热熔挤压法提高赤ursin和赤ursinol Angelate水溶性的当归对白色念珠菌的抗真菌活性

Journal of International Translational Medicine Pub Date : 2022-09-30 DOI:10.3390/ijtm2040038

Suji Ryu, Ha Yeon Lee, S. Nam, Jong-Suep Baek

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引用次数: 3

摘要

热熔挤压(HME)已成为提高低水溶性活性分子的溶解度和生物利用度的一种替代技术。本研究制备了HME-Angelica gigas Nakai (AGN)，以提高AGN的活性成分天竺葵素(D)和天竺葵醇angelate (DA)的水溶性。与未经处理的AGN相比，HME-AGN对D和DA的水溶性增强。通过DPPH自由基清除法，HME-AGN具有较好的抗氧化活性。对白色念珠菌(C. albicans)有明显的抑菌活性。与AGN提取物处理的培养皿相比，HME-AGN提取物处理的培养皿的CFU降低，F2显示出最高的抗真菌活性。

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Antifungal Activity of Angelica gigas with Enhanced Water Solubility of Decursin and Decursinol Angelate by Hot-Melt Extrusion Technology against Candida albicans

Hot-melt extrusion (HME) has been an alternative technique to improve the solubility and bioavailability of active molecules with low water solubility. In this study, HME-Angelica gigas Nakai (AGN) was prepared to increase the aqueous solubility of decursin (D) and decursinol angelate (DA), the active ingredients of AGN. Compared with unprocessed AGN, HME-AGN showed enhanced water solubility of D and DA. The HME-AGN exhibited improved antioxidant activity by the DPPH radical scavenging method. The antifungal activity was confirmed against Candida albicans (C. albicans). There was a decrease in CFU in the plate treated with the HME-AGN extract compared with the plate treated with the AGN extract, and F2 showed the highest antifungal activity.

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来源期刊

Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

自引率

0.00%

发文量

317

审稿时长

8 weeks

期刊介绍： Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.