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Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos最新文献

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Development of Surface Plasmonic Biosensor for Rapid and Large-scale Diagnosis of Hepatitis A 快速大规模诊断甲型肝炎的表面等离子体生物传感器的研制
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32812
G. O. Santos, F. S. Silva, M. A. Pinto, C. R. Alves, L. Leon
{"title":"Development of Surface Plasmonic Biosensor for Rapid and Large-scale Diagnosis of Hepatitis A","authors":"G. O. Santos, F. S. Silva, M. A. Pinto, C. R. Alves, L. Leon","doi":"10.35259/ISI.SACT.2019_32812","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32812","url":null,"abstract":"Introduction: In Brazil, the improvements in sanitary conditions and the recent inclusion of hepatitis A vaccine resulted in an increase in the number of individuals susceptible to the disease. These facts together with the circulation of the virus in the environment, increases the occurrence of epidemic outbreaks. Therefore, a test that enables a rapid and large-scale diagnosis of acute cases may be a promising alternative to the currently available immunoenzymatic assays. In this way, Biosensor assay may help in the adoption of appropriate measures to contain hepatitis A outbreaks, as well as, in the detection of susceptible individuals involved in the outbreak that may be candidates for vaccination, avoiding the spread of the infection","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"10 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113970610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Agile Method of Qualification for Equipment at Pharmaceutical Industry of Biotechnology: A Case Study at Bio-Manguinhos ‘s Henrique Penna Center 生物技术制药行业设备鉴定的敏捷方法:以Bio-Manguinhos的Henrique Penna中心为例
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32771
T. Menezes, C. Gomes, Walter Santos Borges Júnior, J. Magalhães, G. Ferreira
{"title":"Agile Method of Qualification for Equipment at Pharmaceutical Industry of Biotechnology: A Case Study at Bio-Manguinhos ‘s Henrique Penna Center","authors":"T. Menezes, C. Gomes, Walter Santos Borges Júnior, J. Magalhães, G. Ferreira","doi":"10.35259/ISI.SACT.2019_32771","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32771","url":null,"abstract":"","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125170049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogenicity of an inactivated Yellow Fever vaccine in golden-headed lion tamarin (Leontopithecus chrysomelas) 黄热病灭活疫苗对金头狮毛猴的免疫原性研究
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/isi.sact.2019_32589
A. Fernandes, L. Gaspar, Mariana Gomes, J. Linhares, S. B. Moreira, A. Pissinatti, E. Caride, M. Freire, M. Simões, R. Marchevsky
{"title":"Immunogenicity of an inactivated Yellow Fever vaccine in golden-headed lion tamarin (Leontopithecus chrysomelas)","authors":"A. Fernandes, L. Gaspar, Mariana Gomes, J. Linhares, S. B. Moreira, A. Pissinatti, E. Caride, M. Freire, M. Simões, R. Marchevsky","doi":"10.35259/isi.sact.2019_32589","DOIUrl":"https://doi.org/10.35259/isi.sact.2019_32589","url":null,"abstract":"","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125411743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombinant ZIKV envelope proteins for the arbovirosis differential diagnosis by ELISA 重组ZIKV包膜蛋白用于虫媒病毒病的ELISA鉴别诊断
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/isi.sact.2019_32801
Juliana Freitas, P. Terra, J. Gonçalves, M. G. Cavalcanti, M. Castro, R. H. Peralta, J. M. Peralta
{"title":"Recombinant ZIKV envelope proteins for the arbovirosis differential diagnosis by ELISA","authors":"Juliana Freitas, P. Terra, J. Gonçalves, M. G. Cavalcanti, M. Castro, R. H. Peralta, J. M. Peralta","doi":"10.35259/isi.sact.2019_32801","DOIUrl":"https://doi.org/10.35259/isi.sact.2019_32801","url":null,"abstract":"Introduction: The Zika virus is an arbovirus of the Flaviviridae family that causes asymptomatic and symptomatic infections. The clinical diagnosis of arboviroses is difficult in areas with cocirculation of these viruses and, therefore, laboratory confirmation based on host immune response is important, especially for pregnant women. The use of recombinant proteins as antigens aims to improve the sensitivity and specificity of the immunological test.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"321 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120978235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals 抗体工程中的硅定向进化:一种改善抗肿瘤生物制药的有前途的方法
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32699
Thiago Santos Chaves, B. Chaves, F. Conte, Rodrigo Silva, P. C. Neves
{"title":"In silico directed evolution in antibody engineering: a promising approach to improvement antitumor biopharmaceuticals","authors":"Thiago Santos Chaves, B. Chaves, F. Conte, Rodrigo Silva, P. C. Neves","doi":"10.35259/ISI.SACT.2019_32699","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32699","url":null,"abstract":"Introduction: The successful introduction of antibody-based immunotherapies into the arsenal of treatments for cancer patients has been reinvigorated by antibody engineering technology. New antitumor strategies include enhancement of T-cell responses provided by monoclonal antibody activation of costimulatory molecules present on T-cell surface. OX40, a member of the TNF receptor superfamily (TNRFS4), is a key T-cell costimulator and a promising cancer immunotherapy target. Currently, several pharmaceutical companies have invested in clinical studies using mAb anti-OX40 for cancer and/or autoimmune treatment. In this context, in silico antibodies engineering emerges as a promising approach to develop novel biopharmaceuticals with improved specificity and affinity.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126920299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAR-T cells generated using Sleeping Beauty vectors and expanded with a lymphoblastoid cell line (LCL) display in vivo antitumor activity 使用睡美人载体和淋巴母细胞样细胞系(LCL)扩增生成的CAR-T细胞显示出体内抗肿瘤活性
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/isi.sact.2019_32823
L. Chicaybam, M. Carneiro, L. Abdo, Barbara C. Peixoto, M. Viegas, P. D. Sousa, L. Carvalho, M. Bonamino
{"title":"CAR-T cells generated using Sleeping Beauty vectors and expanded with a lymphoblastoid cell line (LCL) display in vivo antitumor activity","authors":"L. Chicaybam, M. Carneiro, L. Abdo, Barbara C. Peixoto, M. Viegas, P. D. Sousa, L. Carvalho, M. Bonamino","doi":"10.35259/isi.sact.2019_32823","DOIUrl":"https://doi.org/10.35259/isi.sact.2019_32823","url":null,"abstract":"","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132622090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison between different automated methodologies for the identification of gram-positive rods isolated from clean rooms 洁净室分离革兰氏阳性棒的不同自动鉴定方法的比较
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32743
L. Costa, E. Fonseca, Natália Gonçalves, Cristhiane Falavina, Adriana Marques Frazão, Joyce Modesto de Andrade, V. V. Vieira
{"title":"Comparison between different automated methodologies for the identification of gram-positive rods isolated from clean rooms","authors":"L. Costa, E. Fonseca, Natália Gonçalves, Cristhiane Falavina, Adriana Marques Frazão, Joyce Modesto de Andrade, V. V. Vieira","doi":"10.35259/ISI.SACT.2019_32743","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32743","url":null,"abstract":"Introduction: One of the major risks associated with drugs and immunobiologicals production is microbial contamination. Therefore, an environmental monitoring program is essential to ensure that aseptic production areas are maintained under appropriate control levels. To be efficient, it must contain an adequate identification level of isolated microorganisms, because the information provided may be extremely relevant in investigating sources of contamination of products or processes. Sporulated Gram-positive rods (SGPR) are among the main contaminant groups of productive clean areas from Bio-Manguinhos in 2016 and 2017. Due to spore resistance, SGPR’s are not easily eliminated. SGPR identification by classical methods is particularly difficult because of similarities between closely related species that share the same morphological and biochemical patterns. The pharmaceutical industry has adopted automated identification systems, due to greater rigidity in regulatory requirements, regarding microbial identification. However, many identification systems have databases directed to medical microorganisms, being more limited considering pharmaceutical and industrial environmental microorganisms, which makes it difficult to obtain results at species level.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130449438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leishmania infantum lipophosphoglycan, a novel carbohydrate-based antigen for the immunodiagnosis of canine visceral leishmaniasis 用于犬内脏利什曼病免疫诊断的新型碳水化合物抗原——婴儿利什曼病脂磷聚糖
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32726
R. Soares, R. Portela, Gabriela Porfirio-Passos, T. D. Barral, R. S. Gonçalves, Marcos Bernardo, S. M. Barrouin-Melo
{"title":"Leishmania infantum lipophosphoglycan, a novel carbohydrate-based antigen for the immunodiagnosis of canine visceral leishmaniasis","authors":"R. Soares, R. Portela, Gabriela Porfirio-Passos, T. D. Barral, R. S. Gonçalves, Marcos Bernardo, S. M. Barrouin-Melo","doi":"10.35259/ISI.SACT.2019_32726","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32726","url":null,"abstract":"","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134073749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Digital Image Processing Methodology WT-MO: An Algorithm of High Accuracy in Detection And Counting of Erythrocytes, Leucocytes, Blasts 数字图像处理方法WT-MO的发展:红细胞、白细胞、母细胞的高精度检测和计数算法
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/ISI.SACT.2019_32728
Ana Carolina Borges Monteiro, Y. Iano, R. P. França, Rangel Arthur, Vania V. Estrela, Abel A. D. Rodriguez, S. Assumpção
{"title":"Development of Digital Image Processing Methodology WT-MO: An Algorithm of High Accuracy in Detection And Counting of Erythrocytes, Leucocytes, Blasts","authors":"Ana Carolina Borges Monteiro, Y. Iano, R. P. França, Rangel Arthur, Vania V. Estrela, Abel A. D. Rodriguez, S. Assumpção","doi":"10.35259/ISI.SACT.2019_32728","DOIUrl":"https://doi.org/10.35259/ISI.SACT.2019_32728","url":null,"abstract":"Introduction: Annually 257.000 people in the world are diagnosed with leukemia. Leukemia is classified as a disorder in the production of blood cells within the bone marrow, and can be triggered from genetic factors to external factors such as chemical agents and radiation. Its main laboratory finding is the presence of blasts in the bloodstream, which can be easily detected by a hemogram, and the early diagnosis is of great importance for the cure rate. However, early diagnosis is often neglected due to the cost of the blood count. In developed countries like the USA, the state does not guarantee health coverage of the population, while in developing countries there is a long queue waiting for the performance of examinations, in underdeveloped countries there is a population that lives on less than a dollar a day, making access to health difficult and other basic needs.","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133983897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Screening immunotherapies in polymer solution microreactors: system evaluation and optimization 聚合物溶液微反应器中免疫疗法的筛选:系统评价与优化
Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos Pub Date : 1900-01-01 DOI: 10.35259/isi.sact.2019_32850
Alyne G. Teixeira, Jun Wang, J. Frampton
{"title":"Screening immunotherapies in polymer solution microreactors: system evaluation and optimization","authors":"Alyne G. Teixeira, Jun Wang, J. Frampton","doi":"10.35259/isi.sact.2019_32850","DOIUrl":"https://doi.org/10.35259/isi.sact.2019_32850","url":null,"abstract":"","PeriodicalId":427855,"journal":{"name":"Anais do IV International Symposium on Immunobiological e VII Seminário Anual Científico e Tecnológico de Bio-Manguinhos","volume":"60 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114040000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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