Journal of Contemporary Medical Sciences最新文献

{"title":"Effect of Hemoglobinopathies on Adolescent's Behaviour at Heredity Blood Diseases Center","authors":"Asmahan Qasim Mohammed","doi":"10.22317/jcms.v9i5.1435","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1435","url":null,"abstract":"Objectives: The objectives of the present study were to determine the effect of hemoglobinopathies disease on adolescent's behavior and to find the relationship between adolescent's socio-demographic characteristics and the effect of Hemoglobinopathies on Adolescent's Behavior.
 Methods: Adolescents male and female with (beta thalassemia and sickle cell anemia) who were between the ages of 12 and 20 were the participants of a descriptive study. The research began on June 17, 2022, and lasted until November 15, 2022 to determine the effect of hemoglobinopathies disease on adolescent's behavior. A non-probability purposive sample of (105) adolescents was chosen at the Heredity Blood Diseases Center in Ibn Al Balady for children. and maternity. The information gathered between the 15th of July and the 15th of August 2022 using a built-in questionnaire and a direct interview method.
 Results: The findings of this study show that hemoglobinopathies disease have a moderate to low effect on adolescents' behavior, with 53.3% of them are showing moderate and 41.9% are showing low.
 Conclusions: The study conclusion that the behaviour was affected at moderate level. The results recommend offering adolescents with hemoglobinopathies an education program to enable self-management and provide them enough knowledge of the disease to avoid complications and make life plans.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"3 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of oncologist adherence to National Comprehensive Cancer Network (NCCN) anti-emetics guidelines for management of chemotherapy induced nausea and vomiting in Karbala province","authors":"Enas F. Atiyah, Ayad A. Hussein","doi":"10.22317/jcms.v9i5.1427","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1427","url":null,"abstract":"Background: Nausea and vomiting induced by chemotherapy is one of the most feared side effects of chemotherapy that affect patients’ quality of life and may lead to discontinuation of chemotherapy cycles. Adherence to antiemetics guidelines such as NCCN antiemetics guidelines significantly improve the quality of treatment provided to patients while minimizing the time and money spent on each individual case.
 Aim: Assessment of the current practice adherence of physicians to NCCN antiemesis guidelines.
 Method: the study is an observational cross-sectional study conducted in three oncology centers in the Iraqi province of Karbala. The study included twenty oncologists who agree to participate in the survey.
 Results: Seventy percent of participants oncologists follow NCCN antiemetics guidelines, while thirty percent do not. The mean patient related risk score for Imam Al-Hussein Oncology Center, Warith International Cancer Institute, and Al-Imam Al-Hasan Al-Mujtaba Hospital was 13.5, 12.4, 14.7 respectively.
 Conclusion: The current study demonstrates the knowledge and practices of participating oncologists regarding nausea and vomiting caused by chemotherapy across various oncology centers. In addition, there are a number of obstacles that make following antiemetics guidelines difficult or inconvenient, such as increased cost, a lack of awareness about antiemetics guidelines, and guidelines that are difficult or inconvenient to use.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Protective Effect of Ramelteon and in combination with Dexamethasone on the Lipopolysaccharide-induced Cytokine Storm in mice","authors":"Marwa A. Al-dabbagh, Hayder B. Sahib","doi":"10.22317/jcms.v9i5.1429","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1429","url":null,"abstract":"Cytokine Storm Syndrome (CSs) is a potentially life threatening condition, characterized by robust elevated; of circulating pro- inflammatory cytokines; occurring after a hyperactive immune system. Is a well-known as a worldwide health problem, leading to multi-organ failure and death. Objectives: This study was carried out to investigate the protective role and probability of additive or synergistic anti-inflammatory activity; of ramelteon and in combination with dexamethasone on the lipopolysaccharide (LPS) induced “Cytokine Storm” on mice model and its potential regulatory mechanism(s). Methods: Sixty Swiss albino male mice of ;( 25 ± 5 grams; 8-12 weeks) had free access to food and water. After 2weeks of adaptation, mice; randomly separated in five groups (n =12): Group I, mice received (0.9% NS i.p.); Group II, mice received (5mgkg i.p.) LPS only .Group III, mice received (2.5mg/kg, i.p.) dexamethasone, Group IV, mice received (100mg/kg i.p.) ramelteon, Group V, mice received half dose of dexamethasone+ ramelteon combination (1.25 mgkg i.p +50mgkg i.p). For systematic inflammatory stimulation mimicking “cytokine storm” LPS; E. coli O55:B5 (5mgkg i.p.) was induced within one hr. After 48h the effects of interventional agents and vehicle or LPS challenge; on lung, heart, liver, kidney histopathological changes, and levels of inflammatory cytokines :( IL-6, IL8 IL-1β, and TNF-α) in the serum were detected. Results: IL-1β, IL-6, IL8 and TNF-α elevated serum levels significantly reduced (p<0.001) in all treatment group. Additionally, they ameliorated the histopathological changes induced by (LPS) and improving macroscopic scores (p<0.001). Conclusion: In conclusion, ramelteon treatment had a diverse protective effects against “Cytokine Storm” with a mechanism based on attenuation serum levels of inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α)and through reduction of histopathological damage during endotoxemia induced via LPS challenge on male mice model. RAM/DEX combination had superior advantage than an agent use alone probably via synergistic anti-inflammatory activity.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"46 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of depression Level among elderly residents in nursing home and community: A comparative study","authors":"Walaa Yehya abed zead, Ali Kareem khadir","doi":"10.22317/jcms.v9i5.1436","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1436","url":null,"abstract":"The percentage of the elderly is expected to nearly double, from 12% to 22%, between 2015 and 2050 due to the rapid aging of the global population. All told, this means that increase the elderly people over the age of 60 to 2 billion from 900 million. Therefore, it is anticipated that older individuals may experience particular physical and mental health issues this study was done to examine the impact of elderly people's levels of depression and to Compare the level of depression among elderly people living with their families and elderly resident in nursing homes.&#x0D; A comparative study non-probability sampling strategy was used choose a judgmental sample of 125 elderly who residents in nursing home and community by using of questionnaire composed of three part: part I demographic characteristic part II, UCLA loneliness scale part III geriatric depression scale, data is analyzed using descriptive statistical data analysis.&#x0D; The results of the study indicated that elderly in nursing home and community show moderate level of depression study reveals that elderly people at nursing home have higher level of depression than those in community as indicated by with a p-value of.001&#x0D; The study conculcated by Providing social and health programs to support the elderly, as well as conducting awareness sessions for caregivers and families on how to take care of the elderly residing in the nursing home or residing with their families","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136136164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Glycolipoprotein Biosurfactant from Enterococcus faecium on the viability of Breast cancer cell lines.","authors":"Dijlah A. Alimeer, Nibras N. Mahmood, Mohammad M. F. Al-Halbosiy","doi":"10.22317/jcms.v9i5.1432","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1432","url":null,"abstract":"Objective : This study , was research for cytotoxicity of bio-surfactant created by Enterococcus faecium isolated from feces of Iraqi healthy breast-fed infants with age < 6 months.&#x0D; Methods : Cold acetone precipitation was used to the extraction of extracellular Glycolipoprotein biosurfactant and partially purify it. Biosurfactant was then evaluated against two the cell lines, a Breast cancer MCF-7 cell line and a human normal fibroblast cell line NHF), specifically for cell survival and proliferation. &#x0D; Results : At all concentrations with varying percentage, The viability of the MCF-7 cancer cell line was shown to be reduced with the addition of biosurfactant.; maximum inhibition percentage was 74.2% at a 100 µg/ml concentration, which is lesser than 45.5% cytotoxicity Of NHF healthy fibroblasts cell line.&#x0D; Conclusions : The findings of this study are highly encouraging in terms of the potential of Glycolipoprotein biosurfactants to treat cancer and encourage additional research with different cell lines.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"73 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Pseudomonas aeruginosa isolates and their antibiotic susceptibility among patients and healthcare workers in three Hospitals of Duhok city/ Iraq","authors":"Haval Khalid, Siham Abdullah Mohammed Said, Wijdan Mohammed Salih Mero","doi":"10.22317/jcms.v9i5.1428","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1428","url":null,"abstract":"Objective Pseudomonas aeruginosa is opportunistic gram-negative bacillus and a major human pathogen belongs to family Pseudomonadaceae, it causes several nosocomial infections including pneumonia, urinary tract, surgical sites, otitis externa, and soft tissues.&#x0D; Methods: The study was conducted from April 2021 to January 2022 and involved the prevalence of Pseudomonas aeruginosa isolates and their susceptibility to different antimicrobial agents among patients and healthcare workers specimens in three hospitals of Duhok city. The collected specimens were examined and cultured on different media in the Advanced Microbiology Laboratory, Azadi teaching hospital. The isolated bacteria were identified according to their morphological and biochemical properties.&#x0D; Results: Out of 324 specimens, 29.32% (95/324) of the isolates were identified as Pseudomonas aeruginosa, isolated from 26.89% patients and 40% healthcare workers. Regarding isolate rates among specimens, the highest rate (48.78%) was from sputum, with a highly significant (P<0.001) difference from other sources. Females had a non-significantly higher isolate rate than males (28.19% vs 25.22%), ages, >50 years had the highest isolate rate (72.88%), while the lowest rate 6.25% was among ages >10-20 years, with highly significant (P< 0.001) differences among them. Specimens from Hevii hospital showed a non-significantly higher isolate rate (28.57%) than other hospitals. Isolates highest susceptibility was to Colistin (88.7%) followed by Imipenem (78.9%), while they were 98.6 % resistant to ampicillin and 100% resistant to Amoxicillin, Erythromycin and Trimethoprim/Sulfamethoxazole. A high rate of extensively drug-resistant (19.72%) Pseudomonas aeruginosa isolates was documented among patients who attended these hospitals with the highest (31.25%) from wounds.&#x0D; Conclusion these findings will be helpful to advise treatment with appropriate antibiotic strategy against multi- and extensively drug -resistant P. aeruginosa to cope with the chances of evolving resistant pathogens.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico study of new carbonic anhydrase inhibitor derivatives bearing 1, 3, 4-Oxadiazole moiety with promising anti-cancer activity.","authors":"Riyam Saad Aljubouri, Noor H. Naser","doi":"10.22317/jcms.v9i5.1434","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1434","url":null,"abstract":"Objectives: Molecular docking simulations were performed to assess the theoretical binding affinities of six (6) compounds created where they are derivatives having 1,3,4, oxadiazole moiety, and their target was cancer and Human carbonic anhydrase IX (PDB code: 6U4T). Using ChemDraw Ultra 12.0, the molecular structure was meticulously sketched. Molecular Operating environment software was used to verify the developed compounds by looking at their S. score and Rmsd values. Promising activity was seen with these proteins from the theoretically generated compounds, which exhibited strong binding contacts with the receptor active pocket.   Methods: Chemically by joining together several oxadiazole derivatives, sulfanilamide analogues (IVa-IVd) may be created in the lab. Molecular docking and ligand/receptor priming by MOE software. Results: Acetazolamide was selected because it had the same pharmacophore as the sulfanilamide group, and cisplatin was used in clinical trials for cancer therapy. IVc and IVa yielded max score and irrevocable relationship compared with acetazolamide and cisplatin. Conclusion: The MOE docking results validated the potent anticancer activity, the identified compounds showing good binding affinity with target proteins relative to the reference drugs (Acetazolamide and cisplatin). The most effective anticancer compounds were IVc and IVa, which yielded a maximum score with a Rmsd of less than 2, the MOE docking results were able prove this. Compounds IVc and IVa exhibited the greatest cytotoxic impact of the synthetic compounds against MCF7, and all four synthesized compounds showed a superior safety profile than the standards in MCF10a.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"314 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can latent toxoplasmosis lead to Alzheimer's disease?","authors":"Shameeran Salman Ismael, Shaimaa Hamid Hasan","doi":"10.22317/jcms.v9i5.1437","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1437","url":null,"abstract":"","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"106 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opuntia ficus-indica and its potential effects on cancer","authors":"Hanadi Talal Ahmedah","doi":"10.22317/jcms.v9i5.1430","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1430","url":null,"abstract":"Cancer is the second leading cause of death worldwide, with an estimated 19.3 million new cases and 10.0 million deaths in 2021. Genetic and environmental factors, including nutrition, play an important role in cancer development. At present, health professionals and the public have become highly interested in natural products and healthy food for preventing or treating cancer. Several natural products, such as fruits and vegetables, have demonstrated anticancer effects. Opuntia ficus-indica (OFI), commonly known as prickly pear or cactus pear, is a plant that has numerous beneficial properties. It serves as a source of dietary fibres, vitamins and various bioactive compounds with diverse health benefits. These compounds are associated with anti-inflammatory, antioxidant, antimicrobial, hypoglycaemic and neuroprotective properties. Different parts of the plant, including the fruit pulp and peel, cladodes (pads) and seeds, have been scientifically studied, and they have demonstrated therapeutic potential while being considered safe for human consumption. However, there is limited awareness and scientific information about OFI as a fruit. Reviewing existing knowledge and research on it is necessary to shed light on its potential anticancer properties. By consolidating the available information on OFI, we can gain a better understanding of this fruit and its potential role in cancer prevention and treatment.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Carbonic Anhydrase Enzyme with Synthesized Benzenesulfonamide Derivatives: Inhibiting Tumor Growth","authors":"Zainab Kifah Abbas, Noor H. Naser, Rana Neama Atiya","doi":"10.22317/jcms.v9i4.1404","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1404","url":null,"abstract":"Objectives: To assess the anticancer effects of recently developed compounds, Sa, Sb, Sc, and Sd. These compounds were designed to specifically target the carbonic anhydrase enzyme in solid tumors.  Methods: The chemical synthesis involved the use of sulfanilamide, chloroacetyl chloride, GABA, thionyl chloride, methanol, hydrazine hydrate, potassium hydroxide, carbon disulfide, and benzyl chloride derivatives. Docking studies were conducted using the MOE software program version 2015.10, and cytotoxic activity was predicted using the MTT assay. Results: The newly synthesized compounds exhibited notable antineoplastic activity in both in silico and cell line investigations. Although they showed a significant difference in potency compared to cisplatin against cancer cells, they also demonstrated significant differences in toxicity towards normal cells. When compared to acetazolamide, compounds Sb displayed an IC50 = 28.41 μM, which was significantly different, and compound Sd showed a non-significant difference with an IC50 = 61.20 μM against MCF7 cells. Additionally, Sb and Sd demonstrated significant difference in toxicity, with IC50 = 279.02 μM and 194.00 μM, respectively, against MCF10a cells. These findings indicate a significant difference compared to acetazolamide for the Sb compound and suggest that the synthesized compounds hold potential for further development as antineoplastic agents. Furthermore, the results from the cell line study align with the in silico study, where both compounds Sb and Sd exhibited higher S scores compared to acetazolamide, implying a stronger binding affinity with the receptor's catalytic site. The presence of a substituted 1,2,4-triazole ring in these compounds contributed to enhanced flexibility and improved interaction with the receptor. Conclusion: A new synthesized compounds exhibited cytotoxicity and demonstrated inhibitory potencies against carbonic anhydrase.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}