Journal of Contemporary Medical Sciences最新文献

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Evaluation of the FAST HUG implementation effect on the mortality and length of stay in admitted patient in Intensive Care Unit (ICU) of a hospital 评估 FAST HUG 的实施对医院重症监护室(ICU)住院病人死亡率和住院时间的影响
IF 0.2
Journal of Contemporary Medical Sciences Pub Date : 2023-12-26 DOI: 10.22317/jcms.v9i6.1341
Mehran Kouchek, Behnam Arabzadeh, Navid Nooraei, Mansour Fathi, Mirmohamad Miri
{"title":"Evaluation of the FAST HUG implementation effect on the mortality and length of stay in admitted patient in Intensive Care Unit (ICU) of a hospital","authors":"Mehran Kouchek, Behnam Arabzadeh, Navid Nooraei, Mansour Fathi, Mirmohamad Miri","doi":"10.22317/jcms.v9i6.1341","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1341","url":null,"abstract":"Objective: We aimed to determine new version of  the FAST HUG implementation effect on the mortality and length of stay in admitted patient in Intensive Care Unit (ICU) of a hospital. Methods: we conducted a prospective cohort study on 406 patients who admitted in medical and surgical ICU of Imam Hossein Hospital of Tehran province in Iran from July 1, 2022, to September 30, 2022. We identified predictors of ICU mortality by logistic regression model, predictors of 28-day mortality/re-hospitalization/recovery by generalized ordered logit model, predictors of length of stay (LOS) by linear regression, predictors of mechanical ventilation by generalized ordered logit and predictors of SOFA score by hurdle model. Result :This mnemonic had protective impact (OR=0.56-p-value=0.01) on the 28-day mortality. One unit increase in mean of FAST HUG score had a preventive effect on the outcome of death (OR=0.21). Surgical admission type (Coefficient =-3.24, p-value= 0.00) and FAST HUG implementation (Coefficient =1.58, p-value= 0.0) were strongest factors on the LOS. Conclusion: Our study results approved the importance of the FAST HUG implementation on the decrease of patient mortality in ICU and 28 days after discharge. Additionally, this checklist had a statistically significant role in declining SOFA scores in ICU patients.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"9 23","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using the Transtheoretical Model of Change to Enhance High School Female Students’ Self-Efficacy of Refraining from Carbonated Drinks Consumption 运用变迁的跨理论模型提升高中女生抑制碳酸饮料消费的自我效能感
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1431
Hawraa Kareem Abed Ali, Wissam Jabbar Qasim
{"title":"Using the Transtheoretical Model of Change to Enhance High School Female Students’ Self-Efficacy of Refraining from Carbonated Drinks Consumption","authors":"Hawraa Kareem Abed Ali, Wissam Jabbar Qasim","doi":"10.22317/jcms.v9i5.1431","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1431","url":null,"abstract":"Objectives: To examine the efficacy of the Transtheoretical Model of Change-based intervention in enhancing students’ Self-Efficacy by refraining from carbonated drinks.
 Methods: We conducted a randomized controlled trial at Al-Russafa High School for girls in Baghdad City. The study involved a random sample of 144 female high school students, with 72 students in the intervention group and 72 in the control group. The research instrument collected data on participants' sociodemographic characteristics, including age, living arrangements, and family socioeconomic status. Additionally, we used the Stages of Change for Carbonated Drinks Consumption Behaviour Scale (Short Form) and the Stages of Change for Carbonated Drinks Consumption Behaviour Scale (Continuous Measure).
 Data analysis was performed using the Statistical Package for Social Science (SPSS) for Windows, version 27.
 Results: The study results exhibit that more than half of participants in the study group are in the Precontemplation Stage of Change in the pretest time (n = 42; 58.3%), followed by those who are in the Preparation Stage of Change (n = 15; 20.8%), those who are in the Contemplation Stage of Change (n = 14; 19.4%), and one who is in the Maintenance Stage of Change (n = 1; 1.4%).
 In posttest 2, less than two-fifths became in the Action Stage of Change (n = 28; 38.9%), followed by those who became in the Preparation Stage of Change (n = 19; 26.4%), those who became in the Maintenance Stage of Change (n = 18; 25.0%), those who became in the Contemplation Stage of Change (n = 6; 8.3%), and one who stayed in the Precontemplation of Change (n = 1; 1.4%).
 The researchers concluded that the administered intervention based on the TTM efficaciously enhanced students’ readiness to refrain from carbonated drinks consumption.
 Conclusion: The administered Stage-matched intervention based on the TTM efficaciously enhanced students’ Self-Efficacy in refraining from carbonated drinks consumption.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"2 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
G6PD Deficiency: Exploring the Relationship with Different Medical Disorders G6PD缺乏症:与不同医学疾病的关系探讨
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1433
Maysaa Alakbaree, Ali Abdulqader, Abbas Hashim Abdulsalam, Muaawia Ahmed Hamza, Syazwani Itri Amran, Mohd Shahir Shamsir, Nurriza AB LATIF
{"title":"G6PD Deficiency: Exploring the Relationship with Different Medical Disorders","authors":"Maysaa Alakbaree, Ali Abdulqader, Abbas Hashim Abdulsalam, Muaawia Ahmed Hamza, Syazwani Itri Amran, Mohd Shahir Shamsir, Nurriza AB LATIF","doi":"10.22317/jcms.v9i5.1433","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1433","url":null,"abstract":"G6PD deficiency (G6PDD) is associated with oxidative stress resulting from an imbalance between reactive oxygen species (ROS) production and the body's ability to counteract. In this review, we explore the adverse effects of G6PDD on diverse physiological processes and disease outcomes. Past studies have demonstrated the association between G6PDD and various other diseases, indicating a link between G6PDD to heightened oxidative stress by accelerating virus replication, worsening infection severity, and weakening the body's defense mechanisms. Such stress is critical in the destruction of red blood cells (RBCs) during infections and has a detrimental impact on redox signaling, ultimately impacting cell health and promoting cancer development. Furthermore, it impairs endothelial function by lowering the nitric oxide (NO) level and increasing stress, resulting in detrimental cardiac consequences and reduced myocardial antioxidant capacity. Because ROS contributes to inflammation, this imbalance causes conditions such as early atherosclerosis. It also compromises the functionality of NO-regulated bronchodilators and conditions such as G6PDD exacerbate the risks of kidney damage. Elevated ROS levels can also induce harm in retinal tissues, blood vessels, brain cells, and Beta-cells, hence quickening the progression of diseases like Diabetic Retinopathy. Furthermore, oxidative stress plays a significant role in cerebral ischemic pathogenesis, contributing to neurodegenerative disorders. Additionally, decreased NADPH level is vital for NO synthesis as it can impact blood vessel relaxation and can potentially lead to ischaemic priapism. Investigating the association between G6PDD and other medical conditions is crucial as it helps to identify possible approaches to mitigate oxidative stress, thereby preventing associated complications and diseases, particularly in situations where current treatment options are insufficient.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Hemoglobinopathies on Adolescent's Behaviour at Heredity Blood Diseases Center 遗传性血液病中心血红蛋白病对青少年行为的影响
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1435
Asmahan Qasim Mohammed
{"title":"Effect of Hemoglobinopathies on Adolescent's Behaviour at Heredity Blood Diseases Center","authors":"Asmahan Qasim Mohammed","doi":"10.22317/jcms.v9i5.1435","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1435","url":null,"abstract":"Objectives: The objectives of the present study were to determine the effect of hemoglobinopathies disease on adolescent's behavior and to find the relationship between adolescent's socio-demographic characteristics and the effect of Hemoglobinopathies on Adolescent's Behavior.
 Methods: Adolescents male and female with (beta thalassemia and sickle cell anemia) who were between the ages of 12 and 20 were the participants of a descriptive study. The research began on June 17, 2022, and lasted until November 15, 2022 to determine the effect of hemoglobinopathies disease on adolescent's behavior. A non-probability purposive sample of (105) adolescents was chosen at the Heredity Blood Diseases Center in Ibn Al Balady for children. and maternity. The information gathered between the 15th of July and the 15th of August 2022 using a built-in questionnaire and a direct interview method.
 Results: The findings of this study show that hemoglobinopathies disease have a moderate to low effect on adolescents' behavior, with 53.3% of them are showing moderate and 41.9% are showing low.
 Conclusions: The study conclusion that the behaviour was affected at moderate level. The results recommend offering adolescents with hemoglobinopathies an education program to enable self-management and provide them enough knowledge of the disease to avoid complications and make life plans.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"3 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of oncologist adherence to National Comprehensive Cancer Network (NCCN) anti-emetics guidelines for management of chemotherapy induced nausea and vomiting in Karbala province 卡尔巴拉省肿瘤科医生对国家综合癌症网络(NCCN)止吐药指南治疗化疗引起的恶心和呕吐的依从性评估
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1427
Enas F. Atiyah, Ayad A. Hussein
{"title":"Assessment of oncologist adherence to National Comprehensive Cancer Network (NCCN) anti-emetics guidelines for management of chemotherapy induced nausea and vomiting in Karbala province","authors":"Enas F. Atiyah, Ayad A. Hussein","doi":"10.22317/jcms.v9i5.1427","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1427","url":null,"abstract":"Background: Nausea and vomiting induced by chemotherapy is one of the most feared side effects of chemotherapy that affect patients’ quality of life and may lead to discontinuation of chemotherapy cycles. Adherence to antiemetics guidelines such as NCCN antiemetics guidelines significantly improve the quality of treatment provided to patients while minimizing the time and money spent on each individual case.
 Aim: Assessment of the current practice adherence of physicians to NCCN antiemesis guidelines.
 Method: the study is an observational cross-sectional study conducted in three oncology centers in the Iraqi province of Karbala. The study included twenty oncologists who agree to participate in the survey.
 Results: Seventy percent of participants oncologists follow NCCN antiemetics guidelines, while thirty percent do not. The mean patient related risk score for Imam Al-Hussein Oncology Center, Warith International Cancer Institute, and Al-Imam Al-Hasan Al-Mujtaba Hospital was 13.5, 12.4, 14.7 respectively.
 Conclusion: The current study demonstrates the knowledge and practices of participating oncologists regarding nausea and vomiting caused by chemotherapy across various oncology centers. In addition, there are a number of obstacles that make following antiemetics guidelines difficult or inconvenient, such as increased cost, a lack of awareness about antiemetics guidelines, and guidelines that are difficult or inconvenient to use.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Protective Effect of Ramelteon and in combination with Dexamethasone on the Lipopolysaccharide-induced Cytokine Storm in mice 拉美替恩及联合地塞米松对小鼠脂多糖诱导的细胞因子风暴的保护作用
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1429
Marwa A. Al-dabbagh, Hayder B. Sahib
{"title":"The Protective Effect of Ramelteon and in combination with Dexamethasone on the Lipopolysaccharide-induced Cytokine Storm in mice","authors":"Marwa A. Al-dabbagh, Hayder B. Sahib","doi":"10.22317/jcms.v9i5.1429","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1429","url":null,"abstract":"Cytokine Storm Syndrome (CSs) is a potentially life threatening condition, characterized by robust elevated; of circulating pro- inflammatory cytokines; occurring after a hyperactive immune system. Is a well-known as a worldwide health problem, leading to multi-organ failure and death. Objectives: This study was carried out to investigate the protective role and probability of additive or synergistic anti-inflammatory activity; of ramelteon and in combination with dexamethasone on the lipopolysaccharide (LPS) induced “Cytokine Storm” on mice model and its potential regulatory mechanism(s). Methods: Sixty Swiss albino male mice of ;( 25 ± 5 grams; 8-12 weeks) had free access to food and water. After 2weeks of adaptation, mice; randomly separated in five groups (n =12): Group I, mice received (0.9% NS i.p.); Group II, mice received (5mgkg i.p.) LPS only .Group III, mice received (2.5mg/kg, i.p.) dexamethasone, Group IV, mice received (100mg/kg i.p.) ramelteon, Group V, mice received half dose of dexamethasone+ ramelteon combination (1.25 mgkg i.p +50mgkg i.p). For systematic inflammatory stimulation mimicking “cytokine storm” LPS; E. coli O55:B5 (5mgkg i.p.) was induced within one hr. After 48h the effects of interventional agents and vehicle or LPS challenge; on lung, heart, liver, kidney histopathological changes, and levels of inflammatory cytokines :( IL-6, IL8 IL-1β, and TNF-α) in the serum were detected. Results: IL-1β, IL-6, IL8 and TNF-α elevated serum levels significantly reduced (p<0.001) in all treatment group. Additionally, they ameliorated the histopathological changes induced by (LPS) and improving macroscopic scores (p<0.001). Conclusion: In conclusion, ramelteon treatment had a diverse protective effects against “Cytokine Storm” with a mechanism based on attenuation serum levels of inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α)and through reduction of histopathological damage during endotoxemia induced via LPS challenge on male mice model. RAM/DEX combination had superior advantage than an agent use alone probably via synergistic anti-inflammatory activity.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"46 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of depression Level among elderly residents in nursing home and community: A comparative study 疗养院与社区长者抑郁水平影响之比较研究
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1436
Walaa Yehya abed zead, Ali Kareem khadir
{"title":"The impact of depression Level among elderly residents in nursing home and community: A comparative study","authors":"Walaa Yehya abed zead, Ali Kareem khadir","doi":"10.22317/jcms.v9i5.1436","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1436","url":null,"abstract":"The percentage of the elderly is expected to nearly double, from 12% to 22%, between 2015 and 2050 due to the rapid aging of the global population. All told, this means that increase the elderly people over the age of 60 to 2 billion from 900 million. Therefore, it is anticipated that older individuals may experience particular physical and mental health issues this study was done to examine the impact of elderly people's levels of depression and to Compare the level of depression among elderly people living with their families and elderly resident in nursing homes.&#x0D; A comparative study non-probability sampling strategy was used choose a judgmental sample of 125 elderly who residents in nursing home and community by using of questionnaire composed of three part: part I demographic characteristic part II, UCLA loneliness scale part III geriatric depression scale, data is analyzed using descriptive statistical data analysis.&#x0D; The results of the study indicated that elderly in nursing home and community show moderate level of depression study reveals that elderly people at nursing home have higher level of depression than those in community as indicated by with a p-value of.001&#x0D; The study conculcated by Providing social and health programs to support the elderly, as well as conducting awareness sessions for caregivers and families on how to take care of the elderly residing in the nursing home or residing with their families","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136136164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Glycolipoprotein Biosurfactant from Enterococcus faecium on the viability of Breast cancer cell lines. 粪肠球菌糖蛋白生物表面活性剂对乳腺癌细胞株活力的影响。
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1432
Dijlah A. Alimeer, Nibras N. Mahmood, Mohammad M. F. Al-Halbosiy
{"title":"Effect of Glycolipoprotein Biosurfactant from Enterococcus faecium on the viability of Breast cancer cell lines.","authors":"Dijlah A. Alimeer, Nibras N. Mahmood, Mohammad M. F. Al-Halbosiy","doi":"10.22317/jcms.v9i5.1432","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1432","url":null,"abstract":"Objective : This study , was research for cytotoxicity of bio-surfactant created by Enterococcus faecium isolated from feces of Iraqi healthy breast-fed infants with age < 6 months.&#x0D; Methods : Cold acetone precipitation was used to the extraction of extracellular Glycolipoprotein biosurfactant and partially purify it. Biosurfactant was then evaluated against two the cell lines, a Breast cancer MCF-7 cell line and a human normal fibroblast cell line NHF), specifically for cell survival and proliferation. &#x0D; Results : At all concentrations with varying percentage, The viability of the MCF-7 cancer cell line was shown to be reduced with the addition of biosurfactant.; maximum inhibition percentage was 74.2% at a 100 µg/ml concentration, which is lesser than 45.5% cytotoxicity Of NHF healthy fibroblasts cell line.&#x0D; Conclusions : The findings of this study are highly encouraging in terms of the potential of Glycolipoprotein biosurfactants to treat cancer and encourage additional research with different cell lines.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"73 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Pseudomonas aeruginosa isolates and their antibiotic susceptibility among patients and healthcare workers in three Hospitals of Duhok city/ Iraq 伊拉克杜霍克市三家医院患者和医护人员中铜绿假单胞菌的流行及其抗生素敏感性
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1428
Haval Khalid, Siham Abdullah Mohammed Said, Wijdan Mohammed Salih Mero
{"title":"Prevalence of Pseudomonas aeruginosa isolates and their antibiotic susceptibility among patients and healthcare workers in three Hospitals of Duhok city/ Iraq","authors":"Haval Khalid, Siham Abdullah Mohammed Said, Wijdan Mohammed Salih Mero","doi":"10.22317/jcms.v9i5.1428","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1428","url":null,"abstract":"Objective Pseudomonas aeruginosa is opportunistic gram-negative bacillus and a major human pathogen belongs to family Pseudomonadaceae, it causes several nosocomial infections including pneumonia, urinary tract, surgical sites, otitis externa, and soft tissues.&#x0D; Methods: The study was conducted from April 2021 to January 2022 and involved the prevalence of Pseudomonas aeruginosa isolates and their susceptibility to different antimicrobial agents among patients and healthcare workers specimens in three hospitals of Duhok city. The collected specimens were examined and cultured on different media in the Advanced Microbiology Laboratory, Azadi teaching hospital. The isolated bacteria were identified according to their morphological and biochemical properties.&#x0D; Results: Out of 324 specimens, 29.32% (95/324) of the isolates were identified as Pseudomonas aeruginosa, isolated from 26.89% patients and 40% healthcare workers. Regarding isolate rates among specimens, the highest rate (48.78%) was from sputum, with a highly significant (P<0.001) difference from other sources. Females had a non-significantly higher isolate rate than males (28.19% vs 25.22%), ages, >50 years had the highest isolate rate (72.88%), while the lowest rate 6.25% was among ages >10-20 years, with highly significant (P< 0.001) differences among them. Specimens from Hevii hospital showed a non-significantly higher isolate rate (28.57%) than other hospitals. Isolates highest susceptibility was to Colistin (88.7%) followed by Imipenem (78.9%), while they were 98.6 % resistant to ampicillin and 100% resistant to Amoxicillin, Erythromycin and Trimethoprim/Sulfamethoxazole. A high rate of extensively drug-resistant (19.72%) Pseudomonas aeruginosa isolates was documented among patients who attended these hospitals with the highest (31.25%) from wounds.&#x0D; Conclusion these findings will be helpful to advise treatment with appropriate antibiotic strategy against multi- and extensively drug -resistant P. aeruginosa to cope with the chances of evolving resistant pathogens.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico study of new carbonic anhydrase inhibitor derivatives bearing 1, 3, 4-Oxadiazole moiety with promising anti-cancer activity. 含有1,3,4 -恶二唑的新型抗癌活性碳酸酐酶抑制剂衍生物的硅片研究。
Journal of Contemporary Medical Sciences Pub Date : 2023-10-29 DOI: 10.22317/jcms.v9i5.1434
Riyam Saad Aljubouri, Noor H. Naser
{"title":"In silico study of new carbonic anhydrase inhibitor derivatives bearing 1, 3, 4-Oxadiazole moiety with promising anti-cancer activity.","authors":"Riyam Saad Aljubouri, Noor H. Naser","doi":"10.22317/jcms.v9i5.1434","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1434","url":null,"abstract":"Objectives: Molecular docking simulations were performed to assess the theoretical binding affinities of six (6) compounds created where they are derivatives having 1,3,4, oxadiazole moiety, and their target was cancer and Human carbonic anhydrase IX (PDB code: 6U4T). Using ChemDraw Ultra 12.0, the molecular structure was meticulously sketched. Molecular Operating environment software was used to verify the developed compounds by looking at their S. score and Rmsd values. Promising activity was seen with these proteins from the theoretically generated compounds, which exhibited strong binding contacts with the receptor active pocket.   Methods: Chemically by joining together several oxadiazole derivatives, sulfanilamide analogues (IVa-IVd) may be created in the lab. Molecular docking and ligand/receptor priming by MOE software. Results: Acetazolamide was selected because it had the same pharmacophore as the sulfanilamide group, and cisplatin was used in clinical trials for cancer therapy. IVc and IVa yielded max score and irrevocable relationship compared with acetazolamide and cisplatin. Conclusion: The MOE docking results validated the potent anticancer activity, the identified compounds showing good binding affinity with target proteins relative to the reference drugs (Acetazolamide and cisplatin). The most effective anticancer compounds were IVc and IVa, which yielded a maximum score with a Rmsd of less than 2, the MOE docking results were able prove this. Compounds IVc and IVa exhibited the greatest cytotoxic impact of the synthetic compounds against MCF7, and all four synthesized compounds showed a superior safety profile than the standards in MCF10a.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"314 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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