European Journal of Therapeutics最新文献

{"title":"Factors Associated with Cytomegalovirus (CMV) Procto-Colitis in Immunocompetent Adults: A Systematic Review","authors":"Timothy Bromley, Keziah Lewis, C. Fitzpatrick, Daniel Richardson","doi":"10.58600/eurjther2148","DOIUrl":"https://doi.org/10.58600/eurjther2148","url":null,"abstract":"Objective: The pathophysiology of CMV procto-colitis in immunocompetent adults is poorly understood. We aimed to systematically review the literature to explore factors, presenting symptoms and endoscopy findings associated with CMV procto-colitis in immunocompetent adults.\u0000Methods: Following PRISMA guidelines, we conducted a narrative systematic review by searching MEDLINE, EMBASE, EMCARE and CINAHL for manuscripts published up to August 2023. One author screened manuscript abstracts; two authors independently conducted a full text review. We included manuscripts which included primary data of immunocompetent adults with CMV procto-colitis except case reports. Quality and risk of bias was assessed independently by two authors using the Joanna Briggs institute critical appraisal tools.\u0000Results: 8 manuscripts were included in the final review from the USA (n=2), China (n=2), Korea (n=2), India (n=1) and Brazil (n=1) and consisted of 6 case series, one case-control study and one cross-sectional study published between 1988-2022. We identified demographic and behavioural factors (older age, lower BMI, receptive anal sex), infection factors (urinary tract infections, shigellosis, Hepatitis C, COVID-19, sepsis, antimicrobial use), medical conditions (cardiovascular disease, respiratory disease, renal disease, auto-immune disease, diabetes) and hospitalisation factors (intensive care admission, longer length of hospital stay) associated with CMV procto-colitis in immunocompetent adults. Patients presented with rectal bleeding, diarrhoea, melaena, fever, nausea/vomiting, abdominal pain/bloating and constipation. Large bowel endoscopy findings were ulcers, erosions, and erythema and polyp/mass lesions.\u0000Conclusion: We have highlighted factors, presenting symptoms and endoscopy findings associated with CMV procto-colitis in immunocompetent patients which provides insight for clinical guideline development and future research.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141126638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Syndrome in Adolescents: Capgras Syndrome and Its Psychopharmacological Treatment","authors":"Tuğçe Canol Özbek, Mutlu Muhammed Özbek","doi":"10.58600/eurjther2140","DOIUrl":"https://doi.org/10.58600/eurjther2140","url":null,"abstract":"In this letter to editor, while explaining the process leading to Capgras syndrome (CS), it will be tried to evaluate the psychodynamic, cognitive, neurological, and systemic factors as a result of the anamnesis and detailed examinations. Clinical aspects of the syndrome, psychopharmacologic agents to be used in the treatment process, and these agents' mechanisms of acts will be discussed. Y.B., a 16-year-old female patient, was admitted to our clinic by her family with complaints of restlessness, introversion, and voices in her ears. A psychiatric examination revealed that the patient had persecutory, referential, and somatic delusions and that her family was replaced with other families in her thought content. In the initial treatment of the patient, risperidone was preferred, and sertraline was added to her treatment after the regression in her symptoms was not at the desired level. CS is the most common type of misidentification syndrome. The patient believes that their parents, friends, or themselves have been replaced by people similar to them and may show strong hostility and distrust toward their environment. Although there is no single cause, biological and psychological factors are thought to play a role in its etiopathogenesis. When the literature is examined, it is seen that there are reports of CS in adults, and the number of case reports in adolescence is lower. It should be kept in mind that although rare, CS can be seen in the pediatric and young population and the addition of selective serotonin reuptake inhibitors may be beneficial in cases that do not respond to antipsychotic treatment.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140964983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Plasma Amino Acid Levels in Crimean-Congo Hemorrhagic Fever Patients","authors":"Zeynep Ertemür, H. Aydın, A. Engin","doi":"10.58600/eurjther2112","DOIUrl":"https://doi.org/10.58600/eurjther2112","url":null,"abstract":"Objective: Crimean Congo Hemorrhagic Fever (CCHF) has an important place in viral hemorrhagic fever. Plasma amino acid (AA) levels of patients who were diagnosed with CCHF in the acute and convalescent period of the disease were investigated in this study. \u0000Methods: 35 patients were included in the study specific polymerase chain reaction (PCR) and/or IgM antibody positivity for CCHF virus. AA levels were measured in the plasma derived from the blood samples of the patient and control groups, using liquid chromatography-mass spectrometry (LC-MS/MS) technique. \u0000Results: In our study, we observed that plasma aspartate, glutamate, histidine, leucine, phenylalanine, tyrosine levels increased statistically significantly (p<0.05), while some AA levels decreased (p<0.05) in acute stage patients compared to the control groups. In addition, while there was an increase in plasma glutamate levels of convalescent patients compared to the control groups (p<0.05), there was a significant decrease in other AA levels (p<0.05). \u0000            Conclusion: Further studies to investigate the relationship between increased or decreased AAs in the plasma levels of these patients and the immune system are likely to contribute to a better understanding of the pathogenesis of the disease and to guide the approach to whether AA supplementation is necessary for treatment. \u0000                Keywords: biochemical analysis, Crimean‐Congo hemorrhagic fever virus, metabolic analysis, research andanalysis methods","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The concept of “the extended mind” can provide a sound philosophical justification for the academic use of AI, but with ethical precautions!","authors":"Abdullah Yıldız","doi":"10.58600/eurjther2157","DOIUrl":"https://doi.org/10.58600/eurjther2157","url":null,"abstract":"","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal Osteonecrosis in Spinal Cord Injury","authors":"Canan Tıkız, İlhan Celil Özbek, Emir Onağ","doi":"10.58600/eurjther2116","DOIUrl":"https://doi.org/10.58600/eurjther2116","url":null,"abstract":"Dear Editors,\u0000Necrosis of the bone marrow and trabecular portion as a result of limited blood flow is known as osteonecrosis (ON) [1]. Several causes have been proposed for the development of ON, including vascular occlusions, ischemia, intravascular coagulation in interosseous tissue, increased intracortical pressure, mechanical stress, precursor cell death, and suppression of angiogenesis. There are multiple risk factors and medical condition associated with ON, including infections, hematological and coagulation problems, connective tissue illnesses, kidney diseases, excessive alcohol and tobacco use, and the use of corticosteroids and cytotoxic drugs [2].\u0000Multifocal osteonecrosis, defined as the presence of osteonecrosis in three or more bone sites, is a rare entity representing less than 3% of osteonecrosis patients [3].\u0000Due to its potent anti-inflammatory properties, methyl prednisolone (MP), one of the most extensively used corticosteroids, has been used for a long time in the acute phase of spinal cord injury and brain edema due to its strong anti-inflammatory properties [4]. Although studies have reported cases of multifocal osteonecrosis (MFON) brought on by corticosteroid medication, this link has never been examined in a patient with a spinal cord injury.\u0000This letter aims to highlight MFON that occurred in a patient who underwent acute spinal cord injury and high-dose steroid therapy.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Referees on Romeo and Juliet","authors":"H. B. Ilgaz","doi":"10.58600/eurjther2146","DOIUrl":"https://doi.org/10.58600/eurjther2146","url":null,"abstract":"Dear Editors,\u0000It is a common situation, especially for young researchers, to receive decision letters from a journal office saying: “Major revision required - No guarantee of acceptance” or “We regret to reject.” It is said that experiencing repeated major revisions and even rejections make a researcher more mature, but what is a young researcher to do when even Dr Hwang is badly affected by this situation? [1] Then I read Kundakçı’s letter [2] and became even more pessimistic. I worried what if the referees turned into artificial intelligence and even more difficult times awaited the writers. So, I decided to write this letter, thinking that it might be interesting to discuss ideas on the subject with the metaphor of Romeo and Juliet. We all know William Shakespeare’s magnificent work Romeo and Juliet [3]. In this work, Romeo and Juliet, who fell in love with each other, failed to be patient in their plans and could not come together until they died. And a great debate has been going on for centuries: What makes their love interesting and unforgettable for all humanity is the greatness of their love or the fact that they could never unite?\u0000In fact, there is a metaphorical relationship between referees and “Romeo and Juliet”. Could it be that what determines our love for science and our desire to write scientific articles and makes it unique is that we cannot achieve success as a result of the comments of the referees? Or is it the magnitude of our love for writing that drives us to our enthusiasm for writing?\u0000Generally, it is not taught how to do peer review for scientific journals. If people have not made a special effort to learn, they learn the role of the referee from their own experiences or from studies previously published in the journal. This is actually a situation that may cause some problems in the standardization of the work done. Since the editors will reach a decision based on the recommendations of the referees, the qualifications of the referees and their scientific article evaluation behavior patterns become decisive in this regard.\u0000Since referees are also writers and are not free from all the prejudices of the age, they must act independently of all positive or negative influences when evaluating the manuscripts [4, 5]. The publishing policies of journals (double blind or single blind, etc.) supporting this independence is the way to prevent this great love from disappearing and not growing further with new separations.\u0000In the story of Romeo and Juliette we see Count Paris who tries to separate them and wants to marry Juliette, and Friar Laurence who is the wise adviser and tries to reunite them. As writers, editors or referees, we scientists perhaps have two options: to hinder this love of science, like Count Paris, or to advance the love of science, like Friar Laurence. Or in other words “to be or not to be” a scientist, that is the question.\u0000Kind Regards","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clock is Ticking: Overcoming Time with Mechanical Thrombectomy for Middle Cerebral Artery Infarct","authors":"Nergiz Aydın, Ahmet Lütfü Sertdemir","doi":"10.58600/eurjther2076","DOIUrl":"https://doi.org/10.58600/eurjther2076","url":null,"abstract":"Coronary angiography is associated with several documented complications, and cardioembolic stroke following angiography is a rare occurrence. This letter presents a case involving thrombotic occlusion of the left middle cerebral artery (MCA) during coronary angiography. A 36-year-old female patient, presenting to the emergency department with chest pain, underwent coronary angiography due to non-ST-segment elevation myocardial infarction. While the responsible lesion underwent revascularization, the patient experienced new-onset motor deficits and aphasia. DSA imaging was conducted on the patient, whose diffusion magnetic resonance imaging and clinical findings were indicative of MCA infarction. Thrombectomy was performed on the patient with a left MCA infarction. Proficient management of neurological complications underscores the potential positive impact of interventional treatment strategies on mortality and morbidity. In this letter to the editor, the significance of early diagnosis, appropriate treatment, and multidisciplinary approach is emphasized.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroids and Immunosuppressants on Oral Lichen Planus’ Treatment","authors":"Mehmet Akyüz, Sultan Uzun, Ali Altındağ, G. Magat, K. Orhan","doi":"10.58600/eurjther2111","DOIUrl":"https://doi.org/10.58600/eurjther2111","url":null,"abstract":"Dear Editor,\u0000Lichen planus (LP), a chronic inflammatory condition primarily targeting skin and mucous membranes, was first outlined by Wilson in 1869 and histologically by Dubreuilh in 1906 [1]. It predominantly affects women in their 4th and 5th decades [2]. Oral lichen planus (OLP) occurs mainly on the buccal mucosa, gingiva, and tongue, presenting in six types, with erosive ones causing eating discomfort. While 25% of LP cases manifest solely orally, some lesions can appear in areas like the anogenital region and esophagus [2].\u0000OLP is postulated to be a T cell-mediated response to antigens, with potential ties to chronic liver diseases and higher prevalence in regions like Japan and Southern Europe [3]. Comorbidities like diabetes, hypertension, and stress may also contribute [4]. Dental materials can mimic OLP, and specific drugs, including NSAIDs and beta-blockers, might induce it in some individuals [5].\u0000Asymptomatic OLP lesions generally need no treatment. For symptomatic forms, treatment targets symptom alleviation and lesion removal, primarily using topical corticosteroids. Resistant lesions may require intralesional or systemic corticosteroids, with alternatives like immunosuppressives, retinoids, antifungals, and metronidazole also being effective [6].\u0000OLP has a premalignant nature with a 0.4-1.74% risk of turning malignant, typically from its atrophic or erosive form [7]. Treatment aims to alleviate pain, heal ulcers, minimize cancer risks, extend symptom-free periods, and uphold oral health. This report presents intralesional corticosteroid therapy for three patients with symptomatic OLP, presenting symptoms like pain and burning.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Alloplastic Total Joint Replacement of the Temporomandibular Joint of Growing Patients: A Scoping Review","authors":"Bernardo Correia Lima, R. Grillo, Bruno Alvarez Quinta Reis, Leonardo Augustus Peral Ferreira Pinto, F. Melhem-Elias","doi":"10.58600/eurjther2152","DOIUrl":"https://doi.org/10.58600/eurjther2152","url":null,"abstract":"Temporomandibular joint (TMJ) disorders pose unique challenges in pediatric patients undergoing craniofacial growth. Alloplastic total temporomandibular joint reconstruction (ATJR) techniques have emerged as promising solutions, offering immediate joint function and symptom relief. However, the efficacy and safety of ATJR in this population remain under scrutiny. This scoping review aims to comprehensively summarize the evolving literature on ATJR in growing patients with end-stage TMJ pathology. Our methodology adhered to PRISMA-ScR guidelines, identifying 9 relevant articles. The discussion emphasizes preoperative considerations, treatment selection criteria, and potential complications. While ATJR offers short-term benefits, concerns regarding long-term outcomes persist, necessitating further research. Collaboration among multidisciplinary teams is crucial for optimal patient care. Future research should focus on comparative efficacy and safety, refining treatment algorithms, and long-term follow-up to enhance outcomes and minimize complications in pediatric TMJ pathology.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140982033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Patients with Postoperative Pancreatic Fistula After Isolated Splenectomy: A Retrospective Study","authors":"S. Celik, Mehmet Bahadir Demir, Yasin Gulap, Hilmi Erencan Polat, Mehmet Mert Hidiroglu, Murat Ozkara, S. Kesikli","doi":"10.58600/eurjther2081","DOIUrl":"https://doi.org/10.58600/eurjther2081","url":null,"abstract":"Objective: Postoperative pancreatic fistula (POPF) is a potentially life-threatening complication. This complication occurs not only after pancreatic surgery but may also arise after other abdominal procedures. In this study, we aimed to determine the incidence and risk factors of POPF in patients undergoing isolated splenectomy.\u0000Methods: Patients who underwent isolated splenectomy were identified. POPF was defined according to the 2016 update of International Study Group of Pancreatic Fistula classification and graded as biochemical leak (BL), grade B fistula, and grade C fistula. Characteristics and perioperative variables were compared between patients who had pancreatic fistula and those who have not.\u0000Results: The study cohort consisted of 59 patients with median age 38.9 years, and 50.8% male. The indication was trauma in 18 (30.5%) patients. Twenty (33.9%) patients were operated upon emergently. Thirty-seven (62.7%) splenectomies were performed open. Out of all patients, 14 (23.7%) developed any sort of pancreatic fistula. BL occurred in 11 (18.6%) patients and 3 (5.1%) patients developed a grade B fistula. Comparison of patients with and without BL/POPF demonstrated no significant differences in demographics, surgical indication, operative method, surgical approach, or postoperative outcome.\u0000Conclusions: Despite higher incidence of pancreatic leak, the rate of clinically relevant fistula is relatively low. In this study, we did not identify any factors associated with BL/POPF. Thus, further studies are needed on pancreatic fistula after splenectomy.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140982966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}