Journal of Scientific Research in Medical and Biological Sciences最新文献

{"title":"Multiple Regressions Analysis to investigate the optimal yield of Guava fruits at different level of NPK Fertilizers in south west Nigeria","authors":"O. P. Popoola, Matthew Taiwo Odusina, W. A. Ayanrinde","doi":"10.47631/jsrmbs.v2i3.265","DOIUrl":"https://doi.org/10.47631/jsrmbs.v2i3.265","url":null,"abstract":"Purpose: This study investigates the effect of fertilizers (Nitrogen, Phosphorus & Potassium) on Guava; examines which of the three elements of NPK contribute most to the weight of guava seed. It thus further determines at what proportion each of the three elements is to be applied for optimum yield.\u0000Subjects and Methods: A 3 x 3 factorial experiments were adopted in the data analysis; further tests were conducted using different Post Hoc test approaches and a multiple regression analysis was derived to investigate at what proportion the elements are to be applied for optimum yield.\u0000Results: The results of the analysis of variance (ANOVA) showed that only Phosphorus and Potassium contribute to the growth and weight yield of guava. The Post-Hoc Tests showed that there was a significant difference between the mean pair of P0 & P20 and P0 & P40 with a p-value of 0.000 and 0.000 respectively. Also, there was a significant difference between the mean pair of K0 & K50 and K0 & P100 with a p-value of 0.004 and 0.008 respectively which is less than the significant level at 0.05. Furthermore, the overall multiple regression models for the weight yield of guava fruits were obtained as: (Y)=5.646+0.0556N-0.3611P+1.5694K+1.7167NP+1.1333NK+1.0361PK.\u0000Conclusion: Thus, to obtain an optimal yield of 12- 20t/ha of guava fruits, phosphorus and potassium are to be applied at 40k.g and 50kg respectively with spacing of 6 x 6m accommodating 277.7 plants per hectare.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116230757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Markers for Early Detection of Neonatal Sepsis","authors":"Lara R. Shoukry, A. Mohamed, A. Sharaf, O. S. Osman","doi":"10.47631/jsrmbs.v2i3.319","DOIUrl":"https://doi.org/10.47631/jsrmbs.v2i3.319","url":null,"abstract":"Background: Neonatal sepsis (NS) is a major health problem throughout the world. The diagnosis of sepsis is challenging due to the non-specific nature of the clinical presentation, the variety of other neonatal disorders with the differential diagnostic workup, lack of sensitivity and specificity of available diagnostic procedures, and the delay in the results of blood cultures in addition to high negative results reported. The diagnosis of suspected sepsis has to be based on clinical symptoms together with biochemical parameters. A diagnostic marker with high diagnostic sensitivity and specificity would be a valuable tool for decreasing the burden of neonatal sepsis \u0000Purpose: Evaluate the validity of interleukin-6 (IL-6) in the early diagnosis of neonatal sepsis or the use of a combination of diagnostic markers, C-reactive protein (CRP), and IL-6.\u0000Methods: The study included 30 patients with NS (Group I) and 30 healthy newborns as control (Group II) were admitted to Neonatal Intensive Care Unit (NICU) from January 2017 to June 2017. All neonates were subjected to history taking, clinical examination, and laboratory investigations including complete blood count (CBC), blood culture and sensitivity testing, CRP, and IL-6.\u0000Results: the most causative organism of neonatal sepsis in NICU was Klebsiella spp. followed by CONS.  IL-6 results with cut-off value 50pg/ml, the sensitivity was 100%, the specificity was 90.32%, the positive predictive value of 90.63%, negative predictive value, and the diagnostic accuracy was 95.16. Moreover, IL-6 levels are significantly higher statistically in NS patients than controls.\u0000Conclusion: This study validated the diagnostic capability of IL-6 and showed that the combination of CRP and IL-6 as a panel for the early diagnosis of NS could enhance the sensitivity in the diagnosis of NS and may provide a new diagnostic strategy for NS patients\u0000Objective: Evaluate the validity of interleukin-6 (IL-6) in early diagnosis of neonatal sepsis or the use of combination of diagnostic markers, C-reactive protein (CRP) and IL-6.\u0000Patients and methods: The study included 30 patients with NS (Group I) and 30 apparently healthy newborns as control (Group II) were admitted to Neonatal Intensive Care Unit (NICU) from January 2017 to June 2017. All neonates were subjected to history taking, clinical examination, and laboratory investigations including: complete blood count (CBC), blood culture and sensitivity testing, CRP, and IL-6.\u0000Results: the most causative organism of neonatal sepsis in NICU was klebsiella spp. followed by CONS.  IL-6 results with cut-off value 50pg/ml, the sensitivity was 100%, the specificity was 90.32%, positive predictive value of 90.63%, negative predictive value, and the diagnostic accuracy was 95.16. Moreover, IL-6 levels are  significant  higher  statistically in NS patients than controls.\u0000Conclusion: This study validated the diagnostic capability of IL-6 and showed that the combination of CRP and IL-6 as a","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133758176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Vitamin D and Simvastatin on Inflammatory and Oxidative Stress Markers of High-Fat Diet-Induced Obese Rats","authors":"Abdelkader Makhlouf, A. Mahmoud, R. Ibrahim, Yasmeen S. Abdel Aziz","doi":"10.47631/jsrmbs.v2i3.297","DOIUrl":"https://doi.org/10.47631/jsrmbs.v2i3.297","url":null,"abstract":"Purpose: This study was aimed to evaluate the antioxidant and anti-inflammatory effects of vitamin D and Simvastatin (SIM) on a high-fat diet (HFD) induced-obese rats.\u0000Methods: 40 adult male rats were divided into four groups: control group, HFD, HFD + vitamin D, and HFD + SIM for 14 weeks. Vitamin D or SIM supplementation was done for the last 6 weeks. Vitamin D dosage was 500 IU/kg, while SIM dosage was 10 mg/kg. Interleukin-6 (IL-6) concentration and markers of oxidative stress including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced glutathione(GSH) concentrations in serum were determined using ELISA kits and spectrophotometry methods, respectively.\u0000Results: Treatment with vitamin D or SIM could significantly reduce IL-6 and MDA and increases SOD, GPx activities, and GSH levels. Oxidative stress can result not only from increased ROS production but also from dysfunctional antioxidant defenses.\u0000Conclusion: From the experimental results, it was observed that SIM and vitamin D could attenuate oxidative stress and inflammation markers associated with obesity.","PeriodicalId":422270,"journal":{"name":"Journal of Scientific Research in Medical and Biological Sciences","volume":"163 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133964812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}