European Journal of Therapeutics最新文献

{"title":"The Relationship Between the Resected Colon Length and the Number of Lymph Nodes in Colorectal Cancer: A Retrospective Cohort Study","authors":"Ulaş Karabay, Latif Yılmaz, Alper Aytekin, Aziz Bulut","doi":"10.58600/eurjther1862","DOIUrl":"https://doi.org/10.58600/eurjther1862","url":null,"abstract":"Objective: The prognostic factors that are important for colorectal cancer are the pathological grade of the tumor and the existence of lymph node involvement. Currently, the curative treatment option is resection of the tumor with adequate length and margin along with complete dissection of lymph nodes draining the site of resection. Our study investigated into retrieving adequate lymph nodes for accurate staging as well as the relationship between lymph nodes and colon and rectum specimen length. Methods: This retrospective cross-sectional study examined the correlation between resected colon length and lymph node count in people with colorectal cancer diagnosed between January 2010 and June 2018. We defined a cutoff value for the segment length to be resected to allow adequate staging of the tumor. Furthermore, we examined the relationship between the resected segment lengths and survival. Results: Of the patients who were included in this study, 211 were men and 169 were women. The mean resected colon length was 26.47±17.09 cm and the mean dissected lymph node count was 29.05±20.84. There was a positive correlation between specimen length and total lymph node count as well as specimen length and the existence of reactive lymph nodes that were statistically significant (r=0.319, p=0.001; r=0.312, p=0.001, respectively). In our study, tumor localization was described in three regions: the right colon, left colon and rectum. The mean right colon region specimen length was 28.8±15.5 cm, while it was 22.0±11.0 cm for the left colon region, and 21.7±10.6 cm for the rectum region. The 5-year overall survival rate was 53.2%, whereas the 5-year disease-specific survival rate was 58.2%. Conclusion: The mean specimen length to achieve the cutoff value for adequate lymph node retrieval (least 12 lymph nodes) was 16 cm in our study (ROC curve, AUC=0.689±0.05, p=0.001). The resected colon length and the number of retrieved lymph nodes were positively correlated in our study. Based on this confirmation, a cutoff value of 16 cm was calculated to achieve an adequate segment length to be resected.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting Treatment Compliance of Patients With COPD During the COVID-19 Pandemic","authors":"Sibel Doğru, Füsun Fakılı, Sema Aytaç, Cengizhan Sezgi, Mahşuk Taylan, Nazan Gülhan Bayram, Meral Uyar","doi":"10.58600/eurjther1752","DOIUrl":"https://doi.org/10.58600/eurjther1752","url":null,"abstract":"Objective: This study aimed to investigate the effects of difficulties experienced in the follow-up and treatment during the Coronavirus 2019 pandemic (COVID-19p), which included COVID-19 phobia and depression, on treatment compliance in patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: This study included 123 patients with COPD. The COVID-19 Phobia Scale (C19P-S), Beck Depression Inventory (BDI), and Medication Adherence Report Scale (MARS) were used to assess the patients. Results: The mean age of patients with COPD was 64.56 ± 9.31 years. It was determined that our patients did not maintain regular outpatient follow-up mostly because of the fear of COVID-19 transmission (75.9%). Overall, 24% of our patients showed treatment noncompliance. A statistically significant relationship was found between COPD stages B and D and treatment compliance (p=0.01). Patients with frequent emergency department admissions (p = 0.01) and those with high BDI (p = 0.01) and C19P-S (p = 0.02) scores during the pandemic were found to have reduced treatment compliance. Conclusion: Patients with COPD with COVID-19 phobia, and depression had reduced treatment compliance. İt is necessary to be aware of these conditions and to plan appropriate interventions.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135432976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline Sodium-Glucose Cotransporter-2 Inhibitor Use Strongly Attenuates the Uric Acid-Elevating Effect of Thiazide Exposure","authors":"Alper Tuna Güven, Murat Özdede, Yusuf Ziya Şener","doi":"10.58600/eurjther1889","DOIUrl":"https://doi.org/10.58600/eurjther1889","url":null,"abstract":"Objective: Thiazide diuretics are among the major anti-hypertensive medications. However, their hyperuricemic effect restricts their use in patients with gout. Sodium glucose co-transporter 2 inhibitor (SGLT-2i) initiation lowers serum uric acid (SUA) levels. It is not known whether existing SGLT-2i use affects the SUA increasing effect of thiazides. Methods: Post-hoc data analysis of our published study was conducted. Hypertensive patients who were initiated on thiazide diuretics or whose dose escalated were included (thiazide exposure). Demographic, clinical, and laboratory data were acquired via an electronic database. Patients were grouped according to SGLT-2i presence at the time of thiazide exposure. Since the number of SGLT-2i users was low, bootstrapping via simple random sampling was performed. Results: 144 patients were included in the study, of whom 13 were on SGLT-2i. Initial sample analysis revealed that while baseline SUA levels were similar between groups, SUA change was significantly lower after thiazide exposure among patients receiving SGLT-2i (0.6 vs. 0.2, p = 0.039). Similarly, baseline SUA levels were similar, but SUA change after thiazide exposure was significantly lower among patients receiving SGLT-2 on bootstrapped data (0.13 [-0.25 - 0.57, 95%CI], vs. 0.61 [0.45 - 0.78, 95%CI], mean difference = 0.48, [0.04 - 0.91, 95%CI], p = 0.029). Conclusion: This study revealed that thiazide diuretics may be a safe anti-hypertensive medication in terms of hyperuricemia among patients using SGLT-2i. Further studies with similar outcomes may result in the elimination of restrictive recommendations for the use of thiazides in patients with hyperuricemia or gout, provided patients are on SGLT-2i.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135432978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Effects of Platelet Indices in Cirrhotic Patients with or without Portal Vein Thrombosis","authors":"Filiz Araz, Barış Soydaş","doi":"10.58600/eurjther1832","DOIUrl":"https://doi.org/10.58600/eurjther1832","url":null,"abstract":"Objective: Portal vein thrombosis (PVT) is a common finding in liver cirrhosis. Besides low portal blood flow, thrombophilia, bacterial translocation and endotoxemia, platelets which are considered as important source of prothrombotic agents may play a role in thrombotic events in cirrhosis. Large platelets have been reported to have numerous granules that result in greater thrombotic and proinflammatory activity. We aimed to define the role of platelet indices in PVT among cirrhotic patients. Method: Cirrhotic patients admitted to Gastroenterology Clinic and having a dynamic radiological examination were assessed retrospectively. Demographic and laboratory findings were recorded including platelet distribution width (PDW) and mean platelet volume (MPV). Severity of cirrhosis was assessed with MELD (Model for End Stage Liver Disease) and Child-Pugh-Turcotte (CPT) scores Results: Study included 255 patients. Mean age was 60.6±10.2 years. 41.6% of patients were female. 50 (19.6%) patients had PVT. Patients with PVT did not differed from those without PVT in age, gender and presence of diabetes mellitus. Median platelet count was lower in patients with PVT (100 (22-370) vs 79,5 (22-573), p: 0,033). Mean MPV and PDW levels were similar between PVT and non-PVT groups (p >0.05). Although median MELD scores did not differ between groups, median CPT scores were significantly higher in PVT compared to non-PVT group (p:0,027). Conclusion: Cirrhotic patients with PVT had more prominent thrombocytopenia, but similar MPV and PDW levels compared to those without PVT.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135475716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zero Draft: A First Step in Research Writing","authors":"Waqar Naqvi, Purva Gulrandhe","doi":"10.58600/eurjther1815","DOIUrl":"https://doi.org/10.58600/eurjther1815","url":null,"abstract":"The zero draft, often termed as the preliminary, unpolished version of a research paper, holds a pivotal role in the research process. Despite its initial status, this early draft offers myriad benefits to researchers. One crucial advantage is its ability to enhance clarity of thought. It compels authors to critically evaluate their research question, objectives, and methodologies, ensuring focused and purposeful work [1]. Additionally, it aids in identifying gaps in the research, shedding light on areas requiring further development or exploration. Furthermore, crafting a zero draft promotes efficiency in time management, providing authors with a clear blueprint for judicious resource allocation. Overcoming writer's block is another advantage, as this initial draft breaks down the task into manageable segments, facilitating the writing process. Moreover, a well-crafted zero draft can serve as a robust foundation for potential publication in academic journals or conferences [1]. To create an effective zero draft, researchers should follow a methodical approach. This involves defining the research question, establishing a comprehensive outline, presenting data or findings succinctly, providing detailed descriptions of research methods, summarising pertinent literature, highlighting contributions to the field, offering a preliminary analysis of discoveries, proposing potential avenues for future research, and ensuring accurate citation of all sources while actively seeking feedback from peers [2]. In conclusion, the zero draft, though initially raw, plays a pivotal role in the research process. It fosters clarity of thought, aids in identifying research gaps, promotes collaboration, streamlines time management, assists in overcoming writer's block, and lays the groundwork for potential publication. By adhering to a systematic approach, researchers can fully harness the potential of their zero drafts to advance their research endeavors effectively.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135584910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Ancient Mythology to Modern Technology: The Historical Evolution of Artificial Intelligence","authors":"Yaşar Kemal Duymaz, Şamil Şahin","doi":"10.58600/eurjther1895","DOIUrl":"https://doi.org/10.58600/eurjther1895","url":null,"abstract":"Dear Editors, Recently, a fascinating article detailing the evolution of Artificial Intelligence (AI) was published, as the article describes it with the bronze creature Talos from ancient Greek myths and the groundbreaking DaVinci Si and DaVinci Xi surgical systems of the modern era [1]. The interaction of ancient myths and medical technology shows how far we have come but how deeply we remain connected to our past. As the article emphasizes, Talos, described in ancient Greek literature, may be the world's first recorded concept of an automaton with Artificial Intelligence capability. Talos, created by the god Hephaestus, used his bronze form and inner fire to patrol the coasts of Crete and deter invaders [2]. The story of a machine that moves independently, driven by an energy source and following specific instructions, is astoundingly pioneering [2]. It is interesting to think that robots, an idea we usually think of as a modern concept, were present in the imagination of ancient civilizations. Leonardo da Vinci's robot knight is a moving tribute to the versatile genius of the Renaissance [3]. However, since its operation depends on external intelligence, it is not a direct precursor to the AI we know today. The article makes this distinction. However, A claim that has been presented is open to discussion. Naming AI surgical tower da Vinci is misleading, article suggests. Although Leonardo's automaton was not autonomous, its extensive notebooks testify to a questioning and innovative mind that was always pushing boundaries. In this sense, it feels appropriate to mention the name of Da Vinci, a technological marvel. The underlying sentiment is concurred with. Hephaestus' creation of Talos offers a more direct line to the concept of autonomous machines and perhaps it deserves a more prominent position in the story of the history of Artificial Intelligence. Highlighting this overlooked intersection of mythology, history, and technology is commendable. Such discussions highlight the importance of understanding our past while understanding our rapidly evolving present and future. Sincerely yours,","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135634650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal ZnT3 (SLC30A3) Levels Reflect Hippocampal Tissue Damage in Chronic Exercising Diabetic Rats","authors":"Abdulkerim Kasim Baltaci, Mehmet Yasli, Saltuk Bugra Baltaci, Rasim Mogulkoc, Esma Menevse, Omer Unal","doi":"10.58600/eurjther1874","DOIUrl":"https://doi.org/10.58600/eurjther1874","url":null,"abstract":"Objective: In this study, it was investigated how chronic exercise affects hippocampus tissue damage and ZnT3 levels in diabetic rats. Methods: The 40 adult rats wereused in the study were divided into 4 equal groups: Control (G1), Exercise Control (G2), Diabetes (G3), Diabetes+Exercise (G4). Diabetes was induced in animals in G3 and G4 by injecting intraperitoneal streptozotocin (STZ) twice, 24 hours apart. The animals in G2 and G4 were runedon the rat treadmill for 45 minutes daily for 4 weeks. MDA (spectrophotometric method) and ZnT3 (ELISA method) levels were determined in hippocampus tissue samples obtained from animals sacrificed at the end of the experimental procedures. Results: In the current study, the highest MDA and lowest ZnT3 levels in the hippocampus tissue were obtained in the diabetes group (G3) (P<0.05). Chronic exercise prevented increased hippocampal tissue damage in diabetic rats and reversed decreased ZnT3 levels (P<0.05). Conclusion: The results of our study showed that 4 weeks of chronic exercise could be prevent increased tissue damage in the hippocampus tissue of diabetic rats and ameliorate the decreased ZnT3 levels. The data obtained in this study indicate that ZnT3 levels in diabetic rats may be an indicator of hippocampal tissue damage.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135584477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Head and Maxillofacial Injuries: FIFA World Cup 2022 Report","authors":"Ricardo Grillo, Alexandre Borba, Mariana Brozoski, Kamran Ali, Sahand Samieirad, Essam Al-Moraissi, Maria da Graça Naclério-Homem","doi":"10.58600/eurjther1873","DOIUrl":"https://doi.org/10.58600/eurjther1873","url":null,"abstract":"Objectives: The aim of this study is to analyze the incidence, causes and consequences of head and maxillofacial injuries in the 2022 FIFA World Cup. Methods: This retrospective study, following the STROBE guideline, conducted an online investigation during the 2022 World Cup, with a specific focus on injuries resulting in player substitutions or absences of at least one match. To mitigate potential injury exaggeration, journalistic reports were prioritized over video analysis. The analysis of injuries involved the utilization of descriptive statistics, the Kolmogorov-Smirnov test, and the Pearson correlation test, with a significance threshold set at p<0.05. The analytical tools Microsoft Excel and RStudio were employed. Comparative insights were derived from previous FIFA World Cup data; however, injuries lacking sufficient recovery time were classified as preseason injuries, potentially introducing an element of bias to the analysis. Results: During the FIFA World Cup 2022, a comprehensive analysis revealed a total of 123 injuries leading to player substitutions or subsequent game absences, of which seven were localized in the head or maxillofacial region. Statistical analysis indicated a departure from normal data distribution, and a robust correlation was observed between the number of players in national leagues and injury incidence. Noteworthy is the participation of 42 distinct national soccer leagues in contributing players to the tournament's national squads, with no specific league demonstrating a predisposition to higher injury rates. Within the dataset, three maxillofacial injuries were identified. It is of interest that five athletes opted for facemasks as protective measures for the maxillofacial region, and remarkably, only one of them experienced an injury during the World Cup but subsequently resumed play in subsequent matches, while the remaining four athletes had sustained injuries prior to the tournament. Conclusion: The 2022 FIFA World Cup was associated with a low number of head and maxillofacial injuries, with collisions with other players being the most common cause. Despite their limited occurrence, these injuries can have severe implications. In response to the increase in concussions, FIFA implemented an improved safety protocol, which involves immediate game halts for medical assessment and allows player substitutions without affecting the team's allotted substitutions. This change has been well-received by stakeholders. Furthermore, the use of protective equipment, such as custom-made shields, is growing in popularity and has the potential to reduce injury severity and shorten recovery time. Modern technology enables the creation of comfortable and effective protective gear, enhancing player safety. Overall, the study emphasizes the importance of injury prevention strategies in sports, calling for continued advancements in protective equipment design and increased transparency in injury reporting.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic Diagnosis of a Non-Pigmented Skin Tumor: Eccrine Poroma","authors":"Hasan Aksoy, Filiz Cebeci Kahraman, Melek Aslan Kayıran, Vefa Aslı Erdemir, Mehmet Salih Gürel, Bengü Çobanoğlu Şimşek","doi":"10.58600/eurjther1886","DOIUrl":"https://doi.org/10.58600/eurjther1886","url":null,"abstract":"Dear Editor, Eccrine poroma stands as a benign adnexal neoplasm that originates from the acrosyringium. It typically emerges as solitary, flesh-colored, or erythematous papules, plaques, or nodules, primarily appearing in areas with sweat glands. As well as pigmented lesions, dermoscopy has proven to enhance the clinical diagnosis of numerous non-pigmented skin tumors, including eccrine poroma. Herein we present a case of eccrine poroma located on the dorsal aspect of the left foot, with characteristic dermoscopic features. A 60-year-old woman was admitted with an asymptomatic lesion on the dorsum of her left foot, which had manifested approximately four years before. Clinically, the lesion presented as a well-circumscribed, violaceous, 0.9x0.9 cm papule (Figure 1a). Dermoscopic examination revealed flower-like and leaf-like vascular patterns, white interlacing areas, glomerular vessels, and milky red globules (Figures 1c-d). The lesion was excised and histopathologic findings were consistent with eccrine poroma (Figure 1b). Eccrine poroma (EP) is an adnexal tumor originating in the intraepidermal part of the eccrine sweat gland duct. Dermoscopy and histopathology help to differentiate EP from pyogenic granuloma, seborrheic keratosis, verruca vulgaris, basal cell carcinoma, squamous cell carcinoma, and amelanotic melanoma. Well-defined dermoscopic features in EP are: White interlacing areas around vessels, milky-red globules, flower-like and leaf-like vascular patterns, glomerular vessels, hairpin vessels, yellow structureless areas, poorly visualized vessels, and well-circumscribed globular or lacuna-like structures separated by white to pink mesh bands [1-3]. Histologically, EP manifests as a well-contained tumor constituted of proliferative cuboidal or poroid cells, often extending from the basal epidermis into the dermal layer. Shave, electrosurgical destruction or simple excision may be the treatment of lesions, depending on the depth of the lesion. Kind Regards","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Bio-based Cements and Radioactive Opacifiers in Endodontic Approaches: A Review of the Materials Used in Clinical Practice","authors":"A.Najah Saud, Erkan Koç, Olcay Özdemir","doi":"10.58600/eurjther1849","DOIUrl":"https://doi.org/10.58600/eurjther1849","url":null,"abstract":"Objective: This study aims to evaluate the importance of endodontic root canal sealers in filling cavities and irregularities in root canals with the primary goal of minimizing or eliminating bacterial residues. Despite this crucial objective, it's noteworthy that several conventional sealers have been linked to adverse effects, such as impaired wound healing, inflammation, and bone resorption. Therefore, there is a constant search for an optimal sealer that can effectively mimic the properties of lost tissue while maintaining an acceptable level of biological, physicochemical and biocompatible properties. The present study analyzes bioceramic cement's properties in endodontics through a comprehensive review of the available literature. Also, to evaluate the beneficial properties and characteristics of the biomaterials highlighted in this work. Methods: The present study used a systematic review approach to conduct a comprehensive literature search to find relevant publications on bioceramic cement properties in the endodontics field. Articles were retrieved using MeSH keywords and digital searches of journal websites. The selected studies were examined to extract data on sealability, bioactivity, pH, cytotoxicity, color change, radiopacity, edge adaptation, adhesive strength, antibacterial properties and biocompatibility. Results: The results of the reviewed research show that bioceramic endodontic cement has favorable properties for the therapeutic treatment of root canals. The literature highlights the material's biocompatibility, low cytotoxicity, bioactivity, radiopacity, appropriate pH value, favorable edge adaptation, high adhesive strength, practical sealability, antibacterial properties and minimal color change. Conclusion: Research results to date indicate that biomaterials used in endodontics have beneficial properties for root canal therapy and mimicking natural tissue regeneration. The beneficial properties of these materials, such as their biocompatibility, bioactivity, radiopacity, pH stability, edge conformability, adhesion strength, sealability and antibacterial properties, make it a promising replacement for traditional sealers. Further studies are needed to investigate the extended clinical effectiveness of the above intervention and to refine its composition to improve the outcomes associated with endodontic therapies.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135197946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}