Polish Journal of Otolaryngology最新文献

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Susac syndrome - the current review of knowledge and own experience presentation. 苏萨克综合征-目前的知识回顾和自己的经验介绍。
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2023-01-31
Katarzyna Sikorska, Karolina Dżaman, Monika Woźniak
{"title":"Susac syndrome - the current review of knowledge and own experience presentation.","authors":"Katarzyna Sikorska,&nbsp;Karolina Dżaman,&nbsp;Monika Woźniak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Susac syndrome is a rare autoimmune vasculopathy involving the small precapillary arterioles of the brain, retina, and inner ear. It is characterized by a triad of symptoms: encephalopathy, visual disturbances due to obstruction of retinal artery branches, and sensorineural hearing loss. The study aimed to review the current medical knowledge on Susac syndrome and present our clinical experience regarding this disease entity. The paper also presents a case of a 25-year-old patient who was diagnosed with Susac&apos;s syndrome based on the clinical picture and the results of additional tests. This syndrome should be considered in the differential diagnosis of multiple sclerosis and other multifocal lesions of the central nervous system because early diagnosis of the disease and immunosuppressive treatment significantly alleviates its course and improves the prognosis.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 2","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9158014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of visits from otolaryngological patients before and during three waves of the COVID-19 pandemic: A retrospective study. 三波COVID-19大流行前和期间耳鼻喉科患者就诊特征:一项回顾性研究
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2023-01-22 DOI: 10.5604/01.3001.0016.2229
Joanna Cieslik, Jerzy Tomik
{"title":"Characteristics of visits from otolaryngological patients before and during three waves of the COVID-19 pandemic: A retrospective study.","authors":"Joanna Cieslik,&nbsp;Jerzy Tomik","doi":"10.5604/01.3001.0016.2229","DOIUrl":"https://doi.org/10.5604/01.3001.0016.2229","url":null,"abstract":"<p><strong>Introduction: </strong>COVID-19 pandemic has had a significant impact on healthcare systems around the world. The rapid spread of the virus caused several restrictions, including limited access to outpatient clinics. The purpose of the study was to compare the characteristics and reasons of the visits of otolaryngological patients conducted during the first three waves of the COVID-19 pandemic with those of the prepandemic period.</p><p><strong>Materials and methods: </strong>Volume, demographic data, type of visits, additional tests, referral types, and reasons for consultation were analyzed.</p><p><strong>Results: </strong>There were 1578 visits performed before the pandemic and, respectively, 434, 1198 and 1299 during the first, second and third waves. The patients in the first and second waves were older than the patients before the pandemic (mean age 59, 56, and 52 years, respectively, for both comparisons p&lt;0.0001). Regarding the type of visit, the vast majority were in-person visits in all groups. The highest percentage of teleconsultations was in the first wave and was equal to 3.46%. Before the pandemic, patients were admitted mainly due to upper respiratory system diseases (52.15%), while during the first wave the main reasons were tumors (39.86%, malignant and benign tumors comprised 29.26% and 10.6%, respectively).</p><p><strong>Conclusions: </strong>The COVID-19 pandemic, especially the first wave, changed the profile of ambulatory patients. In the first wave, a higher prevalence of tumor patients and a lower prevalence of patients with diseases of the upper respiratory system were observed. The COVID-19 pandemic caused an increase in number of teleconsultations, but its role was limited.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 2","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9321561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
PD-1 and PDL-1 gene expression in nasal polyp tissue from patients with asthma exacerbated by non-steroidal anti-inflammatory drugs correlates with the severity of the disease. 非甾体抗炎药加重哮喘患者鼻息肉组织中PD-1和PDL-1基因表达与疾病严重程度相关
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2023-01-22 DOI: 10.5604/01.3001.0016.2204
Katarzyna Malinowska, Anna Merecz-Sadowska, Milena Paprocka-Zjawiona, Jarosław Miłoński, Hanna Zielińska-Bliźniewska
{"title":"PD-1 and PDL-1 gene expression in nasal polyp tissue from patients with asthma exacerbated by non-steroidal anti-inflammatory drugs correlates with the severity of the disease.","authors":"Katarzyna Malinowska,&nbsp;Anna Merecz-Sadowska,&nbsp;Milena Paprocka-Zjawiona,&nbsp;Jarosław Miłoński,&nbsp;Hanna Zielińska-Bliźniewska","doi":"10.5604/01.3001.0016.2204","DOIUrl":"https://doi.org/10.5604/01.3001.0016.2204","url":null,"abstract":"<p><strong>Introduction: </strong>The clinical syndrome that includes asthma, nasal polyps and hypersensitivity to nonsteroidal anti-inflammatory drugs is referred to as airway disease exacerbated by nonsteroidal anti-inflammatory drugs. Patients usually have the most severe form of nasal polyps. Asthma and chronic rhinosinusitis with nasal polyps share a common inflammatory profile, involving type 2 helper T lymphocytes. T-cell activity can be inhibited via the programmed death receptor, PD-1, leading to modulation of the immune response. Therefore, the purpose of this study is to evaluate the expression of genes encoding PD-1 and its ligand PD-L1 in nasal polyp tissue in patients with asthma exacerbated by non-steroidal anti-inflammatory drugs and to correlate the results with clinical data.</p><p><strong>Material and methods: </strong>The material used for the study consisted of 54 tissue sections of nasal polyps. In the specimens, the expression of PD-1 and PD-L1 genes was determined at the mRNA level by qPCR. Statistical analysis was used to evaluate the results of the study.</p><p><strong>Results: </strong>The expression of PD-1 and PD-L1 genes in the tissue of polyps was statistically significantly higher than in the nasal mucosa of patients in the control group. In addition, there was a correlation between the expression of both genes at the mRNA level and the severity of nasal polyps in the paranasal sinuses analyzed from computed tomography images of the paranasal sinuses and assessed using the Kennedy scale.</p><p><strong>Conclusions: </strong>Determining the expression of PD-1 and PD-L1 genes may provide a marker for the severity of polypoid lesions. In addition, learning more about the PD-1/PD-L signaling pathway and how it can be modulated may provide a potential therapeutic strategy for patients with inflammatory diseases.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 2","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10759186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations of the external branch of the superior laryngeal nerve during its course and its importance in surgical approaches: an experimental cadaveric study. 喉上神经外支在手术过程中的变化及其在手术入路中的重要性:一项实验性尸体研究。
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2023-01-14 DOI: 10.5604/01.3001.0016.2167
Gkionoul Nteli Chatzioglou, Elif Sari, Özcan Gayretli, Osman Coşkun, Adnan Ozturk, İlke Ali Gürses
{"title":"Variations of the external branch of the superior laryngeal nerve during its course and its importance in surgical approaches: an experimental cadaveric study.","authors":"Gkionoul Nteli Chatzioglou,&nbsp;Elif Sari,&nbsp;Özcan Gayretli,&nbsp;Osman Coşkun,&nbsp;Adnan Ozturk,&nbsp;İlke Ali Gürses","doi":"10.5604/01.3001.0016.2167","DOIUrl":"https://doi.org/10.5604/01.3001.0016.2167","url":null,"abstract":"<p><strong>Introduction: </strong>Injury of the external branch of the superior laryngeal nerve can cause a hoarse or weak voice due to the functional loss (dysergia) of the cricothyroid muscle. Defining the anatomical variations of the external branch of the superior laryngeal nerve and estimating the frequency of it, it makes crucial for surgical interventions.</p><p><strong>Aim: </strong>To reveal the topography of the external branch in the Anatolian population, to prevent injury of it during the surgical intervention in the anterior neck region.</p><p><strong>Materials and methods: </strong>Twenty-six bilateral hemilarynges (4 females, 22 males) were dissected. The morphometric and morphological features of the external branch were examined. The obtained results were compared statistically left and right.</p><p><strong>Results: </strong>Landmarks such as the thyroid gland and laryngeal prominence were determined for the detection of the external branch. The variations of the course of the external branch and the points of piercing the cricothyroid muscle or inferior constrictor pharyngeal muscle were evaluated.</p><p><strong>Discussion: </strong>Although safe approaches have been described for nerve protection during neck surgeries, it can expose injuries during preliminary surgery approaches as the nerve is thinner and more superficial than other branches of the vagus nerve. However, it can be detected more easily and safely during the surgical approach by knowing the defined anatomical landmarks and morphological variations of the external branch.</p><p><strong>Conclusion: </strong>The anatomical variations described can be a safe and important guide in surgical approaches to be applied in the anterior neck region.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 2","pages":"1-4"},"PeriodicalIF":0.6,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10759189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of bioelectrical impedance analysis in monitoring patients with head and neck cancer after surgical intervention. 生物电阻抗分析在头颈部肿瘤手术后监测中的应用。
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2022-12-27 DOI: 10.5604/01.3001.0016.1853
Kamal Morshed, Radosław Mlak, Agata Smoleń
{"title":"Application of bioelectrical impedance analysis in monitoring patients with head and neck cancer after surgical intervention.","authors":"Kamal Morshed,&nbsp;Radosław Mlak,&nbsp;Agata Smoleń","doi":"10.5604/01.3001.0016.1853","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1853","url":null,"abstract":"<p><strong>Introduction: </strong>It is estimated that about 60% of patients with head and neck cancer (HNC) show poor nutritional status, and approximately 80% lose weight during treatment. The impact of surgical procedures on the risk of further weight loss, severe malnutrition and cachexia is a significant clinical problem that determines the higher incidence of postoperative complications, reduced effectiveness of the treatment used, longer hospitalization time, poor quality of life and higher mortality among patients. Bioelectrical impedance analysis (BIA) is currently recognized as a useful method of assessing the body composition and therefore the nutritional status of cancer patients. The aim of this study is to investigate whether measured and calculated parameters of BIA change shortly after surgery and could reflect the health of cells and body composition changes.</p><p><strong>Materials and methods: </strong>We enrolled 54 patients (males) with advanced HNC in this observational study. We collected detailed anthropometric and BIA derived data. The Subjective Global Assessment (SGA) was used to assess the nutrition.</p><p><strong>Results: </strong>In the assessment performed one week after the surgery, compared to the condition on the day of surgery, the patients had significantly lower values of nutritional status (weight; body mass index - BMI; SGA), body composition (free fat mass - FFM; intracellular fluid - ICF; total body water - TBW). Other changes include a significant increase in fat mass (FM) or extracellular fluid (ECF). Moreover, a significant reduction of phase angle (PA, one of the most important BIA derived prognostic factors) was also noted.</p><p><strong>Conclusions: </strong>Apart from the baseline assessment of the body composition and diagnosing nutritional disorders, it seems, that BIA should be considered also in the monitoring of HNC patients undergoing surgery.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 2","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10759187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allergic rhinitis - effective treatment according to the latest recommendations. 过敏性鼻炎-根据最新建议有效治疗。
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2022-12-15 DOI: 10.5604/01.3001.0016.1488
Magdalena Arcimowicz
{"title":"Allergic rhinitis - effective treatment according to the latest recommendations.","authors":"Magdalena Arcimowicz","doi":"10.5604/01.3001.0016.1488","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1488","url":null,"abstract":"<p><p>Allergic rhinitis (AR) is a common chronic respiratory disease, that affects millions of individuals, has significant impact on their quality of life, productivity, and other existing conditions, including asthma and conjunctivitis. Despite a substantial burden on individuals, society and health economies, AR remains under-diagnosed, under-estimated and under-treated. Main symptoms defining this IgE-dependent inflammation of nasal mucosa are: sneezing, itchy nose, rhinorrhoea and nasal congestion. Real-world data obtained by mobile technology offer new insights into AR phenotypes and therapy. Clinical management aims to relieve or control symptoms, resolve allergic inflammation, and potentially induce allergen tolerance, using allergen immunotherapy. Most cases of AR respond rather satisfied to pharmacotherapy. A very useful tool, especially recommended for everyday clinical practice, is VAS (visual analogue scale) which can help with: to assessing the intensity of AR symptoms as well as choosing the most optimal therapeutic option. Pharmacological treatment of the condition should be safe; effective and easy to administer as we treat patients with chronic condition, sometimes for a long time. Most frequently used treatment of AR include oral, intranasal or ocular antihistamines, intranasal corticosteroids or combined intranasal antihistamines and corticosteroids. Based on real-life clinical experience it can be concluded that a fixed combination of intranasal corticosteroid and intranasal antihistamines (mainly MP-AzeFlu) may be considered to be most beneficial, particularly in monotherapy and AR resistant to previous treatment. Some AR patients are not satisfied with provided treatment results when the disease becomes only partially controlled. We still have unmet patients needs and we are still looking for better therapeutic options in this area. New initiatives such as EUFOREA are developed in parallel with existing ones, such as ARIA to integrate patients and healthcare professionals in the therapeutic process and create new recommendations that are closest to the idea of precision medicine, delivering the right treatment to the right patient at the right time.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"76 6","pages":"45-59"},"PeriodicalIF":0.6,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Sudden death after operation, radiotherapy or chemoradiotherapy for head and neck cancer. 头颈癌手术、放疗或放化疗后猝死。
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2022-12-15 DOI: 10.5604/01.3001.0016.1487
Hiromi Nagano, Takayuki Kyutoku, Hayato Matsumoto, Yuichi Kurono
{"title":"Sudden death after operation, radiotherapy or chemoradiotherapy for head and neck cancer.","authors":"Hiromi Nagano,&nbsp;Takayuki Kyutoku,&nbsp;Hayato Matsumoto,&nbsp;Yuichi Kurono","doi":"10.5604/01.3001.0016.1487","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1487","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this report to determine sudden death following operation, radiotherapy (RT) or chemoradiotherapy (CRT) for head and neck cancer.</p><p><strong>Study design: </strong>Retrospective, observational, single-center.</p><p><strong>Methods: </strong>Data from 729 consecutive patients diagnosed with head and neck cancer (confirmed using multiple modalities) who underwent operation, RT or CRT at Kagoshima University Hospital between April 2011, and March 2020 were analyzed. A total of 199 patients underwent operation, 223 patients underwent RT and 307 underwent CRT. 175 patients who received operation, 118 patients who received RT and 190 who received CRT had a complete response.</p><p><strong>Results: </strong>There were 13 cases of sudden death reported in 10 years. 12 were male and one was female.Sudden death occurred in 3/175 patients (1.7%) who received operation, in 4/118 patients (3.4%) who had received RT and in 6/190 (3.1%) who had received CRT.</p><p><strong>Conclusions: </strong>We present the first report on cases of sudden death after operation, RT and CRT for head and neck cancer. Otolaryngologists should still follow these patients carefully after such treatment given that sudden death does occur in some patients.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 1","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10822930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the causes of the occurrence and treatment results of sudden hearing loss/deafness in the own material. 分析自身资料中突发性听力损失/耳聋的发生原因及治疗效果。
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2022-12-14 DOI: 10.5604/01.3001.0016.0050
Katarzyna Szkutnik, Jurek Olszewski
{"title":"Analysis of the causes of the occurrence and treatment results of sudden hearing loss/deafness in the own material.","authors":"Katarzyna Szkutnik,&nbsp;Jurek Olszewski","doi":"10.5604/01.3001.0016.0050","DOIUrl":"https://doi.org/10.5604/01.3001.0016.0050","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to analyze the causes of the occurrence and treatment results of sudden hearing loss / deafness in own material.</p><p><strong>Material and methods: </strong>The tests were performed in 64 women aged 10-89 years and 70 men aged 18-85 years, who were treated in the Department of Otolaryngology due to sudden hearing loss / deafness in 2011-2020. A retrospective analysis was carried out on the basis of the data contained in the medical documentation, taking into account: gender, age of patients, type of symptoms, establishing the circumstances and possible causes of the appearance of symptoms, audiological and imaging tests, the cause of the sudden hearing loss / deafness and applied treatment.</p><p><strong>Results: </strong>In the conducted research it was found that sudden hearing loss / deafness was the most common in women and men in the age range of 51-60 years and 61-70 years. Sudden hearing loss/ deafness was accompanied by the following symptoms in both women and men: tinnitus in 48,4% and 74,3%, tinnitus and vertigo in 28,1% and 14,3%, and vertigo in 6,3% and in 1,4%. In own research, the most common cause of sudden hearing loss/deafness in women and men was respectively: idiopathic cause in 43,8% and 40,0%, infectious in 18,8%, vascular in 12,4% and 12,9%, and neurovascular conflict (included separately) in 12,4% and 12,9%, while in men the acoustic trauma should also be mentioned in 18,5%. The best results in the treatment of sudden hearing loss / deafness on a three-point scale, which depends on the treatment method used, both in women and men, i.e. complete relief of symptoms obtained after the use of vascular drugs with steroid therapy and hyperbaric oxygen therapy - in 25,0% and 22,9%, partial relief of symptoms occurred after vascular treatment with steroid therapy - in 28,1% and 37,2%.</p><p><strong>Conclusions: </strong>Sudden hearing loss / deafness in both women and men was accompanied by tinnitus, tinnitus and vertigo and vertigo at the same time. In own research the most common cause of sudden hearing loss / deafness in both women and men was: idiopathic, infectious, vascular and neurovascular conflict. The best emergency treatment outcomes of sudden hearing loss / deafness according to a three-level scale, depending on the applied method of treatment, both in women and men, i.e. complete relief of symptoms was obtained after the use of vascular drugs with steroid therapy and hyperbaric oxygen therapyKey words: causes, occurrence, treatment results, sudden hearing loss / deafnes.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"76 6","pages":"22-29"},"PeriodicalIF":0.6,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low intensity whole-body oxidative stress in patients with parotid gland tumors. 腮腺肿瘤患者低强度全身氧化应激的研究。
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2022-12-14 DOI: 10.5604/01.3001.0016.1214
Pawel Sowa, Sławomir Kasperczyk, Adam Dadok, Maciej Misiołek, Monika Adamczyk-Sowa
{"title":"Low intensity whole-body oxidative stress in patients with parotid gland tumors.","authors":"Pawel Sowa,&nbsp;Sławomir Kasperczyk,&nbsp;Adam Dadok,&nbsp;Maciej Misiołek,&nbsp;Monika Adamczyk-Sowa","doi":"10.5604/01.3001.0016.1214","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1214","url":null,"abstract":"<p><p>Recently, there has been a significant increase in the number of patients hospitalized and undergoing surgery due to parotid gland tumors. We have observed an increase in the total number of salivary gland tumors, and hence an increased number of malignant tumors. Etiological factors of salivary gland tumors are still unknown. Oxidative stress (OS) has been suggested to be an important indicator of carcinogenesis in some tumors. Therefore, the aim of our study was to assess the state of OS in patients with selected benign and malignant parotid gland tumors. After final postoperative histological diagnosis of the tumor, patients were divided into the following groups i.e. pleomorphic adenoma 35 patients, Warthins tumor (WT) - 17 patients, mucoepidermoid carcinoma - 9 patients and 45 controls. The final study group included 106 patients. We found an increase in plasma lipofuscin levels in patients with all investigated parotid gland tumors. Furthermore, the activity of Cu/Zn-SOD in Warthins tumor patients was statistically lower compared to the controls, pleomorphic adenoma or mucoepidermoid carcinoma.In conclusion, we sustain the hypothesis on the presence of a low intensity whole-body OS in patients with parotid gland tumors. Furthermore, LPS may be a useful marker of OS in patients with benign and malignant tumors. Moreover, pathological mechanisms connected with WT seem to be different compared to malignant neoplasms and other benign tumors. It seems that Cu/Zn-SOD, as an antioxidative enzyme, may play an important role in those mechanisms taking part in WT.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 1","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10757948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Facial canal dehiscence in patients undergoing surgery for chronic otitis media: analysis of 850 patients. 慢性中耳炎手术患者面神经管破裂:850例分析。
IF 0.6
Polish Journal of Otolaryngology Pub Date : 2022-12-05 DOI: 10.5604/01.3001.0016.1772
Ilhan Topaloglu, Serhat Yaslikaya, Güler Berkiten
{"title":"Facial canal dehiscence in patients undergoing surgery for chronic otitis media: analysis of 850 patients.","authors":"Ilhan Topaloglu,&nbsp;Serhat Yaslikaya,&nbsp;Güler Berkiten","doi":"10.5604/01.3001.0016.1772","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1772","url":null,"abstract":"<p><p>ntroductionIn all otologic surgeries, the facial nerve can be considered the most important structure that must be protected. The surgical damage risk of the facial nerve will be increased in presence of facial canal dehiscence (FCD).AimIn this study, we aimed to evaluate the FCD and its associated situations in patients with chronic otitis media undergoing mastoidectomy.Materials and Methods850 patients who performed ear surgery were reviewed. Patients who did not perform mastoidectomy were excluded. In patients, the ratios, localization of FCD, and association of facial canal dehiscence with cholesteatoma were researched. Association between FCD and closed-cavity tympanomastoidectomy, open-cavity tympanomastoidectomy, and radical mastoidectomy procedures, and also an association between FCD and primary or revision surgery was evaluated. ResultsFacial canal dehiscence was found in 8.4% of patients. The relationship between dehiscence and cholesteatoma was found significant (p&lt;0.001). In the comparison of radical mastoidectomy and closed-cavity tympanomastoidectomy, dehiscence was higher in the radical mastoidectomy group (p&lt;0.03). In revision cases, dehiscence was seen more frequently (p&lt;0.003). FCD incidence was higher in adult patients than in pediatric patients (p&lt;0.001). Twenty of 468 patients who were operated on for cholesteatoma had congenital cholesteatoma. ConclusionFacial canal dehiscence can be seen especially in cases with cholesteatoma and when performing radical mastoidectomy and revision surgeries. Therefore, a detailed evaluation of the status of facial nerve and determination of situations in which occurrence of FCD is more likely both preoperatively and intraoperatively will minimalize potential complications.Keywords: Cholesteatoma, tympanic, radical mastoidectomy, oval window, tympanomastoidectomy.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 1","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9075343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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