Bethany J Hausch, Mary Lu Arpaia, Zachary Kawagoe, Spencer Walse, David Obenland
{"title":"Correction to \"Chemical Characterization of Two California-Grown Avocado Varieties (<i>Persea americana</i> Mill.) over the Harvest Season with an Emphasis on Sensory-Directed Flavor Analysis\".","authors":"Bethany J Hausch, Mary Lu Arpaia, Zachary Kawagoe, Spencer Walse, David Obenland","doi":"10.1021/acs.jafc.5c09310","DOIUrl":"https://doi.org/10.1021/acs.jafc.5c09310","url":null,"abstract":"","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-Collagen Hybrid Composite: A Method for Improving the Functionality of Collagen-Based Materials.","authors":"Zilong Zhao,Weigang Yuwen,Fangfang Ci,Taishan Liu,Jing Chen","doi":"10.1021/acs.jafc.5c09453","DOIUrl":"https://doi.org/10.1021/acs.jafc.5c09453","url":null,"abstract":"","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"14 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andressa Fabiane Faria de Souza,Andrés Calderín García,José Nivaldo de Oliveira Sátiro,Brisa Ribeiro de Lima,Manlio Silvestre Fernandes,Ricardo Luiz Louro Berbara,Leandro Azevedo Santos
{"title":"Humic Acid Regulates Root Growth through ROS-Dependent Pathway and Hormone Signaling in Rice.","authors":"Andressa Fabiane Faria de Souza,Andrés Calderín García,José Nivaldo de Oliveira Sátiro,Brisa Ribeiro de Lima,Manlio Silvestre Fernandes,Ricardo Luiz Louro Berbara,Leandro Azevedo Santos","doi":"10.1021/acs.jafc.5c06288","DOIUrl":"https://doi.org/10.1021/acs.jafc.5c06288","url":null,"abstract":"Humic acid (HA) enhances plant development, but the integration between reactive oxygen species (ROS) and hormone signaling in HA-induced root growth remains unclear. This study investigated the mechanisms of HA extracted from vermicompost on rice root development using ROS scavengers, hormone pathway inhibitors, and gene expression analyses. HA application increased root dry weight by 27% and lateral root length by 20%. ROS staining revealed higher O2•- accumulation in root tips and H2O2 in the elongation zone. Treatments with SB, TIRON, DMTU, DPI, PCIB, and FLD suppressed HA-induced growth, indicating redox and hormonal modulation. HA also upregulated genes related to ROS signaling (OsGPX3, CuZnSOD1, OsPRX112, BAS1) and hormone signaling (OsTOR, OsIAA11). These findings support the idea that HA triggers a controlled oxidative signal that interacts with hormone pathways to regulate gene expression and root development. This ROS-hormone crosstalk reveals a key mechanism underlying HA bioactivity and reinforces its potential as a biostimulant for sustainable crop production.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"150 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurotoxic Domino Effect: Dietary Silica Nanoparticles Spark Microglial Extracellular Traps and Neuronal Pyroptosis.","authors":"Huanyi Liu,Tong Xu,Xu Shi,Yilin Yin,Xuejiao Yang,Jiaqi Wang,Wenying Sun,Shiwen Xu","doi":"10.1021/acs.jafc.5c05403","DOIUrl":"https://doi.org/10.1021/acs.jafc.5c05403","url":null,"abstract":"Silica nanoparticles (SiO2-NPs) are increasingly detected in environmental and food systems, raising concerns about their potential health risks via dietary exposure. Neurotoxicity assessment of SiO2-NPs is a critical aspect, yet the mechanisms underlying their neurotoxic effects remain poorly understood. This study examined depression-like behaviors in mice following 21-day oral administration of three distinct-sized SiO2-NPs (1 μm, 300 nm, and 50 nm), with particular focus on microglia-neuron crosstalk. The results demonstrate that SiO2-NPs disrupt blood-brain barrier integrity, induce microglial release of inflammatory extracellular traps (ETs) accompanied by neuronal pyroptosis, and ultimately cause depression-like behaviors in mice, with effects negatively correlating with particle size. Mechanistically, SiO2-NPs uptake by microglia promoted ROS-driven M1/M2 polarization imbalance and ETs release, while neuronal pyroptosis was mediated via the ROS/NLRP3 axis. Coculture experiments confirmed that microglial ETs exacerbated neuronal pyroptosis, and neuronal pyroptosis induced M1 polarization of microglia and further ETs release, ultimately forming a domino effect of neuroinflammation. These findings clarify key mechanisms underlying SiO2-NPs-induced neurotoxicity, providing critical insights for exposure risk assessment in food applications.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"14 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gang Wang,Huibin Yang,Shuang Liang,Jie Lang,Junwu Ying,Liang Lv,Bin Li,Haibo Yu
{"title":"Design, Synthesis, and Structure-Activity Relationship of Novel Quinazolinone Derivatives.","authors":"Gang Wang,Huibin Yang,Shuang Liang,Jie Lang,Junwu Ying,Liang Lv,Bin Li,Haibo Yu","doi":"10.1021/acs.jafc.5c02611","DOIUrl":"https://doi.org/10.1021/acs.jafc.5c02611","url":null,"abstract":"A series of novel quinazolinone derivatives targeting Aphis fabae were designed and synthesized. Their structures were confirmed through comprehensive analyses of 1H and 13C NMR and MS data. Biological assays showed that compounds 9-4, 9-7, 9-8, and 10-7 exhibit superior insecticidal activity against A. fabae compared to commercial compounds pyrifluquinazon, imidacloprid, and pymetrozine. Field trials further validated 10-7's long-lasting efficacy and enhanced control of imidacloprid-resistant aphid populations. Acute toxicity assays indicated that compound 10-7 had a low mammalian toxicity. A structure-activity relationship (SAR) identified key functional groups critical for bioactivity, while molecular docking simulations elucidated the mechanism of action, revealing hydrogen-bond interactions with ASN 572 of the TRPV channel. These findings establish 10-7 as a promising lead candidate for developing sustainable insecticides with resistance-breaking potential, advancing both agrochemical innovation and integrated pest management strategies.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"1 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"β-Hydroxybutyric Acid-Induced Bovine Endometrial Epithelial Cell Pyroptosis via Activating P2X7R.","authors":"Jiajia Mu,Qiannan Sun,Nanyan Lin,Chenguang Yue,Jiaqiao Zhu,Hui Zou,Hongyan Zhao,Ruilong Song,Zongping Liu,Yonggang Ma","doi":"10.1021/acs.jafc.4c07921","DOIUrl":"https://doi.org/10.1021/acs.jafc.4c07921","url":null,"abstract":"Ketosis in dairy cows is linked to endometritis, but the molecular mechanisms are unclear. We investigated whether P2X7R is crucial in ketosis-induced endometritis. Ketotic cows had higher levels of NLRP3, caspase-1, GSDMD, GSDME, and P2X7R in the uterine tissue. β-Hydroxybutyric acid (BHBA) exposure in bovine endometrial epithelial cells induced pyroptosis, increased pyroptosis protein and gene expression, and raised pyroptosis rates. P2X7R levels rose with BHBA, and BHBA also increased the level of extracellular ATP. Inhibitors of NLRP3, caspase-1, caspase-3, and P2X7R reduced BHBA-induced pyroptosis. P2X7R inhibition suppressed NLRP3, caspase-1, and caspase-3 activation, preventing pyroptosis. In P2rx7-/- mice with a ketosis model, blood BHBA was lower, and uterine tissue showed less pyroptosis-related protein expression compared to ketotic mice. P2X7R appears to regulate BHBA-induced pyroptosis through NLRP3 and caspase-3 signaling, suggesting it is a potential therapeutic target.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"96 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaimeng Liu, Yanchao Wang*, Yaoguang Chang*, Feifei Shi and Changhu Xue,
{"title":"","authors":"Kaimeng Liu, Yanchao Wang*, Yaoguang Chang*, Feifei Shi and Changhu Xue, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"73 30","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.5c02262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juntao Jia, Hanghang Yu, Dengqin Wei, Jason C. White, Yuantian Guo, Khansa Saleem, Mengshuang Li, Yu Wang and Chun Song*,
{"title":"","authors":"Juntao Jia, Hanghang Yu, Dengqin Wei, Jason C. White, Yuantian Guo, Khansa Saleem, Mengshuang Li, Yu Wang and Chun Song*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"73 30","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.5c03290","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}