Journal of Scientific Research in Medical and Biological Sciences最新文献

{"title":"Assessment of Mothers' Knowledge about Premature infants with cerebral palsy in the Maternity and Children Hospital in Diwaniyah City","authors":"Aqeel Abd Al-Hamza Marhoon, Sabri Shather Hadi, Haider.Kadhum ALjebore","doi":"10.47631/jsrmbs.v4i3.643","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i3.643","url":null,"abstract":"Background: Cerebral palsy is one of the most common health problems for premature babies. About 1 to 2 out of every 1,000 babies born at full term will develop cerebral palsy. For babies born at less than 37 weeks of gestation, the risk is twice as high, nearly 100 out of 1,000 live births. Objectives: Assessing mothers' knowledge Premature infants with cerebral palsy. Finding a relationship between demographic information and Premature infants with cerebral palsy.  Methodology: A descriptive questionnaire-based study conducted at mothers from (20 October 2021 to the 17 May 2022). Non probability (purposive) sample of 50 of women's selected from maternity and Child Hospital in Diwaniyah City. The demographic characteristics were obtained through interview with the mothers. The statistical analysis program SPSS was used to analyze the data entered in the form of an excel table and by using the Chi-square for statistical analysis. Results and Discussion: The results of show that there is association between mother' knowledge with their demographic data at p value of less than (0.05). Except item (Occupational) there is no association between mother' knowledge with demographic data at p value of more than (0.05). Conclusion: The study showed that mothers have insufficient knowledge about Premature infants with cerebral palsy. And the factors that effects such as, mother's education, mother's age, and economic level are relation with the mother's knowledge. Recommendations: Organizing educational courses for mothers. Increasing the cultural awareness of mothers and families. Establishing educational programs for pregnant women that play a key role in avoiding complications and reducing the risk of Premature infants with cerebral palsy. Creating recommendations on radio and television that contribute to raising the awareness of mothers. There is a need for more large sample studies to generalize these results, as well as efforts must be adopted by the Iraqi Ministry of Health to establish educational programs.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115075707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tagraxofusp: Expanding Therapeutic Horizons in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)","authors":"Dr sugreev Dwivedi Anuj Dwivedi","doi":"10.47631/jsrmbs.v4i3.623","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i3.623","url":null,"abstract":"Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematological malignancy with limited treatment options. The development of tagraxofusp, a CD123-directed recombinant fusion protein, has revolutionized the management of BPDCN. This manuscript reviews the current understanding of BPDCN pathophysiology, clinical presentation, and diagnostic challenges. We delve into the mechanisms of action of tagraxofusp, explore its clinical efficacy and safety profile, and discuss its role as a potential frontline and salvage therapy. Additionally, we highlight ongoing research and future directions to optimize the use of tagraxofusp in BPDCN treatment.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114061329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of some immunological parameters for Staphylococcus xylosus infections in patients with Systemic lupus erythematosus","authors":"Burhan T. Burhan, Layla S. Abdul-Hassan","doi":"10.47631/jsrmbs.v4i3.649","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i3.649","url":null,"abstract":"Purpose: Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune illness that manifests clinically as well as immunologically and in several lab tests abnormalities. Patients with SLE frequently get infections, which account for 30–50% of morbidity and death. The bacterial species Staphylococcus xylosus is a member of the Staphylococcus genus. This study's objective was to assess several immunological indicators of S.xylosus infections in individuals with systemic lupus erythematosus in the Najaf Governorate of Iraq.\u0000Subjects and Methods: Blood samples were taken from 60 SLE patients ranging in age from 16 to 56. Each patient has had a sample of 10 milliliters of blood taken. 5 ml were used to measure immunologic parameters, and another 5 ml were used to diagnose S. Xylosus by culturing a sample on blood agar and mannitol salt agar. culture on mannitol salt agar and blood agar.\u0000Results: According to the microbiological tests, 26 specimens (or 43.3%) had isolated bacteria, whereas 34 specimens (or 56.7%) had no sign of bacterial growth. Out of the 26 blood samples collected, S.xylosus was detected in 2 samples. normal amounts of ANA and anti ds-DNA despite SLE sufferers. The results of this study showed that serum levels of CD69, IL-21, and IL-35 significantly increased when compared with controls, despite a substantial drop in Hb, WBC, and platelet counts but an elevated ESR.\u0000Conclusions: xylosus produces normal autoantibody levels that are utilized to diagnose SLE. An important factor in the pathophysiology of SLE, which causes the disease to develop, is a high concentration of inflammatory cytokines.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129159152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Level of Microbial Contamination of Freshly Prepared Fufu and Retailed Fufu","authors":"Nnenna Omorodion J.P., Amakiri Beniye D","doi":"10.47631/jsrmbs.v4i3.625","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i3.625","url":null,"abstract":"Fufu is an acid-fermented products produced through submerged fermentation of cassava root in water for days. The study was set to determine the microbiological quality and the physiochemical composition of freshly prepared fufu (FF) and retailed fufu (RF). A standard microbiological method was used in enumerating and identify bacteria and fungi species isolated. The total heterotrophic bacteria count ranges from Log10 cfu/g 2.14 to 6.18 and 3.56 to 7.06 for retailed fufu and freshly prepared fufu respectively. Predominant bacteria found in the samples studied and their percentage of distribution were Lactobacillus 17(23%), Escherichia coli and Staphylococcus sp. 14(19%), Bacillus sp. 13(18%), Micrococcus sp. 5(7%), Enterobacter and Corynebacterium were 4(5%) and Proteus has the least 3(4%). Among the fungi were Mucor sp. and Candida sp. were 6(26.1%), Aspergillus niger 4(17.4%), Saccharomyces sp. 5(21.7%), and Rhizopus sp.2(8.7). The proximate analysis revealed an insignificant difference in crude protein ranging from 1.36% in FF to 1.24 in RF, carbohydrates content 82.88% to83.12% in RF and FF, ash content is higher in FF ranging 7.33% to 1.53%  RF, while the moisture content is higher in RF with 9.47% and 1.78% in FF. Magnesium ranges from 38.4mg/ml in FF to 35.3mg/ml in RF .The results obtained showed that the fufu samples that were retailed were more contaminated than the freshly prepared fufu  which might pose risk to health. Therefore, there is a need for proper sanitary conditions and best processing and production especially during packing is recommended.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132098021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Sestrin 1 in Women with Polycystic Ovary Syndrome","authors":"Abdullah Abd n lhusseiAbd_ A Assala, Ghosoun Ghanem Kaem, Liqaa Hameed Hasan","doi":"10.47631/jsrmbs.v4i3.648","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i3.648","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder that affects at least 10% of women of reproductive age. Cystic ovaries, low or absent ovulation, and high circulating testosterone levels are the the group of symptoms that define polycystic ovary syndrome (PCOS).The aim of study: To investigate whether sestrin 1 can serve a prognostic indicator in polycystic ovary syndrome. The study included 100 women  with age ranged between (18 – 44) years involving 70 PCOS patients and 30 apparently healthy women as a control in reproductive age, at the reproductive fertility consultant of gynecological and obstetric teaching hospital, Kerbala health directorate Iraq and College of Applied Medical Sciences, University of Kerbala Iraq during the duration from October ., 2022 to April, 2023. The Rotterdam criteriOn-2003 was presumed to PCOS females. The result showed there were highly significant decreasing in woman with PCOS in contrast to woman without PCOS. According to BMI showed highly significant in the overweight at( P =0.001) whereas in the obesity at( P= 0.004) and normal weight at (P= 0.004). According to age showed highly significant in age group (18_23) while  in the age group( 24_29)at (P =0.000) and age group (30_35) at (P=0.006)  whereas age group (36_41) at( P=0.274) The conclusion indicated that reduced serum sestrin 1 levels may be has potential as a new PCOS diagnostic biomarker .","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"35 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113938511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Healthcare Provider Adherence to Safe Injection Practice","authors":"Noora Farhan Hassan ALAbedi, Zahraa Abdulabbass Taher Al-Khafaji, Hawra’a Ghannam Abdul-Hussien Al-Nassar, Narjes Ali abdul Ameer AL-Radhi","doi":"10.47631/jsrmbs.v4i2.610","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i2.610","url":null,"abstract":"Purpose:  The aim is to evaluate health care provider adherence to safe injection practice and also to find out the relationship between health care providers' adherence to safe injection adherence and their demographical characteristics.\u0000Methods: Descriptive analytical study was carried out with non-probability convenient (Accidental) sampling technique. The study was carried out from February 15th, 2022 up to May 28th, 2022. The study instrument consisted of a structured questionnaire divided into 2 parts to assess awareness and practices of safe injection. The score for each question was one, two or three.\u0000Results: The finding of the study show that the overall evaluation of health care provider adherence to safe injection practice was fair at mean of score (2.22). In addition, there are non-significant relationships between the nurse’s safe injection practices and their demographic data at p-value more than 0.05, except in one item (economic status) at p-value less than 0.05.\u0000Conclusions: The overall assessment of the nurses' injection practice was fair. The result of the study reveals a high significant relationship between the nurse’s economic status and their adherence to safe injection practice.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125114504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capecitabine, Oxaliplatin, and Irinotecan (XELOXIRI) as Neoadjuvant Chemotherapy in Locally Advanced Rectal Cancer","authors":"J. Xiao, Hongyu Zhang","doi":"10.47631/jsrmbs.v4i2.599","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i2.599","url":null,"abstract":"Purpose: This study describes the efficacy and safety of irinotecan and oxaliplatin in combination with capecitabine (XELOXIRI) as a neoadjuvant chemotherapy (NAC) regimen for patients with locally advanced rectal cancer (LARC).\u0000Methods: From January 2019 through December 2022, 68 LARC patients treated with XELOXIRI were enrolled in the study. XELOXIRI is administered in a three-week cycle consisting of oxaliplatin 70-110 mg/m2 IV for >120 min on day 1; irinotecan 120-160 mg/m2 IV for 90 min on day 1; and capecitabine 700-1100 mg/m2 orally twice daily for 14 days followed by 7 days off. Sixteen cases were treated with combined radiotherapy, including 8 with long-course radiotherapy and 8 with short-course radiotherapy. The efficacy was evaluated based on pelvic MRI (including TNM stage, CRM, and EMVI status), tumor downstaging rate (to ypT0-2N0M0), pCR rate, R0 resection rate, DFS, and OS, and the safety was assessed according to the incidence of adverse events.\u0000Results: Sixty-six people had surgery; the R0 resection rate was 100%, and the rate of anal preservation was 97%. The tumor downstaging rate (to ypT0-2N0M0) in the entire group was 53.0%, and the pCR rate was 12.1%. In the XELOXIRI alone group (N = 47), the tumor downstaging rate was 55.3%, and the pCR rate was 12.8%. In the group receiving radiotherapy (N = 16), the tumor downstaging rate was 56.3%, and the pCR rate was 12.5%. In the whole group, the 3-year DFS was 89.0%, and the 3-year survival rate was 98.5%. The 3-year DFS of the XELOXIRI and XELOXIRI + RT groups was 89.9% and 87.2%, respectively. The most frequent grade 3–4 preoperative toxic reactions were neutropenia (8.8%), diarrhea (4.4%), and anemia (2.9%). All adverse events were tolerable.\u0000Conclusions: Neoadjuvant chemotherapy with XELOXIRI appears to be feasible and efficacious for patients with LARC. Although neoadjuvant XELOXIRI alone did not yield our expected pCR rate as NAC for LARC, tumor downstaging, R0 resection, sphincter preservation, local recurrence rate, 3-year DFS, OS, and safety were all satisfactory.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128761114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selection of Therapeutic Strategies after Preoperative Neoadjuvant Chemoradiotherapy for Rectal Cancer","authors":"Youzhong Ke, Yuan Liu, Hao Zhang, Houjun Jia","doi":"10.47631/jsrmbs.v4i2.612","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i2.612","url":null,"abstract":"Rectal cancer is one of the most common malignant tumors in China, which is mainly middle and low rectal cancer. Due to the particularity of the physiological and anatomical location of the rectum and the neglect of the relevant clinical symptoms, patients with rectal cancer in real life often have the local progression stage. A large number of studies have shown that neoadjuvant chemoradiotherapy should be performed in such patients, to achieve tumor downstaging before rectal cancer surgery. In this study, different treatment measures for rectal cancer patients after neoadjuvant chemoradiotherapy are presented.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132704742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Preoperative Dietary Dehavior and Weight Loss after Laparoscopic Sleeve Gastrectomy","authors":"Tao Tan, M. Zeng, Jun Zhang","doi":"10.47631/jsrmbs.v4i2.598","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i2.598","url":null,"abstract":"Purpose: The study aimed to investigate the relationship between preoperative dietary habits and weight loss in individuals with simple obesity who have undergone laparoscopic sleeve gastrectomy.\u0000Methods: From January 2020 to August 2021, the clinical data of 75 patients with simple obesity who underwent laparoscopic sleeve gastrectomy at the Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University were retrospectively analyzed, including gender, age, height, weight, calculated percentage of total weight loss (TWL), percentage of excess weight loss (%EWL), and the three-factor diet questionnaire, and correlation tests were performed.\u0000Results: At 1 month, 3 months, and 1 year postoperatively, postoperative follow-up weight and BMI were considerably reduced (P 0.001), while %TWL and %EWL levels were significantly higher (P 0.001). Emotional eating (EE) and unrestrained eating habits (UE) reduced considerably 1 month postoperatively (P 0.001). There was no significant link between preoperative CR and %TWL and %EWL at 1 month, 3 months, or 1 year postoperatively, while preoperative EE and UE were marginally positively connected with %TWL and %EWL at 1 month (r > 0.3, P＜0.05).\u0000Conclusions: Following LSG, dietary habits improved dramatically, and preoperative EE and UE were shown to be weakly closely connected with early weight loss in obese patients after LSG.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133765214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Probabilities and Lifestyle of Lung and Throat Cancer Patients in Bangladesh","authors":"M. O. Ullah, Md. Abrar Ashfaq Khan","doi":"10.47631/jsrmbs.v4i2.608","DOIUrl":"https://doi.org/10.47631/jsrmbs.v4i2.608","url":null,"abstract":"Purpose: In this study, we aimed to find out the survival probabilities and lifestyle of lung and throat cancer patients in Bangladesh.\u0000Methods: The dataset was collected from the several hospitals of eight divisional cities in Bangladesh using a semi-structured questionnaire in two time points initially and after 12 months. Descriptive statistical tools, Multiple Reponses analysis, Factor analysis and Kaplan –Meier survival curve were used to analyze the data.\u0000Results: The results revealed that prevalence of lung cancer is 6.7% and for throat it is 9.6%. It was observed that whose father had lung or throat cancer; they have more chance to be affected by the cancer. It was also found that median survival time of lung cancer (18.88 months) patients is more than that of throat cancer ( 10.67 months)  patients.  Communalities of Smoking (0.788) and fast food (0.785) were found highest compare to other lifestyle factors.\u0000Conclusions: Taken together, we conclude that survival probabilities of lung cancer patients are higher than throat cancer patients and smoking and fast food are highly related with lung and throat cancer. Therefore, we should avoid smoking and fast food to improve public health sectors in Bangladesh.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125299241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}