Journal of Contemporary Medical Sciences最新文献

{"title":"Impact of Covid-19 Pandemic upon Iraqi women’s Sexual and Reproductive Health at Primary Health Care Centers","authors":"Hawraa Hussein Ghafel","doi":"10.22317/jcms.v9i4.1395","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1395","url":null,"abstract":"
 
 
 Objectives: The aim of this study was to assess the repercussions of the COVID-19 pandemic on the sexual and reproductive well-being of women.
 Methods: Employing a descriptive design with a correlational approach, the study was conducted between November 2021 and July 2022. The sample consisted of (180) women within the reproductive age range of 17 to 49 years. This non-probability 'purposive sample' was chosen deliberately. Data analysis was conducted using descriptive and correlational statistics.
 Results: The investigation divulged significant findings. A considerable proportion of women (55.6%) reported being unable to access contraception during the pandemic. Moreover, (45%) experienced unintended pregnancies amid the pandemic. Additionally, concerns linked to the pandemic led to a lack of follow-up visits for (73.3%) of participants. The study also highlighted the distressing issue of domestic violence during COVID-19: Over half of the women (51.1%) reported exposure to domestic violence, attributing it to prolonged periods of their husbands staying at home. Furthermore, (51.7%) noted an escalation in domestic violence, and (38.3%) revealed that their husbands showed inadequate concern for their sexual well-being.
 Conclusion: The COVID-19 pandemic detrimentally affected the sexual and reproductive health of women, manifested through challenges encountered during pregnancy, childbirth, postpartum phases, and family planning. Furthermore, a significant proportion of women faced an increased risk of domestic violence due to the pandemic and the extended presence of their husbands at home.
 
 
","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moxifloxacin's Therapeutic Effects in AA-Induced Colitis: Anti-Inflammatory Action through NF-κB Pathway Inhibition, Including TNF-α Pathway and Downstream Inflammatory Processes","authors":"Jaffar O. Dawood, Ahmed Abu-Raghif","doi":"10.22317/jcms.v9i4.1407","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1407","url":null,"abstract":"Objectives: The aim of the present study was to evaluate possible therapeutic effects of moxifloxacin against acetic acid-induced colitis in a rat model.
 Methods: Forty adult Wistar rats were separated into 4 groups, including the negative control group, acetic acid (AA) group, AA + sulfasalazine (100 mg/kg/day) group, and AA+ moxifloxacin (MFX) (8 mg/kg/day) group. Experimental colitis was induced in rats by rectal administration of (4%v/v) acetic acid. Rats with colitis were received either MFX 8mg/kg/day or sulfasalazine 100mg/kg orally for 7days.The parameters measured are macroscopical assessment, colon weight (indicator of edema) and the measurement of concentrations of the proinflammatory cytokine TNF-α, oxidative stress marker malondialdehyde (MDA), adhesion molecule selectin and the inflammatory mediator NF-κB in colonic tissue homogenate.
 Results: This study had shown that AA elevate macroscopical scores, colon weight and biochemical homogenate parameters and all measured parameters were significantly reduced by both moxifloxacin and sulfasalazine with nonsignificant difference between them.
 Conclusions: The study explain that moxifloxacin possesses therapeutic potential in in AA induced colitis and its anti-inflammatory actions may involve inhibition of NF-κB inflammatory pathways including TNF-α pathway with its downstream inflammatory process such as elevation of adhesion molecule synthesis and oxidative species overproduction in the colonic tissues.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythropoietin protects against renal ischemia/reperfusion injury in rats via inhibition of oxidative stress, inflammation and apoptosis","authors":"Elaf R. Alaasam, Ali M. Janabi","doi":"10.22317/jcms.v9i4.1405","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1405","url":null,"abstract":"Objective: Study investigates erythropoietin's nephroprotective effect in adult male rats with renal ischemia and reperfusion injury, examining biochemical parameters and renal tissue alterations.
 Methods: twenty-eight male rats of Sprague Dawley randomized into four groups: Sham, Iscemia/Reperfusion, NS, and Erythropoietin. Sham group treated kidneys identically without clamping pedicles. Ischemia/Reperfusion group underwent midline laparotomy, 30 minutes ischemia, 2 hours reperfusion, Rats received NS vehicle for Erythropoietin 30 minutes before ischemia, Erythropoietin dose administered 30 minutes before ischemia/reperfusion. Operation performed under maintained anesthesia using ketamine and xylazine injections.
 Results: Renal ischemia /reperfusion increased serum Cr, BUN, IL-1β, NF-kB, Caspase-3, while SOD, GSH, Bcl-2 decreased in induced rats. Erythropoietin treatment reduced Cr and BUN levels, Reduced inflammation, and inflammatory markers. Renal tissue antioxidant markers increased; apoptotic markers decreased. Significant increase in Bcl-2 antiapoptotic marker. Erythropoietin-treated group had significantly better renal histological score compared to induced group.
 Conclusion: Erythropoietin protects against Ischemia/Reperfusion-mediated renal injury, possessing antioxidant, anti-inflammatory, and anti-apoptotic properties.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Utility of Aldosterone/Direct Renin Concentration Ratio in Iraqi Patients with High Arterial Blood Pressure: A Pilot Study","authors":"Zaid Q. Abd Al-Razaq, Mahmood Shakir Khudhair, Khalid Abdulhussein Sabry","doi":"10.22317/jcms.v9i4.1398","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1398","url":null,"abstract":"
 
 
 Objectives: Primary aldosteronism is a prevalent contributor to secondary hypertension, posing an elevated risk of morbidity and mortality. The initial step in diagnosing this condition involves screening individuals suspected of having it.
 Methods: In our study, we enrolled 50 patients who were suspected of having hyperaldosteronism. We provided specific recommendations and instructions to these patients concerning drug therapy and implemented measures to enhance testing accuracy. The tests were conducted using the Chemiluminescence Immunoassay (CLIA) system procedure, relying on plasma direct renin concentration rather than activity. Our findings were meticulously validated, compared, and aligned with the references from ARUP laboratories.
 Results: Among our participants, 4 patients (8%) were unequivocally diagnosed with primary aldosteronism based on the Aldosterone Direct Renin Concentration (ADRR) criteria. These patients exhibited the trifecta of hypokalemia, elevated aldosterone levels, and diminished renin levels, obviating the need for further confirmatory testing. Furthermore, 13 patients (26%) were deemed likely candidates for primary aldosteronism, given their plasma aldosterone levels exceeding 15 ng/dl and renin levels below 2.5 pg/ml. Additionally, 7 patients (14%) displayed strong indications of primary aldosteronism, characterized by plasma aldosterone levels surpassing 21 ng/dl and plasma renin concentrations below 2.5 pg/ml, accompanied by high ADRR values. However, both the \"likely\" and \"strong indication\" groups necessitated confirmatory testing. Notably, our results revealed no significant disparities in age, gender, personal or family history of atherosclerotic cardiovascular disease (ASCVD), or the presence of adrenal adenomas between patients diagnosed with primary aldosteronism and those in the non-aldosteronism group within the study.
 Conclusion: Primary aldosteronism is a prevalent health concern, warranting the screening of highly suspicious patients. Utilizing direct renin concentration, instead of renin activity, offers a straightforward, cost-effective, rapid, and reproducible method for diagnosis.
 
 
","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of TLR7 and MyD88 Gene Polymorphism with Trichomoniasis vaginalis Infection","authors":"Zainab Waddah Kermasha, Hayam Khalis Al-Masoudi, Suhaila Fadhil Al-Shaikh","doi":"10.22317/jcms.v9i4.1390","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1390","url":null,"abstract":"Objective: Toll-like receptor 7 (TLR7) and MyD88 represent important components of the innate immune response which play a crucial role in recognition of T. vaginalis. Single nucleotide polymorphisms (SNPs) in TLRs and MyD88 were manifested as key determinant affecting the susceptibility to trichomoniasis. This study aims to examine the impact of two SNPs, designated rs179008 and rs4988453 in TLR7 and MyD88, respectively, on Iraqi women infected with T. vaginalis.&#x0D; Methods: Women vaginal swabs as well as blood samples were collected from 186 female patients diagnosed clinically by gynecologists. These pateints were admitting the gynecology clinics in three public hospitals in Babel governorate in Iraq. Clinical samples were obtained for molecular identification of the parasite, sequencing of the TLR7 and MyD88 genes as well as performing the corresponding immunological studies.&#x0D; Results: The PCR assays showed 40 positive women (95% CI, 15.85 to 28.11) of T. vaginalis β-tubulin gene. Genetic studies of rs179008 SNP in TLR7 showed that the mutant T allele revealed significantly more prevalence in women infected with T. vaginalis in comparison with controls (p<0.001), furthermore, AT and TT genotypes distribution were significantly greater in patients than that in controls (p<0.01). Moreover, genetic analysis of rs4988453 SNP in MyD88 demonstrated that the mutant A allele almost has close frequency between patients and controls, and the heterozygous CA and homozygous AA genotypes were almost normally distributed between controls and patients. Finally, the concentrations of TLR7 and MyD88 were significantly elevated in the majority of women patients aged between 16-40 years.&#x0D; Conclusion: The mutant allele A of rs4988453 SNP in MyD88 did not show an association with increased risk of trichomonas infection, however, the mutant allele T of rs179008 SNP in TLR7 might make women more sensitive for infection with T. vaginalis. However, more studies are needed to confirm these findings and to understand the underlying involved mechanisms.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Sleeve Gastrectomy on Thyrotropin Hormone (TSH) and Vitamin D Levels among Obese Patients in Nineveh Governorate","authors":"Samar Jassim Ibrahim, Lelas Farhan Bdaiwi, Muthanna Asaad Al Sherbit, Yasser Fawzi Zidan","doi":"10.22317/jcms.v9i4.1408","DOIUrl":"https://doi.org/10.22317/jcms.v9i4.1408","url":null,"abstract":"Objectives: This study aimed to assess the impact of bariatric surgery on thyrotropin (TSH), calcium, vitamin D, and lipid profile levels three months post-surgery among patients who underwent the procedure. We also investigated the prevalence of micronutrient deficiencies during the initial three months before and after surgery, along with monitoring the effects of gastric sleeve surgery on body mass index (BMI) reduction.&#x0D; Methods: The study involved the analysis of data from a cohort comprising 30 patients of both genders who had undergone sleeve gastrectomy due to obesity, with a preoperative BMI of 40 kg/m² or higher. The research spanned from July 2022 to January 2023, with patients undergoing gastric sleeve surgery at Al-Zahrawi Hospital in Nineveh. These patients were subsequently followed up for a period of three months post-surgery.&#x0D; Results: The study findings demonstrated a significant reduction in TSH, vitamin D, calcium, total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDLc), very low-density lipoproteins (VLDLc) cholesterol, and BMI in patients who underwent gastric sleeve surgery within the three-month follow-up period, in comparison to their pre-surgery levels. Additionally, there was a noteworthy increase in high-density lipoproteins of cholesterol (HDLc) in the serum of these patients post-operation. The results further indicated positive correlations between TSH, vitamin D, cholesterol, LDLc, and the Atherogenic Index. Likewise, positive correlations were observed between vitamin D, TSH, total cholesterol, triglycerides (TG), and LDLc.&#x0D; Conclusion: Post-surgery deficiencies in vitamin D, calcium, and TSH levels are attributed to inadequate intake and absorption of micronutrients, highlighting the importance of nutritional supplementation. Sleeve gastrectomy offers a promising avenue for sustained BMI reduction in the long term.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135236375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Adding Pertuzumab to Adjuvant Trastuzumab in Early HER2-Positive Breast Cancer","authors":"Ahmed H. Al-Azawi, Riyadh Abd-Alrasool Hneua, R. Hameed, D. Hassan","doi":"10.22317/jcms.v9i3.1351","DOIUrl":"https://doi.org/10.22317/jcms.v9i3.1351","url":null,"abstract":"Objectives: In this trial, It has been investigated whether pertuzumab, when added to adjuvant trastuzumab and chemotherapy, improves outcomes among patients with HER2-positive early breast cancer in compares to patients who received only Herceptin \u0000Methods: After surgery and central HER2-positive confirmation, about randomly 220 patients assigned with high-risk HER2-positive, operable breast cancer to received Anthracycline based chemotherapy 3 cycles fallowed by Taxotere 3 + either pertuzumab + hercetin 3 or standard adjuvant Herceptin alone, 17 cycles in 1 year. The patients were followed up for 3 years. \u0000Results: Results were indicated that about 50% of the patients who were randomly assigned to arm A received pertuzumab+Herceptin 3 cycles every 3 weeks (110 patients) and arm B 50% (110 patients) received Herceptin alone 17 cycles every 3 weeks. Disease recurrence occurred in 12 patients (10.9 %) in the pertuzumab group and 8 patients (7.2%) in the arm B group (hazard ratio, 0.81; 95% confidence interval [CI], 0.66 to 1.00; P=0.045). The estimates of the 3-year rates of invasive-disease-free survival were 89% in the pertuzumab+ herceptin group and 93% in the herceptin group. Heart failure, cardiac death, and cardiac dysfunction were infrequent in both treatment groups. Diarrhea of grade 3 or higher occurred almost exclusively during chemotherapy and it was more frequent with pertuzumab than with group B (7.9% vs. 2.8%). \u0000Conclusions: The study showed that pertuzumab + Trastuzumab adjuvant in 3 cycles worse rates of invasive-disease-free survival among patients with HER2-positive, operable breast cancer in compares with classical trastuzumab alone in 17 cycles. Diarrhea was more common with pertuzumab than with classical Trastuzumab therapy. ","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48602104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glyceryl Trinitrate, a Vasodilating Drug Acts as an Antibiofilm Agent in Serratia marcescens","authors":"Z. Al-Fayyadh, A. Turki, H. Al-Mathkhury","doi":"10.22317/jcms.v9i3.1329","DOIUrl":"https://doi.org/10.22317/jcms.v9i3.1329","url":null,"abstract":"Objectives: Serratia marcescens is a gram-negative pathogen of many species. The ability of S. marcescens to form biofilms and its potent innate resistance to antimicrobials and cleaning solutions are both essential for its pathogenicity and survival. The present study was conducted to investigate the effect of glyceryl trinitrate (GTN) on the biofilm of S. marcescens, as an alternative for antibiotic therapy. \u0000Methods: Different specimens, including ear swabs, burns, mid-stream urine, wound swabs, and sputum, were collected from patients who were brought to Al-Ramadi Hospital, Iraq. All samples were cultured, and the colonies that were obtained were detected using the VITEK® 2 compact. The ability of biofilms to develop was examined using the microtiter plate technique. The bactericidal effectiveness of GTN was estimated by the broth microdilution technique. The presence of fimA and fimC in S. marcescens isolates was detected using the polymerase chain reaction (PCR) method. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess the effect of GTN on fimA and fimC gene expression. \u0000Results: The results demonstrated that GTN has no effect on S. marcescens growth; while its biofilm was significantly (p<0.05) influenced. Moreover, all S. marcescens isolates had fimA and fimC, and the presence of GTN reduced the expression of these genes. \u0000Conclusion: The findings of this study reveal that GTN can act as a promising antibiofilm agent in reference to S. marcescens.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41613906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins in combination with Ibrutinib bypasses resistance to Ibrutinib in mantle cell lymphoma","authors":"A. Al-Zebeeby, A. Abbas","doi":"10.22317/jcms.v9i3.1330","DOIUrl":"https://doi.org/10.22317/jcms.v9i3.1330","url":null,"abstract":"Objective: In this study, we report that a novel combination therapy of different statins with Ibrutinib can overcome such resistance.\u0000Methods: For this, we generated a cell line model, exhibiting resistance to Ibrutinib, by repeated exposure of mantle cell lymphoma cell line to Ibrutinib. Apoptosis was assessed by the extent of phosphatidylserine externalisation.\u0000Results: Our results indicated that resistance to Ibrutinib could be overcome by targeting a key enzyme, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in the cholesterogenesis pathway.\u0000Conclusion: Reusing different statins in combination with Ibrutinib could improve therapy and enhance sensitivity to Ibrutinib mediated apoptosis.","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46232597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Vitamin D3 Receptor Genotypes in T2DM of Iraqi Obese Women","authors":"Baraa Abdul-Kareem Mutar, T. A. Allwsh, Ammar Yassin, F. J. Al-Tu’ma, H. S. Taghi","doi":"10.22317/jcms.v9i3.1352","DOIUrl":"https://doi.org/10.22317/jcms.v9i3.1352","url":null,"abstract":"Objective: This study aims to examine the association between the (rs1544410) polymorphism of the VDR gene with the pathogenesis of T2DM in Iraqi obese women. \u0000Methods: A case-control study was performed on 50 patients with T2DM and 50 apparently healthy subjects who were admitted to Al-Hussein Teaching Hospital and Al-Hassan Center of Diabetes and Endocrinology unit / Kerbala health directorate – Iraq during (April 2022 – March 2023). The T2DM groups were divided into two groups, 25 obese and 25 non-obese; the control group was divided into 25 obese and 25 non-obese as apparently healthy groups. The ELISA Kit was used to measure serum 25(OH)D3, heat shock protein-70, VDBP, insulin and C-peptide. Also HbA1c% and insulin resistance (HOMA-IR) were evaluated. The vitamin D3 receptor gene (VDR) variant and the SNP (rs1544410) polymorphism was determined using allele specific polymerase chain reaction, 1.5% agarose gel electrophoresis and then visualized by gel photo-documentation system. \u0000Results: The result of vitamin D3 variants genotype (rs 1544410) was a clear band with a molecular size of 200 bps. The size of the amplicon was determined by compare with DNA ladder 100 - 1500 bp. The result of the comparison between observed and anticipated values for SNIP with (rs 1544410) in the tested population was statistically significant, P= < 0.001 and the difference between demographic characteristics and (rs 1544410) SNP, age and BMI shows non-significant difference among all groups. The difference between biomarkers and (rs1544410) SNP was performed using one-way ANOVA test to compare the mean levels of HSP-70, VDBP, C-peptide,  RBC and HbA1c% which shown a non-significant difference among the variants of VDBP Genotype (rs1544410) in  obese women (patients and control) studied groups, p value > 0.05.   \u0000Conclusion: The logistic analysis of the (rs1544410) SNP of the patients concluded that HSP-70, VDBP, and C-peptide  level was no significantly related to the also C-peptide, was shown to be a related risk factor to both CT and CT alleles (1.003, p > 0.05) in comparison with CC alleles. Furthermore, HbA1c% level was demonstrated to be related as a risk factor for the CG allele in comparison with CC and GG alleles (1.009, p < 0.05).","PeriodicalId":42860,"journal":{"name":"Journal of Contemporary Medical Sciences","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46541360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}