Journal of Contemporary Medical Sciences最新文献_第3页

Evaluation of Newly Synthesized Compounds Targeting Carbonic Anhydrase Enzyme for Antineoplastic Activity in Solid Tumors 以碳酸酐酶为靶点的新合成化合物对实体肿瘤抗肿瘤活性的评价

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1394

Esraa M. Naji, Sahar A. Hussein, Noor H. Naser

{"title":"Evaluation of Newly Synthesized Compounds Targeting Carbonic Anhydrase Enzyme for Antineoplastic Activity in Solid Tumors","authors":"Esraa M. Naji, Sahar A. Hussein, Noor H. Naser","doi":"10.22317/jcms.v9i4.1394","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1394","url":null,"abstract":"   Objective: This study was conducted with the aim of assessing the antineoplastic potential of recently developed compounds, namely F3, F4, and F5. These compounds were designed to target the carbonic anhydrase enzyme in solid tumors. Methods: The synthesis of these compounds involved the utilization of sulfanilamide, chloroacetylchloride, thiourea, benzyl chloride derivatives, and silver nitrate. Docking studies were carried out using the MOE software program version 2015.10, and the cytotoxic activity was predicted through the implementation of the MTT assay. Results: The compounds that were synthesized displayed noteworthy antineoplastic activity, as evidenced by both in silico simulations and cell line investigations. Notably, Compound F5 exhibited an IC50 value of 9.02 μg/ml for MCF7 cells, signifying a substantial difference when compared to the IC50 value of cisplatin. Moreover, Compounds F3 and F4 exhibited higher S scores in the docking study compared to acetazolamide, implying a more robust binding affinity to the catalytic site of the receptor. The inclusion of a substituted thiazole ring contributed to increased flexibility and enhanced receptor interaction. Conclusion: The synthetic compounds put forth in this study demonstrated notable antineoplastic properties. Furthermore, the complexation process notably augmented the inhibition of cancer cell growth, underscoring their potential as promising agents for combating cancer.  ","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Case Study on the Successful Treatment of Perianal Fistula in a Four-Year-Old Male 成功治疗一名四岁男童肛周瘘的综合个案研究

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1406

Aliaa A. Abdulqadir, MADANU DAVID PAUL RAJU, Mukul H Patel

引用次数: 0

Can Autistic Traits Severity Predict Autism Parenting Stress? 自闭症特征的严重程度能预测自闭症父母的压力吗?

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1392

Rabab Khalil Ibrahim, Ali Kareem Al-Juboori

引用次数: 0

Docking Study, Synthesis, Characterization and Preliminary Cytotoxic Evaluation of New 1,3,4- Thiadiazole Derivatives 新型1,3,4-噻二唑衍生物的对接研究、合成、表征及初步细胞毒性评价

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1409

Noor M. Mohammed, Mohammed Hassan Mohammed, Zainab M. Abdulkhaleq

{"title":"Docking Study, Synthesis, Characterization and Preliminary Cytotoxic Evaluation of New 1,3,4- Thiadiazole Derivatives","authors":"Noor M. Mohammed, Mohammed Hassan Mohammed, Zainab M. Abdulkhaleq","doi":"10.22317/jcms.v9i4.1409","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1409","url":null,"abstract":"Objectives: This study has determined that these newly synthesized analogs hold promise as potential sources of novel anticancer agents for combating breast cancer. Methods: We initiated our research by obtaining the crystal structure of Histone deacetylases (HDACs-8) bound with Vorinostat (SAHA) from the Protein Data Bank (PDB code 4QA0). Subsequently, we conducted docking experiments, which revealed that compounds (V c,s, V d,s, V c,t, and V d,t) exhibited favorable docking scores when compared to the standard. These compounds, synthesized through multi-step procedures involving the reaction of intermediate derivatives (IV c,d) with thiosemicarbazide or semicarbazide, were subjected to confirmation of their chemical structures using FT-IR and 1H NMR analysis. Results: The results of our in-vitro cytotoxicity assay (MTT assay) highlighted that compounds V c,t and V d,t exhibited notable inhibition ratios in the breast cancer cell line (MCF-7), while V c,t displayed similar efficacy in human colon adenocarcinoma (HRT-18) compared to the control drug, Vorinostat (SAHA). Conclusion: Our docking analysis led us to conclude that the C=S moiety demonstrated exceptional binding affinity to the zinc binding group of the HDAC enzyme, establishing multiple interaction modes. This finding suggests the potential of these compounds as valuable candidates in the development of anticancer treatments.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between regular breakfast consumption and academic performance among 6th-grade elementary school male students in Makkah, Saudi Arabia 沙特阿拉伯麦加六年级男生定期吃早餐与学习成绩的关系

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1399

Fahad Khulaif Alruwaili, Adeel Ahmed Khan, Amal Alruwaili, Wardah Alruwaili, Fahdah Alruwaili

引用次数: 0

Study the Gene Expression of PIK3CA in Tissue and Blood Samples of Iraqi Patients with Colorectal Cancer 伊拉克结直肠癌患者组织及血液中PIK3CA基因表达的研究

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1393

Rasha Abbas Azeez, Suha Abdul-Khaliq Al-Jowari, Hayder Jamal Mahmood

{"title":"Study the Gene Expression of PIK3CA in Tissue and Blood Samples of Iraqi Patients with Colorectal Cancer","authors":"Rasha Abbas Azeez, Suha Abdul-Khaliq Al-Jowari, Hayder Jamal Mahmood","doi":"10.22317/jcms.v9i4.1393","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1393","url":null,"abstract":"Objective: The primary objective of this investigation is to explore the correlation between gene expression of PIKCA3 and colorectal cancer in both tissue and blood samples, while also performing a comparative analysis between these sample types. Methods: This research involved the collection of blood and tissue samples. The study was conducted at the Gastroenterology Hospital within the Medical City Department in Baghdad, Iraq, spanning from December 2021 to December 2022. A total of 80 volunteers, encompassing both genders and aged between 24 and 77, participated in the study. The Real Time qRT-PCR analysis method was employed to assess the expression of PIKCA3 genes within patient and control groups. Results: The findings indicate significant distinctions in Ct PIK3CA between blood and tissue samples across all study groups. Moreover, PIK3CA expression displayed a notable association with CRC patients, showing higher expression levels compared to the other groups. This disparity was particularly pronounced when comparing tissue and blood samples. Statistical analysis, specifically Receiver Operating Characteristic (ROC) Curve Analysis, affirmed the excellent predictive capacity of the AUC (Area Under the Curve) value. The study established that PIK3CA gene expression in tissue outperformed that in blood, demonstrating a considerably elevated gene expression in tissue (p<0.001). Notably, the fold increase in gene expression within CRC patients was significantly higher compared to the group of healthy participants, with values of 23.630 in blood samples and 124.810 in tissue samples, respectively. The present study underscores the prevalence of PIK3CA gene mutations in colorectal carcinomas. Conclusion: The frequent occurrence of PIK3CA gene mutations in colorectal carcinomas may hold promise for the development of targeted therapy combinations. These could involve inhibiting both the PI3K kinase itself and addressing associated pathway anomalies.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"521 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Zonulin and Growth Differentiation Factor-15 levels support link between Coronary Artery Disease: The Liver-Heart Axis 血清Zonulin和生长分化因子-15水平支持冠状动脉疾病之间的联系:肝-心轴

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1391

Aliaa Ahmed Jasim, Hanaa Addai Ali, Maha Mohammed Kadhim, Ahmed Qasim Al-haidari, Fadhil Jawad Al-Tu’ma

{"title":"Serum Zonulin and Growth Differentiation Factor-15 levels support link between Coronary Artery Disease: The Liver-Heart Axis","authors":"Aliaa Ahmed Jasim, Hanaa Addai Ali, Maha Mohammed Kadhim, Ahmed Qasim Al-haidari, Fadhil Jawad Al-Tu’ma","doi":"10.22317/jcms.v9i4.1391","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1391","url":null,"abstract":"Objectives: This study aimed to evaluate associations between serum zonulin and GSF-15 levels in coronary arteries with NAFLD patients and to study their correlations with different parameters. Methods: In this case-control study, 90 subjects were collected, consisting of 45 coronary artery disease with non-alcoholic fatty liver (Grade one) patients and 45 controls, Clinical demographic information, including family history of coronary disease, lifestyle factors including hypertension and diabetes, and certain blood parameters data (lipid profile, liver functions test). Results: The patients' mean age was 55.64±8.462 years. Among all participants, 64(71.1%) were male and 26(28.9%) female. Zonulin, GDF-15, triglycerides, ALT, AST, ALP, and LDL levels were significantly higher in the patients (p≤0.001, p≤0.001, p=0.022, p≤0.001, p=0.035, p≤0.001, p≤0.001, respectively). In comparison to the controls, HDL and total cholesterol were considerably higher (p≤0.001 and p≤0.001). Conclusion: Patients who suffer from non-alcoholic fatty liver disease and coronary arteries had higher levels of zonulin and GDF-15.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"173 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Covid-19 Pandemic upon Iraqi women’s Sexual and Reproductive Health at Primary Health Care Centers Covid-19大流行对伊拉克初级卫生保健中心妇女性健康和生殖健康的影响

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1395

Hawraa Hussein Ghafel

{"title":"Impact of Covid-19 Pandemic upon Iraqi women’s Sexual and Reproductive Health at Primary Health Care Centers","authors":"Hawraa Hussein Ghafel","doi":"10.22317/jcms.v9i4.1395","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1395","url":null,"abstract":"   Objectives: The aim of this study was to assess the repercussions of the COVID-19 pandemic on the sexual and reproductive well-being of women. Methods: Employing a descriptive design with a correlational approach, the study was conducted between November 2021 and July 2022. The sample consisted of (180) women within the reproductive age range of 17 to 49 years. This non-probability 'purposive sample' was chosen deliberately. Data analysis was conducted using descriptive and correlational statistics. Results: The investigation divulged significant findings. A considerable proportion of women (55.6%) reported being unable to access contraception during the pandemic. Moreover, (45%) experienced unintended pregnancies amid the pandemic. Additionally, concerns linked to the pandemic led to a lack of follow-up visits for (73.3%) of participants. The study also highlighted the distressing issue of domestic violence during COVID-19: Over half of the women (51.1%) reported exposure to domestic violence, attributing it to prolonged periods of their husbands staying at home. Furthermore, (51.7%) noted an escalation in domestic violence, and (38.3%) revealed that their husbands showed inadequate concern for their sexual well-being. Conclusion: The COVID-19 pandemic detrimentally affected the sexual and reproductive health of women, manifested through challenges encountered during pregnancy, childbirth, postpartum phases, and family planning. Furthermore, a significant proportion of women faced an increased risk of domestic violence due to the pandemic and the extended presence of their husbands at home.  ","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moxifloxacin's Therapeutic Effects in AA-Induced Colitis: Anti-Inflammatory Action through NF-κB Pathway Inhibition, Including TNF-α Pathway and Downstream Inflammatory Processes 莫西沙星对aa性结肠炎的治疗作用:通过抑制NF-κB通路，包括TNF-α通路和下游炎症过程的抗炎作用

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1407

Jaffar O. Dawood, Ahmed Abu-Raghif

{"title":"Moxifloxacin's Therapeutic Effects in AA-Induced Colitis: Anti-Inflammatory Action through NF-κB Pathway Inhibition, Including TNF-α Pathway and Downstream Inflammatory Processes","authors":"Jaffar O. Dawood, Ahmed Abu-Raghif","doi":"10.22317/jcms.v9i4.1407","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1407","url":null,"abstract":"Objectives: The aim of the present study was to evaluate possible therapeutic effects of moxifloxacin against acetic acid-induced colitis in a rat model. Methods: Forty adult Wistar rats were separated into 4 groups, including the negative control group, acetic acid (AA) group, AA + sulfasalazine (100 mg/kg/day) group, and AA+ moxifloxacin (MFX) (8 mg/kg/day) group. Experimental colitis was induced in rats by rectal administration of (4%v/v) acetic acid. Rats with colitis were received either MFX 8mg/kg/day or sulfasalazine 100mg/kg orally for 7days.The parameters measured are macroscopical assessment, colon weight (indicator of edema) and the measurement of concentrations of the proinflammatory cytokine TNF-α, oxidative stress marker malondialdehyde (MDA), adhesion molecule selectin and the inflammatory mediator NF-κB in colonic tissue homogenate. Results: This study had shown that AA elevate macroscopical scores, colon weight and biochemical homogenate parameters and all measured parameters were significantly reduced by both moxifloxacin and sulfasalazine with nonsignificant difference between them. Conclusions: The study explain that moxifloxacin possesses therapeutic potential in in AA induced colitis and its anti-inflammatory actions may involve inhibition of NF-κB inflammatory pathways including TNF-α pathway with its downstream inflammatory process such as elevation of adhesion molecule synthesis and oxidative species overproduction in the colonic tissues.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythropoietin protects against renal ischemia/reperfusion injury in rats via inhibition of oxidative stress, inflammation and apoptosis 促红细胞生成素通过抑制氧化应激、炎症和细胞凋亡对大鼠肾缺血再灌注损伤具有保护作用

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1405

Elaf R. Alaasam, Ali M. Janabi

{"title":"Erythropoietin protects against renal ischemia/reperfusion injury in rats via inhibition of oxidative stress, inflammation and apoptosis","authors":"Elaf R. Alaasam, Ali M. Janabi","doi":"10.22317/jcms.v9i4.1405","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1405","url":null,"abstract":"Objective: Study investigates erythropoietin's nephroprotective effect in adult male rats with renal ischemia and reperfusion injury, examining biochemical parameters and renal tissue alterations. Methods: twenty-eight male rats of Sprague Dawley randomized into four groups: Sham, Iscemia/Reperfusion, NS, and Erythropoietin. Sham group treated kidneys identically without clamping pedicles. Ischemia/Reperfusion group underwent midline laparotomy, 30 minutes ischemia, 2 hours reperfusion, Rats received NS vehicle for Erythropoietin 30 minutes before ischemia, Erythropoietin dose administered 30 minutes before ischemia/reperfusion. Operation performed under maintained anesthesia using ketamine and xylazine injections. Results: Renal ischemia /reperfusion increased serum Cr, BUN, IL-1β, NF-kB, Caspase-3, while SOD, GSH, Bcl-2 decreased in induced rats. Erythropoietin treatment reduced Cr and BUN levels, Reduced inflammation, and inflammatory markers. Renal tissue antioxidant markers increased; apoptotic markers decreased. Significant increase in Bcl-2 antiapoptotic marker. Erythropoietin-treated group had significantly better renal histological score compared to induced group. Conclusion: Erythropoietin protects against Ischemia/Reperfusion-mediated renal injury, possessing antioxidant, anti-inflammatory, and anti-apoptotic properties.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0