Journal of Contemporary Medical Sciences最新文献

{"title":"Impact of CYP2D6 polymorphisms on the efficacy of tamoxifen in Iraqi women with breast cancer","authors":"Sura Sagban, Ahmed S. Sahib, Ahmed S. Abdulamir, Haitham M. Kadhim","doi":"10.22317/jcms.v9i6.1396","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1396","url":null,"abstract":"Background: Tamoxifen remains the primary therapeutic option for breast cancer treatment and for the primary prevention of metastatic disease. Understanding the variability in tamoxifen response may provide clues to help personalize cancer treatment as well as maximize the therapeutic efficacy. One area of particular interest that merits attention in hormonal therapy is the impact of the CYP2D6 genetic polymorphisms on tamoxifen metabolism and consequently, on patient The aim of the present study was to investigate the impact of the CYP2D6 genetic polymorphism on clinical outcome in Iraqi breast cancer patients who were candidates for tamoxifen therapy. Methods: Comprehensive CYP2D6 genotyping was performed in 140 Iraqi women with breast cancer who were women on adjuvant treatment with tamoxifen. Breast cancer patients recruited into the study were divided into two groups: seventy breast cancer women who had no history of recurrence at the time of sampling and had a long time on tamoxifen without recurrence and seventy breast cancer women who had recurrence at the time of sampling after one year of treatment with tamoxifen therapy. Recurrence free survival (RFS) was determined in the recruited patients.  Results: Multiple genetic variants of the gene encoding the CYP2D6 enzyme were detected with significant differences in their frequencies and percentages in both recurrent and non-recurrent groups of breast cancer patients. The findings of this study suggest that interindividual variation in clinical outcome may be related to genetic variation in CYP2D6 enzyme, which is characterized by variable RFS periods. Conclusions: This study revealed that the CYP2D6 enzyme of breast cancer patients who participated in this study is highly polymorphic. The CYP2D6 gene of study participants exhibited different allelic combinations with variable frequencies. The multiple genetic variants (alleles) of the gene encoding the CYP2D6 enzyme exhibited significant differences in their frequencies and percentages in both recurrent and non-recurrent groups of breast cancer patients. .The study revealed variable Recurrence free survival (RFS) with highly polymorphic gene. Our study quotes the presence of increased CYP2D6 enzyme polymorphism is associated with variable clinical response.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"3 6","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of COVID-19 on the quality of life among University students with obsessive-compulsive disorder","authors":"Reem Almustafa, Abdulaziz Alkhoshi, Jumana Alshaikh, Reema Ayoub, Zainalabden Aljifri, Sulhi A. Alfakeh","doi":"10.22317/jcms.v9i6.1474","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1474","url":null,"abstract":"Background: The coronavirus disease 2019 (COVID-19) pandemic has necessitated precautionary measures to prevent the transmission of the virus, affecting individuals with obsessive-compulsive disorder (OCD). We investigated the impact of the COVID-19 pandemic on the quality of life of university students with OCD. Methods: Students with validated confirmed diagnosis of OCD at King Abdulaziz University, Jeddah, received two online surveys: the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) to approve the diagnosis and the 36-Item Short-Form Health Survey (SF-36) to assess symptom severity and overall quality of life during the pandemic. Students with psychotic disorders were excluded from this study. Results: The majority were females (62.5%), with an average age of 23.13 years. The participants had mild to moderate of OCD symptoms. The SF-36 role limitation due to emotional problems domain was significantly associated with the level of OCD symptoms (p=0.023), with higher scores reported for those with mild symptoms. Age was positively correlated with social functioning and pain domains but negatively correlated with Y-BOCS scores. The general health domain was significantly associated with current OCD symptoms and family history of OCD diagnosis. Conclusions: The self-reported decline in the severity of OCD symptoms in adult students indicates that the participants in our study with diagnosable OCD perceive an improvement in their symptoms from the previous year.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"13 22","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Talh Honey, Whey Protein, and Collagen Based Novel Formulation Against Wound-Associated Skin Microbiota","authors":"Hanaa Abbas Yamani, Muna Mordi Al-Zahrani","doi":"10.22317/jcms.v9i6.1454","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1454","url":null,"abstract":"Diabetes, immunosuppressive treatments, and obesity could severely impair the complicated wound-healing process. The skin serves as a dynamic and complex ecosystem for fungi, archaea, viruses, and bacteria, which collectively represent the skin microbiota. These microbes infect the underlying tissues through the injured skin. Delayed wound healing could make the injured site more prone to microbial infection. Several cultures have utilized honey as a traditional medicine for centuries. It was primarily used to treat wounds (infected and chronic) even before the discovery of bacteria. Honey is known for its antimicrobial properties. Whey protein is rich in growth factors, which promote cell proliferation and differentiation. They also facilitate tissue repair and can effectively stimulate the wound-healing process. Therefore, this study evaluates a novel wound-healing formulation consisting of honey, whey protein, and collagen against the skin microbiota associated with delayed wound healing. A rat excisional model was followed to test the formulation through pathogen contraction rate on different days after the onset of wounds. The tested formulation effectively promoted the wound-healing process in rats.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"15 11","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The DNA methylation of the interleukin6 as a biomarker for the early detection of colorectal cancer","authors":"Sakar Ahmed Abdullah, Dlnya Assad Mohamad","doi":"10.22317/jcms.v9i6.1440","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1440","url":null,"abstract":"Objectives: To identify the DNA methylation pattern of the interleukin6 promoter region in colorectal cancer patients and colorectal polys patients that could be a biomarker for early detection of colorectal cancer. Methods: For this purpose, we examined the DNA methylation pattern of the promoter region of the IL6 specifically 358 bp (-292 to +67) including 7 CpG sites (-228, -213, -163, -119, +10, +19, +25) in a total of ninety samples with thirty samples each for controls, cancer patients, and colorectal polyps using the bisulfite conversion sequencing method. Result: Our results indicate that CpG +25 and CpG -119 can serve as biomarkers for early detection of colon cancer, showing a significant difference in P-values of 0.001 at CpG +25 and 0.004 at CpG-119. The hypomethylation of CpG -119 in cancer groups facilitates the binding of the methyl-sensitive transcription factor Sp1. It enhances the overexpression of IL6 besides hypermethylation of CpG +25 that prevents binding of the methyl-sensitive insulator CTF, unbinding the insulator to the promoter region of the cancer samples makes the promoter region open access to the TFs that enhances overexpression. Furthermore, a remarkable non-recorded SNP at CpG -228 was observed in 98.6% of the enrolled groups. Conclusion: In the state of DNA methylation, IL 6 could contribute to the onset of colorectal polyps and colorectal polyps cancer due to a significant level of methylation in CpG +25 and CpG -119.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid cancer, risk factors, clinical features, prognosis, and its incidence preference in Saudi populations: review","authors":"A. Alhozali","doi":"10.22317/jcms.v9i6.1476","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1476","url":null,"abstract":"Within the diverse cancers reported, the epidemiology of thyroid cancer increased 3-fold in the latest years which may be due lifestyle changes, lack of cancer awareness, lack of screening, and early cancer investigations and detection programs in addition to genetics and deficiency of iodine and vitamin D.  The aim of this review was to discuss Thyroid cancer incidence, risk factors, and clinical features and prognosis. The cause of thyroid cancer is unknown, but because the thyroid gland is very sensitive to radiation, exposure to radiation can cause precancerous changes. For unclear reasons, thyroid cancer like almost all diseases of the thyroid, occurs about 3 times more often in women than in men at any age, but the risk peaks earlier for women at 40 to 50 years. Several inherited conditions have been linked to different types of thyroid cancer but some patients with thyroid cancer do not have inherited conditions or a family history of the disease. Four general types of thyroid cancer were explained, Papillary, Follicular, Medullary, and Anaplastic. Over the last decade, the incidence of Papillary and Follicular thyroid cancers increased at the same time.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"24 17","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apelin as a potential marker in Iraqi children with Type 1 Diabetes Mellitus","authors":"Noor Thair Tahir, Israa Qusay Falih, Mithal R. Alkubaisi, Abdilya Riyadh Alabdaly","doi":"10.22317/jcms.v9i6.1425","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1425","url":null,"abstract":"Apelin is a peptide has receptors in several locations, involved in regulating cardiac homeostasis, angiogenesis and metabolic regulation. It is also consider as adipokine secretion by adipocytes. This study aimed to evaluate apelin levels and other biochemical parameters in Iraqi pre-pubertal and pubertal T1DM. Ninety children participated in current study, divided into three groups: 30 pre-pubertal patients with type 1 diabetes, 30 at pubertal patients with type 1 diabetes, and 30 healthy subjects. Measurements of fasting blood glucose (FBS), random blood sugar (RBS), glycosylated hemoglobin (HbA1c), apelin, lipid profile, thyroid hormones, Blood urea, and serum creatinine were perform for the comparison groups.Apelin has a positive correlation coefficient (P< 0.01) with FSB, TG and (P <0.05) with BMI, HbA1c, TC, TSH also has a negative correlation coefficient with HDL-C, in pubertal and pre-pubertal respectively.  The relationship among levels of apelin, glucose, and insulin sensitivity shows the participation of apelin in the pathogenesis of diabetes and its rise in adulthood is an indicator to beginning diabetes complications, Aside from the potential use of apelin as a diagnostic marker in early discrimination of cardiovascular disease.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"17 4","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139155420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Nurse’s job Satisfaction upon Quality of Nursing Care for Patients Undergoing Hemodialysis","authors":"Luay A. Mansoor, Tahseen Rajab Muhammad","doi":"10.22317/jcms.v9i6.1458","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1458","url":null,"abstract":"Introduction: Job satisfaction among nurses is a global concern for its crucial impact on nursing shortage and quality of care Objectives: This study aimed to asses’ nurses' job satisfaction levels at hemodialysis units and to find out the relationship between nurses' job satisfaction and quality of nursing care. Methods: A descriptive cross-sectional design study was carried out among nursing working in hemodialysis units at Baquba Teaching Hospital and Baladrooz general Hospital, study starting from 14th December 2022 to 10th March 2023.A non-probability (purposive) sample of (80) nurses working in hemodialysis units in Baquba and Baladrooz Hospital . The study instruments consist of three parts; Part one is involved the demographic information of nurses (8) items; the second part is involved Job Satisfaction Scale for Clinical Nurses (JSS-CN), it is comprised of (38) items and observational checklist for nurses practices of hemodialysis procedures consist from (29) items  .Content validity of the questionnaire was determine through a panel of (12) experts .Reliability of the instrument scales is determined by using Pearson Correlations )0.87,084) for of job satisfaction scale and observational checklist for nurses practices respectively . The collected data will be categorized, scored, tabulated, and analyzed by computer using statistical package for social science (SPSS) version 25. Descriptive statistics will be used in the form of frequency distribution and percentages. Pearson correlation coefficient statistical tests were applied for data analysis. Results: Findings of the current study showed that (75%,65%), of the studied nurses offered moderate job satisfaction level and good quality of nursing care respectively. There was highly statistically significant relation between job satisfaction and quality of nursing care offered to patient undergoing haemodialysis. Conclusion: This study concluded that, nearly three quarter of the nurses were coping with their jobs and they are satisfied to certain extent. However, nearly two third of them offered good quality of nursing care to patient undergoing hemodialysis","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"14 15","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the FAST HUG implementation effect on the mortality and length of stay in admitted patient in Intensive Care Unit (ICU) of a hospital","authors":"Mehran Kouchek, Behnam Arabzadeh, Navid Nooraei, Mansour Fathi, Mirmohamad Miri","doi":"10.22317/jcms.v9i6.1341","DOIUrl":"https://doi.org/10.22317/jcms.v9i6.1341","url":null,"abstract":"Objective: We aimed to determine new version of  the FAST HUG implementation effect on the mortality and length of stay in admitted patient in Intensive Care Unit (ICU) of a hospital. Methods: we conducted a prospective cohort study on 406 patients who admitted in medical and surgical ICU of Imam Hossein Hospital of Tehran province in Iran from July 1, 2022, to September 30, 2022. We identified predictors of ICU mortality by logistic regression model, predictors of 28-day mortality/re-hospitalization/recovery by generalized ordered logit model, predictors of length of stay (LOS) by linear regression, predictors of mechanical ventilation by generalized ordered logit and predictors of SOFA score by hurdle model. Result :This mnemonic had protective impact (OR=0.56-p-value=0.01) on the 28-day mortality. One unit increase in mean of FAST HUG score had a preventive effect on the outcome of death (OR=0.21). Surgical admission type (Coefficient =-3.24, p-value= 0.00) and FAST HUG implementation (Coefficient =1.58, p-value= 0.0) were strongest factors on the LOS. Conclusion: Our study results approved the importance of the FAST HUG implementation on the decrease of patient mortality in ICU and 28 days after discharge. Additionally, this checklist had a statistically significant role in declining SOFA scores in ICU patients.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"9 23","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139156367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the Transtheoretical Model of Change to Enhance High School Female Students’ Self-Efficacy of Refraining from Carbonated Drinks Consumption","authors":"Hawraa Kareem Abed Ali, Wissam Jabbar Qasim","doi":"10.22317/jcms.v9i5.1431","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1431","url":null,"abstract":"Objectives: To examine the efficacy of the Transtheoretical Model of Change-based intervention in enhancing students’ Self-Efficacy by refraining from carbonated drinks.&#x0D; Methods: We conducted a randomized controlled trial at Al-Russafa High School for girls in Baghdad City. The study involved a random sample of 144 female high school students, with 72 students in the intervention group and 72 in the control group. The research instrument collected data on participants' sociodemographic characteristics, including age, living arrangements, and family socioeconomic status. Additionally, we used the Stages of Change for Carbonated Drinks Consumption Behaviour Scale (Short Form) and the Stages of Change for Carbonated Drinks Consumption Behaviour Scale (Continuous Measure).&#x0D; Data analysis was performed using the Statistical Package for Social Science (SPSS) for Windows, version 27.&#x0D; Results: The study results exhibit that more than half of participants in the study group are in the Precontemplation Stage of Change in the pretest time (n = 42; 58.3%), followed by those who are in the Preparation Stage of Change (n = 15; 20.8%), those who are in the Contemplation Stage of Change (n = 14; 19.4%), and one who is in the Maintenance Stage of Change (n = 1; 1.4%).&#x0D; In posttest 2, less than two-fifths became in the Action Stage of Change (n = 28; 38.9%), followed by those who became in the Preparation Stage of Change (n = 19; 26.4%), those who became in the Maintenance Stage of Change (n = 18; 25.0%), those who became in the Contemplation Stage of Change (n = 6; 8.3%), and one who stayed in the Precontemplation of Change (n = 1; 1.4%).&#x0D; The researchers concluded that the administered intervention based on the TTM efficaciously enhanced students’ readiness to refrain from carbonated drinks consumption.&#x0D; Conclusion: The administered Stage-matched intervention based on the TTM efficaciously enhanced students’ Self-Efficacy in refraining from carbonated drinks consumption.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"2 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"G6PD Deficiency: Exploring the Relationship with Different Medical Disorders","authors":"Maysaa Alakbaree, Ali Abdulqader, Abbas Hashim Abdulsalam, Muaawia Ahmed Hamza, Syazwani Itri Amran, Mohd Shahir Shamsir, Nurriza AB LATIF","doi":"10.22317/jcms.v9i5.1433","DOIUrl":"https://doi.org/10.22317/jcms.v9i5.1433","url":null,"abstract":"G6PD deficiency (G6PDD) is associated with oxidative stress resulting from an imbalance between reactive oxygen species (ROS) production and the body's ability to counteract. In this review, we explore the adverse effects of G6PDD on diverse physiological processes and disease outcomes. Past studies have demonstrated the association between G6PDD and various other diseases, indicating a link between G6PDD to heightened oxidative stress by accelerating virus replication, worsening infection severity, and weakening the body's defense mechanisms. Such stress is critical in the destruction of red blood cells (RBCs) during infections and has a detrimental impact on redox signaling, ultimately impacting cell health and promoting cancer development. Furthermore, it impairs endothelial function by lowering the nitric oxide (NO) level and increasing stress, resulting in detrimental cardiac consequences and reduced myocardial antioxidant capacity. Because ROS contributes to inflammation, this imbalance causes conditions such as early atherosclerosis. It also compromises the functionality of NO-regulated bronchodilators and conditions such as G6PDD exacerbate the risks of kidney damage. Elevated ROS levels can also induce harm in retinal tissues, blood vessels, brain cells, and Beta-cells, hence quickening the progression of diseases like Diabetic Retinopathy. Furthermore, oxidative stress plays a significant role in cerebral ischemic pathogenesis, contributing to neurodegenerative disorders. Additionally, decreased NADPH level is vital for NO synthesis as it can impact blood vessel relaxation and can potentially lead to ischaemic priapism. Investigating the association between G6PDD and other medical conditions is crucial as it helps to identify possible approaches to mitigate oxidative stress, thereby preventing associated complications and diseases, particularly in situations where current treatment options are insufficient.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136135299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}