IP Indian Journal of Neurosciences最新文献_第7页

Surgery for Lumbar disc prolapse in pregnancy: Case series 妊娠期腰椎间盘突出症的手术治疗:病例系列

IP Indian Journal of Neurosciences Pub Date : 2022-09-15 DOI: 10.18231/j.ijn.2022.044

R. Bharti

引用次数: 0

Effectiveness and safety of intravenous alteplase in patients with acute ischemic stroke: Results of a single centre study 急性缺血性脑卒中患者静脉注射阿替普酶的有效性和安全性:单中心研究结果

IP Indian Journal of Neurosciences Pub Date : 2022-09-15 DOI: 10.18231/j.ijn.2022.033

A. Dahiya, Nadeem Motlekar, Mrinalini Singh, Jerestyn Khapoliwala

{"title":"Effectiveness and safety of intravenous alteplase in patients with acute ischemic stroke: Results of a single centre study","authors":"A. Dahiya, Nadeem Motlekar, Mrinalini Singh, Jerestyn Khapoliwala","doi":"10.18231/j.ijn.2022.033","DOIUrl":"https://doi.org/10.18231/j.ijn.2022.033","url":null,"abstract":": To evaluate effectiveness and safety of intravenous alteplase (tPA) for the treatment of acute ischemic stroke. In this prospective observational study, adult patients with ischemic stroke were treated with intravenous alteplase. We recorded baseline demographics and NIHS score was calculated at baseline, 2 hours, 24 hours and 7 days. Improvement was assessed by evaluating total NIH stroke score at different time points. Based on the neurological assessment, patients were categorised into three categories: unchanged (U), improving (I) and deteriorating (D). Blood pressure was closely monitored until 24 hours after infusion of alteplase. Both neurological assessment and blood pressure was monitored every 15 minutes for the first 2 hours after start of infusion, then every 30 minutes for next 6 hours, and hourly from the post infusion hour until 24 hours after infusion. Twenty-six patients [male 16 (61.50%); female 10 (38.50%)] between 34 to 86 years of age were enrolled in this study. Total NIHS score reduced from 10.77 (+5.01) at pre-treatment to 4.04 (+4.00) at 7 days. The improvement in NIHS score at two hours versus pre-treatment (p<0.001), at 24 hours versus 2 hours (p=0.002) and 7 days versus 24 hours (p<0.001) was statistically significant. Clinically no significant change was observed in the blood pressure of the patients till 24 hours after thrombolysis. At the end of 24 hours, 40% patients showed improved status and in 60% patients, status was unchanged. Intravenous alteplase is effective and safe treatment approach for treatment of acute ischemic stroke. No major complications were observed in this study.","PeriodicalId":415114,"journal":{"name":"IP Indian Journal of Neurosciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129059637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis and comparison of synovitis in rheumatoid arthritis and osteoarthritis patients 类风湿关节炎与骨关节炎患者滑膜炎的分析与比较

IP Indian Journal of Neurosciences Pub Date : 2022-06-15 DOI: 10.18231/j.ijn.2022.029

U. Kalluri, S. Babu, Roshan Ajoy Kadavan

{"title":"Analysis and comparison of synovitis in rheumatoid arthritis and osteoarthritis patients","authors":"U. Kalluri, S. Babu, Roshan Ajoy Kadavan","doi":"10.18231/j.ijn.2022.029","DOIUrl":"https://doi.org/10.18231/j.ijn.2022.029","url":null,"abstract":"Idiopathic intracranial hypertension (IIH) is a disorder that leads to isolated raised intracranial pressure characterized by classical symptoms and signs such as headache, papilledema, sixth nerve palsy causing diplopia and pulsatile tinnitus.In our case report, we present a 20-year-old primigravida suffering from IIH presenting with unusual clinically elicited signs, including bilateral proptosis, unilateral ophthalmoplegia, and unilateral facial nerve palsy. Fundoscopy revealed bilateral papilledema and visual field examination showed enlarged blind spots in both eyes. Lumbar puncture was done to detect the opening pressure of cerebrospinal fluid which was measured to be 57cm of water. MRI brain + venogram was suggestive of vertical kinking of right optic nerve and tortuosity of bilateral optic nerves along with stenosis in bilateral transverse sinuses. In previous literature, there are only two reported cases of IIH that were associated with proptosis, both presenting unilaterally, and one reported case of IIH presenting with complete unilateral facial palsy. When a patient presents with these unorthodox signs, the diagnosis of IIH cannot be excluded.","PeriodicalId":415114,"journal":{"name":"IP Indian Journal of Neurosciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126400820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amending the unknown to known: Case series from the emergency psychiatric social work perspective in neurosurgery before and after COVID-19 pandemic 化未知为已知:从COVID-19大流行前后神经外科急诊精神病学社会工作视角的病例系列

IP Indian Journal of Neurosciences Pub Date : 2022-06-15 DOI: 10.18231/j.ijn.2022.030

V. S. Nair, L. Ponnuchamy, Raghavendra Kukehalli, R. Kumar K., Harish Kumar DP

引用次数: 0

Migraine and zinc deficiency in women - A mini review 女性偏头痛和缺锌——一个小综述

IP Indian Journal of Neurosciences Pub Date : 2022-06-15 DOI: 10.18231/j.ijn.2022.020

Pinky Sultana

{"title":"Migraine and zinc deficiency in women - A mini review","authors":"Pinky Sultana","doi":"10.18231/j.ijn.2022.020","DOIUrl":"https://doi.org/10.18231/j.ijn.2022.020","url":null,"abstract":"Migraine is a frequently occurring multifactorial neurovascular disorder affecting over a billion people globally. Migraine load is distinctive concerning gender, i.e. it is more severe in women and has a prolonged healing period. People with migraine have a primary headache disorder, a public health concern in low and middle-income countries. Studies have shown that brainstem regions and the trigeminovascular pathway are linked to the migraine attack's symptomatology. The episode is mediated by the release of Calcitonin Gene-Related Peptide (CGRP). It is a widely expressed neuropeptide with a sole role in sensory neurotransmission. Treatment of migraine remains underdiagnosed; its frequency and intensity are poorly understood. Although patients consume the antagonists of CGRP, migraine still prevails heavily in women. Dietary factors are often considered migraine triggers. One such dietary factor is Zinc deficiency. Zinc deficiency is mainly observed in women with poor dietary intake in rural and sub-rural areas of India. Recently Zinc has been shown to play a role in migraine disorders. This review briefly summarizes how supplementary Zinc may be a potential therapeutic strategy to overcome migraine pain.","PeriodicalId":415114,"journal":{"name":"IP Indian Journal of Neurosciences","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133608546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noise removal of deep brain stimulation artifacts in subthalamic nucleus neurons local field induced electrical potentials 丘脑底核神经元局部场诱发电位的脑深部刺激伪影噪声去除

IP Indian Journal of Neurosciences Pub Date : 2022-06-15 DOI: 10.18231/j.ijn.2022.027

V. R. Raju

{"title":"Noise removal of deep brain stimulation artifacts in subthalamic nucleus neurons local field induced electrical potentials","authors":"V. R. Raju","doi":"10.18231/j.ijn.2022.027","DOIUrl":"https://doi.org/10.18231/j.ijn.2022.027","url":null,"abstract":"This study presents a noise-removal technique for the microelectrode signals of subthalamic-nuclei (STN) neurons acquired by MER machine through electrical stimulations with subthalamic-nuclei deep brain stimulation/or stimulator (STN-DBS) in local field potentials (LFPs). We proposed a novel method for the removal of induced stimuli-artifacts triggered by pulse-generators differed in typical LFPs (low-frequency potentials) signals. The method is processed and tested for accuracy and computed for execution in vitro-states. Results indicated that the stimulus-artifacts are well suppressed by this method. And also it is tested in vivo-states of Parkinson’s disease (PD) subjects (patients). It is applied to process signals of LFPs gathered intra operatively from PDs to preliminarily explore quantitative dependencies-of beta-band synchronous variations within STN, DBS parameters (stimulus-intensity, stimulus-voltage, frequency, and amplitude pulse-width). Findings showed that the DBS process can overcome excessive beta-frequency (30Hz) activity plus that the degree of reduction rises with increasing DBS current in the range-of 1-3Volts then boosting stimulus-frequency within a range of 60-120Hz. The method offers scientific-research and technical support for exploring the instant effect by induced electrical stimulations in the Parkinson brain activities and it can be utilized as a research tool in the future technologies.","PeriodicalId":415114,"journal":{"name":"IP Indian Journal of Neurosciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122780963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An observational cross-sectional study of clinical profile of posterior circulation ischemic stroke in a tertiary care teaching hospital in Eastern India 一项观察性横断面研究后循环缺血性卒中的临床概况在印度东部的三级护理教学医院

IP Indian Journal of Neurosciences Pub Date : 2022-06-15 DOI: 10.18231/j.ijn.2022.025

Bhabani Sankar Samantaray, Subhransu Jena, Anup K Budhia, S. K. Tripathy

{"title":"An observational cross-sectional study of clinical profile of posterior circulation ischemic stroke in a tertiary care teaching hospital in Eastern India","authors":"Bhabani Sankar Samantaray, Subhransu Jena, Anup K Budhia, S. K. Tripathy","doi":"10.18231/j.ijn.2022.025","DOIUrl":"https://doi.org/10.18231/j.ijn.2022.025","url":null,"abstract":": Posterior circulation strokes account for approximately 15% of all strokes with diverse clinical presentation. They are different from anterior circulation strokes, with reference to risk factors, clinical features, management stratergy and prognosis. We conducted a study in a tertiary care teaching hospital in Eastern India to understand the clinical profile of patients with posterior circulation ischemic stroke. : The study was conducted at Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, with a total of 282 patients during the period from January 2020 to June 2021 (Eighteen months). A detailed medical history and clinical examination aided with neuro-imaging was done in all patients. : Incidence of posterior circulation ischemic stroke was 16.2%. The male to female ratio being 2.27:1, the mean age at presentation was 54.4 (± 13.6) years. Diabetes, hypertension, dyslipidemia and tobacco use were identified as the major risk factors. The common clinical manifestations were motor disturbances, vertigo, gait ataxia, cranial nerve deficits, altered sensorium and visual disturbances. Infratentorial infarcts were seen more frequently and most common anatomical site of involvement was cerebellum (30.5%). Large artery diseases (58.8%) were the most common aetiological causes and 15.6% had cardioembolic source according to TOAST Criteria. Posterior cerebral artery involvement was the most common (43.6%) finding and the incidence of mortality was 6.3% noted in our series.","PeriodicalId":415114,"journal":{"name":"IP Indian Journal of Neurosciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122175982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of real-time multi channel microelectrode recordings of rats: A study with computational simulation 大鼠多通道微电极实时记录分析:计算模拟研究

IP Indian Journal of Neurosciences Pub Date : 2022-06-15 DOI: 10.18231/j.ijn.2022.026

V. R. Raju

引用次数: 0

Systematic assessment of pathophysiological mechanisms and their interrelation in progression of Alzheimer’s disease 阿尔茨海默病进展的病理生理机制及其相互关系的系统评估

IP Indian Journal of Neurosciences Pub Date : 2022-06-15 DOI: 10.18231/j.ijn.2022.023

S. Mittal, Akriti Sharma, Gauri Mittal, Ashwini A Mahadule, Monica Pathania

{"title":"Systematic assessment of pathophysiological mechanisms and their interrelation in progression of Alzheimer’s disease","authors":"S. Mittal, Akriti Sharma, Gauri Mittal, Ashwini A Mahadule, Monica Pathania","doi":"10.18231/j.ijn.2022.023","DOIUrl":"https://doi.org/10.18231/j.ijn.2022.023","url":null,"abstract":"Alzheimer’s disease (AD) consists of 60-80% of all dementia cases, thus is recognized as the commonest form of dementia. The current challenge to clinicians and researchers in the field of AD is development of treatment plans that can target the progression of pathology at molecular level as well newer diagnostic techniques for early detection and prevention of AD. This could be achieved by enhancing our understanding of the underlying pathophysiology of AD. This is systematic and concise review of various pathophysiological mechanisms contributing to AD. Legitimate indexing portals and search websites were used to carry out the literature search for this article. A combination of MeSH terms and Boolean operators were used. Obtained research articles were carefully assessed first by reading title and abstract and finally by reading the whole text. A set of inclusion and exclusion criteria were used to select the reference articles.: In our literature search 75 articles were obtained from PubMed, Google scholar and Cochrane Library after removing duplicate records. These were screened using titles and abstract. 23 articles were excluded from the study as per the exclusion criteria. Full text of 52 articles were read. 7 articles were excluded, 45 were studied thoughrouly and 30 were referenced during the writing of this review.Various risk factors – old age, diabetes, smoking, mutation etc contribute to Aβ plaque accumulation due to cleavage of APP protein by α and ϒ secretase. Aβ plaque further contributes to accumulation of neurofibrillary tangles, neuroinflammation and oxidative stress. This together with disturbance in Calcium homeostasis and excitotoxicity at glutamate receptors contribute to neurodegeneration and synaptic toxicity.","PeriodicalId":415114,"journal":{"name":"IP Indian Journal of Neurosciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114957958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis and outcomes of diffuse axonal injury in tertiary care centre 三级保健中心弥漫性轴索损伤的分析和结果

IP Indian Journal of Neurosciences Pub Date : 2022-06-15 DOI: 10.18231/j.ijn.2022.028

S. Uppal, Visvanathan K

引用次数: 0