Journal of International Translational Medicine最新文献_第5页

Successful Treatment of Pancreatic Pseudocysto-Duodenum Fistula with Ultrasound Endoscopic Drainage: A Case Report 超声内镜引流术治疗胰假十二指肠瘘1例

Journal of International Translational Medicine Pub Date : 2022-11-03 DOI: 10.3390/ijtm2040040

B. Lattanzi, I. Febbraro, E. Pironti, M. Bianchi

引用次数: 0

Characterization of Engineered Cerium Oxide Nanoparticles and Their Effects on Lung and Macrophage Cells 工程氧化铈纳米颗粒的表征及其对肺和巨噬细胞的影响

Journal of International Translational Medicine Pub Date : 2022-10-17 DOI: 10.3390/ijtm2040039

M. Bushell, F. Kunc, X. Du, A. Zborowski, L. Johnston, D. Kennedy

引用次数: 1

Antifungal Activity of Angelica gigas with Enhanced Water Solubility of Decursin and Decursinol Angelate by Hot-Melt Extrusion Technology against Candida albicans 热熔挤压法提高赤ursin和赤ursinol Angelate水溶性的当归对白色念珠菌的抗真菌活性

Journal of International Translational Medicine Pub Date : 2022-09-30 DOI: 10.3390/ijtm2040038

Suji Ryu, Ha Yeon Lee, S. Nam, Jong-Suep Baek

引用次数: 3

Using the Gaucher Earlier Diagnosis Consensus (GED-C) Delphi Score in a Real-World Dataset 使用戈歇早期诊断共识(GED-C)德尔福评分在一个真实世界的数据集

Journal of International Translational Medicine Pub Date : 2022-09-09 DOI: 10.3390/ijtm2030037

S. Revel-Vilk, G. Chodick, V. Shalev, Roni Lotan, K. Zarakowska, N. Gadir

{"title":"Using the Gaucher Earlier Diagnosis Consensus (GED-C) Delphi Score in a Real-World Dataset","authors":"S. Revel-Vilk, G. Chodick, V. Shalev, Roni Lotan, K. Zarakowska, N. Gadir","doi":"10.3390/ijtm2030037","DOIUrl":"https://doi.org/10.3390/ijtm2030037","url":null,"abstract":"Early and accurate diagnosis of Gaucher disease, a rare, autosomal recessive condition characterized by hepatosplenomegaly, thrombocytopenia, and anemia, is essential to facilitate earlier decision-making and prevent unnecessary tests and procedures. However, diagnosis can be challenging for non-specialists, owing to a wide variability in age, severity of disease, and types of clinical manifestation. The Gaucher Earlier Diagnosis Consensus (GED-C) scoring system was developed by a panel of 22 expert physicians using Delphi methodology on the signs and covariables considered important for diagnosing Gaucher disease. This study aimed to use the scoring system in a real-world dataset. We applied the GED-C scoring system to 265 confirmed cases of Gaucher disease identified in the Maccabi Health Services (MHS) database from 1998 to 2022. Overall Delphi scores were calculated using features applicable to type 1 Gaucher disease. Based on all available patient data up to one year after diagnosis, the median (interquartile range (IQR)) Delphi score was 8.0 (5.5–11.5), with patients reporting up to 15 variables each. A score of 9.5 (6.5–12.5) was determined for 205 patients diagnosed from 2000 to 2022. The overall GED-C score was highly dependent on the extraction of all relevant data. The number of features collected in the MHS database was fewer than those required to achieve a high score on the GED-C score.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86051126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significant Differences in the Reversal of Cellular Stress Induced by Hydrogen Peroxide and Corticosterone by the Application of Mirtazapine or L-Tryptophan 应用米氮平或l -色氨酸逆转过氧化氢和皮质酮诱导的细胞应激的显著差异

Journal of International Translational Medicine Pub Date : 2022-09-03 DOI: 10.3390/ijtm2030036

A. Correia, A. Cardoso, N. Vale

{"title":"Significant Differences in the Reversal of Cellular Stress Induced by Hydrogen Peroxide and Corticosterone by the Application of Mirtazapine or L-Tryptophan","authors":"A. Correia, A. Cardoso, N. Vale","doi":"10.3390/ijtm2030036","DOIUrl":"https://doi.org/10.3390/ijtm2030036","url":null,"abstract":"Depression is a prevalent and debilitating disease worldwide. This pathology is very complex and the lack of efficient therapeutic modalities, as well as the high rates of relapse, makes the study and treatment of depression a global healthcare challenge. Thus, an intense investigation of this disease is crucial and urgent. In this study, we focused on hydrogen peroxide and corticosterone-induced stress on SH-SY5Y and HT-22 cells. Additionally, we aimed to study the potential attenuation of these induced stress with the exposure of both cells to mirtazapine and L-tryptophan, focusing on cell viability assays (MTT and Neutral Red) and reactive oxygen species production assays (DCFDA fluorescence). Taken together, our results indicate that mirtazapine and L-tryptophan counteract the cellular stress induced by hydrogen peroxide but not by corticosterone, revealing a potential role of these agents on oxidative stress relief, highlighting the role of serotonergic pathways in the oxidative stress present in depressed individuals. This study allows the investigation of depression using cellular models, enabling the screening of compounds that may have potential to be used in the treatment of depression by acting on cellular mechanisms such as oxidative stress protection.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"315 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72391893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Early Empirical Antibiotic Therapy Modification in Sepsis Using Beta-Lacta Test Directly on Blood Cultures 直接血培养β -乳酸试验对脓毒症早期经验性抗生素治疗的改进

Journal of International Translational Medicine Pub Date : 2022-08-26 DOI: 10.3390/ijtm2030034

A. Mizrahi, F. Jauréguy, H. Petit, G. Péan de Ponfilly, E. Carbonnelle, A. Le Monnier, J. Zahar, B. Pilmis

{"title":"Early Empirical Antibiotic Therapy Modification in Sepsis Using Beta-Lacta Test Directly on Blood Cultures","authors":"A. Mizrahi, F. Jauréguy, H. Petit, G. Péan de Ponfilly, E. Carbonnelle, A. Le Monnier, J. Zahar, B. Pilmis","doi":"10.3390/ijtm2030034","DOIUrl":"https://doi.org/10.3390/ijtm2030034","url":null,"abstract":"Background: Sepsis caused by multi-drug-resistant Gram-negative bacilli lead physicians to prescribe broad-spectrum antibiotic therapy, such as carbapenems. Rapid susceptibility testing can help with the rational use of antibiotics. The aim of this study was to measure the clinical impact associated with rapid reporting of Beta-Lacta test (BLT) directly on blood cultures positive with Gram-negative bacilli. Methods: In an observational, multicentric, prospective study, we included patients with sepsis caused by Enterobacterales observed on Gram staining of the positive blood cultures. BLT and antimicrobial susceptibility testing (AST) were performed directly on the blood cultures. Clinical impact was measured on the proportion of patients for whom the probabilistic antibiotic therapy was modified according to BLT, including patients receiving carbapenem. Results: 170 patients were included, of whom 44 (25.9%) were receiving inadequate empirical antibiotic therapy. Among them, 27 (15.9%) benefited from an early modification, according to the BLT results. Among 126 (74.1%) patients receiving appropriate probabilistic antibiotic therapy, we modified the antibiotic therapy for 28 (16.5%) of them, including 4/14 (28.5%) de-escalation from carbapenem to a third-generation cephalosporin. Conclusions: Implementation of BLT performed directly on blood cultures allowed us to rapidly modify the empirical antibiotic therapy for about one-third of patients with sepsis caused by Enterobacterales.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81687125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Osteopontin in Cancer: Mechanisms and Therapeutic Targets 骨桥蛋白在癌症中的作用:机制和治疗靶点

Journal of International Translational Medicine Pub Date : 2022-08-19 DOI: 10.3390/ijtm2030033

Y. Kariya, Yukiko Kariya

{"title":"Osteopontin in Cancer: Mechanisms and Therapeutic Targets","authors":"Y. Kariya, Yukiko Kariya","doi":"10.3390/ijtm2030033","DOIUrl":"https://doi.org/10.3390/ijtm2030033","url":null,"abstract":"Despite significant advances in the understanding of cancer biology, cancer is still a leading cause of death worldwide. Expression of the tumor microenvironment component, osteopontin, in tumor tissues, plasma, and serum, has been shown to be associated with a poor prognosis and survival rate in various human cancers. Recent studies suggest that osteopontin drives tumor development and aggressiveness using various strategies. In this review, we first provide an overview of how osteopontin promotes tumor progression, such as tumor growth, invasion, angiogenesis, and immune modulation, as well as metastasis and chemoresistance. Next, we address how the functional activities of osteopontin are modulated by the interaction with integrins and CD44 receptors, but also by the post-translational modification, such as proteolytic processing by several proteases, phosphorylation, and glycosylation. Then, we review how osteopontin activates tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs), and functions as an immunosuppressor by regulating immune surveillance and immune checkpoint in the tumor microenvironment. Finally, we discuss the potential applications of osteopontin as a biomarker and as a therapeutic target.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80024807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Molecular Interactions between Gasotransmitters in Patients with Obstructive Sleep Apnea 阻塞性睡眠呼吸暂停患者气体递质的分子相互作用

Journal of International Translational Medicine Pub Date : 2022-08-17 DOI: 10.3390/ijtm2030032

S. Pusalavidyasagar, L. B. Hovde, Jessie E Lee, Lei Zhang, A. Abbasi, Reena V. Kartha

{"title":"Molecular Interactions between Gasotransmitters in Patients with Obstructive Sleep Apnea","authors":"S. Pusalavidyasagar, L. B. Hovde, Jessie E Lee, Lei Zhang, A. Abbasi, Reena V. Kartha","doi":"10.3390/ijtm2030032","DOIUrl":"https://doi.org/10.3390/ijtm2030032","url":null,"abstract":"Patients with obstructive sleep apnea (OSA) have an increased risk of cardiovascular disease (CVD). Nitric oxide (NO) and heme oxygenase-1 (HO-1) affect vascular tone and are vasoprotective. Furthermore, hydrogen sulfide (H2S), an HO-1 inducer, is known to be a major effector molecule driving apneas. This study was conducted to examine the molecular relationships between these gasotransmitters and HO-1 in patients with OSA. Individuals who presented for evaluation for possible OSA were recruited and underwent overnight polysomnography. Individuals with an apnea-hypopnea index (AHI) of >5 per hour (OSA diagnosis) were considered cases (n = 19), while those with an AHI of <5 per hour (n = 6) were the controls. Blood samples were obtained before sleep and again from OSA cases prior to initiating treatment. H2S, NO, and HO-1 levels were assayed. Patients with OSA showed lower NO and H2S levels at baseline compared to controls. NO levels further decreased significantly from baseline in patients at the time of OSA diagnosis, while H2S levels largely showed an increasing trend, which was observed only when the subjects showing a baseline H2S level of >0.5 μM were excluded. Interestingly, analysis of HO-1 did not show a significant change from baseline, confirming the inverse relationship between the two gasotransmitters. The alterations in the bioavailability of endogenous H2S and its molecular interactions with NO and HO-1 regulating vascular tone may play a role in the pathogenesis of CVD in OSA patients.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"34 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75915983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder 老年患者血液滤过:尿毒症毒素、炎症、内皮和骨矿物质紊乱的行为

Journal of International Translational Medicine Pub Date : 2022-08-12 DOI: 10.3390/ijtm2030031

Armando Morales-Jr, W. Pinto, V. Fanchini, Luana Cristina de Almeida Silva, T. Gonçalves, P. Choque, Fernanda Kussi, L. Nakao, R. M. Elias, M. Dalboni

{"title":"Older Patients on Hemodiafiltration: Behavior of Uremic Toxins, Inflammation, Endothelium, and Bone Mineral Disorder","authors":"Armando Morales-Jr, W. Pinto, V. Fanchini, Luana Cristina de Almeida Silva, T. Gonçalves, P. Choque, Fernanda Kussi, L. Nakao, R. M. Elias, M. Dalboni","doi":"10.3390/ijtm2030031","DOIUrl":"https://doi.org/10.3390/ijtm2030031","url":null,"abstract":"Chronic kidney disease (CKD) affects 10% of the world’s population. Uremic toxins, such as indoxyl sulfate (IS), p-Cresylsulfate (PCS) and indole acetic acid (IAA), are not sufficiently removed by conventional hemodialysis (HD) and have been associated with inflammation, poor quality of life, bone mineral disease (BMD) and endothelial injury. Online hemodiafiltration (OL-HDF) may promote greater clearance of uremic toxins than HD. However, there are few studies evaluating the effect of OL-HDF on serum levels of IS, PCS, IAA, and biomarkers associated with inflammatory, endothelial, and bone and mineral disorder in the elderly population. We evaluated the effect of 6 months of OL-HDF on the serum concentration of uremic toxins, biomarkers of inflammation, endothelial and bone mineral disorder in older patients on OL-HDF. IS, PCS, and IAA were measured by high-performance liquid chromatography. We included 31 patients (77.4 ± 7.1 years, 64.5% male, 35.5% diabetic, on maintenance dialysis for 45 ± 20 days). From baseline to 6 months there was a decrease in serum concentration of IS but not PCS and IAA. We found no change in serum concentration of inflammatory, endothelial, or mineral and bone biomarkers. In summary, OL-HDF was capable to reduce IS in older patients. Whether this reduction may have an impact on clinical outcomes deserves further evaluation.","PeriodicalId":43005,"journal":{"name":"Journal of International Translational Medicine","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90883516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The In Vitro Virucidal Effects of Mouthwashes on SARS-CoV-2 漱口水对SARS-CoV-2的体外杀病毒作用

Journal of International Translational Medicine Pub Date : 2022-07-31 DOI: 10.3390/ijtm2030030

Miriam Ting, J. Suzuki

引用次数: 2