{"title":"Developing a portable pulse oximeter for telemetry application","authors":"Kamran Shiraliyev, O. Sahin","doi":"10.1109/BIYOMUT.2014.7026379","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026379","url":null,"abstract":"Pulse oximeter is an optical medical device that measures heart rate and oxygen saturation level of the arterial blood in a non-invasive way. In this study a remote portable fingertip pulse oximeter was developed. The bluetooth connection of the device provides the data transfer between device and PC. The measured values of device can be stored on a PC as “xml” files. In this study, some physical activities were also carried out using the developed device. The effect of indoor and outdoor areas to the variability of oxygen saturation of blood during exercise was monitored and the average measured oxygen saturation of the participated volunteers during indoor and outdoor exercises were calculated and they were compared graphically.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122934930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of chemoattractant properties of various molecules in three-dimensional microenvironment to metastasis of breast cancer cells to bone","authors":"Gulben Avsar, B. Zeybek, Aylin Sendemir-rkmez","doi":"10.1109/BIYOMUT.2014.7026344","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026344","url":null,"abstract":"Metastasis is the most destructive step of cancer and it is defined as spreading of tumor cells from the primary tumor cite to other organs. Because of the fact that the molecular and cellular mechanisms underlying bone metastasis have not been yet understood, the development of an effective therapy is not possible. Chemo-attractant properties of some molecules in the bone extracellular matrix has been considered among possible reasons of metastasis. In this study, collagen scaffolds were produced by electrospinning method mimicking natural porous bone structure to understand possible chemo-attractant molecules that are common in bone metastases of metastatic breast cancer cells. MCF-7 metastatic breast cancer cells' adhesion kinetics were studied on the surfaces and scaffolds which are functionalized by osteopontin, collagen type I and hydroxyapatite. Three dimensional chemotaxis slides were used for visualizing the migration. Both cell adhesion kinetics and migration results showed that collagen type 1 and hydroxyapatite combination was more effective as a chemo-attractant than only collagen type 1 in the bone metastasis of breast cancer cells. Osteopontin caused migration and cell adhesion relatively more than collagen type I; and it was showed that this protein is an effective chemo-attractant in the bone metastasis of breast cancer cells. It was shown that micro environments of the bone minerals play an important role in the formation of metastatic niche because of their support to the development and colonization of tumor cells in the bone.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128305871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sensitive prediction of bacterial type IV effectors","authors":"K. Açıcı, Duygu Dede Sener, H. Oğul","doi":"10.1109/BIYOMUT.2014.7026341","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026341","url":null,"abstract":"Diverse human pathogens secret effector proteins into host cells via the type IV secretion system (T4SS). Effector proteins are important elements in the interaction between bacteria and hosts. Computational methods for T4SS effector prediction will be of great value. This paper introduces five types of feature representation schemes for prediction of effectors from sequence namely, amino acid composition, dipeptide composition, three-peptide composition, BLAST similarity scores and pseudo amino acid composition. SVM, k-NN, Naïve Bayes and Fisher LDA classification methods were performed in a newly established the dataset to predict T4SS effectors with using generated features. The experimental results indicate that classification methods we used are useful to discriminate IVA and IVB effectors with positive rates 83,3%, 96,5% respectively. The overall accuracy of 95.5% shows that the present method is accurate for distinguishing the T4SS effector in unidentified sequences.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124568239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A dual band antenna design for implantable medical devices","authors":"Damla Alptekin, N. G. Gencer, F. Kucukdeveci","doi":"10.1109/BIYOMUT.2014.7026386","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026386","url":null,"abstract":"In this study, design and the numerical analysis of a dual band (MICS (Medical Implant Communications Service; 402-405MHz) and ISM (Industrial, Scientific and Medical; 2.4-2.48GHz)) implantable antenna which is planned to be inserted in the header of the medical device is presented. The proposed medical implantable antenna (MIA) is in the type of planar inverted F Antenna (PIFA). For miniaturization, the metallic patch of the antenna is meandered and a shorting-pin is used between the patch and ground plane. Numerical analysis of the implant antenna is carried out using HFSS (High Frequency Structure Simulator) software. It is showed that return losses in the MICS and ISM band is lower than -10 dB and the gain of the antenna is consistent with the gain characteristics of the microstrip antennas.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131634312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"White matter changes in thalamic stroke","authors":"Sami Yumerhodzha, D. G. Duru, A. Duru, N. Bebek","doi":"10.1109/BIYOMUT.2014.7026376","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026376","url":null,"abstract":"Stroke as one the most significant health problems can be diagnosed by clinical symptoms and medical imaging modalities. Stroke patients mostly suffer from white matter changes, so the detection of any change in the white matter is important in that the white matter is directly affecting the brain functions. Diffusion tensor imaging, which allows the determination of the microstructural properties of white matter noninvasively yields to extract the tissue changes due to pathology. This study focuses on the brain areas of patients affected by thalamic stroke using the brain fiber tracts' distribution which allows the quantitative tracking of white matter changes. Besides the comparison of the stroke patients with the healthy control group, variations in white matter volume and the fiber tract distribution between the right and left thalamic stroke cases are also computed in a voxel-wise manner. The statistical analyses result that in thalamic stroke patients, the total number of voxels with white matter and the total volume of white matter have been decreased with respect to controls. The developed spatial masks aid to investigate the structural properties of the stroke whether it's in the right or left side of thalamus. Results allow one to discuss the voxel statistics of thalamic stroke cases and subjectwise comparison of the same fibers.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116013694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of ceria nanoparticles synthesis on their cytotoxicity against CaCo2 Cells in vitro","authors":"G. Yelken","doi":"10.1109/BIYOMUT.2014.7026355","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026355","url":null,"abstract":"In recent year's cerium oxide has been used productively in various engineering and biological applications, such as solid oxide fuel cells, catalytic materials, solar cells and biomedical applications as biological antioxidants [1-4]. Aim of this study is to investigate effects of synthesis conditions of nanoceria on cytotoxicity against CaCo2 (human colon adenocar-cinoma) Cells in vitro. The morphological and structural characterization of ceria nanopowders were performed by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectra (FTIR), size distribution, electrokinetic analysis (zeta potential measurements), surface area. Cytotoxicity test using colon cancer cells showed that nanoceria have no cytotoxic effect against Caco-2 cells at low concentration and cytotoxicity change with respect to synthesis conditions.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124722702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uluç Pamuk, A. Karakuzu, Pinar Akyazi, B. Acar, C. Ozturk, C. Yucesoy
{"title":"MRI analyses indicate non-uniform human muscle tissue deformations and confirm theoretically anticipated sarcomere length heterogeneity, in vivo","authors":"Uluç Pamuk, A. Karakuzu, Pinar Akyazi, B. Acar, C. Ozturk, C. Yucesoy","doi":"10.1109/BIYOMUT.2014.7026392","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026392","url":null,"abstract":"Using magnetic resonance imaging local deformations occuring within the human lower leg upon knee joint angle change have been quantified. Major deformations found are not confined to the target gastrocnemius muscle, and have been also observed within all muscles of the lower limb. Moreover, diffusion tensor imaging is used to tract gastrocnemius fibers and both lengthening and shortening deformations are found. These findings suggest that in human lower limb in vivo condition (i) myofascial force transmission occurs between muscles and (ii) sarcomere length nonuniformity occurs intramuscularly.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128340070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Yıldırım, G. H. Hatay, E. Okeer, K. Nicolay, B. Hakyemez, E. Ozturk‐Isik
{"title":"Fast phosphorus MR spectroscopic imaging of human brain using compressed sensing","authors":"M. Yıldırım, G. H. Hatay, E. Okeer, K. Nicolay, B. Hakyemez, E. Ozturk‐Isik","doi":"10.1109/BIYOMUT.2014.7026389","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026389","url":null,"abstract":"This study aims at acquiring and reconstructing compressed sensing accelerated phosphorus MR spectroscopic imaging (31P-MRSI) of human brain in vivo. Accelerated 31P-MRSI volunteer data were acquired using pulse and acquire with compressed sensing at 3T. k-space data was randomly undersampled for a five fold scan time reduction while preserving the central portion, and reconstructed using three dimensional compressed sensing algorithm. This study showed that compressed sensing method could be applied for faster 31P MR spectroscopic imaging of human brain at 3T.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130662885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet Topkara, E. Okeer, B. Hakyemez, E. O. Isik, Bahadir Olcay
{"title":"Computational fluid dynamics simulations based on time-of-flight magnetic resonance angiography","authors":"Ahmet Topkara, E. Okeer, B. Hakyemez, E. O. Isik, Bahadir Olcay","doi":"10.1109/BIYOMUT.2014.7026390","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026390","url":null,"abstract":"Computation fluid dynamics (CFD)is widely used to simulate blood flow in vascular systems. Most of the studies focus on identification of reasons behind the cardiovascular disorders. In this study, magnetic resonance angiography data belonging to a patient were used to obtain brain vasculature solid model. This model prior to CFD simulations was evaluated in terms of surface quality and critical region was identified to be investigated. After CFD analysis, the regions with low and high velocity vector fields, pressure, contours and wall shear stresses (WSS) were obtained. The effect of shape and orientation of vessels was observed. It was seen that increased blood velocity increases the pressure and WSS especially in narrow regions.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121113442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preprocessing effects on group independent component analysis of fMRI data","authors":"Duygu Sahin, A. Duru, A. Ademoglu","doi":"10.1109/BIYOMUT.2014.7026333","DOIUrl":"https://doi.org/10.1109/BIYOMUT.2014.7026333","url":null,"abstract":"Functional connectivity networks (FCN) might differ due to tissue loss in brain. Spatially independent components can be gathered with the group independent component analysis, which is one of the methods that can extract FCNs from fMRI data. Comparison of spatial or temporal results of group-wise data is possible for the differences in parameters of the preprocessing or processing steps. In this study, after the fMRI data, which is taken from Alzheimer's disease and mild cognitive impairment patients during an oddball paradigm, is preprocessed by two different methods; a group independent component analysis is done. Both of the preprocessing methods include slice time correction, motion correction, coregistration, normalization and spatial smoothing while they differ in normalization step as the chosen algorithm varies. After the preprocessing, group independent component analysis is applied with the same parameters for both of the methods. As a consequence, the effect of the difference between the two preprocessing methods are investigated. Depending on the results, stability, power spectrums and spatial maps of the components show an alteration by the algorithm used in normalization step.","PeriodicalId":428610,"journal":{"name":"2014 18th National Biomedical Engineering Meeting","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133899174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}