European Journal of Therapeutics最新文献

Adalimumab Treatment in a Case of Treatment-Resistant Acne Conglobata 阿达木单抗治疗一例难治性痤疮患者

IF 0.3

European Journal of Therapeutics Pub Date : 2024-06-13 DOI: 10.58600/eurjther2220

M. Daye, Şeyma Kaya Bulut

引用次数: 0

A Rare Cause of Unilateral Breast Mass: Burkitt Lymphoma 单侧乳房肿块的罕见病因：伯基特淋巴瘤

IF 0.3

European Journal of Therapeutics Pub Date : 2024-06-11 DOI: 10.58600/eurjther2179

Cemre Ozenbas, Hamza Eren Guzel, S. Karaarslan

引用次数: 0

Uncommon HLA Alleles Observed in a Poopulation of Istanbul Province 伊斯坦布尔省粪便中发现的不常见 HLA 等位基因

IF 0.3

European Journal of Therapeutics Pub Date : 2024-06-11 DOI: 10.58600/eurjther2163

Yeliz Duvarcı Ogret, Rüştü Oğuz, Sedat Karadeniz, Hayriye Senturk Ciftci, D. Kıvanç, Fatma Savran Oğuz

{"title":"Uncommon HLA Alleles Observed in a Poopulation of Istanbul Province","authors":"Yeliz Duvarcı Ogret, Rüştü Oğuz, Sedat Karadeniz, Hayriye Senturk Ciftci, D. Kıvanç, Fatma Savran Oğuz","doi":"10.58600/eurjther2163","DOIUrl":"https://doi.org/10.58600/eurjther2163","url":null,"abstract":"Objective: New polymorphisms are formed in human leucocyte antigen (HLA) genes with point mutations, gene conversions, and duplication, and the diversity continues to increase. Various new HLA alleles have significant roles in transplantation, and epidemiologic and population studies. The aim of our study was to determine the status of HLA alleles in the Turkish population, which is uncommon, well-defined, and non-defined in the world population according to the international ImMunoGeneTics information system® (IMGT) database.\u0000Methods: We performed HLA-A, -B, -C, -DQB1, and DRB1 loci at the four-field resolution level, using Sanger- sequence-based typing (SBT) for 5592 healthy, unrelated bone marrow donor volunteers from Istanbul Province. The uncommon alleles were also confirmed using high-throughput next-generation sequencing (NGS).\u0000Results: Uncommon alleles were determined at five loci as follows: HLA-A*01:155, 02:66, 02:90, 02:110, 02:343, 03:82, 24:28, 24:146, 24:276, 24:356, 31:23,33:33, 68:38; HLA-B *07:240, 18:19, 35:193, 40:303, 51:69, 51:169; HLA-C*04:39, 06:40, 07:93, 12:149, 15:73; HLA-DRB1*11:149, 13:14:02 and HLA-DQB1*03:27. All alleles were arranged according to the common and well‐documented (CWD) 3.0.0 catalog.\u0000Conclusion: This is the first study to show uncommon alleles in our population. These reported data increase the knowledge of HLA polymorphisms in the Turkish population and provide a basis for further studies in population genetics. This information may also be useful in determining whether a matched, unrelated donor is unlikely to be found so that a mismatch strategy, an extended family search, or alternate therapy, can be pursued, thus saving time and cost for patients.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hello AI: Is it Time for A Revolutionary Change in the Health Professional Education System? 你好，人工智能：卫生专业教育系统是否到了革命性变革的时候？

IF 0.3

European Journal of Therapeutics Pub Date : 2024-06-11 DOI: 10.58600/eurjther2201

Waqar M. Naqvi, G. Mishra

引用次数: 0

Cavitating Mesenteric Lymph Node Syndrome in a Patient with Celiac Disease: Differential Diagnosis Based on Radiological Findings 一名乳糜泻患者的肠系膜淋巴结空洞化综合征：基于放射学检查结果的鉴别诊断

IF 0.3

European Journal of Therapeutics Pub Date : 2024-06-11 DOI: 10.58600/eurjther2188

S. Oner, Hazal Kıran, Mustafa Harman

引用次数: 0

Artificial Intelligence in Periodontology: Advantages and Challenges 人工智能在牙周病学中的应用：优势与挑战

IF 0.3

European Journal of Therapeutics Pub Date : 2024-06-11 DOI: 10.58600/eurjther2211

Dicle Altındal

引用次数: 0

Comparison of Outpatient and Inpatient Consultations Requested from Child and Adolescent Psychiatry 儿童与青少年精神病学门诊咨询与住院咨询的比较

IF 0.3

European Journal of Therapeutics Pub Date : 2024-06-10 DOI: 10.58600/eurjther2178

Mustafa Tolga Tunagür, M. Özbek, S. A. İpek Baş, S. Karakoç, Hatice Aksu

{"title":"Comparison of Outpatient and Inpatient Consultations Requested from Child and Adolescent Psychiatry","authors":"Mustafa Tolga Tunagür, M. Özbek, S. A. İpek Baş, S. Karakoç, Hatice Aksu","doi":"10.58600/eurjther2178","DOIUrl":"https://doi.org/10.58600/eurjther2178","url":null,"abstract":"Objective: This study aims to examine the sociodemographic and clinical characteristics of child and adolescent psychiatry consultations and to compare characteristics of outpatient and inpatient consultations.\u0000Methods: A total of 354 patients who were consulted to child and adolescent psychiatry department of a university hospital were included in the study. Data were collected regarding sociodemographic characteristics of patients, departments requesting consultation, diagnoses, and treatment methods.\u0000Results: The cases included in the study had a mean age of 10.6±4.8 years,with 51.4% being girls. Adolescent girls formed the majority of the inpatient group. The pediatric neurology outpatient clinic had the highest frequency of requested consultations (22.3%), and the most common reason for consultation was a suicide attempt (12.1%). Of the cases for which consultation was requested, 67.8% were diagnosed with at least one psychiatric disorder, and the most common diagnoses were anxiety disorders, with 12.7%. In the inpatient group, impulsive suicide attempts and depressive disorders were more frequent compared to the outpatient group, while intellectual disability was less common. Parent education was provided for 97.2% of the cases, pharmacological treatment was recommended for 44.6% of the cases, and the most commonly prescribed medications were selective serotonin reuptake inhibitors. Psychotherapy and special education were significantly more common in the outpatient group compared to the inpatient treatment group.\u0000Conclusion: The current study revealed significant differences in consultations requested from child and adolescent psychiatry between the outpatient and inpatient groups regarding consultation reasons, diagnoses, and treatment modalities. The findings provide valuable information for clinical practice and service development.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141362872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smokers Versus Non-Smokers: Comparing Cognitive Flexibility and Dyspnea Symptoms in Medical Students 吸烟者与非吸烟者：比较医学生的认知灵活性和呼吸困难症状

IF 0.3

European Journal of Therapeutics Pub Date : 2024-05-23 DOI: 10.58600/eurjther2093

Ayşe Erdoğan Kaya, Büşra Durak

{"title":"Smokers Versus Non-Smokers: Comparing Cognitive Flexibility and Dyspnea Symptoms in Medical Students","authors":"Ayşe Erdoğan Kaya, Büşra Durak","doi":"10.58600/eurjther2093","DOIUrl":"https://doi.org/10.58600/eurjther2093","url":null,"abstract":"Objective: Smoking is an escalating public health concern globally, notably for its frequency among young individuals and the medical conditions it induces. This research aims to explore the association between smoking and the symptoms of dyspnea as well as cognitive flexibility levels in medical students.\u0000Methods: This cross-sectional study included 188 volunteer medical school students. Participants were administered a sociodemographic data form, the Dyspnea-12 Scale, and the Cognitive Flexibility Scale. The participants were divided into two groups as smokers and non-smokers and compared in terms of the applied scale scores. The data were analyzed using the appropriate statistical methods with IBM SPSS v.22 software.\u0000Results: Of the 188 participants, 56.9% (n:107) were female, while 43.1% (n: 81) were male. The prevalence of smoking among participants was 26.1% (n: 49), with rates at 38.3% (n:31) for males and 16.8% (n: 18) for females. The smoking rate was significantly higher in males (p<0.001). No significant difference was detected between smokers and non-smokers regarding the Dyspnea-12 score. However, the Cognitive Flexibility Scale scores were significantly lower in the smoker group (p:0.018).\u0000Conclusion: In our study, we found that the smoking rate among medical students was quite high and that smoking negatively affected cognitive flexibility. It may be beneficial to consider this when evaluating cognitive functions in educated individuals who smoke.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141104970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic and Predictive Significance of HER2-low Expression in Metastatic Hormone Receptor Positive Breast Cancer Patients Receiving CDK4-6 Inhibitor Therapy 接受 CDK4-6 抑制剂治疗的转移性激素受体阳性乳腺癌患者中 HER2 低表达的预后和预测意义

IF 0.3

European Journal of Therapeutics Pub Date : 2024-05-23 DOI: 10.58600/eurjther2151

H. Arak, T. Kus

{"title":"Prognostic and Predictive Significance of HER2-low Expression in Metastatic Hormone Receptor Positive Breast Cancer Patients Receiving CDK4-6 Inhibitor Therapy","authors":"H. Arak, T. Kus","doi":"10.58600/eurjther2151","DOIUrl":"https://doi.org/10.58600/eurjther2151","url":null,"abstract":"Objective: This study aimed to analyze the predictive and prognostic value of HER2-low expression in hormone receptor (HR) positive human epidermal growth factor receptor-2 (HER2) negative metastatic breast cancer patients receiving cyclin-dependent kinase-4/6 inhibitor (CDK4/6i) therapy.\u0000Methods: This retrospective study included patients who received CDK4/6i plus endocrine therapy (ET). The pathological and clinical characteristics and survival times of the patients were compared and analyzed.\u0000Results: Our study included 122 patients. There were HER2-zero 88(72%) and HER2-low 34 (28%) patients. The median progression free survival (mPFS) of all patients who received CDK4/6i+ET was 21 (95% confidence interval (CI),18.5–23.5) months, while mPFS was not reached in the HER2-zero group, and mPFS in the HER2-low group was 12 (95%CI, 6.8–17.1) months (p=0.001). The mPFS was shorter in patients with primary endocrine resistance (6 vs. 21 months, p=0.001). There was a change in the HER2-low status of 26(45%) patients with recurrence compared to the first biopsy. In the HER2-zero and HER2-low groups, 22(25%) and 24(71%) patients, respectively, progressed with CDK4/6i+ET (p=0.001). Estrogen receptor (ER) levels less than and greater than 50% resulted different mPFS (6 and 21 months, respectively) (p=0.025). Median PFS differed based on CDK4/6i+ET combination, treatment line, and best treatment response (all p=0.001). In multivariate analysis, HER2 status(p=0.018), chemotherapy status(p=0.006), best response status with CDK4/6i (p=0.001) for PFS, and best response status with CDK4/6i therapy (p=0.007) for OS were significant.\u0000Conclusions: In patients with HR+HER- metastatic breast cancer receiving CDK4/6i therapy, the duration of mPFS was lower in the HER2-low group than that in the HER2-zero group. HER2-low expression is a predictive biomarker of response to CDK4/6 inhibitor therapy.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141107363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are Plaque Disclosing Agents Effective for Improving Self-Performed Dental Hygiene in Patients with Space Maintainers? A Randomized Controlled Clinical Trial 牙菌斑揭露剂对改善牙间隙保持器患者的自我牙科卫生有效吗？随机对照临床试验

IF 0.3

European Journal of Therapeutics Pub Date : 2024-05-23 DOI: 10.58600/eurjther2103

Mihriban Gökcek Taraç

{"title":"Are Plaque Disclosing Agents Effective for Improving Self-Performed Dental Hygiene in Patients with Space Maintainers? A Randomized Controlled Clinical Trial","authors":"Mihriban Gökcek Taraç","doi":"10.58600/eurjther2103","DOIUrl":"https://doi.org/10.58600/eurjther2103","url":null,"abstract":"Objective: In the event of premature loss of primary teeth, the placement of a space maintainer is the safest option for preserving dental arch length; however, the appliances and bands of space maintainers can change the contours of the teeth, causing plaque accumulation and making it difficult to maintain oral hygiene. The aim of this study was to evaluate changes in dental plaque accumulation and the effectiveness of a plaque disclosing agent (PDA) in providing oral hygiene with the use of space maintainers.\u0000Methods: Patients were divided into two groups (Group A: intervention; Group B: control) and the study was carried out in four stages. At each stage, pocket depth (PD), gingival index (GI), and plaque index (PI) were measured.\u0000Results: There was an increase in PD, GI, and PI after space maintainers were placed. Following oral hygiene education (with and without the use of a PDA), PD, GI, and PI significantly decreased in both groups.\u0000Conclusion: PDAs are effective for improving oral hygiene, especially in young children; however, training should be repeated at frequent intervals to maintain good, continuous oral hygiene.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141104621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0