系统性红斑狼疮患者木糖葡萄球菌感染的免疫学指标评价

Burhan T. Burhan, Layla S. Abdul-Hassan
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摘要

目的:系统性红斑狼疮(SLE)是一种慢性、全身性自身免疫性疾病,在临床以及免疫学和一些实验室检查中表现异常。SLE患者经常发生感染,占发病和死亡的30-50%。木糖葡萄球菌是葡萄球菌属的一种。本研究的目的是评估伊拉克纳杰夫省系统性红斑狼疮患者中木孢子虫感染的几个免疫学指标。对象和方法:采集60例SLE患者血液样本,年龄16 ~ 56岁。每个病人都取了10毫升的血样。用5 ml测定免疫参数,另用5 ml在血琼脂和甘露醇盐琼脂上培养样品诊断木糖酵母菌。甘露醇盐琼脂和血琼脂培养。结果:微生物检出细菌26份(43.3%),未检出细菌34份(56.7%)。在采集的26份血液样本中,2份样本检出木孢子菌。尽管SLE患者的抗抗ds-DNA含量正常。本研究结果显示,与对照组相比,血清CD69、IL-21和IL-35水平显著升高,尽管Hb、WBC和血小板计数大幅下降,但ESR升高。结论:木糖产生正常的自身抗体水平,用于诊断SLE。在SLE的病理生理学中,导致疾病发展的一个重要因素是炎症细胞因子的高浓度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of some immunological parameters for Staphylococcus xylosus infections in patients with Systemic lupus erythematosus
Purpose: Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune illness that manifests clinically as well as immunologically and in several lab tests abnormalities. Patients with SLE frequently get infections, which account for 30–50% of morbidity and death. The bacterial species Staphylococcus xylosus is a member of the Staphylococcus genus. This study's objective was to assess several immunological indicators of S.xylosus infections in individuals with systemic lupus erythematosus in the Najaf Governorate of Iraq. Subjects and Methods: Blood samples were taken from 60 SLE patients ranging in age from 16 to 56. Each patient has had a sample of 10 milliliters of blood taken. 5 ml were used to measure immunologic parameters, and another 5 ml were used to diagnose S. Xylosus by culturing a sample on blood agar and mannitol salt agar. culture on mannitol salt agar and blood agar. Results: According to the microbiological tests, 26 specimens (or 43.3%) had isolated bacteria, whereas 34 specimens (or 56.7%) had no sign of bacterial growth. Out of the 26 blood samples collected, S.xylosus was detected in 2 samples. normal amounts of ANA and anti ds-DNA despite SLE sufferers. The results of this study showed that serum levels of CD69, IL-21, and IL-35 significantly increased when compared with controls, despite a substantial drop in Hb, WBC, and platelet counts but an elevated ESR. Conclusions: xylosus produces normal autoantibody levels that are utilized to diagnose SLE. An important factor in the pathophysiology of SLE, which causes the disease to develop, is a high concentration of inflammatory cytokines.
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