European Journal of Therapeutics最新文献

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Assessment of Extruded Root Canal Filling Materials in Single-Rooted Teeth Using Cone Beam Computed Tomography 锥形束计算机断层扫描评价单根牙挤压根管充填材料的应用
IF 0.3
European Journal of Therapeutics Pub Date : 2023-08-16 DOI: 10.58600/eurjther1720
Emre Çulha, F. Tunç
{"title":"Assessment of Extruded Root Canal Filling Materials in Single-Rooted Teeth Using Cone Beam Computed Tomography","authors":"Emre Çulha, F. Tunç","doi":"10.58600/eurjther1720","DOIUrl":"https://doi.org/10.58600/eurjther1720","url":null,"abstract":"Objective: Overfilling a root canal has a negative influence on the prognosis of teeth with apical periodontitis. This study proposed to assess extruded sealer and gutta-percha in single-rooted teeth within a Turkish subpopulation using cone-beam computed tomography.\u0000Methods: The study included cone-beam computed tomography scans of 2,346 endodontically treated teeth with a single root and foramen from a private dental clinic's archive. Teeth were divided into four groups: maxillary anteriors, mandibular anteriors, mandibular premolars, and maxillary second premolars. Two endodontists analyzed the scans at all planes and recorded information pertaining to tooth number, tooth type, and presence of extrusion. To examine the data, a chi-square test with a 0.05 p-value was performed.\u0000Results: Extrusion was detected in 256 (10.91%) of the single-rooted teeth. There was significant difference among the groups (p<0.05). Extrusion was significantly higher in the maxillary anteriors than in the other tooth groups. Maxillary second premolars had lower extrusion compared to the other tooth groups. There was no statistical relationship between the maxillary anterior tooth groups and the presence of extrusion (p=0.338).\u0000Conclusion: Maxillary anteriors had higher root canal filling material extrusion than the other tooth groups, while maxillary second premolars had lower extrusion.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"49 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85415605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperinsulinemic Hypoglycemia in Childhood 儿童期高胰岛素性低血糖症
IF 0.3
European Journal of Therapeutics Pub Date : 2023-08-15 DOI: 10.58600/eurjther1758
Özhan Orhan, M. Özbek
{"title":"Hyperinsulinemic Hypoglycemia in Childhood","authors":"Özhan Orhan, M. Özbek","doi":"10.58600/eurjther1758","DOIUrl":"https://doi.org/10.58600/eurjther1758","url":null,"abstract":"Hyperinsulinemic Hypoglycemia (HH) is the most common cause of permanent hypoglycemia, especially in the neonatal period. Childhood HH is mostly related to genes encoding proteins in the insulin secretion pathways, and may also be seen in syndromes such as Beckwidth Wiedemann, Kabuki, and Turner. The majority of congenital HH cases are the result of KATP channel gene defect. Most of these cases are unresponsive to diazoxide treatment. In this review, recent genetic studies and recent updates in treatment options in childhood HH are reviewed.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"4 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89598125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological and Morphometric Variations of the Hyoid Bone in Anatolian Population 安纳托利亚人群舌骨形态学和形态计量学差异
IF 0.3
European Journal of Therapeutics Pub Date : 2023-08-14 DOI: 10.58600/eurjther1721
Gkionoul Nteli Chatzioglou, Elif Toklu, Elif Bayraktar, A. Ertaş, Ayşin Kale, O. Coşkun, A. Öztürk, Ö. Gayretli
{"title":"Morphological and Morphometric Variations of the Hyoid Bone in Anatolian Population","authors":"Gkionoul Nteli Chatzioglou, Elif Toklu, Elif Bayraktar, A. Ertaş, Ayşin Kale, O. Coşkun, A. Öztürk, Ö. Gayretli","doi":"10.58600/eurjther1721","DOIUrl":"https://doi.org/10.58600/eurjther1721","url":null,"abstract":"Objective: The morphological and morphometric variations of the hyoid bone (os hyoideum) are known to be significant in cervical surgeries and also serve as important evidence in forensic cases involving hanging and strangulation. The aim of this study is to investigate the morphological and morphometric differences of the hyoid bone.\u0000Methods: Sixty-four adult hyoid bones of unknown age and gender were used in our study. Ethical approval for the study was obtained from the Istanbul Faculty of Medicine Clinical Research Ethics Committee (date/number: 15.12.2021/632888). The bone shape variations were classified into four main groups: D, U, B, and V types according to the morphometric measurements of the hyoid bone. Also the hyoid bones were evaluated based on their symmetry and isometry properties. Morphometric measurements were analyzed for reliability and repeatability using TEM, rTEM, and R tests, with the same person measuring twice. Measurements were calculated using the Image J program. The data were analyzed using SPSS v.21.\u0000Results: The percentages of D, U, B, and V types were found to be 53.84%, 23.07%, 15.38%, and 11.53%, respectively. Among the hyoid bones, 34 (53.12%) were found to be asymmetrical, 30 (46.88%) symmetrical, 35 (54.69%) anisometric, and 29 (45.31%) were isometric.\u0000Conclusion: Our study's results indicate that the hyoid bone of Anatolian individuals exhibits morphological differences compared to other populations. Understanding the morphological and morphometric values of the hyoid bone can contribute to clinical and forensic applications.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"11 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78844540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence: From Talos to da Vinci 人工智能:从塔洛斯到达芬奇
European Journal of Therapeutics Pub Date : 2023-08-14 DOI: 10.58600/eurjther1775
Konstantinos Christodoulou, Gregory Tsoucalas
{"title":"Artificial Intelligence: From Talos to da Vinci","authors":"Konstantinos Christodoulou, Gregory Tsoucalas","doi":"10.58600/eurjther1775","DOIUrl":"https://doi.org/10.58600/eurjther1775","url":null,"abstract":"The mythical bronze creature Talos (Greek: Τάλως) was worshiped initially as the god of light or the sun in the Hellenic Island of Crete. He is supposed to have lived in the peak Kouloukona of the Tallaia Mountains in the Gerontospelio cave. His relation towards bronze and fire and his continuous voyage circling the island of Crete most probably introduces the concept of the change of the four seasons. The sun was considered in the area of the South-East Mediterranean nations as just judge, a guardian who monitors and judges from above all the actions of the commoners, a controller for the faithful application of laws in Crete [1]. Hesychios in his Lexicon notes that talos means sun and that the name Tallaios was initially attributed to Zeus [2]. The birth of the Olympian gods forged a new Pantheon and nomenclature forcing some of the old gods to fell into lower deities. This happened to Talos who soon became a mythical hero [1]. According to Apollodorus, the bronze creature was forged by the magnificent constructor Hephaestus as a gift to the mythical King Minoa to help him guard the island [3]. Although the verb “peritrohazo” (Greek: περιτροχαζω) was used, meaning a movement in a steady orbit (track), some depictions image him as a winged being. To protect the island, he was throwing rocks into unknown ships or in the case of a foreign landing he was burning with fire or with his flamed bronze body the intruders. He was holding copper plates with the laws of the island and his circle allowed him to pass all island sores three times daily [1,4-6]. Plato, speaks of him as a real person, suggesting he was the brother of King Rhadamanthys, thus a son of Zeus [5]. Talos may be considered as the token of the Cretan power, a symbol of technological development in the field of metalworking in prehistoric and Minoan times. An animated, programmed gigantic android to enforce its will. A primitive robot for basic actions having a power source, fire and ichor (Greek: ιχώρ) the sacred fluid in the vessels of the gods. The first manufactured being with his individual intelligence, a primary concept of artificial intelligence (AI) [7]. Homer was the first to introduce the term automata (Greek: αυτόματα), to describe ingenious machines built by the supreme blacksmith god of invention and technology, God of metal and fire, Hephaestus, manufactured devices “acting of one’s own will” as the Hellenic word indicates [8]. Eons later, the humanoid automaton the “Automa cavaliere” (English: Automaton knight) appeared in the court of the nobleman and Duke of Milan Ludovico Maria Sforza. It was the year 1495, when Leonardo da Vinci presented his robotic knight, an innovative construction operated by a series of pulleys and cables, presenting though no individual mind. Although it was manufactured by a highly intelligent polymath, it could only be operated through an outer intelligence [9]. Advancements made during the Fourth Industrial Revolution allowed modern technolo","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135214679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence Co-Authorship: Perspectives on Scientific Accuracy and Responsibility 人工智能合著者:科学准确性和责任的观点
IF 0.3
European Journal of Therapeutics Pub Date : 2023-08-14 DOI: 10.58600/eurjther1770
Ayşe Bahşi, Çağatay Küçükbingöz
{"title":"Artificial Intelligence Co-Authorship: Perspectives on Scientific Accuracy and Responsibility","authors":"Ayşe Bahşi, Çağatay Küçükbingöz","doi":"10.58600/eurjther1770","DOIUrl":"https://doi.org/10.58600/eurjther1770","url":null,"abstract":"Dear Editors,\u0000Amidst the rapid advancements in artificial intelligence tools, we have read the editorials published in your journal on the subject of “artificial intelligence and academic articles” with great interest [1, 2]. First and foremost, we would like to express our gratitude for fostering an essential platform for discourse on this current topic. Thank you for creating a significant environment for discussion.\u0000The rapid advancements emerging in artificial intelligence tools undoubtedly promise significant contributions not only in various fields but also in the realm of science. However, just as in scientific progress, it is clear that the opportunities supporting science and enabling its advancement are also evolving. For instance, had we sent this letter to your journal thirty years ago, we might have needed to send it through postal mail. Alternatively, if our writing had been published in your journal twenty years ago, we could have read it in hard copy rather than in an online environment. Similarly, had we been practising medicine hundreds of years ago, we wouldn't have had the capability to do anything for patients that we can easily treat today with the aid of ultrasound guidance in the operating room.\u0000It is highly likely that in the future, thanks to artificial intelligence tools, many tasks will become significantly more efficient and practical. From this perspective, we believe that incorporating artificial intelligence tools into the realm of science is a necessity. However, as you have also pointed out in your editorial articles [1, 2], we believe that the inclusion of artificial intelligence tools as authors in academic research is a significant topic of debate. Based on our current knowledge and perspective, we believe this situation may not be entirely appropriate.\u0000We believe that one of the most crucial points of contention regarding the inclusion of artificial intelligence tools as authors in academic research is the concept of “accuracy”. Artificial intelligence provides us with information it finds on the internet. Whether these sources are genuinely obtained from reputable journals cannot be definitively determined. This poses a significant challenge in ensuring the accuracy of such contributions. This also suggests that articles written by artificial intelligence may not be sufficiently reliable. For instance, when we input “the lumbar transforaminal injection method” into ChatGPT, it provides a lot of information on the topic. However, when asked for references, it responds with, “The information I provide is based on a vast dataset of text from a wide range of sources available on the internet, including books, websites, research papers, and more.” Indeed, it can also retrieve information from virtual and/or fake accounts. In essence, as of now, artificial intelligence lacks a truth filter similar to that of a human. While artificial intelligence facilitates rapid access to information, the uncertainty arising fro","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"53 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81890161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Multiple Eruptive Dermatofibromas in a Patient with Primary Sjögren’s Syndrome 原发性Sjögren综合征患者多发发疹性皮肤纤维瘤
IF 0.3
European Journal of Therapeutics Pub Date : 2023-08-14 DOI: 10.58600/eurjther1745
M. Kaya, D. Tecer, S. Yılmaz
{"title":"Multiple Eruptive Dermatofibromas in a Patient with Primary Sjögren’s Syndrome","authors":"M. Kaya, D. Tecer, S. Yılmaz","doi":"10.58600/eurjther1745","DOIUrl":"https://doi.org/10.58600/eurjther1745","url":null,"abstract":"Multiple eruptive dermatofibromas (MEDF) are rare tumors and thought to be associated with the disturbances in the immune system. In our 40-year-old case, 5 nodules have developed in a 4-month period. The patient was diagnosed by a dermatologist to have MEDF, and referred to rheumatology outpatient clinic because of the symptoms such as dry mouth, and polyarthralgia. After clinical and laboratory evaluation, the diagnosis of primary Sjögren’s syndrome (SS) was made. According to the best of our knowledge, this case is the first reported association between MEDF and primary SS. Therefore, when the diagnosis of MEDF is made, SS should also been included in the comprehensive evaluation of associated diseases.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"93 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83817773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Follow-up of Artificial Intelligence Development and its Controlled Contribution to the Article: Step to the Authorship? 人工智能发展的后续及其对文章的受控贡献:迈向作者?
IF 0.3
European Journal of Therapeutics Pub Date : 2023-08-11 DOI: 10.58600/eurjther1733
Ekrem Solmaz
{"title":"Follow-up of Artificial Intelligence Development and its Controlled Contribution to the Article: Step to the Authorship?","authors":"Ekrem Solmaz","doi":"10.58600/eurjther1733","DOIUrl":"https://doi.org/10.58600/eurjther1733","url":null,"abstract":"Dear Editors,\u0000I am excited to see a current discussion in this journal [1]. In another editorial article, the questions and answers directed to Chat Generative Pre-Trained Transformer (ChatGPT), an artificial intelligence (AI) product, about the authorship process contributed to my idea of conducting a similar study [2]. In addition, addressing the editorial question, the second answer partially satisfied me because it was more innovative. Although the answers of ChatGPT in this article are apparent in the text, their contribution is not included in the footnote, explanation, acknowledgment, or reference; in some studies, it is shown in the footnote [3]; in some, it is included in the acknowledgment section [4]. Such contributions or the nature of the support received should also be evaluated and clearly stated. Which section should be included for AI-enabled content such as ChatGPT? Since accessing the previous accesses is impossible, it may be better to copy them to a visual or open access place instead of giving them a reference in the sources.\u0000Although many subjects need to be read further and a detailed examination is required, a brief description of the working mechanism should be made. AI's deep learning is to experiment with a given set of inputs and outputs and make suggestions, and when it encounters a new input, it gives it an appropriate output. As I analyze the book chapters [5] that examine the success of AI programs in the process of inventing, producing art, and doing the work of different professional groups, such as lawyers or doctors in some fields, with appropriate learning algorithms, I think that they may have a promising potential for the future in terms of writing articles. In an environment without prejudice, such as the Turing test, there has been much discussion about the superiority of intelligence only when compared to the machine [5]. In addition, the fact that AI provides a contribution whose authorship cannot be detected by similarity or plagiarism programs, which are different software products, makes this situation difficult to understand.\u0000In one of the studies contributing to this editorial correspondence, various AI examples with different functions and more capabilities are given, apart from ChatGPT. In addition, while drawing attention to the trust problem, margin of error, and differences in the level of development between programs, it was emphasized that the suitability of using AI applications for general and simple service operations such as article language editing to reduce financial costs should be treated without prejudice [6]. Another article stated that the support to be received from AI after the article was written would be more reliable, controlled, and risk-free [7]. The article that questioned AI's identity on philosophical and ethical grounds was also remarkable [8]. In a different approach, it was stated that with the increase of pseudoscience authors, scientific and unethical situations may","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"58 2 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86068624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Moderator Effect of Chronic Disease on The Relationship Between Marriage Adjustment and Satisfaction in Married Couples 慢性病对已婚夫妇婚姻适应与满意度关系的调节作用
IF 0.3
European Journal of Therapeutics Pub Date : 2023-08-10 DOI: 10.58600/eurjther1722
Feyza Inceoğlu, Esra Porgalı Zayman
{"title":"Moderator Effect of Chronic Disease on The Relationship Between Marriage Adjustment and Satisfaction in Married Couples","authors":"Feyza Inceoğlu, Esra Porgalı Zayman","doi":"10.58600/eurjther1722","DOIUrl":"https://doi.org/10.58600/eurjther1722","url":null,"abstract":"Objective: The purpose of our study is to show how the relationship between marital adjustment and satisfaction will change in cases of chronic disease in either or both spouses of married couples using a multivariate statistical analysis method.\u0000Methods: Marriage adjustment ve marriage satisfaction scales were used. A structural equation modeling - multiple group analysis method was used in the study, which was designed as a relational screening model.\u0000Results: In the study, which included 898 participants, 56.6% of the participants were female and 43.4% were male. The mean age of the participants was 36.94 ± 8.72 standard deviations. First, the relationship between marital adjustment and satisfaction was analyzed using structural equation modeling, and the relationship between the scales was found to be statistically significant (p=0.001). In the model, which was significant and sufficient, the variable of chronic disease was coded on the arrow representing the regression coefficient between the scales, and multiple group analysis was applied. The relationship between marital adjustment and satisfaction was found to be weak among individuals with chronic diseases. The rate of marriage satisfaction explaining marriage adjustment was lower in individuals without chronic disease (R2=0.16) than in those without chronic disease (R2=0.10). While ego scores were not significant in individuals without chronic disease (p=0.237), they were statistically significant in individuals with chronic disease (p=0.017).\u0000Conclusion: Chronic diseases has been found to have a significant impact on the relationship between spouses. Many studies have examined the effects of chronic diseases on marriage. However, our study differs from other studies because of the analytical methods used. In the scales, it was determined whether the chronic disease showed a change in the relationship between the scales, not the scores in the chronic disease state.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"43 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79006081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Clinical Characteristics and Prognosis of Exon 2 Mutations in Familial Mediterranean Fever 家族性地中海热外显子2突变的临床特征和预后
European Journal of Therapeutics Pub Date : 2023-08-10 DOI: 10.58600/eurjther1739
Begüm Avcı, Gönül Parmaksız, Feride Şahin, Aytül Noyan
{"title":"The Clinical Characteristics and Prognosis of Exon 2 Mutations in Familial Mediterranean Fever","authors":"Begüm Avcı, Gönül Parmaksız, Feride Şahin, Aytül Noyan","doi":"10.58600/eurjther1739","DOIUrl":"https://doi.org/10.58600/eurjther1739","url":null,"abstract":"Objective: It is unclear whether exon 2 mutations are variations or a mutations that causes the disease. This study aimed to evaluate the clinical features and prognosis exon 2 mutations in Familial Mediterranean Fever. Methods: The clinical features, disease severity and prognosis of all patients with at least one exon 2 mutations were evaluated retrospectively. These data were compared seperately for homozygous (Group 1), heterozygous (Group 2), compound heterozygous (Group 3), and complex alleles (Group 4), and the data were compared by grouping patients into those with and without exon 10 mutations. Results: There were a total of 119 patients with exon 2 mutations, including 11.7% in Group 1, 36.1% in Group 2, 21.8% in Group 3, and 30.2% in Group 4 were similar in terms of demographic data, clinical characteristics, and disease course. When compared patients with exon 10 mutations (+) to those with exon 10 mutations (-), the exon 10 mutations (+) group had a higher presence of chest pain (100%, p=0.02) and a significantly higher mean Pras severity score (6.66±1.87, 6.01±1.40; p=0.02). Additionally, a higher number of patients with exon 10 mutation (-) achieved remission with treatment (76 (67.9%), 36 (32.1%); p=0.03). Conclusion: Exon 2 mutations have a milder course and higher remission rates but they should be considered as Familial Mediterranean Fever disease because of their similar clinical presentation and response to colchicine treatment with exon 10 mutations. Early treatment and close follow-up should be performed.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135492605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hormonal Status Comparison of Unilateral and Bilateral Adrenal Adenomas: Are They the Same? 单侧和双侧肾上腺腺瘤的激素水平比较:它们是一样的吗?
IF 0.3
European Journal of Therapeutics Pub Date : 2023-08-09 DOI: 10.58600/eurjther665
Burak Özbaş, A. Gökçay Canpolat, Cansu Özbaş, D. Çorapçıoğlu, M. Şahin
{"title":"The Hormonal Status Comparison of Unilateral and Bilateral Adrenal Adenomas: Are They the Same?","authors":"Burak Özbaş, A. Gökçay Canpolat, Cansu Özbaş, D. Çorapçıoğlu, M. Şahin","doi":"10.58600/eurjther665","DOIUrl":"https://doi.org/10.58600/eurjther665","url":null,"abstract":"Objective: It is not yet clear whether unilateral/bilateral adenomas are different in terms of both functionality and etiology. We investigated whether there were differences in hormonal profiles and evaluate the cortisol secretion profiles of unilateral and bilateral adenomas.\u0000Methods: Hormonal secretory profiles and clinical features of patients with adenomas were collected. Detailed evaluation was made in terms of hypercortisolemia.\u0000Results: Of the 184 patients examined, 140 had unilateral and 44 had bilateral adenomas. 73% of the patients were female and the mean body mass index was 34±8.1kg/m2. The mean age was 57.1±9.8 years. The average size of the adrenal masses was 23.3±10.5mm. While 83% of the evaluated adenomas were nonfunctional, ACS was found in 11% (n:20), hyperaldosteronism in 4% (n:8), and pheochromocytoma (PCC) in 2% (n:3) of the patients. The prevalence of ACS in bilateral/unilateral adenomas was 20.5%/7.9%, respectively. While serum adrenocorticotropic hormone level (25.6±16.6vs19.3±15µg/dL), urinary free cortisol level (162.3±108.3vs243.3±234.2µg/day), and low-dose-dexamethasone-suppression-test results (1.6±1.9vs1.73±1.7µg/dL) were not statistically different, the only difference between unilateral and bilateral adenomas was in serum DHEA-S level (141.4±85vs77.7±73.8 µg/dL, p:0.003).\u0000Conclusion: Although there is no significant difference between the two groups in terms of clinical findings, it is clear that ACS is more prevalent in bilateral adenomas than unilateral. Because of the negative effects of long-term hypercortisolism, precise management of ACS is noteworthy. The evaluation of ACS should be done more carefully in bilateral adenomas considering that ACS is more in bilateral adenomas than unilateral. According to our findings, we also suggest that DHEA-S may be an indicator for ACS.","PeriodicalId":42642,"journal":{"name":"European Journal of Therapeutics","volume":"22 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83349655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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