Journal of International Translational Medicine最新文献_第4页

Screening and Druggability Analysis of Marine Active Metabolites against SARS-CoV-2: An Integrative Computational Approach 海洋活性代谢物抗SARS-CoV-2的筛选及药物活性分析:综合计算方法

Journal of International Translational Medicine Pub Date : 2022-12-28 DOI: 10.20944/preprints202212.0008.v1

Selvakumar Murugesan, C. Ragavendran, Amir Ali, Velusamy Arumugam, D. Lakshmanan, P. Palanichamy, M. Venkatesan, C. Kamaraj, J. Luna-Arias, Fernández-Luqueño Fabián, S. Khan, Z. Mashwani, M. Younas

{"title":"Screening and Druggability Analysis of Marine Active Metabolites against SARS-CoV-2: An Integrative Computational Approach","authors":"Selvakumar Murugesan, C. Ragavendran, Amir Ali, Velusamy Arumugam, D. Lakshmanan, P. Palanichamy, M. Venkatesan, C. Kamaraj, J. Luna-Arias, Fernández-Luqueño Fabián, S. Khan, Z. Mashwani, M. Younas","doi":"10.20944/preprints202212.0008.v1","DOIUrl":"https://doi.org/10.20944/preprints202212.0008.v1","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have triggered a recent pandemic of respiratory disease and affected almost every country all over the world. A large amount of natural bioactive compounds are under clinical investigation for various diseases. In particular, marine natural compounds are gaining more attention in the new drug development process. The present study aimed to identify potential marine-derived inhibitors against the target proteins of COVID-19 using a computational approach. Currently, 16 marine clinical-level compounds were selected for computational screening against the 4 SARS-CoV-2 main proteases. Computational screening resulted from the best drug candidates for each target based on the binding affinity scores and amino acid interactions. Among these, five marine-derived compounds, namely, chrysophaentin A (−6.6 kcal/mol), geodisterol sulfates (−6.6 kcal/mol), hymenidin (−6.4 kcal/mol), plinabulin (−6.4 kcal/mol), and tetrodotoxin (−6.3 kcal/mol) expressed minimized binding energy and molecular interactions, such as covalent and hydrophobic interactions, with the SARS CoV-2 main protease. Using molecular dynamic studies, the root-mean-square deviation (RMSD), root-mean-square fluctuation (RMSF), radius of gyration (ROG), and hydrogen bond (H-Bond) values were calculated for the SARS-CoV-2 main protease with a hymenidin docked complex. Additionally, in silico drug-likeness and pharmacokinetic property assessments of the compounds demonstrated favorable druggability. These results suggest that marine natural compounds are capable of fighting SARS-CoV-2. Further in vitro and in vivo studies need to be carried out to confirm their inhibitory potential.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86123773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association between Peer Victimization (PV) in Childhood/Adolescence and Personality Disorders among Adult Patients 儿童/青少年同伴受害与成人人格障碍的关系

Journal of International Translational Medicine Pub Date : 2022-12-26 DOI: 10.3390/ijtm3010002

R. Fernández-Martínez, C. Fernandez-Pereira, D. Pérez-Rodríguez, Á. Salgado-Barreira, Cesar Veiga García, Sara Teso-Cuesta, J. Prieto-González, J. M. Olivares Díez, R. Agís-Balboa

{"title":"Association between Peer Victimization (PV) in Childhood/Adolescence and Personality Disorders among Adult Patients","authors":"R. Fernández-Martínez, C. Fernandez-Pereira, D. Pérez-Rodríguez, Á. Salgado-Barreira, Cesar Veiga García, Sara Teso-Cuesta, J. Prieto-González, J. M. Olivares Díez, R. Agís-Balboa","doi":"10.3390/ijtm3010002","DOIUrl":"https://doi.org/10.3390/ijtm3010002","url":null,"abstract":"Peer Victimization (PV) or being bullied in childhood/adolescence has been associated with several negative outcomes in mental health conditions beyond the time of its occurrence. However, its possible association with personality disorders has been slightly explored. In the present study we have compared the frequency of DSM IV personality disorders among adult patients with (N = 28) or without (N = 418) a reported history of PV. For this purpose, axis II was evaluated with the Self-Report Checklist for Preliminary Items for Major Categories, whereas self-esteem and self-assessment of functioning were evaluated with single questions. Patients with PV history have met the diagnostic criteria of the avoidant (60.7% vs. 12.2%), depressive (28.5% vs. 5.2%) and paranoid (17.9% vs. 5%) personality disorders more frequently than patients without history of PV. Moreover, these patients with antecedents of being bullied have also reported lower self-esteem (2 vs. 3) and in the assessment of social functioning (4 vs. 5). Our study indicated that there is a clear association between PV and avoidant, depressive and paranoid personality patterns. These results suggest that the stress related with the experience of PV threatens a basic psychobiological need such as social acceptance with implications for the beginning of long-term dysfunctional personality trajectories.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80075871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Basic Reproduction Numbers for COVID-19 through Four Waves of the Pandemic in Vietnam 越南四波新冠肺炎基本复制数比较

Journal of International Translational Medicine Pub Date : 2022-12-21 DOI: 10.3390/ijtm3010001

N. T. Mai, G. Tran, A. H. Dang, Phuong Cao, T. Nguyen, H. Pham, Tra Thi Thu Vu, Hieu Van Dong, Le Thi My Huynh

{"title":"Comparison of the Basic Reproduction Numbers for COVID-19 through Four Waves of the Pandemic in Vietnam","authors":"N. T. Mai, G. Tran, A. H. Dang, Phuong Cao, T. Nguyen, H. Pham, Tra Thi Thu Vu, Hieu Van Dong, Le Thi My Huynh","doi":"10.3390/ijtm3010001","DOIUrl":"https://doi.org/10.3390/ijtm3010001","url":null,"abstract":"Estimating the basic reproduction number (R0) of an infectious disease is a crucial step to describe the contagiousness and provides suggestions for interventions. To lift the effectiveness of preventive measures for the COVID-19 pandemic, we need to minimize the newly infected cases by reaching adequate herd immunity. This study thus aimed to compare the R0 through four waves of COVID-19 outbreaks in Vietnam and to calculate the minimal vaccination coverage in different populations. The data on the number of daily confirmed COVID-19 patients were collected from 21 January 2020 to 16 November 2021 from the daily reports through the four waves of the pandemic in Vietnam. The R0 values were estimated by exponential growth and the maximum likelihood methods to range from 1.04 to 3.31 from the first to the third wave. The fourth wave was the most severe, especially in the southern provinces, and the highest R0 was in Ho Chi Minh City. The herd immunity would range from 43.50% to 95.76% by various R0 values from different populations. Overall, the presence of new viral mutants increased the infectiousness and the vaccination coverage was higher to establish the required herd immunity in a high-density population. The results provide the basis for policy recommendations and resource allocation for vaccine management and distribution at a time when the COVID-19 pandemic is not yet over.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81091781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Brazilian Green Propolis in Biochemically Recurrent Prostate Cancer after Radical Prostatectomy: A Single-Arm Phase II Study 巴西绿蜂胶治疗根治性前列腺切除术后复发前列腺癌的疗效和安全性:一项单组II期研究

Journal of International Translational Medicine Pub Date : 2022-12-17 DOI: 10.3390/ijtm2040047

Takayuki Goto, H. Kimura, T. Yoshino, A. Sawada, S. Akamatsu, Takashi Kobayashi, Toshinari Yamasaki, Shigemi Tazawa, M. Fujimoto, Y. Hidaka, R. Uozumi, S. Morita, Osamu Ogawa, Takahiro Inoue

{"title":"Efficacy and Safety of Brazilian Green Propolis in Biochemically Recurrent Prostate Cancer after Radical Prostatectomy: A Single-Arm Phase II Study","authors":"Takayuki Goto, H. Kimura, T. Yoshino, A. Sawada, S. Akamatsu, Takashi Kobayashi, Toshinari Yamasaki, Shigemi Tazawa, M. Fujimoto, Y. Hidaka, R. Uozumi, S. Morita, Osamu Ogawa, Takahiro Inoue","doi":"10.3390/ijtm2040047","DOIUrl":"https://doi.org/10.3390/ijtm2040047","url":null,"abstract":"Background: Radiation or hormonal therapy is considered for prostate cancer patients with biochemical recurrence (BCR) after radical prostatectomy (RP). However, these therapies have their own complications. To delay the start of these therapies, we investigated the efficacy and safety of Brazilian green propolis for the treatment for BCR after RP. Materials and Methods: This single-center, single-arm open trial included 22 patients who experienced BCR after RP between 2016 and 2019. The patients received nine softgels of Brazilian green propolis (containing 40 mg propolis per capsule) daily for 6 months. The primary outcome was the prostate-specific antigen (PSA) response rate. The secondary outcomes included progression-free time, PSA slope (1/PSA doubling time) response rate, quality of life, and safety profile. Results: The PSA response rate was 0%. The mean PSA slopes before and after baseline were 0.12 month−1 and 0.08 month−1, respectively. Fifteen patients (68%) showed a decreased PSA slope after treatment. There were no negative effects on quality of life or serious adverse events leading to treatment discontinuation. Conclusion: There was no significant anticancer response in patients who received Brazilian green propolis. However, the PSA slope was decreased after propolis administration. Further, Brazilian green propolis may be safely consumed by patients.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91344358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water-Soluble Carbon Nanotube Enhances Gossypol Production in Cotton Cell Suspension Culture 水溶性碳纳米管提高棉花细胞悬浮培养棉酚产量

Journal of International Translational Medicine Pub Date : 2022-12-05 DOI: 10.3390/ijtm2040046

S. Dixit, Akanchha Shukla, Santosh Kumar Upadhyay, P. Verma

{"title":"Water-Soluble Carbon Nanotube Enhances Gossypol Production in Cotton Cell Suspension Culture","authors":"S. Dixit, Akanchha Shukla, Santosh Kumar Upadhyay, P. Verma","doi":"10.3390/ijtm2040046","DOIUrl":"https://doi.org/10.3390/ijtm2040046","url":null,"abstract":"Plant secondary metabolites are well-recognized medicinally important compounds. Gossypol is an important plant secondary metabolite with several medicinal properties. Carbon nanotubes (CNTs) are allotropes of carbon with diverse applicability in chemical, physical, and biological sciences due to their high surface area. The current study demonstrates the enhancement of gossypol production in cotton cell suspension culture in culture media supplemented with water-soluble carbon nanotubes. The fresh and dry weights of cotton cell suspension culture grown in MS media with 20 µg/mL CNTs were, respectively, 1.9 and 2.13 fold higher than in control MS media after one month. The net enhancement of gossypol production in MS media supplemented with 20 µg/mL CNTs was 2.47 fold higher than the control. Confocal and SEM imaging showed the presence CNTs on the cell surface, which mediated the formation of extra channels that resulted in high biomass production in cotton cell suspension culture. The gossypol produced by this cell suspension culture showed antiproliferative activity against the prostate cancer cell line. Thus, this study demonstrated a new method for enhanced gossypol production, which can prove beneficial for the production of other plant-based biological active compounds.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80607985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Variations in Urinary Renin-Angiotensin-Aldosterone Component Concentrations in Paediatric IgA Vasculitis Nephritis 小儿IgA血管炎肾炎患者尿肾素-血管紧张素-醛固酮成分浓度的变化

Journal of International Translational Medicine Pub Date : 2022-12-02 DOI: 10.3390/ijtm2040045

Andrew J Chetwynd, Julien Marro, S. Northey, Daniel J. Hughes, L. Oni

{"title":"Variations in Urinary Renin-Angiotensin-Aldosterone Component Concentrations in Paediatric IgA Vasculitis Nephritis","authors":"Andrew J Chetwynd, Julien Marro, S. Northey, Daniel J. Hughes, L. Oni","doi":"10.3390/ijtm2040045","DOIUrl":"https://doi.org/10.3390/ijtm2040045","url":null,"abstract":"IgA Vasculitis (IgAV) is the most common form of vasculitis in children, and 1–2% of patients develop chronic kidney disease. In other forms of glomerulonephritis, there is strong evidence to support the role of the renin-angiotensin-aldosterone system (RAAS); however, data are lacking in IgAV nephritis. This study evaluated urinary RAAS components in children with IgA vasculitis, both with nephritis (IgAVN) and without nephritis (IgAVwoN). Urinary concentrations of renin, angiotensinogen and aldosterone were quantified using ELISAs. In total, 40 patients were included: IgAVN n = 9, IgAVwoN n = 17, HC n = 14, with a mean age of 8.3 ± 3.3 years. Urinary renin demonstrated no trend with nephritis. Urinary angiotensinogen was statistically significantly elevated in IgAV (1.18 ± 1.16 ng/mmol) compared to HC (0.28 ± 0.27 ng/mmol, p = 0.0015), and IgAVN (2.00 ± 1.22 ng/mmol) was elevated compared to IgAVwoN (0.74 ± 0.89 ng/mmol, p = 0.0492) and HC (p = 0.0233). Urinary aldosterone levels were significantly elevated in IgAV (1236 ± 1438 pg/mmol) compared to HC (73.90 ± 65.22 pg/mmol, p < 0.0001); this was most increased in IgAVwoN patients (1793 ± 1507 pg/mmol; IgAVN 183.30 ± 111.30 pg/mmol, p = 0.0035, HC p < 0.0001). As expected, the RAAS system is activated in patients with IgAVN and, more surprisingly, even in those without active nephritis. Further studies are needed to fully understand the role of the RAAS system in IgA vasculitis.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87543945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of Phototherapy on Free Vitamin D Levels in Ten Patients with Atopic Dermatitis 光疗对10例特应性皮炎患者游离维生素D水平的影响

Journal of International Translational Medicine Pub Date : 2022-12-01 DOI: 10.3390/ijtm2040044

Andrea Elmelid, A. Osmancevic, M. Gillstedt, M. Alsterholm

{"title":"Effects of Phototherapy on Free Vitamin D Levels in Ten Patients with Atopic Dermatitis","authors":"Andrea Elmelid, A. Osmancevic, M. Gillstedt, M. Alsterholm","doi":"10.3390/ijtm2040044","DOIUrl":"https://doi.org/10.3390/ijtm2040044","url":null,"abstract":"The role of vitamin D in atopic dermatitis (AD) is controversial. Conflicting data could be due to the use of inadequate markers for assessing vitamin D status. So far, directly measured free 25(OH)D concentrations have not been reported in AD patients. Ten adults with AD were treated with narrow band ultraviolet light B (NB-UVB) for 10–12 weeks. SCORing atopic dermatitis (SCORAD) and the visual analogue scale (VAS) were used to assess disease severity before and after NB-UVB therapy. Total and free 25(OH)D and 1,25(OH)2D serum levels were analyzed before and after treatment. Free 25(OH)D concentrations were measured with a two-step immunosorbent assay (ELISA). The majority of patients had sufficient levels of 25(OH)D before treatment (mean 76.4 nmol/L). Mean free 25(OH)D was 11.9 pmol/L and mean 1,25(OH)2D was 108.9 pmol/L. Median SCORAD decreased from 37.1 to 19.8 and VAS improved significantly after phototherapy. Total and free 25(OH)D increased in all subjects. No correlations between disease severity and vitamin D levels were found. There was no correlation between total and free 25(OH)D levels. Larger studies are needed to test the applicability of the free hormone hypothesis in AD pathogenesis.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88549498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Celosia trigyna Linn (Cucurbitaceae) Annihilate Human Breast, Colon, and Lung Cancer Cells: Combination of Cheap Template for Anticancer Screening 三叶草(葫芦科)消灭人乳腺癌、结肠癌和肺癌细胞:用于抗癌筛选的廉价模板组合

Journal of International Translational Medicine Pub Date : 2022-11-30 DOI: 10.3390/ijtm2040043

Adedokun Oluwasegun, E. Ntungwe, Ayinde Bunyamin, L. Saraíva, S. Princiotto, P. Rijo

{"title":"Celosia trigyna Linn (Cucurbitaceae) Annihilate Human Breast, Colon, and Lung Cancer Cells: Combination of Cheap Template for Anticancer Screening","authors":"Adedokun Oluwasegun, E. Ntungwe, Ayinde Bunyamin, L. Saraíva, S. Princiotto, P. Rijo","doi":"10.3390/ijtm2040043","DOIUrl":"https://doi.org/10.3390/ijtm2040043","url":null,"abstract":"Celosia trigyna is a well-known vegetable used in the preparation of many indigenous soups in Southwestern Nigeria. The aim of this study was to evaluate the anticancer property of C. trigyna of crude and solvent fractions using antioxidant, cytotoxic bench-top bioassays, and cancer cell line experiments. Cytotoxicity was carried out using Raniceps ranninus, Saccharomyces cerevisiae, and Sorghum bicolor models, as well as cytotoxicity studies against human breast (MCF), colon (HCT116), and lung (H460) cancer cell lines; radical scavenging potential against DPPH was likewise performed. A concentration of nondependent cytotoxicity against S. cerevisiae was observed in CTA, with the lowest inhibition of organism growth at 31.2 µg/mL (26.40 ± 1.92%) and highest activity at 250 µg/mL (56.00 ± 2.12%). Concentration-dependent inhibition was observed in CTA with 84.80 ± 1.97% at 250 µg/mL, which is significantly different from values observed in DMSO (negative control) at 33.84 ± 1.03% at p < 0.01. Moreover, 100% motility of R. ranninus (tadpoles) was recorded for all concentrations (20–40 µg/mL) in CT and CTA, with significantly different p < 0.05 from values obtained for the vehicle (distilled water). Concentration-dependent DPPH radical scavenging potential was likewise noted both in CT and CTA at 20–100 µg/mL. The lowest inhibition was observed at 20 µg/mL (41.35% and 32.31%), while the highest was noted at 100 µg/mL (63.26% and 41.73%) for CT and CTA, respectively. CT showed cytotoxic effects against all cancer cell lines examined, with CTA exhibiting improved activity compared to CT against human lung (H460), breast (MCF-7), and colon (HCT116) cancer cell lines, with IC50 51.69 ± 5.13, 39.16 ± 9.21, and 38.52 ± 7.65, respectively. Findings from this research experimentally justify the ethnomedicinal claim of usage of C. trigyna in the treatment of cancer in southwestern Nigeria.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85483451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Clear Cell Renal Cell Carcinoma: Molecular Pathogenesis, Innovative Modeling, and Targeted Therapeutic Approaches 非透明细胞肾细胞癌:分子发病机制、创新模型和靶向治疗方法

Journal of International Translational Medicine Pub Date : 2022-11-23 DOI: 10.3390/ijtm2040042

Niloofar Khoshdel Rad, Maryam Vahidyeganeh, M. Mohammadi, A. Shpichka, P. Timashev, N. Hossein-khannazer, M. Vosough

引用次数: 3

Trigeminal Neuralgia Treatment Outcomes Following Gamma Knife Stereotactic Radiosurgery 伽玛刀立体定向放射治疗三叉神经痛的疗效

Journal of International Translational Medicine Pub Date : 2022-11-22 DOI: 10.3390/ijtm2040041

Abbas Jarrahi, R. Cantrell, Cynthia Norris, K. Dhandapani, J. Barrett, J. Vender

{"title":"Trigeminal Neuralgia Treatment Outcomes Following Gamma Knife Stereotactic Radiosurgery","authors":"Abbas Jarrahi, R. Cantrell, Cynthia Norris, K. Dhandapani, J. Barrett, J. Vender","doi":"10.3390/ijtm2040041","DOIUrl":"https://doi.org/10.3390/ijtm2040041","url":null,"abstract":"Trigeminal neuralgia (TN) is a chronic pain condition causing lancinating pain in the distribution of one or more divisions of the trigeminal nerve. Gamma knife stereotactic radiosurgery (GKSRS) is a surgical option for TN refractory to medical therapy. To report our experience and to analyze the reasons for the variance in radiosurgery outcomes between patients in our diverse population, we conducted a retrospective analysis of a prospectively created database. The 178 patients completed a pain assessment questionnaire before surgery, and at 1 and 2 year follow-ups. We used the “Trigeminal Neuralgia Gamma Knife Outcome Scale” (TN GKOS) to report the response. At 1-year, 35.4% of patients had grade 1A outcome (pain-free and off all pain medications), 24.7% had grade 1B (pain-free on pain medications), 24.2% had grade 1C (some pain but improved with radiosurgery), 12.9% had grade 2 (same as before radiosurgery) and 2.8% had grade 3 (worse pain compared to before radiosurgery). At 2 years, 42.3% had grade 1A, 20.5% had grade 1B, 19.2% had grade 1C, 14.1% had grade 2 and 3.8% had grade 3 outcome. Remarkably, a statistically significant association was found between GKOS and age, racial background and obesity.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72500389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0