Journal of Agricultural and Food Chemistry最新文献_第5页

Innovative Research on the Agricultural Insecticidal Activity of Lotilaner and Its Derivatives 农业杀虫活性及其衍生物的创新研究

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-05 DOI: 10.1021/acs.jafc.6c13537

Senhui Wu,Pan Zhou,Xinyu Zhuang,Jiahong Wu,Yongqiang Li,Hongjian Song,Yuxiu Liu,Yi Ma,Ziwen Wang,Qingmin Wang

{"title":"Innovative Research on the Agricultural Insecticidal Activity of Lotilaner and Its Derivatives","authors":"Senhui Wu,Pan Zhou,Xinyu Zhuang,Jiahong Wu,Yongqiang Li,Hongjian Song,Yuxiu Liu,Yi Ma,Ziwen Wang,Qingmin Wang","doi":"10.1021/acs.jafc.6c13537","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c13537","url":null,"abstract":"Isoxazolines exhibit potent insecticidal activity, but their toxicity to beneficial insects limits agricultural applications. Here, we first explored the veterinary isoxazoline lotilaner as a lead for agricultural insecticide discovery. We designed and synthesized a series of diacylhydrazine-containing derivatives. Lotilaner showed strong activity against P. xylostella (LC50 = 0.305 mg/L), while I-9S exhibited activity against S. frugiperda (LC50 = 2.69 mg/L) comparable to that of lotilaner (3.41 mg/L). I-9S also outperformed its enantiomer I-9R, indicating stereoselective insecticidal activity. Molecular docking, molecular dynamics simulations, and DFT calculations provided insights into potential receptor interactions and electronic properties. Notably, the honeybee acute oral LD50 increased from 0.297 μg/bee for lotilaner to 3.32 μg/bee for I-9S, representing an approximately 11-fold increase in LD50 and reduced honeybee toxicity. These findings support scaffold modification of lotilaner as a promising approach to developing agricultural isoxazoline insecticides with favorable activity and improved honeybee safety.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"9 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149359894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate Phosphorus Application Reshapes Rhizosphere Microbial Ecology and Coordinates Host Metabolic Responses to Improve Sweet Potato Yield and Quality: A Multiomics System-Level Analysis 适度施磷重塑根际微生物生态和协调宿主代谢反应以提高甘薯产量和品质：多组学系统水平分析

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-05 DOI: 10.1021/acs.jafc.6c10961

Jinyang Zhao,Yujie Li,Muhammad Shahid,Kashif Khan,Luqman Khan,Chengcheng Si

{"title":"Moderate Phosphorus Application Reshapes Rhizosphere Microbial Ecology and Coordinates Host Metabolic Responses to Improve Sweet Potato Yield and Quality: A Multiomics System-Level Analysis","authors":"Jinyang Zhao,Yujie Li,Muhammad Shahid,Kashif Khan,Luqman Khan,Chengcheng Si","doi":"10.1021/acs.jafc.6c10961","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c10961","url":null,"abstract":"Sweet potato is an important food, feed, and industrial crop whose storage root development and quality depend on phosphorus (P) availability, yet plant–soil–microbe responses to P fertilization remain unclear. We integrated agronomic, metagenomic, transcriptomic, metabolomic, and WGCNA analyses comparing moderate P application (P110; 110 kg P2O5 ha–1) with no P (P0). P110 increased soil organic carbon by 45.03% and available potassium by 9.58%; organic/inorganic P declined, while available P remained unchanged. Rhizosphere shifts included higher Acidobacteriota, Basidiomycota, and fungal diversity. P-cycling genes pckA, gcd, and ppk were higher, indicating altered metagenomic potential for soil P turnover. P110 increased storage roots per plant by 20.31–27.83%, yield by 31.88–41.45%, and plant P accumulation by 134.01%. Multiomics-linked hub genes (ARR6, LRR4, LRR3, FKF1, TIC100) and pathways to root traits, yield, and quality. Moderate P coordinates rhizosphere microbial ecology with host transcriptional and metabolic responses, improving P-use, yield, and quality.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"29 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149359896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous Improvement of Acid Tolerance and Thermostability of Bacillus acidicola α-Amylase via Semi-Rational Design and Its Application in the Production of Resistant Dextrin 半合理设计同时提高酸性芽孢杆菌α-淀粉酶耐酸性和热稳定性及其在抗性糊精生产中的应用

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-05 DOI: 10.1021/acs.jafc.6c11647

Jie-Wen Tan,Song-Qing Hu,Jia-Hui Liao,Yi Hou,Wei-Zheng Sun,Xin Yuan

{"title":"Simultaneous Improvement of Acid Tolerance and Thermostability of Bacillus acidicola α-Amylase via Semi-Rational Design and Its Application in the Production of Resistant Dextrin","authors":"Jie-Wen Tan,Song-Qing Hu,Jia-Hui Liao,Yi Hou,Wei-Zheng Sun,Xin Yuan","doi":"10.1021/acs.jafc.6c11647","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c11647","url":null,"abstract":"Thermostable and acid-tolerant α-amylases are highly desirable for efficient starch processing and resistant dextrin production. Here, an α-amylase from Bacillus acidicola (Ba-amy) was engineered to simultaneously improve the thermostability and acid tolerance by semirational design. Residues 178–179 in a protruding loop were deleted, a 37-residue N-terminal fragment from acid-tolerant α-amylase was introduced and surface residue Val332 was substituted with Asp. The resulting mutant Mut-V332D exhibited a 14.0-fold increase in specific activity (6734.8 U/mg), improved acid tolerance at pH 5.5, and a 5.8-fold longer half-life at 90 °C (85.5 min) compared with Ba-amy. Mechanistic analysis suggested that enhanced thermostability resulted from reduced loop flexibility, strengthened hydrogen-bond interactions and optimized surface electrostatics, while the N-terminal extension contributed to acid tolerance. Furthermore, Mut-V332D demonstrated potential for resistant dextrin production without repeated pH adjustment. This work provides an effective strategy for engineering robust α-amylases for industrial applications.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"12 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149359934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic and Antagonistic ACE Inhibition by Food-Derived Tripeptide-Polyphenol Pairs: Roles of Binding Stability and Peptide Dissociation 食源性三肽-多酚对的协同和拮抗ACE抑制作用：结合稳定性和肽解离的作用

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-04 DOI: 10.1021/acs.jafc.6c08896

Jinhong Wang,Yi Zhao,Shuang Yu,Xinlan Zhuo,Xiang Li,Guizhao Liang

{"title":"Synergistic and Antagonistic ACE Inhibition by Food-Derived Tripeptide-Polyphenol Pairs: Roles of Binding Stability and Peptide Dissociation","authors":"Jinhong Wang,Yi Zhao,Shuang Yu,Xinlan Zhuo,Xiang Li,Guizhao Liang","doi":"10.1021/acs.jafc.6c08896","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c08896","url":null,"abstract":"Interactions between food-derived angiotensin-I-converting enzyme (ACE)-inhibitory peptides and polyphenols may influence multicomponent inhibitor performance. Enzymatic assays and Chou-Talalay combination index analysis evaluated leucyl-alanyl-phenylalanine (LAF), leucyl-leucyl-leucine (LLL), quercetin (QU), chlorogenic acid (CA), epigallocatechin gallate (EGCG), and their mixtures at five peptide-to-polyphenol molar ratios. EGCG-containing mixtures showed synergistic inhibition, with mean CI values of 0.89 and 0.81 for LAF-EGCG and LLL-EGCG, respectively, whereas LAF-QU and LLL-QU were antagonistic (mean CI: 1.51 and 1.19). LAF-CA and LLL-CA showed mean CI values of 0.81 and 0.72, respectively, although these values remain provisional due to the limited characterization of CA’s individual dose–effect relationship. Simulations associated CA- and EGCG-containing systems with persistent peptide contacts, more compact active-pocket conformations, and higher calculated peptide-dissociation barriers; QU-containing systems showed greater pocket overlap and lower barriers. These in vitro and computational results provide a target-level framework for prioritizing peptide-polyphenol pairs for further food-matrix, digestion, transport, and in vivo validation.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"12 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149359383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Diterpenoids from Yemeni Coffea arabica: Isolation, Structural Elucidation, and Glucose Uptake Activity 从也门阿拉比卡咖啡中提取的新型二萜：分离、结构解析和葡萄糖摄取活性

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-04 Epub Date: 2026-10-20 DOI: 10.1021/acs.jafc.6c05370

Abdulbaset Al-Romaima, Xiaocui Liu, Guilin Hu, Jameel Alafifi, Shiheng Zong, Chenxi Quan, Minghua Qiu

{"title":"Novel Diterpenoids from Yemeni Coffea arabica: Isolation, Structural Elucidation, and Glucose Uptake Activity","authors":"Abdulbaset Al-Romaima, Xiaocui Liu, Guilin Hu, Jameel Alafifi, Shiheng Zong, Chenxi Quan, Minghua Qiu","doi":"10.1021/acs.jafc.6c05370","DOIUrl":"10.1021/acs.jafc.6c05370","url":null,"abstract":"A phytochemical investigation of Yemeni Coffea arabica green beans led to the isolation offifty-one diterpenoids, including18 new compounds (1–5, 9–15, 26, 27, 31, 33, 34, 42). Structures were establishedby 1D/2D NMR, HRESIMS, IR, and X-ray crystallography. Compound 11 possesses a novel rearranged skeleton, while compounds 1–15 represent a series of diterpenoid glycosides featuringdiverse aromatic acylations (p-hydroxybenzoyl, p-coumaroyl, feruloyl, sinapoyl, or 6,7-dimethoxycinnamoyl)on a C-19 β-glucosyl moiety. Bioactivity screening in insulin-resistantHepG2 cells identified nine compounds that significantly enhancedglucose uptake, with improvements ranging from 24.91% to 81.10%. Thisstudy elucidates the structural diversity of diterpenoids in coffeeand highlights their potential relevance to glucose metabolism.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 43","pages":"34203–34220"},"PeriodicalIF":6.7,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aflatoxin B1 (AFB1) Accelerates the Pathological Process of Hepatic Aging by Hijacking the Aryl Hydrocarbon Receptor (AHR) Signaling Pathway 黄曲霉毒素B1 （AFB1）通过劫持芳烃受体（AHR）信号通路加速肝脏衰老的病理过程

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-04 Epub Date: 2026-10-25 DOI: 10.1021/acs.jafc.6c11275

Jian Sun, Zehui Li, Yu Zhao, Bi Mao, Zhengwang Yi, Yang Zhao, Ziheng Zou, Zhijie Liu, Juyu Wang, Weijie Qu, Bundit Tengjaroensakul, Limei Zhang, Yi Wu, Xiaolong Gu

{"title":"Aflatoxin B1 (AFB1) Accelerates the Pathological Process of Hepatic Aging by Hijacking the Aryl Hydrocarbon Receptor (AHR) Signaling Pathway","authors":"Jian Sun, Zehui Li, Yu Zhao, Bi Mao, Zhengwang Yi, Yang Zhao, Ziheng Zou, Zhijie Liu, Juyu Wang, Weijie Qu, Bundit Tengjaroensakul, Limei Zhang, Yi Wu, Xiaolong Gu","doi":"10.1021/acs.jafc.6c11275","DOIUrl":"10.1021/acs.jafc.6c11275","url":null,"abstract":"Aflatoxin B1 (AFB1) is a environmental hepatotoxicant,yet themolecular circuitry through which it drives hepatic senescence remainsincompletely defined. Employing murine models and AML-12, and demonstratedthat AFB1 exposure upregulated aryl hydrocarbon receptor (AHR) expression,promoted its nuclear translocation, and elicited DNA double-strandbreaks as evidenced by γ-H2AX foci formation. This genotoxicinsult activated the p53/p21 checkpoint axis, downregulated CDK4/CyclinD1, and induced G1-phase cell cycle arrest, while concurrently augmentingthe senescence-associated secretory phenotype (SASP) via interleukin(IL)-6 and IL-1β upregulation. Pharmacological inhibition ofAHR with CH223191 effectively abrogated these AFB1-induced molecularand pathological alterations, reversing hepatocyte injury and senescencemarkers. Collectively, this study defines a novel ″AFB1-AHR-aging″axis, revealing that environmental AFB1 subverts AHR signaling toorchestrate a pro-senescent program in the liver, highlighting AHRas a potential therapeutic target for AFB1-associated hepatopathies.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 43","pages":"34369–34384"},"PeriodicalIF":6.7,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propionyl-Fructooligosaccharide Alleviates DSS-Induced Colitis in Association with Changes in Gut Microbiota, Inflammatory Responses, and Intestinal Barrier Function 丙酰低聚果糖与肠道菌群、炎症反应和肠道屏障功能的改变有关，减轻了dss诱导的结肠炎

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-04 Epub Date: 2026-10-25 DOI: 10.1021/acs.jafc.6c08347

Diming Tan, Yihang Lou, Weiwen Chen, Qiongyao Wang, Weibin Bai, Lingmin Tian

{"title":"Propionyl-Fructooligosaccharide Alleviates DSS-Induced Colitis in Association with Changes in Gut Microbiota, Inflammatory Responses, and Intestinal Barrier Function","authors":"Diming Tan, Yihang Lou, Weiwen Chen, Qiongyao Wang, Weibin Bai, Lingmin Tian","doi":"10.1021/acs.jafc.6c08347","DOIUrl":"10.1021/acs.jafc.6c08347","url":null,"abstract":"Propionyl-fructooligosaccharide (P-FOS), an esterifiedprebioticsynthesized from fructooligosaccharides and propionic acid, was evaluatedin a dextran sulfate sodium (DSS)-induced colitis mouse model. P-FOStreatment was associated with lower disease activity, attenuated colonshortening, reduced histological injury, and the preservation of gobletcells. P-FOS also decreased the expression of several inflammation-associatedmarkers and increased barrier-related gene and protein expression,including Muc2 mRNA and occludin protein. In addition,P-FOS treatment was associated with changes in gut microbial diversityand composition and with altered colonic short-chain fatty acid profiles.Because gastrointestinal stability, ester bond cleavage, and directpropionate release from P-FOS were not determined, these findingsshould not be interpreted as direct evidence of a colon-targeted releasemechanism. Overall, P-FOS showed protective effects in DSS-inducedcolitis and warrants further investigation as an esterified prebiotic.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 43","pages":"34398–34407"},"PeriodicalIF":6.7,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical-Related Signals in Lung Tissue and Preventive Effects of Fermented Rosa roxburghii Tratt against Lipopolysaccharide-Induced Lung Injury in Mice 肺组织中的植物化学相关信号及发酵刺梨提取物对小鼠脂多糖性肺损伤的预防作用

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-04 Epub Date: 2026-10-25 DOI: 10.1021/acs.jafc.6c06350

Zhiyu Chen, Shuo Zhang, Chencen Lai, Ganxi Zhong, Xuncai Huang, Pengjiao Wang, Min Zhang, Xiuli Gao

{"title":"Phytochemical-Related Signals in Lung Tissue and Preventive Effects of Fermented Rosa roxburghii Tratt against Lipopolysaccharide-Induced Lung Injury in Mice","authors":"Zhiyu Chen, Shuo Zhang, Chencen Lai, Ganxi Zhong, Xuncai Huang, Pengjiao Wang, Min Zhang, Xiuli Gao","doi":"10.1021/acs.jafc.6c06350","DOIUrl":"10.1021/acs.jafc.6c06350","url":null,"abstract":"Fermented fruit products contain diverse phytochemicalsand mayexert biological effects after oral intake. This study qualitativelyscreened for phytochemical-related signals in lung tissue after oraladministration of fermented Rosa roxburghii Tratt (FRRT) and separately evaluated its preventive effects againstlipopolysaccharide-induced lung injury in mice. UHPLC–MS/MSdetected ten tentatively annotated phytochemical-related signals inmouse lung tissue after FRRT administration. The corresponding candidatecompounds were quantified in FRRT by UHPLC–QqQ–MS/MS.FRRT preadministration attenuated bronchoalveolar protein leakage,inflammatory cytokine production, neutrophil-associated responses,epithelial barrier disruption, and histopathological injury followingLPS challenge. These effects were accompanied by modulation of TLR4/MyD88/NF-κB,MAPK, JAK2/STAT3, Nrf2/HO-1, and NLRP3-related signaling. These findingsdocument the qualitative detection of phytochemical-related signalsin lung tissue under the screening conditions and support the preventiveeffects of FRRT against subsequent LPS-induced pulmonary injury.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 43","pages":"33888–33903"},"PeriodicalIF":6.7,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inulin Combined with Rosmarinic Acid Alleviates D-Galactose-Induced Cognitive Impairment by Regulating Indoxyl Sulfate and the AhR/NF-κB/NLRP3 Inflammatory Pathway 菊粉联合迷迭香酸通过调节硫酸吲哚酚和AhR/NF-κB/NLRP3炎症通路减轻d -半乳糖诱导的认知功能障碍

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-04 Epub Date: 2026-10-23 DOI: 10.1021/acs.jafc.6c11116

Huajian Xu, Jinghong Xu, Zheng Li, Qing Zhang, Jing Che, Haozhe Yi, Binjia Zhang, Bowen Li

{"title":"Inulin Combined with Rosmarinic Acid Alleviates D-Galactose-Induced Cognitive Impairment by Regulating Indoxyl Sulfate and the AhR/NF-κB/NLRP3 Inflammatory Pathway","authors":"Huajian Xu, Jinghong Xu, Zheng Li, Qing Zhang, Jing Che, Haozhe Yi, Binjia Zhang, Bowen Li","doi":"10.1021/acs.jafc.6c11116","DOIUrl":"10.1021/acs.jafc.6c11116","url":null,"abstract":"Age-related cognitive impairment is associated with oxidativestress,intestinal barrier dysfunction, and gut–brain axis disruption.This study evaluated how rosmarinic acid (RA), alone or combined withthe prebiotic inulin, ameliorates D-galactose-induced cognitive impairmentin mice. Male ICR mice received D-galactose for 6 weeks with RA, orRA plus inulin, followed by behavioral testing, histology, biochemicalassays, 16S rRNA sequencing, serum metabolomics, molecular dynamicsand inflammatory signaling analyses. RA ameliorated exploratory behaviorand recognition and spatial memory, restored antioxidant enzyme (SOD/CAT/GSH-Px)activities, reduced lipid peroxidation (MDA), and attenuated hippocampalneuronal injury and glial activation. The RA-inulin combination exhibitedadditional protection, improving colonic barrier markers, increasing Lactobacillus and Lachnospiraceae, loweringindoxyl sulfate, and modulating AhR/NF-κB/NLRP3 activation.Meanwhile, the level of IL-1β/IL-18 (in the hippocampus) decreasedby 15.96% and 24.41%, respectively. These findings suggest that thecombined dietary intervention of RA and inulin mitigates aging-relatedcognitive impairment through the gut–brain axis.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 43","pages":"34050–34066"},"PeriodicalIF":6.7,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Antifungal Activity of Benzoxazole Amides: Focusing on Target Research against Verticillium Dahliae 苯并恶唑酰胺类化合物的设计、合成及抗真菌活性研究——以大丽花黄萎病为重点

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-11-04 Epub Date: 2026-10-23 DOI: 10.1021/acs.jafc.6c02693

Qiu-ju Liu, Bing-yu Che, Xiao-mei Pan, Jun-you Jian, Yun-mi Tang, Jiao-jiao Zhang, Xiao-jiang Hao, Lie-jun Huang

引用次数: 0