Polish Journal of Otolaryngology最新文献

{"title":"Serum concentration of total sialic acids in patients with primary laryngeal carcinoma.","authors":"Izabela Bronikowska,&nbsp;Elżbieta Świętochowska,&nbsp;Robert Morawski,&nbsp;Wojciech Ścierski,&nbsp;Eugeniusz Czecior","doi":"10.5604/01.3001.0016.1094","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1094","url":null,"abstract":"<p><p>SummaryPurpose. The aim of the study was to evaluate serum concentrations of total sialic acids (TSA) in patients with squamous cell carcinoma of the larynx preoperatively and 4 years postoperatively and to compare the results with the serum concentration of sialic acids in patients with non-neoplastic laryngeal lesions.</p><p><strong>Methods: </strong>The study comprised 52 patients with squamous cell carcinoma of the larynx and 25 patients with non-neoplastic laryngeal lesions. Serum TSA concentrations were assessed in all patients preoperatively. Four years after surgery, serum TSA concentrations were assessed again in 21 patients from the study group in whom recurrence was not detected.</p><p><strong>Results: </strong>Significantly higher serum concentrations of TSA were found in patients with laryngeal cancer compared to the control group (p&lt; 0.0000001). Changes in TSA concentrations in the study group depended only on cancer grade (G). Significantly higher TSA concentrations were found in G3 patients. Such a relationship was not found for other parameters assessed. Alcohol consumption was the only important factor that affected TSA concentration in the control group. Significantly higher TSA concentrations were found in patients who admitted alcohol abuse. Significantly lower TSA concentrations were observed in patients with laryngeal cancer who were assessed 4 years postoperatively (p &lt; 0.000106).</p><p><strong>Conclusion: </strong>Serum concentration of TSA was increased significantly in laryngeal cancer and decreased significantly after several years of successful treatment. Further studies are warranted to assess the possibility of using sialic acids as a marker or target for immunotherapy.</p><p><strong>Key words: </strong>sialic acids, squamous cell carcinoma of the larynx, markers in laryngeal cancer, N-acetyl-5-neuraminic acid.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 2","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10759188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of acute rhinosinusitis in COVID-19 a post hoc analysis of a longitudinal study.","authors":"Zuzanna Steć,&nbsp;Zofia Burska,&nbsp;Eliza Brożek-Mądry,&nbsp;Marcin Straburzyński,&nbsp;Marta Waliszewska-Prosół,&nbsp;Antoni Krzeski","doi":"10.5604/01.3001.0016.1076","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1076","url":null,"abstract":"<p><strong>Background: </strong>Acute rhinosinusitis (ARS) is a common and well-defined disorder, primarily of viral aetiology, with rhinovirus and coronavirus accounting for more than 50% of viral ARS. The fight with COVID-19 pandemic resulted in an increased availability viral testing, which in turn allowed testing for presence of SARS-Cov-2 in all patients presenting common cold (or ARS) symptoms. The aim of this study was to assess the clinical characteristics of acute rhinosinusitis in patients diagnosed with COVID-19.</p><p><strong>Methodology/principal: </strong>This study is a post-hoc analysis. Patients symptoms were evaluated using a structured questionnaire twice: directly after a positive SARS-Cov-2 result and 7-12 days following the first evaluation. Subjects were asked about presence of nasal and systemic symptoms as well as headache.</p><p><strong>Results: </strong>A total of 130 COVID-19 symptomatic patients were recruited into the study, 58 (45%) patients met EPOS2020 diagnostic criteria for ARS. Of all ARS patients, 72% presented with rhinorrhoea, 69% with pain perceived over paranasal sinuses, 62% with nasal congestion, 52% with cough, 45% with olfactory dysfunction, 38% with fever, 33% with facial pressure and in 22% pain was exacerbated by sinus palpation.</p><p><strong>Conclusions: </strong>Half of COVID-19 subjects has ARS. The course of SARS-Cov-2 ARS does not seem to differ significantly from ARS of other aetiologies. Since ARS in the course of COVID-19 seems to meet the definition of ARS proposed by EPOS 2020, we hypothesize that substances validated for ARS treatment, such as intranasal corticosteroids could be effective in SARS-Cov-2 ARS.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 1","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10757946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very high concentrations of birch pollen in the air of selected Polish cities in 2022 - clinical implications.","authors":"Anna Rapiejko,&nbsp;Dariusz Jurkiewicz,&nbsp;Agnieszka Lipiec","doi":"10.5604/01.3001.0016.0832","DOIUrl":"https://doi.org/10.5604/01.3001.0016.0832","url":null,"abstract":"<p><strong>Introduction: </strong>In the Polish population, the most common cause of allergic rhinitis (AR) in the spring is birch pollen.</p><p><strong>Aim: </strong>The aim of this study was to assess the basic characteristics of the birch pollen season in selected cities in central and northern Poland including Warsaw, Piotrkow Trybunalski, and Bydgoszcz in 2022, considering their clinical implications.</p><p><strong>Material and method: </strong>Pollen monitoring was conducted using the volumetric method with the Hirst-type continuous volumetric sampler. Measurements were taken in 7-day cycles, and the microscopic analysis was performed for each 24-hour period. Results During the studied period, birch pollen posed a threat in the 2nd and 3rd decades of April and the 1st and 2nd decades of May. The birch pollination intensity was reflected by the very high values of maximum average daily pollen concentration 4102 pollen/m3 in Warsaw, 4389 pollen/m3 in Piotrkow Trybunalski, 3832 pollen/m3 in Bydgoszcz and the sum of the average daily pollen concentrations (i.e. Annual Pollen Integral, APIn) from 32439 in Bydgoszcz to 37638 in Warsaw, and long periods of exposure to high concentrations (2930 days).</p><p><strong>Conclusions: </strong>The pollen season 2022 is part of an alternating 2-year cycle of the birch pollen season intensity. The variability of parameters describing the dynamics of pollen seasons over years makes it necessary to monitor information on the pollen concentration in the air during the pollen season, both by the patients with inhalant allergy and their physicians.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"76 6","pages":"30-36"},"PeriodicalIF":0.6,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence, or just statistics done different?","authors":"Maciej J Wróbel,&nbsp;Bartosz Lewandowski","doi":"10.5604/01.3001.0016.0540","DOIUrl":"https://doi.org/10.5604/01.3001.0016.0540","url":null,"abstract":"<p><p>As interest in AI in medicine grows, so too does the need for education on the topic. Despite the technology itself being so close, our understanding of the essence of how it works remains remote. A greater, more judicious acceptance of AI tools can be fostered in medicine by a broader appreciation of what the technology can and cannot do.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"76 6","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual rhinomanometry based on computed tomography of the paranasal sinuses in patients with nasal septum deviation a pilot study.","authors":"Robert Chrzan,&nbsp;Joanna Szaleniec,&nbsp;Krzysztof Karbowski,&nbsp;Bartosz Kopiczak,&nbsp;Jolanta Gawlik,&nbsp;Jerzy Tomik,&nbsp;Tadeusz Popiela","doi":"10.5604/01.3001.0016.0539","DOIUrl":"https://doi.org/10.5604/01.3001.0016.0539","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the study was to compare the flow disturbances in computational fluid dynamics (CFD) technique based on computed tomography (CT) to the results of active anterior rhinomanometry (RMM), in patients with nasal septum deviation (NSD).</p><p><strong>Material and methods: </strong>In 24 patients with NSD, RMM and CT of the paranasal sinuses were performed as a part of typical clinical management. For each patient, 3D models of air-filled spaces in the nasal cavity were created, based on CT images, and air flow simulations during inhalation were performed using CFD technique. Correlations between RMM, both before and after anemization, during inspiration, and CFD were tested, independently for the left and right side.</p><p><strong>Results: </strong>The obtained correlation coefficients for the comparison of flow in RMM during inspiration and in CFD during simulated inspiration were: before anemization 0.46 for the left side and 0.52 for the right side, after anemization 0.65 for the left side and 0.61 for the right side (p &lt; 0.05).</p><p><strong>Conclusions: </strong>Moderate correlation was found between the results of real and virtual rhinomanometry, with higher correlation coefficients obtained after anemization, compared to the values before anemization.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 1","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10757947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of the Polish Universal Neonatal Hearing Screening Program 2021year review.","authors":"Grażyna Greczka,&nbsp;Monika Zych,&nbsp;Piotr Dąbrowski,&nbsp;Małgorzata Wierzbicka","doi":"10.5604/01.3001.0016.0051","DOIUrl":"https://doi.org/10.5604/01.3001.0016.0051","url":null,"abstract":"<p><p>The Polish Universal Neonatal Hearing Screening Program (PUNHSP) has been carried out in Poland for 20 years. Its main goal is to screen newborns for hearing. This examination is performed on the 2-3 days of a child&apos;s life, and in addition, information is collected on the risk factors for the development of hearing loss. In total, 486 centers participate in PPPBSuN at three reference levels. By the end of 2021, 7 million children were registered in the PPPBSuN Central Database. The most common type of hearing loss in children was bilateral sensorineural hearing loss, diagnosed in 2021 in 160 children. The report below presents the most important results and conclusions from the functioning of PPPBSuN in 2021.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"77 1","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10816191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and clinical characteristics of 407 salivary glands neoplasms in surgically treated patients in 2010-2020.","authors":"Weronika Jaremek-Ochniak,&nbsp;Julia Skulimowska,&nbsp;Iga Płachta,&nbsp;Tomasz Szafarowski,&nbsp;Wojciech Kukwa","doi":"10.5604/01.3001.0015.9816","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9816","url":null,"abstract":"<p><p>INTRODUCTION Tumors of the salivary glands account for approximately 3 to 4% of all head and neck neoplasms. It is estimated that 10-15% of them are malignant. The most common benign tumor is pleomorphic adenoma, while the most common malignant tumors are adenoid cystic carcinoma and mucoepidermoid carcinoma. Neoplasms of the salivary glands are extremely histologically diverse, which results from the complex embryogenesis of the salivary glands. The identified risk factors for tumors of the salivary glands are: ultraviolet radiation, ionizing radiation, viral infections, nicotine and alcohol. MATERIAL AND METHOD The aim of the study was an epidemiological analysis of patients with salivary gland neoplasms, the distribution and histopathological characteristics of individual neoplasms treated at the Department of Otorhinolaryngology of the Medical University of Warsaw in 2010-2020. The diagnoses were analyzed according to the latest WHO 2017 histological classification of salivary gland tumors. In addition, the material was supplemented with data on the 5-year survival rates of patients with malignant neoplasms obtained from the Registry of Marital Status. RESULTS AND DISCUSSION The material contained 407 neoplasms of the salivary glands over a 11-year period, of which malignant neoplasms accounted for 17.4%. The malignant tumors were dominated by: adenoid cystic carcinoma (28,2%), mucoepidermoid carcinoma (12,7%), and acinic cell carcinoma (9,9%). Lymphomas (15,5%) were also a large group. The benign neoplasms were dominated by pleomorphic adenoma (54.1%) and Warthin&apos;s tumor (36%). Tumors of the salivary gland the most often affected the parotid gland (92%). CONCLUSIONS The obtained data are consistent with the general epidemiological data described in the current literature.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"76 5","pages":"29-36"},"PeriodicalIF":0.6,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10569420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of positron emission tomography/ computed tomography in the initial staging of head and neck squamous cell carcinoma: Accuracy in evaluation of the primary site of the tumor, metastases to cervical lymph nodes, and distant metastases.","authors":"Zuzana Krátká,&nbsp;Jan Paska,&nbsp;Ales Kavka,&nbsp;Monika Jaruskova,&nbsp;Radka Lohynska,&nbsp;Katerina Lickova,&nbsp;Ales Cocek","doi":"10.5604/01.3001.0015.9817","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9817","url":null,"abstract":"AIM\u0000Our study aimed to evaluate the use of positron emission tomography/computed tomography (PET/CT) in the initial staging of head and neck squamous cell carcinoma (HNSCC), including assessment of local and distant spread of the disease. We also aimed to compare the accuracy of PET/CT in the evaluation of human papillomavirus (HPV) positive and HPV-negative oropharyngeal carcinoma.\u0000\u0000\u0000MATERIAL AND METHODS\u0000This single-center, prospective study was conducted between August 2016 and September 2021. A total of 198 patients with HNSCC who underwent PET/CT within the primary staging were included. We compared PET/CT results with histological findings. We calculated the accuracy, sensitivity, specificity, and positive and negative predictive values to assess the primary tumor, cervical lymph nodes, and distant metastases.\u0000\u0000\u0000RESULTS\u0000PET/CT showed a high success rate (32%) in revealing the primary site of carcinoma of unknown primary (CUP). The accuracy of PET/CT in displaying the primary tumor, cervical lymph node metastases, and distant metastases was 89.4%, 85.4%, and 87.4%, respectively. The method provided high sensitivity but lower specificity in all three areas. Specifically, PET/CT showed low specificity in the assessment of small tumors (75%), metastatic involvement of cervical lymph nodes (69.6%), and HPV-positive oropharyngeal carcinoma (55.6%).\u0000\u0000\u0000CONCLUSIONS\u0000The high accuracy of PET/CT to identify distant metastases and whole-body staging in one diagnostic step accelerated primary staging and resulted in earlier commencement of therapy. However, it also led to an overestimation of clinical findings and thus to extensive surgical treatment, especially in patients with small tumors, metastatic involvement of cervical lymph nodes, and HPV- positive oropharyngeal carcinoma. PET/CT is also useful for CUP diagnostics.","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"76 6","pages":"14-21"},"PeriodicalIF":0.6,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant radiotherapy in parotid gland pleomorphic adenoma - recommendations.","authors":"Małgorzata Wierzbicka,&nbsp;Jacek Fijuth,&nbsp;Krzysztof Składowski,&nbsp;Dariusz Jurkiewicz,&nbsp;Paweł Burduk,&nbsp;Jarosław Miłoński,&nbsp;Kazimierz Niemczyk,&nbsp;Wioletta Pietruszewska,&nbsp;Marek Rogowski,&nbsp;Dominik Stodulski,&nbsp;Boguslaw Mikaszewski","doi":"10.5604/01.3001.0015.9818","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9818","url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Standard treatment for pleomorhic adenoma (PA) of the parotid gland is complete surgical excision. Radiotherapy (RT) as a primary treatment method is controversial and generally is not applied. However, RT might be considered as an adjuvant therapy in some selected cases. &lt;/br&gt;&lt;/br&gt; &lt;b&gt;Aim:&lt;/b&gt; The aim of this work was to define recommendations for RT in patients with parotid gland PA after primary surgical treatment.&lt;/br&gt;&lt;/br&gt; &lt;b&gt;Material and methods:&lt;/b&gt; Based on the results currently published in the literature and the authors' own experiences from leading Polish laryngological and oncological clinical centers dealing with the treatment of salivary gland tumors, the indications for irradia- tion and its methods in patients with PA of the salivary glands were discussed. &lt;/br&gt;&lt;/br&gt; &lt;b&gt;Results and discussion:&lt;/b&gt; Authors recommend personalized treatment based on multidisciplinary panel decisions in each patient. Adjuvant RT should be considered in cases of suboptimal resection of primary PA (close margin, intraoperative tumor spillage, risk of recurrence based on clinical factors and histological features), and in cases of PA recurrence. Doses/ fractions and techniques of irradiation are recommended depending on the clinical extension of the primary or recurrent tumor. &lt;/br&gt;&lt;/br&gt; &lt;b&gt; Conclusions:&lt;/b&gt; Adjuvant RT in PA treatment should be a result of a personalized multidisciplinary decision after considering all possible risks of irradiation consequences. Recommendations for this treatment should be taken into consideration.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"76 5","pages":"1-7"},"PeriodicalIF":0.6,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10865296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of the gut microbiota in the promotion, development, and treatment outcomes of cancer with special regard to the gut-respiratory axis.","authors":"Piotr Nogal,&nbsp;Małgorzata Wierzbicka,&nbsp;Natalia Zagozda,&nbsp;Joanna Jackowska","doi":"10.5604/01.3001.0015.9677","DOIUrl":"https://doi.org/10.5604/01.3001.0015.9677","url":null,"abstract":"<p><p>The role of oral and pharyngeal microbiota is important in the promotion and development of head and neck cancers, as discussed in detail in this publication. The object of this work is to gather scientific information on the importance of the gut- respiratory axis in the promotion, development, and treatment outcome of head and neck cancer (HNSCC). Scientific knowledge about the interaction of head and neck cancer tumor cells and gut microbiota is residual, so examples of the relationship between the gut microbiota and the promotion of development in cases of other malignancies are also discussed. The subject of this work is also to present the importance of the gut-respiratory axis in promotion, development, and its impact on treatment outcomes of head and neck cancers.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":"76 6","pages":"6-13"},"PeriodicalIF":0.6,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}