Role of Sestrin 1 in Women with Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder that affects at least 10% of women of reproductive age. Cystic ovaries, low or absent ovulation, and high circulating testosterone levels are the the group of symptoms that define polycystic ovary syndrome (PCOS).The aim of study: To investigate whether sestrin 1 can serve a prognostic indicator in polycystic ovary syndrome. The study included 100 women  with age ranged between (18 – 44) years involving 70 PCOS patients and 30 apparently healthy women as a control in reproductive age, at the reproductive fertility consultant of gynecological and obstetric teaching hospital, Kerbala health directorate Iraq and College of Applied Medical Sciences, University of Kerbala Iraq during the duration from October ., 2022 to April, 2023. The Rotterdam criteriOn-2003 was presumed to PCOS females. The result showed there were highly significant decreasing in woman with PCOS in contrast to woman without PCOS. According to BMI showed highly significant in the overweight at( P =0.001) whereas in the obesity at( P= 0.004) and normal weight at (P= 0.004). According to age showed highly significant in age group (18_23) while  in the age group( 24_29)at (P =0.000) and age group (30_35) at (P=0.006)  whereas age group (36_41) at( P=0.274) The conclusion indicated that reduced serum sestrin 1 levels may be has potential as a new PCOS diagnostic biomarker .