European Journal of Therapeutics最新文献

{"title":"Micro-Computed Tomographic Evaluation of the Sealing Quality and Bond Strength of Different MTA Apical Plugs","authors":"Taibe Tokgöz Kaplan, M. Botsalı","doi":"10.58600/eurjther1919","DOIUrl":"https://doi.org/10.58600/eurjther1919","url":null,"abstract":"Objective: This study aimed to compared the effects of different placement techniques to the sealing quality of mineral triokside aggregate (MTA) apical plugs at apexification technique by micro-computed tomography (micro-CT) and compared the bond strength to root dentin of an injectable MTA (BIOfactor MTA), MTA Angelus and AH Plus. Methods: Sixty dentinal root slices were obtained from 20 maxillary centrals.A canal-like hole was drilled into each slices canal space.The samples were divided into 3 groups (n=20).All materials were delivered into the holes. Push-out tests were performed and fracture types were analysed with a strereomicroscope. In the second part of the study,72 maxillary central teeth with standardised artificial divergent open apex were divided into 4 groups; MTA Angelus and BIOfactor MTA were mixed mechanically, and introduced to form 4 mm thick apical plugs by hand condensation or indirect-ultrasonic activation for 10 seconds. Incidence of external voids between dentin walls and MTA apical plugs and porosity inside MTA were determined by volumetric analysis with micro-CT. Results: No significantly difference was found between the bond strength values of the materials (p:0.370; p>0.05).The external voids and porous voids are similar in both MTA (p: 0.685; p>0.05).When indirect-ultrasonic activation was applied,there was significantly less porosity statistically than hand condensation (p:0.00; p<0.05). Conclusion: MTA Angelus and BIOfactor MTA materials showed similar results in terms of bond strength to root dentin, fracture types, adaptation to dentin walls and structural porosity rate. Both MTA materials showed less structural porosity when placed by indirect ultrasonic activation technique compared to manual condensation.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"99 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139174470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural Adaptation of the Activity Questionnaire for Adults and Adolescents into Turkish and Investigation of its Validity and Reliability","authors":"Akın Süzer, Özlem Çinar Özdemir","doi":"10.58600/eurjther1898","DOIUrl":"https://doi.org/10.58600/eurjther1898","url":null,"abstract":"Objective: The Activity Questionnaire for Adults and Adolescents (AQuAA) is used to evaluate physical activity (PA) levels in different age groups. Its validity and reliability in the Turkish language have not been studied yet. This study aims to adapt the AQuAA into Turkish and to investigate its validity and reliability.\u0000Methods: A total of 124 volunteers were included in the study. After the Turkish adaptation of AQuAA, the AQuAA-Tr version was administered to the volunteers for test-retest reliability twice, with an interval of two weeks, and the International Physical Activity Questionnaire Short Form (IPAQ-SF) for criterion validity. For construct validity, the step counts of the volunteers were followed for two weeks with the Samsung Health® smartphone pedometer application. The reliability of the AQuAA-Tr was evaluated with intra-class correlation coefficients (ICC). Spearman correlation coefficients (r) were used to analyze the relationships between continuous variables.\u0000Results: A total of 72 adolescents (51 females and 21 males, mean age 14.5 ± 0.1 years) and 52 young adults (32 females and 20 males, mean age 25.8 ± 1.3 years) participated in the test-retest reliability and criterion validity study. Thirty-four adolescents (26 female, 8 male, mean age 14.7 ± 0.2 years) and 39 young adults (27 female, 12 male, mean age 25.6 ± 1.5 years) were included in the construct validity study. The test-retest reliability of the questionnaire was in the range of strong to very strong (ICC = 0.704 to 0.982) in adolescents and moderate to strong (ICC = 0.606 to 0.851) in adults for different levels of PA. In the context of the criterion validity, although there were moderate to strong correlations (r = 0.413 to 0.768) between some PA levels of the IPAQ-SF and AQuAA-Tr in adolescents and moderate correlations (r = 0.422 to 0.525) in adults, the correlations were mostly weak or negligible. In relation to construct validity, although there were moderate correlations (r = 0.435 to 0.504) between the Samsung Health® data and some PA levels of the AQuAA-Tr in adults, the correlations were mostly weak or negligible. There were no correlations between the Samsung Health® data and AQuAA-Tr in adolescents.\u0000Conclusion: The reliability of the AQuAA-Tr was confirmed in both adolescents and adults. However, the criterion and construct validity of the AQuAA-Tr were not confirmed for either adolescents or adults. Introducing a PA questionnaire, which can provide detailed information about sedentary, light, moderate, and vigorous PA scores separately and total PA scores and allows the evaluation of PA in different categories, into our language is considered beneficial. Yet, the results of AQuAA-Tr should be interpreted carefully in the clinic.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":" 37","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138964439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging of the Ethmomaxillary Sinus, its Prevalence, and Evaluation of its Relationship with Chronic Rhinosinusitis","authors":"Melike Taşci, Z. Fazlıoğulları, B. Ulusoy, M. Durmaz, Vedat Uslu, N. Unver Dogan, A. Karabulut","doi":"10.58600/eurjther1891","DOIUrl":"https://doi.org/10.58600/eurjther1891","url":null,"abstract":"Objective: The presence of an ethmomaxillary sinus (EMS) may increase the susceptibility to inflammatory paranasal sinus diseases such as chronic rhinosinusitis (CRS) and cause difficulties in surgical interventions to the paranasal sinuses. Therefore, this study aimed to examine the EMS in patients with and without CRS. Methods: The study included 150 patients (300 sides) diagnosed with CRS by the ear–nose–throat clinic and 151 individuals (302 sides) without CRS. Paranasal sinus computed tomography images were reviewed retrospectively. The presence of an EMS (bilateral or not) and its relationship with age and sex were examined. The severity of CRS was determined with the Lund–Mackay scoring system, and its relationship with EMS was evaluated. Results: The EMS was detected in 7 patients (7/301, 2.32%) and 9 sides (9/602, 1.49%) of 301 patients (602 sides) included. The incidence in the CRS group was 2.6%. Three cases were unilateral, and one was bilateral. The incidence in the control group was 1.98%, two cases were unilateral, and one was bilateral. According to the Lund–Mackay scoring system, the mean CRS severity was 8.62 (±5.47). Its severity was 5.25 (±3.94) in the EMS group and 8.71 (±5.48) in the non-EMS group. Conclusion: No statistically significant difference was found between the groups with and without CRS in terms of the presence of EMS (p = 0.723). No evidence reveals that EMS increased the severity of CRS.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"19 6","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139175189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Approach in Colorectal Anastomotic Stricture: Bougie Dilatation","authors":"A. K. Taşkın","doi":"10.58600/eurjther1920","DOIUrl":"https://doi.org/10.58600/eurjther1920","url":null,"abstract":"Dear Editor, Anostomotic stricture (AS) is seen in 2-30% of patients after colorectal surgery. Various factors such as tissue ischaemia, anastomotic leakage and radiotherapy have been suggested in its pathogenesis [1,2]. Endoscopic methods (balloon dilatation, bougie dilatation, stents, endoscopic electroincision), digital dilatation, surgical methods (stapler stricturoplasty, transanal circular stapler resection, transabdominal redo-anastomosis) and corticosteroids are used in AS [3,4]. Surgery is generally preferred in complete/near complete AS [1]. Stents; the benefit of stents in AS after oncological surgery has not been shown [3]. However, Philip BC Pangg et al. treated near-total AS non-operatively with the colonic/rectal endoscopic ultrasound (EUS) anastomosis technique and a hot lumen metallic stent [5]. We applied 3-stage bougie dilation to the patient with near complete anastomotic stricture. A 59-year-old female patient who underwent laparoscopic anterior resection due to sigmoid colon tumor was followed up with complaints of abdominal swelling, intermittent abdominal pain and difficulty in defecation. One month later, when colonoscopy was performed, near complete anastomotic stricture was observed. Bougie dilatation was performed with maloney flexible bougie dilators under wire guidance. Bougie dilatation was performed 3 times with fifteen days intervals. After the first (33, 36 and 42 F) and the second bougie dilatation (36, 42 F), the upper segment of the anastomotic stricture was reached by gastroscopy. After dilatation with a bougie (42, 45 F) for the third time, the colonoscope was easily passed through the anastomosis line to the upper segment. Six months later, colonoscopy was performed and the proximal part of the anastomosis was easily passed without the use of bougie dilators. Balloon dilatation is the first method used in AS. However, several repetitions are necessary for the success of the procedure. In addition, the risk of perforation increases when the stricture diameter is &lt;5 mm and length &gt;1 cm. The chances of success in AS are lower compared to bougie dilatation. Endoscopic electroincision is recommended in failure of balloon dilatation. Digital dilatation: used in distal anorectal anostamotic strictures. Corticosteroid application: very large studies are not available. Bougie dilatation in AS provides tactile feedback, allowing the amount of resistance to the passage of the dilator to be estimated and perforation to be avoided. Bougie dilatation method is simple, inexpensive and low risk of complications. Especially Maloney flexible silicone bougie minimise the risk of complications. Bougie dilatators can remain intact for many years and can be reused. But balloon dilatators are not reused. Surgical methods are used in 3-4% (complete/near complete AS) in the failure of endoscopic methods. But mortality risk is high [1,4-6]. Therefore, the alternative method of Philip BC Pang et al. can be applied [5]. However, due t","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"378 ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139173995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Accuracy of Different Apex Locator Systems in Detecting Root Perforations in the Presence of Different Irrigation Solutions","authors":"Oğuz Burhan Çetinkaya, Emre Çulha, Uğur Aydın","doi":"10.58600/eurjther1936","DOIUrl":"https://doi.org/10.58600/eurjther1936","url":null,"abstract":"Objective: One of the most studied topics in electronic apex locators (EALs) is the effect of root canal condition on the accuracy of EALs. In this study, the accuracy of Root ZX Mini, Raypex 6, and Apex ID in detecting root perforation was evaluated in a dry environment and in the presence of saline, ethylenediamine tetraacetic acid (EDTA), and sodium hypochlorite (NaOCl) solutions.\u0000Methods: The mesiobuccal roots of 64 human maxillary first molars were selected for the study. These root canals were perforated from buccal root surface using a #1 Freze Beutherlock Peeso to form a 0.4 mm cavity. After perforation, the area where #40 K type file appeared was recorded as the actual length (AL) and the length measured by EAL devices both in dry canals and in the presence of solutions was recorded as the electronic measurement (EL). All electronic measurements were statistically compared with the actual length.\u0000Results: All EALs achieved AL-consistent results on EL measures. Consistency was determined using Root ZX Mini measurements in dry canals and canals irrigated with saline. The consistency of EL and AL conducted with Raypex 6 and Apex ID in canals irrigated with NaOCl, saline, and EDTA was found. There was a statistically significant difference in ELs with irrigation solutions among all EALs (p<0.05). In the dry environment, there was no statistically significant difference between the EALs (p>0.05). A consistency was discovered between ELs generated with the Root ZX Mini and ALs in both dry and saline-irrigated canals. Consistency was observed between ELs measured with Raypex 6 and Apex ID and ALs in canals irrigated with NaOCl, saline, and EDTA.\u0000Conclusion: The accuracy rates of the EALs used in this research were 97%–100% in the 1 mm range and 83%–92% in the 0.5 mm range. Despite the fact that ALs and ELs differed statistically significantly at the 0.05 level, these variations weren't thought to be clinically relevant. In the presence of conditions with different electro conductors, EALs from different generations may be used safely, and in a range of canal situations, these devices can yield measurements that are most similar to the AL.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"6 11","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of the Role and Limitations of Surgical Versus Non-Surgical Management of Dentofacial Deformities","authors":"R. Grillo, Alexandre Meireles Borba, Y. Slusarenko da Silva, Mariana Aparecida Brozoski Aparecida Brozoski","doi":"10.58600/eurjther1933","DOIUrl":"https://doi.org/10.58600/eurjther1933","url":null,"abstract":"Objectives: The amount of dermal filler procedures is increasing. Some patients opt to undergo dermal fillers instead of orthognathic surgery to treat unesthetic complaints from dentofacial deformities. The aim of this work is to carry out a literature review with regard to a comparison of role and limitations between aesthetic indications of orthognathic surgery and dermal fillers.\u0000Methods: A scoping review was performed according to the PRISMA-ScR guidelines on Pubmed, Web of Science and Google Scholar. A second search was conducted to highlight topics very close subjects to the main subject: the importance of social media and measures to avoid litigation in facial aesthetics.\u0000Results: Literature on the subject is very rare. Clinical facial analysis is fundamental to both procedures. Although patients wishes are important issues, facial analysis cannot be neglected due to its objectivity. Body dysmorphic disorder is considered a contraindication for both procedures. Social media is important in patient decision-making, but should not influence treatment planning by experts. Preventing litigation or reducing financial and reputational damage can be accomplished with a few simple steps.\u0000Conclusions: A helpful list of indications and particularly contraindications for orthognathic surgery and dermal fillers was drawn up. Dermal fillers must not substitute orthognathic surgery. Further studies are urgently needed to discuss this contemporary issue.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"14 7","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of MitoTEMPO on Rat Diaphragm Muscle Contraction Parameters in an Experimental Diabetes Model Induced with Streptozotocin","authors":"Ahmet Akkoca, S. Tuncer, M. Çelen, N. Dalkılıç","doi":"10.58600/eurjther1912","DOIUrl":"https://doi.org/10.58600/eurjther1912","url":null,"abstract":"Objective: Diabetes Mellitus (DM) not only causes hyperglycemia but also leads to clinical challenges involving respiratory functional impairments. The contraction of the diaphragm reduces pleural pressure, thereby contributing significantly to the process of breathing. This study examines the functional impairments in diaphragm muscle isometric contraction parameters due to increased reactive oxygen species (ROS) associated with DM, as well as the effects of MitoTEMPO, a mitochondria-specific antioxidant, on these impairments.\u0000Methods: Wistar Albino male rats at 12-14 weeks of age were randomly divided into three groups: the control group (CON, n=6), the diabetes group (DM, n=6), and the diabetes + MitoTEMPO (MT, n=6) group. A single dose of 50 mg/kg streptozotocin (STZ) was administered to the rats in the DM and MT groups. When the rats in the MT group reached a blood glucose level of 300 mg/dl, they were administered MitoTEMPO at a dose of 0.7 mg/kg/day for 28 days. Isometric contraction recordings were obtained from diaphragm muscle preparations isolated from the experimental animals at the end of the 28-day period.\u0000Results: Although the effectiveness of mitochondria-specific antioxidants in reducing blood glucose levels in DM is debated in the literature, results for the MT group were interestingly indicative of a statistically significant decrease in blood glucose levels following MitoTEMPO administration at the end of the fourth week. Furthermore, MitoTEMPO exhibited therapeutic effects on diaphragm muscle contraction parameters impaired by DM.\u0000Conclusion: The findings suggest that in DM patients, MitoTEMPO could be utilized for blood glucose control and might also be effective in the treatment of DM-induced diaphragm muscle mechanical dysfunction.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"485 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue","authors":"Aysegul Karadayi, Nilufer Akgun Unal, Elif Gulbahce Mutlu, Begum Korunur Engiz, Ahmet Akkoca, Salih Varol","doi":"10.58600/eurjther1875","DOIUrl":"https://doi.org/10.58600/eurjther1875","url":null,"abstract":"Objective: The increasing use of electronic devices, accompanied by advancing technologies, has led to heightened exposure to non-ionizing electromagnetic radiation (EMR). This exposure instigates the accumulation of free radicals and oxidative damage in tissues, consequently impacting biological systems. Notably, the testis is among the tissues adversely affected by EMR. Numerous studies have highlighted the pivotal role of the testis in sperm production, emphasizing the potential implications of any damage on the reproductive system. This study aims to assess the levels of lipid peroxidation through histological evaluation in the testicular tissue of prepubertal male rats exposed to electromagnetic radiation at varying electric field intensities within the 2.45 GHz radiofrequency (RF) range.\u0000Methods: The experimental group comprises six subdivisions, including a sham control group, as well as groups exposed to varying electric field strengths (EFS) of 0.6 V/m, 1.9 V/m, 5 V/m, 10 V/m, and 15 V/m, respectively. Excluding the sham control group, the remaining subgroups were subjected to a daily 2.45 GHz RF exposure for 1 hour starting immediately after fertilization. This exposure to different electric field intensities continued for 45 days post-birth.\u0000Results: The samples obtained from the RF radiation-exposed rats exhibited elevated malondialdehyde (MDA) values and decreased glutathione (GSH) values in the testicular tissue. Furthermore, a comparative analysis between the microwave radiation-exposed group and the control group revealed distinct histological alterations in the testicular tissue.\u0000Conclusion: In conclusion, our findings indicate that exposure to microwave radiation at an electric field intensity of 15 V/m can lead to significant histopathological and oxidative parameter changes in Wistar rats. These results underscore the potential effects of such exposure on human health.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"39 8","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Different Dentin Desensitizers and Self- Adhesive Resin Cement on Shear Bond Strength: In Vitro Study","authors":"Işıl Keçik Büyükhatipoğlu, Derya Gürsel Sürmelioğlu","doi":"10.58600/eurjther1892","DOIUrl":"https://doi.org/10.58600/eurjther1892","url":null,"abstract":"Objectives: The aim of this study is to evaluate and compare the bond strength of different dentin desensitizers and self-adhesive resin cements to dentin surfaces.\u0000Methods: The flat dentin surfaces of 72 wisdom molar teeth were randomly divided into six groups for bond strength analysis (n=12): Group CP: No desensitizer + Primer II A&B+ Panavia F 2.0, Group CM: No desensitizer+ Primer A&B+ Multilink N, Group TP: Tokuyama Shield Force+ Primer II A&B + Panavia F 2.0, Group TM: Tokuyama Shield Force + Primer A&B+ Multilink N, Group UP: Universal dentin sealant + Primer II A&B+ Panavia F 2.0 and Group UM: Universal dentin sealent + Primer A&B+ Multilink N. The shear bond strength test was performed using a universal testing machine (0.5 mm/min). ANOVA test was used to detect significant differences at a p < 0.05.\u0000Results: The results indicated that bond strength values varied according to the desensitizing and resin cement materials (p < 0.05). The Tokuyama Shield Force desensitizer did not affect the bond strength of the resin cements to dentin (p > 0.05).\u0000Conclusion: The different types of dentin desensitizer applications affected on the shear bond strength results of the self-adhesive resin cements.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"43 9","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Odontogenic Cyst and P53 Codon 72 And P53 Codon 175 Variants in Turkish Patients","authors":"Mehmet Kemal Tümer, Adem Keskin, Recai Acı, S. Yıgıt","doi":"10.58600/eurjther1911","DOIUrl":"https://doi.org/10.58600/eurjther1911","url":null,"abstract":"Objective: Odontogenic cysts that cause bone destruction can exhibit various types of metaplasia. Inherited genetic variants in codons 72 and 175, the hotspot codons of p53, known as the guardian of the genome, can cause a wide variety of cancers. We aimed to investigate the effects of the p53 codon 72 and p53 codon 175 variants on odontogenic cyst formation.\u0000Methods: This research encompassed 71 individuals with odontogenic cysts and 90 without any conditions as a control group. After DNA was extracting, the p53 codon 72 was detected using PCR techniques, while p53 codon 175 was identified through allele-specific amplification-PCR.\u0000Results: The presence of the p53 codon 72 GG genotype and its G allele was less frequent in the group with odontogenic cysts compared to the healthy participants. Conversely, the C allele was found more often in the cyst-afflicted group. For the p53 codon 175, the AA genotype and A allele were more common in the affected group, while the G allele was more predominant in the control group.\u0000Conclusion: The p53 codon 175 AA genotype and A allele, p53 codon 72 C allele, and p53 codon 72/codon 175 CCAA combined genotype may be associated with odontagenic cyst formation. Individuals with this allele and genotype can be considered at risk for odontagenic cyst formation.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"93 7","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138595870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}