstract":"During the last two decades, programs have been relied on to detect scientific plagiarism, as it is found that some authors use previous published results or scientific ideas without attributing them to their original authors. But the term similarity has been confused with scientific plagiarism. This led to the need for procedures that are not justified by intuition of mind, and led to the difficulty of conducting important research, unnecessary time wasting and difficulties.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39729722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omicron: The pandemic propagator and lockdown instigator - what can be learnt from South Africa and such discoveries in future.","authors":"Indrajit Banerjee,&nbsp;Jared Robinson,&nbsp;Indraneel Banerjee,&nbsp;Brijesh Sathian","doi":"10.3126/nje.v11i4.41569","DOIUrl":"https://doi.org/10.3126/nje.v11i4.41569","url":null,"abstract":"<p><p>The SARS-CoV-2 virus which causes the disease termed COVID-19 ripped through the globe in the latter part of 2019 and has left a state of fear, death and destruction in its wake. The Omicron variant was officially announced by the South African authorities on the 24th of November 2021, with the first confirmed sample of the infection being collected on the 9th of November 2021. The initial cases were flagged as a possible new variant due to the stark differences in the presentation and clinical features of the patients. At the time of Omicron's discovery, the predominant variant circulating within South Africa was the Delta variant B.1.617.2 which typically presented with more severe and distinct symptoms. Omicron spread rapidly within the Southern Africa and abroad, principally South Africa, Botswana, Hongkong and Israel were among the first countries to record cases of the new variant. The first European case of the Omicron variant was confirmed on the 26th of November 2021 in Belgium. Towards the end of November 2021 cases of the new variant had been confirmed and recorded in France, the United Kingdom, Germany, Portugal and Scotland. Additional cases of the Omicron variant have been confirmed in Canada, Australia, India and United States. At this current point in the development of the Omicron upsurge in cases the international community should aim for further vaccinations among their fellow countrymen, but more so vaccine equality should be ensured. Such equality should be ensured in the developing nations as the virus does not respect any boundaries or territories and thus a higher level of vaccination worldwide will confer greater protection to the global community as a whole.</p>","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10264875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycystic ovary syndrome among Indian adolescent girls - A systematic review and metanalysis.","authors":"Megha Sharma,&nbsp;Meenakshi Khapre,&nbsp;Vartika Saxena,&nbsp;Pawna Kaushal","doi":"10.3126/nje.v11i3.38460","DOIUrl":"https://doi.org/10.3126/nje.v11i3.38460","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is a common endocrine disorder in the progenitive age group and the leading cause of infertility. The worldwide prevalence of PCOS in women varies between 2.2% to 26%. Due to limited literature on burden of PCOS among adolescent girls, its significance is still unfathomed as a research is few and far between in the present time. We conducted Systematic review and metanalysis to estimate the pooled prevalence of PCOS among Indian adolescent girls (14-19 years).</p><p><strong>Methods: </strong>With the help of a search strategy, two authors searched Scopus, Embase and Pubmed independently. We screened studies considering eligibility criteria and extracted data. Selected studies were assessed for quality and risk biases using the NIH tool. R software was used for analysis.</p><p><strong>Results: </strong>Twelve studies were included in the meta-analysis. The total number of participants in the study was 4473. All studies scored average and above as per the NIH quality assessment tool. The prevalence of PCOS among adolescents based on the Rotterdam criteria was 17.74 per 100 (CI = 11.77-23.71) with I² =97 %. Hospital-based studies had a comparatively higher prevalence of PCOS as compared to community-based.</p><p><strong>Conclusion: </strong>Pooled prevalence of PCOS among Indian adolescents' girls was high, approximately one in five.</p>","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Molecular facets of Dengue Virus infection from Bengaluru, South India.","authors":"Shantala Gowdara Basawarajappa,&nbsp;Ambica Rangaiah,&nbsp;Shwetha Jinnahalli Venugopal,&nbsp;Chakrakodi N Varun,&nbsp;Vijay Nagaraj,&nbsp;Shashiraja Padukone,&nbsp;Sathyanarayan Muthur Shankar","doi":"10.3126/nje.v11i3.37712","DOIUrl":"https://doi.org/10.3126/nje.v11i3.37712","url":null,"abstract":"<p><strong>Background: </strong>Dengue virus (DENV) continues to be an epidemic with high mortality rates. The clinical features, especially in the early phase of infection, are nonspecific and there is no single marker that can be reliably deployed for diagnostics. Further, serotype and genotype diversity is not clearly understood. This study was conceived to understand the performance characteristics of various diagnostic markers; serotype and genotype distribution is thus a vital requirement.</p><p><strong>Methods: </strong>A subset of blood samples was obtained for all the clinically suspected Dengue cases during the period January to December 2017. The samples were tested for IgM and IgG antibodies and NS1 antigen by both ELISA and rapid tests. Real-time PCR, Conventional PCR and sequencing was performed based on the serology results. Correlation of the data with demographic and clinical details was used to analyze the performance characteristics of various tests.</p><p><strong>Results: </strong>Clinical signs and symptoms could not predict dengue positivity due to lack of specific symptoms. The performance of IgM rapid test was found to be lower than the ELISA method (53.5% agreement). The NS1 rapid and NS1 ELISA tests were comparable (89.2% agreement). Majority of the infections were caused due to DEN-2 serotype and phylogenetic analysis revealed all the sequenced DEN-2 serotypes belong to Genotype IV. Three sequences were deposited into NCBI GenBank (GenBank accession number MW583116, MW579054 and MW579053).</p><p><strong>Conclusion: </strong>Our comprehensive data suggests that NS1 ELISA and PCR are best used in the early phase of dengue infection (< 5 days post-onset of fever), whereas IgM antibody detection is reliable only in the late phase. We also highlight the unreliable performance of rapid tests.</p>","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 airborne transmission: a new frontier of infection.","authors":"Indrajit Banerjee,&nbsp;Jared Robinson","doi":"10.3126/nje.v11i3.40000","DOIUrl":"https://doi.org/10.3126/nje.v11i3.40000","url":null,"abstract":"COVID-19 has spread around the globe and infections are still rising despite the development of vaccinations and protocols. Various mutations of the SARS-CoV-2 virus have arisen with a greater rate of transmission and increased virulence. New found research has proven that the new strains of the virus are more virulent and use airborne aerosolized transmission to enable long range spread of the virus.  \u0000By virtue of the fact that the virus spreads through such means, increases the risk of transmission and contamination highly as the virus can be transmitted via long range and through common ventilation and duct systems. In light of this it is now pertinent for legislation to support the use of personal protection equipment to safeguard the health of the public.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroid induced avascular necrosis and COVID-19: The drug dilemma.","authors":"Indrajit Banerjee,&nbsp;Jared Robinson,&nbsp;Brijesh Sathian","doi":"10.3126/nje.v11i3.39309","DOIUrl":"https://doi.org/10.3126/nje.v11i3.39309","url":null,"abstract":"The severe and life-threatening nature of the COVID-19 infection, the ARDS (acute respiratory distress syndrome) as well as the cytokine storm induced by the infection, commands lifesaving high doses of steroid therapy. As in all pharmacological therapies adverse effects are present. One such adverse effect which is being reported is corticosteroid induced avascular necrosis of the femoral head/ osteonecrosis of the femoral head. \u0000It must be noted that AVN principally affects the femoral head and most commonly the anterolateral aspect thereof as it is the crux of weight bearing.  Corticosteroids induce fat mobilization and this thus innately enhances the likelihood of fat emboli developing from the liver to occlude minor blood vessels in the femur, this thereby compromises the microvascular environment. Superadded to this the steroid therapy disrupts calcium metabolism and homeostasis which induces hypertrophy in the intramedullary fat cells, Gaucher cells and inflammatory cells; whilst increasing the activity of osteoclasts, thus increasing bone resorption and decreasing calcium uptake and deposition; ultimately leading to an insufficiency in the trabecular and cortical bone. This insufficiency thus equates to an increased intraosseous pressure which impedes intramedullary circulation and results in avascular necrosis. \u0000 It is evident that avascular necrosis is directly caused by high dose steroid therapy, however the case reports have very clearly indicated that the rapid onset of AVN post recovery from the COVID-19 infection cannot be solely attributed to steroid therapy and that another benefactor induced by the COVID-19 infection is at play. It is thus vital for treating physicians to take cognisance of this adverse effect post recovery and therefore should ensure that prophylactic bisphosphonate therapy is initiated timeously and congruently.","PeriodicalId":43600,"journal":{"name":"Nepal Journal of Epidemiology","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}