丘脑底核神经元局部场诱发电位的脑深部刺激伪影噪声去除

V. R. Raju
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引用次数: 0

摘要

本研究提出了一种对丘脑下核(STN- dbs)脑深部电刺激器(STN- dbs)局部场电位(LFPs)电刺激获得的丘脑下核(STN)神经元微电极信号的去噪技术。我们提出了一种新的方法来去除由脉冲发生器触发的不同于典型LFPs(低频电位)信号的诱导刺激伪影。对该方法进行了处理和准确性测试,并计算了在体外状态下的执行情况。结果表明,该方法能很好地抑制刺激伪影。它也在帕金森病(PD)受试者(患者)的体内状态中进行了测试。将其应用于处理术中从pd采集的lfp信号,初步探索STN、DBS参数(刺激强度、刺激电压、频率和幅度脉宽)内β波段同步变化的定量依赖关系。研究结果表明,DBS过程可以克服过度的β频率(30Hz)活动,并且在1- 3v范围内,DBS电流增加,刺激频率在60-120Hz范围内增加,减少程度随之增加。该方法为探索诱导电刺激对帕金森脑活动的即时效应提供了科学研究和技术支持,可作为未来技术研究的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Noise removal of deep brain stimulation artifacts in subthalamic nucleus neurons local field induced electrical potentials
This study presents a noise-removal technique for the microelectrode signals of subthalamic-nuclei (STN) neurons acquired by MER machine through electrical stimulations with subthalamic-nuclei deep brain stimulation/or stimulator (STN-DBS) in local field potentials (LFPs). We proposed a novel method for the removal of induced stimuli-artifacts triggered by pulse-generators differed in typical LFPs (low-frequency potentials) signals. The method is processed and tested for accuracy and computed for execution in vitro-states. Results indicated that the stimulus-artifacts are well suppressed by this method. And also it is tested in vivo-states of Parkinson’s disease (PD) subjects (patients). It is applied to process signals of LFPs gathered intra operatively from PDs to preliminarily explore quantitative dependencies-of beta-band synchronous variations within STN, DBS parameters (stimulus-intensity, stimulus-voltage, frequency, and amplitude pulse-width). Findings showed that the DBS process can overcome excessive beta-frequency (30Hz) activity plus that the degree of reduction rises with increasing DBS current in the range-of 1-3Volts then boosting stimulus-frequency within a range of 60-120Hz. The method offers scientific-research and technical support for exploring the instant effect by induced electrical stimulations in the Parkinson brain activities and it can be utilized as a research tool in the future technologies.
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