Journal of Contemporary Medical Sciences最新文献_第3页

Can latent toxoplasmosis lead to Alzheimer's disease? 潜伏性弓形虫病会导致阿尔茨海默病吗?

Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1437

Shameeran Salman Ismael, Shaimaa Hamid Hasan

引用次数: 0

Opuntia ficus-indica and its potential effects on cancer 无花果树及其对癌症的潜在影响

Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1430

Hanadi Talal Ahmedah

{"title":"Opuntia ficus-indica and its potential effects on cancer","authors":"Hanadi Talal Ahmedah","doi":"10.22317/jcms.v9i5.1430","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1430","url":null,"abstract":"Cancer is the second leading cause of death worldwide, with an estimated 19.3 million new cases and 10.0 million deaths in 2021. Genetic and environmental factors, including nutrition, play an important role in cancer development. At present, health professionals and the public have become highly interested in natural products and healthy food for preventing or treating cancer. Several natural products, such as fruits and vegetables, have demonstrated anticancer effects. Opuntia ficus-indica (OFI), commonly known as prickly pear or cactus pear, is a plant that has numerous beneficial properties. It serves as a source of dietary fibres, vitamins and various bioactive compounds with diverse health benefits. These compounds are associated with anti-inflammatory, antioxidant, antimicrobial, hypoglycaemic and neuroprotective properties. Different parts of the plant, including the fruit pulp and peel, cladodes (pads) and seeds, have been scientifically studied, and they have demonstrated therapeutic potential while being considered safe for human consumption. However, there is limited awareness and scientific information about OFI as a fruit. Reviewing existing knowledge and research on it is necessary to shed light on its potential anticancer properties. By consolidating the available information on OFI, we can gain a better understanding of this fruit and its potential role in cancer prevention and treatment.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting the Carbonic Anhydrase Enzyme with Synthesized Benzenesulfonamide Derivatives: Inhibiting Tumor Growth 合成苯磺酰胺衍生物靶向碳酸酐酶:抑制肿瘤生长

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1404

Zainab Kifah Abbas, Noor H. Naser, Rana Neama Atiya

{"title":"Targeting the Carbonic Anhydrase Enzyme with Synthesized Benzenesulfonamide Derivatives: Inhibiting Tumor Growth","authors":"Zainab Kifah Abbas, Noor H. Naser, Rana Neama Atiya","doi":"10.22317/jcms.v9i4.1404","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1404","url":null,"abstract":"Objectives: To assess the anticancer effects of recently developed compounds, Sa, Sb, Sc, and Sd. These compounds were designed to specifically target the carbonic anhydrase enzyme in solid tumors. Methods: The chemical synthesis involved the use of sulfanilamide, chloroacetyl chloride, GABA, thionyl chloride, methanol, hydrazine hydrate, potassium hydroxide, carbon disulfide, and benzyl chloride derivatives. Docking studies were conducted using the MOE software program version 2015.10, and cytotoxic activity was predicted using the MTT assay. Results: The newly synthesized compounds exhibited notable antineoplastic activity in both in silico and cell line investigations. Although they showed a significant difference in potency compared to cisplatin against cancer cells, they also demonstrated significant differences in toxicity towards normal cells. When compared to acetazolamide, compounds Sb displayed an IC50 = 28.41 μM, which was significantly different, and compound Sd showed a non-significant difference with an IC50 = 61.20 μM against MCF7 cells. Additionally, Sb and Sd demonstrated significant difference in toxicity, with IC50 = 279.02 μM and 194.00 μM, respectively, against MCF10a cells. These findings indicate a significant difference compared to acetazolamide for the Sb compound and suggest that the synthesized compounds hold potential for further development as antineoplastic agents. Furthermore, the results from the cell line study align with the in silico study, where both compounds Sb and Sd exhibited higher S scores compared to acetazolamide, implying a stronger binding affinity with the receptor's catalytic site. The presence of a substituted 1,2,4-triazole ring in these compounds contributed to enhanced flexibility and improved interaction with the receptor. Conclusion: A new synthesized compounds exhibited cytotoxicity and demonstrated inhibitory potencies against carbonic anhydrase.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Newly Synthesized Compounds Targeting Carbonic Anhydrase Enzyme for Antineoplastic Activity in Solid Tumors 以碳酸酐酶为靶点的新合成化合物对实体肿瘤抗肿瘤活性的评价

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1394

Esraa M. Naji, Sahar A. Hussein, Noor H. Naser

{"title":"Evaluation of Newly Synthesized Compounds Targeting Carbonic Anhydrase Enzyme for Antineoplastic Activity in Solid Tumors","authors":"Esraa M. Naji, Sahar A. Hussein, Noor H. Naser","doi":"10.22317/jcms.v9i4.1394","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1394","url":null,"abstract":"   Objective: This study was conducted with the aim of assessing the antineoplastic potential of recently developed compounds, namely F3, F4, and F5. These compounds were designed to target the carbonic anhydrase enzyme in solid tumors. Methods: The synthesis of these compounds involved the utilization of sulfanilamide, chloroacetylchloride, thiourea, benzyl chloride derivatives, and silver nitrate. Docking studies were carried out using the MOE software program version 2015.10, and the cytotoxic activity was predicted through the implementation of the MTT assay. Results: The compounds that were synthesized displayed noteworthy antineoplastic activity, as evidenced by both in silico simulations and cell line investigations. Notably, Compound F5 exhibited an IC50 value of 9.02 μg/ml for MCF7 cells, signifying a substantial difference when compared to the IC50 value of cisplatin. Moreover, Compounds F3 and F4 exhibited higher S scores in the docking study compared to acetazolamide, implying a more robust binding affinity to the catalytic site of the receptor. The inclusion of a substituted thiazole ring contributed to increased flexibility and enhanced receptor interaction. Conclusion: The synthetic compounds put forth in this study demonstrated notable antineoplastic properties. Furthermore, the complexation process notably augmented the inhibition of cancer cell growth, underscoring their potential as promising agents for combating cancer.  ","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Case Study on the Successful Treatment of Perianal Fistula in a Four-Year-Old Male 成功治疗一名四岁男童肛周瘘的综合个案研究

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1406

Aliaa A. Abdulqadir, MADANU DAVID PAUL RAJU, Mukul H Patel

引用次数: 0

Can Autistic Traits Severity Predict Autism Parenting Stress? 自闭症特征的严重程度能预测自闭症父母的压力吗?

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1392

Rabab Khalil Ibrahim, Ali Kareem Al-Juboori

引用次数: 0

Docking Study, Synthesis, Characterization and Preliminary Cytotoxic Evaluation of New 1,3,4- Thiadiazole Derivatives 新型1,3,4-噻二唑衍生物的对接研究、合成、表征及初步细胞毒性评价

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1409

Noor M. Mohammed, Mohammed Hassan Mohammed, Zainab M. Abdulkhaleq

{"title":"Docking Study, Synthesis, Characterization and Preliminary Cytotoxic Evaluation of New 1,3,4- Thiadiazole Derivatives","authors":"Noor M. Mohammed, Mohammed Hassan Mohammed, Zainab M. Abdulkhaleq","doi":"10.22317/jcms.v9i4.1409","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1409","url":null,"abstract":"Objectives: This study has determined that these newly synthesized analogs hold promise as potential sources of novel anticancer agents for combating breast cancer. Methods: We initiated our research by obtaining the crystal structure of Histone deacetylases (HDACs-8) bound with Vorinostat (SAHA) from the Protein Data Bank (PDB code 4QA0). Subsequently, we conducted docking experiments, which revealed that compounds (V c,s, V d,s, V c,t, and V d,t) exhibited favorable docking scores when compared to the standard. These compounds, synthesized through multi-step procedures involving the reaction of intermediate derivatives (IV c,d) with thiosemicarbazide or semicarbazide, were subjected to confirmation of their chemical structures using FT-IR and 1H NMR analysis. Results: The results of our in-vitro cytotoxicity assay (MTT assay) highlighted that compounds V c,t and V d,t exhibited notable inhibition ratios in the breast cancer cell line (MCF-7), while V c,t displayed similar efficacy in human colon adenocarcinoma (HRT-18) compared to the control drug, Vorinostat (SAHA). Conclusion: Our docking analysis led us to conclude that the C=S moiety demonstrated exceptional binding affinity to the zinc binding group of the HDAC enzyme, establishing multiple interaction modes. This finding suggests the potential of these compounds as valuable candidates in the development of anticancer treatments.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between regular breakfast consumption and academic performance among 6th-grade elementary school male students in Makkah, Saudi Arabia 沙特阿拉伯麦加六年级男生定期吃早餐与学习成绩的关系

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1399

Fahad Khulaif Alruwaili, Adeel Ahmed Khan, Amal Alruwaili, Wardah Alruwaili, Fahdah Alruwaili

引用次数: 0

Study the Gene Expression of PIK3CA in Tissue and Blood Samples of Iraqi Patients with Colorectal Cancer 伊拉克结直肠癌患者组织及血液中PIK3CA基因表达的研究

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1393

Rasha Abbas Azeez, Suha Abdul-Khaliq Al-Jowari, Hayder Jamal Mahmood

{"title":"Study the Gene Expression of PIK3CA in Tissue and Blood Samples of Iraqi Patients with Colorectal Cancer","authors":"Rasha Abbas Azeez, Suha Abdul-Khaliq Al-Jowari, Hayder Jamal Mahmood","doi":"10.22317/jcms.v9i4.1393","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1393","url":null,"abstract":"Objective: The primary objective of this investigation is to explore the correlation between gene expression of PIKCA3 and colorectal cancer in both tissue and blood samples, while also performing a comparative analysis between these sample types. Methods: This research involved the collection of blood and tissue samples. The study was conducted at the Gastroenterology Hospital within the Medical City Department in Baghdad, Iraq, spanning from December 2021 to December 2022. A total of 80 volunteers, encompassing both genders and aged between 24 and 77, participated in the study. The Real Time qRT-PCR analysis method was employed to assess the expression of PIKCA3 genes within patient and control groups. Results: The findings indicate significant distinctions in Ct PIK3CA between blood and tissue samples across all study groups. Moreover, PIK3CA expression displayed a notable association with CRC patients, showing higher expression levels compared to the other groups. This disparity was particularly pronounced when comparing tissue and blood samples. Statistical analysis, specifically Receiver Operating Characteristic (ROC) Curve Analysis, affirmed the excellent predictive capacity of the AUC (Area Under the Curve) value. The study established that PIK3CA gene expression in tissue outperformed that in blood, demonstrating a considerably elevated gene expression in tissue (p<0.001). Notably, the fold increase in gene expression within CRC patients was significantly higher compared to the group of healthy participants, with values of 23.630 in blood samples and 124.810 in tissue samples, respectively. The present study underscores the prevalence of PIK3CA gene mutations in colorectal carcinomas. Conclusion: The frequent occurrence of PIK3CA gene mutations in colorectal carcinomas may hold promise for the development of targeted therapy combinations. These could involve inhibiting both the PI3K kinase itself and addressing associated pathway anomalies.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"521 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Zonulin and Growth Differentiation Factor-15 levels support link between Coronary Artery Disease: The Liver-Heart Axis 血清Zonulin和生长分化因子-15水平支持冠状动脉疾病之间的联系:肝-心轴

Journal of Contemporary Medical Sciences Pub Date : 2023-08-26 DOI: 10.22317/jcms.v9i4.1391

Aliaa Ahmed Jasim, Hanaa Addai Ali, Maha Mohammed Kadhim, Ahmed Qasim Al-haidari, Fadhil Jawad Al-Tu’ma

{"title":"Serum Zonulin and Growth Differentiation Factor-15 levels support link between Coronary Artery Disease: The Liver-Heart Axis","authors":"Aliaa Ahmed Jasim, Hanaa Addai Ali, Maha Mohammed Kadhim, Ahmed Qasim Al-haidari, Fadhil Jawad Al-Tu’ma","doi":"10.22317/jcms.v9i4.1391","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1391","url":null,"abstract":"Objectives: This study aimed to evaluate associations between serum zonulin and GSF-15 levels in coronary arteries with NAFLD patients and to study their correlations with different parameters. Methods: In this case-control study, 90 subjects were collected, consisting of 45 coronary artery disease with non-alcoholic fatty liver (Grade one) patients and 45 controls, Clinical demographic information, including family history of coronary disease, lifestyle factors including hypertension and diabetes, and certain blood parameters data (lipid profile, liver functions test). Results: The patients' mean age was 55.64±8.462 years. Among all participants, 64(71.1%) were male and 26(28.9%) female. Zonulin, GDF-15, triglycerides, ALT, AST, ALP, and LDL levels were significantly higher in the patients (p≤0.001, p≤0.001, p=0.022, p≤0.001, p=0.035, p≤0.001, p≤0.001, respectively). In comparison to the controls, HDL and total cholesterol were considerably higher (p≤0.001 and p≤0.001). Conclusion: Patients who suffer from non-alcoholic fatty liver disease and coronary arteries had higher levels of zonulin and GDF-15.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"173 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0