光疗对10例特应性皮炎患者游离维生素D水平的影响

Journal of International Translational Medicine Pub Date : 2022-12-01 DOI:10.3390/ijtm2040044

Andrea Elmelid, A. Osmancevic, M. Gillstedt, M. Alsterholm

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引用次数: 1

摘要

维生素D在特应性皮炎(AD)中的作用存在争议。相互矛盾的数据可能是由于使用了不适当的标记来评估维生素D水平。到目前为止，还没有在AD患者中直接测量游离25(OH)D浓度的报道。10例成人AD患者接受窄带紫外线B (NB-UVB)治疗10-12周。采用评分特应性皮炎(SCORAD)和视觉模拟量表(VAS)评估NB-UVB治疗前后疾病严重程度。分析治疗前后血清总25(OH)D、游离25(OH)D、1,25(OH)2D水平。用两步免疫吸附法(ELISA)测定游离25(OH)D浓度。大多数患者在治疗前25(OH)D水平足够(平均76.4 nmol/L)。平均游离25(OH)D为11.9 pmol/L，平均1.25 (OH)2D为108.9 pmol/L。光疗后中位SCORAD由37.1降至19.8,VAS明显改善。所有受试者的总25(OH)D和游离25(OH)D均增加。没有发现疾病严重程度与维生素D水平之间的相关性。总25(OH)D水平与游离25(OH)D水平无相关性。需要更大规模的研究来验证游离激素假说在AD发病机制中的适用性。

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Effects of Phototherapy on Free Vitamin D Levels in Ten Patients with Atopic Dermatitis

The role of vitamin D in atopic dermatitis (AD) is controversial. Conflicting data could be due to the use of inadequate markers for assessing vitamin D status. So far, directly measured free 25(OH)D concentrations have not been reported in AD patients. Ten adults with AD were treated with narrow band ultraviolet light B (NB-UVB) for 10–12 weeks. SCORing atopic dermatitis (SCORAD) and the visual analogue scale (VAS) were used to assess disease severity before and after NB-UVB therapy. Total and free 25(OH)D and 1,25(OH)2D serum levels were analyzed before and after treatment. Free 25(OH)D concentrations were measured with a two-step immunosorbent assay (ELISA). The majority of patients had sufficient levels of 25(OH)D before treatment (mean 76.4 nmol/L). Mean free 25(OH)D was 11.9 pmol/L and mean 1,25(OH)2D was 108.9 pmol/L. Median SCORAD decreased from 37.1 to 19.8 and VAS improved significantly after phototherapy. Total and free 25(OH)D increased in all subjects. No correlations between disease severity and vitamin D levels were found. There was no correlation between total and free 25(OH)D levels. Larger studies are needed to test the applicability of the free hormone hypothesis in AD pathogenesis.

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来源期刊

Journal of International Translational Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

自引率

0.00%

发文量

317

审稿时长

8 weeks

期刊介绍： Journal of International Translational Medicine (JITM, ISSN 2227-6394), founded in 2012, is an English academic journal published by Journal of International Translational Medicine Co., Ltd and sponsored by International Fderation of Translational Medicine. JITM is an open access journal freely serving to submit, review, publish, read and download full text and quote. JITM is a quarterly publication with the first issue published in March, 2013, and all articles published in English are compiled and edited by professional graphic designers according to the international compiling and editing standard. All members of the JITM Editorial Board are the famous international specialists in the field of translational medicine who come from twenty different countries and areas such as USA, Britain, France, Germany and so on.