European Journal of Therapeutics最新文献_第9页

The Effect of MitoTEMPO on Rat Diaphragm Muscle Contraction Parameters in an Experimental Diabetes Model Induced with Streptozotocin MitoTEMPO 对链脲佐菌素诱导的实验性糖尿病模型中大鼠膈肌收缩参数的影响

IF 0.3

European Journal of Therapeutics Pub Date : 2023-12-10 DOI: 10.58600/eurjther1912

Ahmet Akkoca, S. Tuncer, M. Çelen, N. Dalkılıç

{"title":"The Effect of MitoTEMPO on Rat Diaphragm Muscle Contraction Parameters in an Experimental Diabetes Model Induced with Streptozotocin","authors":"Ahmet Akkoca, S. Tuncer, M. Çelen, N. Dalkılıç","doi":"10.58600/eurjther1912","DOIUrl":"https://doi.org/10.58600/eurjther1912","url":null,"abstract":"Objective: Diabetes Mellitus (DM) not only causes hyperglycemia but also leads to clinical challenges involving respiratory functional impairments. The contraction of the diaphragm reduces pleural pressure, thereby contributing significantly to the process of breathing. This study examines the functional impairments in diaphragm muscle isometric contraction parameters due to increased reactive oxygen species (ROS) associated with DM, as well as the effects of MitoTEMPO, a mitochondria-specific antioxidant, on these impairments.\u0000Methods: Wistar Albino male rats at 12-14 weeks of age were randomly divided into three groups: the control group (CON, n=6), the diabetes group (DM, n=6), and the diabetes + MitoTEMPO (MT, n=6) group. A single dose of 50 mg/kg streptozotocin (STZ) was administered to the rats in the DM and MT groups. When the rats in the MT group reached a blood glucose level of 300 mg/dl, they were administered MitoTEMPO at a dose of 0.7 mg/kg/day for 28 days. Isometric contraction recordings were obtained from diaphragm muscle preparations isolated from the experimental animals at the end of the 28-day period.\u0000Results: Although the effectiveness of mitochondria-specific antioxidants in reducing blood glucose levels in DM is debated in the literature, results for the MT group were interestingly indicative of a statistically significant decrease in blood glucose levels following MitoTEMPO administration at the end of the fourth week. Furthermore, MitoTEMPO exhibited therapeutic effects on diaphragm muscle contraction parameters impaired by DM.\u0000Conclusion: The findings suggest that in DM patients, MitoTEMPO could be utilized for blood glucose control and might also be effective in the treatment of DM-induced diaphragm muscle mechanical dysfunction.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue 2.45 千兆赫射频暴露对青春期前大鼠睾丸组织脂质过氧化相关结构变化的影响

IF 0.3

European Journal of Therapeutics Pub Date : 2023-12-06 DOI: 10.58600/eurjther1875

Aysegul Karadayi, Nilufer Akgun Unal, Elif Gulbahce Mutlu, Begum Korunur Engiz, Ahmet Akkoca, Salih Varol

{"title":"Effects of Exposure to Radiofrequency at 2.45 GHz on Structural Changes Associated with Lipid Peroxidation in Prepubertal Rat Testicular Tissue","authors":"Aysegul Karadayi, Nilufer Akgun Unal, Elif Gulbahce Mutlu, Begum Korunur Engiz, Ahmet Akkoca, Salih Varol","doi":"10.58600/eurjther1875","DOIUrl":"https://doi.org/10.58600/eurjther1875","url":null,"abstract":"Objective: The increasing use of electronic devices, accompanied by advancing technologies, has led to heightened exposure to non-ionizing electromagnetic radiation (EMR). This exposure instigates the accumulation of free radicals and oxidative damage in tissues, consequently impacting biological systems. Notably, the testis is among the tissues adversely affected by EMR. Numerous studies have highlighted the pivotal role of the testis in sperm production, emphasizing the potential implications of any damage on the reproductive system. This study aims to assess the levels of lipid peroxidation through histological evaluation in the testicular tissue of prepubertal male rats exposed to electromagnetic radiation at varying electric field intensities within the 2.45 GHz radiofrequency (RF) range.\u0000Methods: The experimental group comprises six subdivisions, including a sham control group, as well as groups exposed to varying electric field strengths (EFS) of 0.6 V/m, 1.9 V/m, 5 V/m, 10 V/m, and 15 V/m, respectively. Excluding the sham control group, the remaining subgroups were subjected to a daily 2.45 GHz RF exposure for 1 hour starting immediately after fertilization. This exposure to different electric field intensities continued for 45 days post-birth.\u0000Results: The samples obtained from the RF radiation-exposed rats exhibited elevated malondialdehyde (MDA) values and decreased glutathione (GSH) values in the testicular tissue. Furthermore, a comparative analysis between the microwave radiation-exposed group and the control group revealed distinct histological alterations in the testicular tissue.\u0000Conclusion: In conclusion, our findings indicate that exposure to microwave radiation at an electric field intensity of 15 V/m can lead to significant histopathological and oxidative parameter changes in Wistar rats. These results underscore the potential effects of such exposure on human health.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Different Dentin Desensitizers and Self- Adhesive Resin Cement on Shear Bond Strength: In Vitro Study 不同牙本质脱敏剂和自粘树脂粘接剂对剪切粘接强度的影响：体外研究

IF 0.3

European Journal of Therapeutics Pub Date : 2023-12-06 DOI: 10.58600/eurjther1892

Işıl Keçik Büyükhatipoğlu, Derya Gürsel Sürmelioğlu

{"title":"The Effect of Different Dentin Desensitizers and Self- Adhesive Resin Cement on Shear Bond Strength: In Vitro Study","authors":"Işıl Keçik Büyükhatipoğlu, Derya Gürsel Sürmelioğlu","doi":"10.58600/eurjther1892","DOIUrl":"https://doi.org/10.58600/eurjther1892","url":null,"abstract":"Objectives: The aim of this study is to evaluate and compare the bond strength of different dentin desensitizers and self-adhesive resin cements to dentin surfaces.\u0000Methods: The flat dentin surfaces of 72 wisdom molar teeth were randomly divided into six groups for bond strength analysis (n=12): Group CP: No desensitizer + Primer II A&B+ Panavia F 2.0, Group CM: No desensitizer+ Primer A&B+ Multilink N, Group TP: Tokuyama Shield Force+ Primer II A&B + Panavia F 2.0, Group TM: Tokuyama Shield Force + Primer A&B+ Multilink N, Group UP: Universal dentin sealant + Primer II A&B+ Panavia F 2.0 and Group UM: Universal dentin sealent + Primer A&B+ Multilink N. The shear bond strength test was performed using a universal testing machine (0.5 mm/min). ANOVA test was used to detect significant differences at a p < 0.05.\u0000Results: The results indicated that bond strength values varied according to the desensitizing and resin cement materials (p < 0.05). The Tokuyama Shield Force desensitizer did not affect the bond strength of the resin cements to dentin (p > 0.05).\u0000Conclusion: The different types of dentin desensitizer applications affected on the shear bond strength results of the self-adhesive resin cements.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship Between Odontogenic Cyst and P53 Codon 72 And P53 Codon 175 Variants in Turkish Patients 土耳其患者牙源性囊肿与 P53 密码 72 和 P53 密码 175 变体之间的关系

IF 0.3

European Journal of Therapeutics Pub Date : 2023-12-06 DOI: 10.58600/eurjther1911

Mehmet Kemal Tümer, Adem Keskin, Recai Acı, S. Yıgıt

{"title":"The Relationship Between Odontogenic Cyst and P53 Codon 72 And P53 Codon 175 Variants in Turkish Patients","authors":"Mehmet Kemal Tümer, Adem Keskin, Recai Acı, S. Yıgıt","doi":"10.58600/eurjther1911","DOIUrl":"https://doi.org/10.58600/eurjther1911","url":null,"abstract":"Objective: Odontogenic cysts that cause bone destruction can exhibit various types of metaplasia. Inherited genetic variants in codons 72 and 175, the hotspot codons of p53, known as the guardian of the genome, can cause a wide variety of cancers. We aimed to investigate the effects of the p53 codon 72 and p53 codon 175 variants on odontogenic cyst formation.\u0000Methods: This research encompassed 71 individuals with odontogenic cysts and 90 without any conditions as a control group. After DNA was extracting, the p53 codon 72 was detected using PCR techniques, while p53 codon 175 was identified through allele-specific amplification-PCR.\u0000Results: The presence of the p53 codon 72 GG genotype and its G allele was less frequent in the group with odontogenic cysts compared to the healthy participants. Conversely, the C allele was found more often in the cyst-afflicted group. For the p53 codon 175, the AA genotype and A allele were more common in the affected group, while the G allele was more predominant in the control group.\u0000Conclusion: The p53 codon 175 AA genotype and A allele, p53 codon 72 C allele, and p53 codon 72/codon 175 CCAA combined genotype may be associated with odontagenic cyst formation. Individuals with this allele and genotype can be considered at risk for odontagenic cyst formation.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138595870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro Diagnosis of Approximal Caries in Teeth Periapical Radiography with Different Exposure Parameters 不同曝光参数下牙齿根尖周 X 射线近端龋的体外诊断

IF 0.3

European Journal of Therapeutics Pub Date : 2023-12-06 DOI: 10.58600/eurjther1900

O. Altun, Duygu Çelik Özen, N. Dedeoğlu, Ş. Duman, Gözde Eşer, Edanur Topaloğlu, Begüm Özemre, Kardelen Demirezer

{"title":"In-vitro Diagnosis of Approximal Caries in Teeth Periapical Radiography with Different Exposure Parameters","authors":"O. Altun, Duygu Çelik Özen, N. Dedeoğlu, Ş. Duman, Gözde Eşer, Edanur Topaloğlu, Begüm Özemre, Kardelen Demirezer","doi":"10.58600/eurjther1900","DOIUrl":"https://doi.org/10.58600/eurjther1900","url":null,"abstract":"Objective: The aim of this study was to evaluate periapical radiographs of enamel caries, dentin caries, and deep caries with exposed pulp and intact teeth obtained in vitro using photo-stimulated phosphor plates (PSP) under different exposure parameters.\u0000Methods: 3 non-carious extracted molars were selected. The obtained molars were embedded in the wax created from pink wax by ensuring approximal contact and a base was created. 14 different imaging protocols were used with 60 kVp, 4 mA 0.02-0.1 second and 70 kVp 7 mA, 0.25-1.25 second exposure parameters. Intact teeth were imaged with these various imaging protocols. Artificial cavities were then created for enamel caries, dentin caries and deep caries with exposed pulp and imaged according to the same protocols. The images were evaluated by 3 clinicians who were blind to the exposure protocol and caries status. Inter-observer agreement with actual situations was examined with Kappa statistics.\u0000Results: In the low-dose group, the kappa values of observer 1, observer 2, and observer 3 were 0.905, 0.952, 0.952, respectively. The kappa values of observer 1, observer 2, and observer 3 in the ultralow-dose group were 0.833, 1, 1, and the kappa values of observer 1, observer 2, and observer 3 in the high-dose group were 1, 1, 0.833, respectively. The results obtained in all groups showed a statistically significant-excellent agreement (p<0.001).\u0000Conclusion: Approximal caries can be diagnosed with intraoral radiography obtained with low radiation doses with PSP in dentistry. Thus, patients could be exposed to less ionizing radiation.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and Topographical Features of the Radial Recurrent Artery and Its Possible Clinical Significance 桡侧回旋动脉的形态和地形特征及其可能的临床意义

IF 0.3

European Journal of Therapeutics Pub Date : 2023-12-06 DOI: 10.58600/eurjther1908

Latif Sağlam, Ö. Gayretli, O. Coşkun, İ. Gürses, B. Çandir, Aysi˙n Kale, Adnan Öztürk

{"title":"Morphological and Topographical Features of the Radial Recurrent Artery and Its Possible Clinical Significance","authors":"Latif Sağlam, Ö. Gayretli, O. Coşkun, İ. Gürses, B. Çandir, Aysi˙n Kale, Adnan Öztürk","doi":"10.58600/eurjther1908","DOIUrl":"https://doi.org/10.58600/eurjther1908","url":null,"abstract":"Objective: The anatomy of the radial recurrent artery (RRA) is very important for interventional procedures. The aim of this study was to investigate the morphological and topographic anatomy of the RRA.\u0000Methods: The study was conducted on 20 human cadavers (14 male and 6 female, 40 upper limbs). The RRA was classified into 4 groups as follows according to the observed origin: RRA originated from the radial artery (RA) (Type A), the root of the RA (Type B), the brachial artery (BA) (Type C), and the ulnar artery (UA). The relative positioning of the RRA in relation to the biceps brachii muscle tendon (TBB), in terms of the antero-posterior direction was determined. The vertical distance of the origin point of the RRA to the intercondylar line and the diameters of this artery were determined. Morphometric evaluation was performed with a digital caliper. The obtained data were analyzed using SPSS version 21.00 software.\u0000Results: The artery most commonly originated from the RA (Type A 47.5%, 19 extremities). This was followed by RA root (Type B 32.5%, 13 extremities), BA (Type C 17.5%, 7 extremities), and UA (Type D 2.5%, 1 extremity). The RRAs coursed anteriorly to the TBB in 38 extremities (95%) and passed behind the tendon in 2 extremities (5%). The vertical distance of the origin point of the RRA to the intercondylar line was meanly 32.20 ±6.86 mm. The diameter of the artery at its origin point was meanly 2.57 ± 0.58 mm and just after its first branch was meanly 2.05 ± 0.48 mm. Our study documents a rare morphological variation of the RRA originating from the UA (Type D).\u0000Conclusion: While many of our findings align with previous studies, this research presents novel anatomical findings and elucidates the superficial course and topographical positioning of the RRA to estimate its origin point.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red Cell Distribution Width Is an Independent Predictor of 1-Year Mortality in a Turkish Patient Population with Acute Decompensated Heart Failure 红细胞分布宽度是土耳其急性失代偿性心力衰竭患者 1 年死亡率的独立预测因子

IF 0.3

European Journal of Therapeutics Pub Date : 2023-11-26 DOI: 10.58600/eurjther1803

Umit Yuksek

{"title":"Red Cell Distribution Width Is an Independent Predictor of 1-Year Mortality in a Turkish Patient Population with Acute Decompensated Heart Failure","authors":"Umit Yuksek","doi":"10.58600/eurjther1803","DOIUrl":"https://doi.org/10.58600/eurjther1803","url":null,"abstract":"Objective: Heart failure (HF) is a significant public health issue in Turkey. The goal of this study was to look into how red cell distribution width (RDW) affected patients with acute decompensated HF (ADHF) patients' prognoses. Methods: A total of 101 ADHF patients under the age of 18 were enrolled in the study. Venous blood was drawn to measure the serum rdw. After a year of follow-up, the patients' survival status was determined. Results: The patients' mean age was 72. Forty-nine patients had heart failure (HF) with a reduced ejection fraction (EF), 8 had HF with a mildly reduced EF, and 44 had HF with a preserved EF. The median RDW value was 15.9%. In the hospital, nine patients passed away, and 92 others were discharged. 14 patients were lost to follow-up after one year, 87 patients completed the trial, and 40 patients passed away. Inotropic medication use, and serum RDW value were identified as independent predictors of 1-year death in ADHF patients by multivariate logistic regression analysis. According to this data, there was a 44% increase in 1-year mortality for every 1% increase in RDW. Conclusion: In Turkish patients hospitalized for ADHF, red cell distribution width represents an independent prognostic predictor for 1-year mortality.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139235044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Herbal Products/Dietary Supplements and Affecting Factors in Patients Applying to a Pediatric Neurology Outpatient Clinic: A Descriptive Questionnaire Study 儿科神经病学门诊患者使用草药产品/膳食补充剂的情况及其影响因素：描述性问卷调查研究

IF 0.3

European Journal of Therapeutics Pub Date : 2023-11-20 DOI: 10.58600/eurjther1858

İçim Gökkaya, Tuğba Subaş, Gülin Renda, Sevim Şahin, U. Özgen, Nihal Yıldız, Ali Cansu

{"title":"The Use of Herbal Products/Dietary Supplements and Affecting Factors in Patients Applying to a Pediatric Neurology Outpatient Clinic: A Descriptive Questionnaire Study","authors":"İçim Gökkaya, Tuğba Subaş, Gülin Renda, Sevim Şahin, U. Özgen, Nihal Yıldız, Ali Cansu","doi":"10.58600/eurjther1858","DOIUrl":"https://doi.org/10.58600/eurjther1858","url":null,"abstract":"Objectives: The use of herbal products/dietary supplements (HP/DS) in the pediatric population is increasing day by day. The interaction of HP/DSs with drugs with a narrow therapeutic index such as phenytoin, phenobarbital, and valproic acid, may cause problems in treatment. In this respect, it is very important to determine the use of HP/DS in children with neurological diseases and/or complaints. In this study, it was aimed to determine the use of HP/DS and the factors affecting the use of these products in individuals with a neurological complaint and/or disease who applied to the pediatric neurology outpatient clinic. Methods: Parents were questioned face-to-face as part of the descriptive questionnaire research. 174 questionnaires with appropriate data quality were included in the study. The statistical software tool SPSS 23.0 was used to analyze the data. Results: 44.6% of the parents stated that they gave HP/DS to their children. The findings of the analysis showed that kids whose parents use HP/DS are more likely to utilize these items themselves (p<0.001). The most commonly used products are linden (70.1%), bee products (26.0%), carob (18.2%), chamomile (13.0%), and lemon (13.0%). It has been determined that the reasons for parents to have their children use HP/DS are to strengthen the immune system (51.9%), improve general health status (40.3%), and supplement normal nutrition (27.3%), respectively. Conclusions: This study revealed a high frequency of HP/DS use in children with pediatric neurological diseases/complaints in Türkiye. The frequency of HP/DS use was higher in children whose parents tended to consume HP/DS. Considering the high use of these products, healthcare professionals need to inform parents to prevent adverse effects caused by HP/DS.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139259402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blocking the Apelin Receptor (APJ) Attenuates TNBS-Induced Colitis in Rats 阻断杏仁蛋白受体 (APJ) 可减轻 TNBS 诱发的大鼠结肠炎

IF 0.3

European Journal of Therapeutics Pub Date : 2023-11-20 DOI: 10.58600/eurjther1883

I. Birsen, Osman Sinen, Simla Su Akkan, I. Üstünel, V. İzgüt-Uysal, Prof. Dr. V. Nimet, Simla Su, PhD Akkan

{"title":"Blocking the Apelin Receptor (APJ) Attenuates TNBS-Induced Colitis in Rats","authors":"I. Birsen, Osman Sinen, Simla Su Akkan, I. Üstünel, V. İzgüt-Uysal, Prof. Dr. V. Nimet, Simla Su, PhD Akkan","doi":"10.58600/eurjther1883","DOIUrl":"https://doi.org/10.58600/eurjther1883","url":null,"abstract":"Objective: The apelinergic system, consisting of apelin, ELABELA, and the apelin receptor (APJ), has a wide range of roles in physiological and pathophysiological processes in tissues. The effects of increased apelin and APJ as an indicator of damage in inflammatory conditions or as a compensatory mechanism are not fully clear in inflammatory bowel disease (IBD). This study was designed to assess the role of APJ in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Methods: Colitis in adult male Wistar rats were induced by intrarectally administered TNBS (30 mg b.w. in 50% ethanol). While the control group was treated with only saline to the colon, the TNBS+F13A and F13A groups received the APJ antagonist F13A (30 µg/kg/day, i.v.) for 3 days, starting immediately after TNBS or saline administration, respectively. Results: A decrease in body weight and an increase in colon weight/length ratio and stool consistency score were observed in the TNBS group. TNBS caused an increase in the myeloperoxidase (MPO) activity and the number of proinflammatory cytokines (TNF-α, IL-1β, and IL-6), as well as apelin production, leading to mucosal ulceration, necrosis, and submucosal edema in the colon. While F13A administration to the control did not cause any change in the colon, F13A administration immediately after TNBS greatly reduced the effects of TNBS. Conclusion: APJ is involved in the development of damage in colitis induced by TNBS. F13A reduces the level of damage, inflammatory cell infiltration, and MPO enzyme activity. APJ may be a therapeutic target in IBD.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of the Renal Artery Anatomy: In Chronic Kidney Disease and Healthy Individuals 肾动脉解剖回顾：慢性肾病和健康人的肾动脉解剖

IF 0.3

European Journal of Therapeutics Pub Date : 2023-11-20 DOI: 10.58600/eurjther1854

Gülsüm Derya Aktaş, Nadire Ünver Doğan, Gülperi Çelik, Mustafa Koplay, Z. Fazlıoğulları, İbrahim Altındaş, A. Karabulut

{"title":"Review of the Renal Artery Anatomy: In Chronic Kidney Disease and Healthy Individuals","authors":"Gülsüm Derya Aktaş, Nadire Ünver Doğan, Gülperi Çelik, Mustafa Koplay, Z. Fazlıoğulları, İbrahim Altındaş, A. Karabulut","doi":"10.58600/eurjther1854","DOIUrl":"https://doi.org/10.58600/eurjther1854","url":null,"abstract":"Objective: The purpose of this study was to evaluate renal arteries and aorta anatomy in patients with chronic kidney disease (CKD) and compare them with a control group. Methods: Computed tomography images of 800 individuals (551 of that were with CKD and 249 of them were completely healthy in terms of urinary system) were evaluated retrospectively. Age range of the individuals 19 - 91 years (mean 61.15 ± 12.58). The differences between the renal arteries diameters, diameters of aorta, courses of the renal arteries, their separation levels from the aorta was investigated between the control group and patients with CKD. Results: Diameters of aorta and renal arteries are statistically significantly larger in CKD patients than healthy individuals and there was a negative correlation between the diameters of aorta with glomerular filtration rate. No statistically significant difference was observed between CKD patients and healthy individuals in terms of renal artery course. No statistically significant difference was detected between CKD patients and healthy individuals in terms of the branching level of the renal arteries from the aorta. Conclusion: Our study is one of the first studies which these measurements were made in individuals with CKD, according to the available literature. This study is important in that it reveals that the diameters of the renal arteries and aorta is statistically significantly larger in patients with CKD than in healthy individuals. These data may be important for the surgeons in interventional applications.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139259000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0