Journal of Translational Medicine and Research最新文献

{"title":"Depression in postpartum women-Ibarra","authors":"María Ximena Tapia Paguay, A. Pineda, Samantha AbigailMontenegro Tapia","doi":"10.15406/oajtmr.2018.02.00056","DOIUrl":"https://doi.org/10.15406/oajtmr.2018.02.00056","url":null,"abstract":"The World Health Organization (who) defines mental health as “a State of well-being in which the individual is aware of his own abilities, can cope with the normal stresses of life, can work productively and fruitful and is able to make a contribution to their community.2 Depression instead is a common disease in the world, and it is estimated to affect more than 300 million people. It is different from the usual swings of mood and short emotional responses to the problems of everyday life. You can become a serious health problem, especially when it’s long lasting and moderate to severe, and may cause great suffering and alter work, school and family activities. In the worst cases it can lead to suicide. Each year they kill themselves close to 800 000 people and suicide is the second leading cause of death in the age group of 15 to 29 years.3 It is the mental disorder that affects the population and is also one of the leading causes of disability in the world. Although it is a treatable disease, six of every ten people who suffer from it in Latin America and the Caribbean, do not seek or do not receive the treatment they need; It is more common in women than in men. Between two and four in ten mothers in developing countries suffer from depression during pregnancy or postpartum.4","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"275 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123381785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthesia in severe preeclampsia","authors":"Jayavelan Ramkumar, Nidhi Sharma","doi":"10.15406/OAJTMR.2018.02.00054","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00054","url":null,"abstract":"The word “Preeclampsia” is derived from the Greek word Eklampsis meaning “lightening” or “convulsions”. A pregnancy with preeclampsia whose hypertension has been treated ante partum generally present for delivery with contracted plasma volume, normal or increased cardiac output, vasoconstriction, and hyper dynamic left ventricular function. There may also be a coexisting left ventricular systolic and diastolic dysfunction. Other problems are increased airway edema, decreased glomerular filtration, platelet dysfunction, or a spectrum of hemostatic derangements (the exaggerated hypercoagulable state).1 In severe preeclampsia there is chronic placental hypo perfusion.2 The uteroplacental circulation is not auto regulated and the fetus may poorly tolerate any further decline in perfusion. Thus the primary peripartum goals in the severely preeclampsia parturient are the optimization of maternal blood pressure, cardiac output, and uteroplacental perfusion and the prevention of seizures and stroke. The main concerns to the anaesthetist are an edematous airway, dysfunction of the cardio respiratory system, dysfunction of cerebro-vascular system and the dysfunction of coagulation system.3","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134052508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature’s intrinsic “Erythrocyte Associated Necrosis Factor” (EANF) explains the anomalous lack of metastases in “bulky” lung cancers","authors":"W. Onuigbo","doi":"10.15406/oajtmr.2018.2.00055","DOIUrl":"https://doi.org/10.15406/oajtmr.2018.2.00055","url":null,"abstract":"Under Professor D. F. Cappell, I went through the Scottish Pathology Residency Program in the University Department of Pathology which was housed in the Glasgow Western Infirmary. Incidentally, that Institution was acknowledged recently in the Bulletin of the History of Medicine as being second to none in Britain.1 Therein, I soon realized that the usual displaying of human parts on the Table was not sufficient for recognizing topographical relationships. Instead, I introduced the “Mono-Block FormalinFixation Method,” whose advantage was the precious preservation of the axial tissues from the neck to the pelvis.2 See Figure 1. Moreover, on account of serendipity, I used the Swiss-roll method to ensure that the difficult 45 cm long thoracic duct was easily prepared routinely and stained on but a single microscope slide.3 The revealed amazing panorama was strikingly that of lung cancer cells being carried more or less leisurely at the moment of death along this obviously strategic avenue. See Figure 2. In particular, I observed that, when cancer cells and red cells became commingled, necrosis occurred in this auspicious microenvironment. Accordingly, I named this extraordinary killing entity as the “Erythrocyte Associated Necrosis Factor” (EANF).4 It may be charged that it is not Necrosis per se but “coagulation.” If so, only red cells would have been seen. Moreover, if it is “inflammation,” white corpuscles alone would be involved. The thrust on EANF is on the oddity of comingling of cancer cells and red cells. Accepting this hypothesis concerning this poignant program of enduring natural events, its decoding has become necessary. Figure 1 Specimen of mono-block formalin-fixed bodily tissues extending from above the thyroid gland to beyond the aortic bifurcation.","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126429606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The requirement of insulin and intravenous fluid in adult Diabetic ketoacidosis management: a review","authors":"Rozana Rouf, M. A. Rahim, Z. Latif","doi":"10.15406/OAJTMR.2018.02.00053","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00053","url":null,"abstract":"","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114978599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema multiforme: a case series and review of literature","authors":"K. Krishnankutty, Kanad Chaudhuri, L. Ashok","doi":"10.15406/oajtmr.2018.02.00052","DOIUrl":"https://doi.org/10.15406/oajtmr.2018.02.00052","url":null,"abstract":"The term erythema multiforme was first coined by Ferdinand von Hebra in 1860. Erythema Multiforme (EM) is an acute mucocutaneous condition caused by a hypersensitivity reaction. Despite being listed with many etiological factors, the exact pathogenic mechanism of EM remains unclear, and as a consequence, there are no evidence-based, reliably effective therapies.1 EM can be triggered by a range of factors, but the best-reported stimulus is with a preceding viral infection with herpes simplex virus (HSV) and other cases are most often triggered by drugs.2 EM has been classified into a number of variants, mainly minor and major forms, as it may involve the mouth alone, or present as a skin eruption with or without oral or other lesions on the mucous membrane.2","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127912594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Croton caudatus geiseler toxicity evaluation in swiss albino mice transplanted or not with dalton’s lymphoma ascite tumor before exposure to 6 gy γ-radiation","authors":"Ganesh Ch, R. Jagetia","doi":"10.15406/OAJTMR.2018.02.00050","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00050","url":null,"abstract":"Radiotherapy is one of the important modalities to treat malignant diseases. Radiotherapy alone is not enough to control tumor therefore, it is usually combined with other modalities to treat difficult neoplasia in the clinical condition. Radiotherapy is usually combined with chemotherapeutic agents to get better response and cure rates in patients.1 Despite the fact that radiotherapy is used to treat approximately 50% tumors, the induction of radiotoxicity in the normal cells remains the major limiting factor.2 The curative effects of irradiation are temporary and are highly localized to the irradiated area. It is well known that irradiation causes long term adverse side effects on body’s healthy normal tissues. The radiotherapy usually leads to tiredness, feeling of run down, sore throat, difficulty in swallowing, cough, hair loss, chest pain, increased body, temperature, shivering, sick feeling and sore skin.3 Radiotherapy uses high-energy Xor γrays to kill cancer cells and shrink tumors. Ionizing radiations belong to electromagnetic radiation category, and their wavelength is very short that make them highly effective. The major cell killing effect of radiotherapy is brought by causing various types of DNA damages and in particular DNA double strand breaks in cells.4 This indicates that tumor shall be made more vulnerable to radiation so as to spare the normal cells. Combination chemotherapy or chemoradiotherapy has been tried to treat difficult neopalsia and several combinations of chemotherapeutic drugs are used as cancer treatment regimens.5The combination chemoradiotherapy is also utilized in an attempt to increase the effectiveness and reduce the radiotoxicity in the patients by lowering the dose of the agent/s.6 Traditionally Croton caudatus Geiseler (family Euphorbiaceae) or kam-sabut has been utilized to treat several disorders including sprains, fever and liver diseases in the northeastern part of India. Its roots have been found to be purgative and it has low toxicity.7The leaves are applied on festering wounds of injured cattles and to ward off against the maggots. Our earlier studies have shown that kam-sabut acts as an antioxidant at low doses.8 Therefore, the aim of this study was to examine various biochemical lesions induced by kam-sabut in the liver and kidney of Dalton’s lymphoma transplanted mice following exposure to 6 Gy γradiation.","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115272786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukocyte morphology on an anti-CD antibody microarray for acute leukemia diagnosis: morphology rejuvenated","authors":"S. A. Kuznetsova, O. Fedyanina","doi":"10.15406/OAJTMR.2018.02.00045","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00045","url":null,"abstract":"Acute leukemia diagnosis steadily shifts towards automated analysis and precise molecular methods banishing the methods resistant to complete automatization (such as cytochemistry and bone marrow morphology). The reasons for this lie above all in the desire to eliminate the human factor as well as to find a way to cope with increasing work load. The better understanding of the biology of the disease achieved with the advanced molecular technologies led to the inclusion of new recurrent cytogenetic abnormalities, mutations and gene fusions into the revised WHO classification of tumors of the hematopoietic and lymphoid tissues. Wherever possible the acute leukemias are classified by mutations rather than by underlying subtypes according to French-American-British (FAB) classification.1 FAB classification is retained only in the “not otherwise specified” category. These changes give a probably involuntary message that as mutations prevail over morphologic and immunophenotypic characteristics of leukemic cells the latter at a certain point will not be needed for the diagnosis.","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114926700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of surgical referrals to minimize cost","authors":"Kambiz Farahm, S. S. Wadhwa","doi":"10.15406/OAJTMR.2018.02.00044","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00044","url":null,"abstract":"One facility is located in Tucson, which serves patients in Arizona and one in Albuquerque, which serves patients in New Mexico and West Texas. Patients who live in Southern or Northern New Mexico and West Texas who require non-emergency surgery are referred to the Albuquerque Medical Center surgical department. All emergency surgeries are referred to the nearest clinic or hospital with surgical capability for the procedure provided fee-care availability.","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"148 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115128625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare cause of acute abdomen: epiploic appendagitis","authors":"Yassine Nhamoucha, Y. Bouabdellah","doi":"10.15406/OAJTMR.2018.02.00042","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00042","url":null,"abstract":"","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130113500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A severe case of Mediterranean spotted fever: value of ocular examination","authors":"Brour Jihen, Daldoul Nadia, Ouederni Meriem, Ben Romdhane Bochra, Sassi Héla, Cheour Monia","doi":"10.15406/oajtmr.2018.02.00041","DOIUrl":"https://doi.org/10.15406/oajtmr.2018.02.00041","url":null,"abstract":"Rickettsiosis is diseases caused by obligate intracellular bacteria. It is a zoonosis distributed throughout the world and transmitted to human by the bite of contaminated arthropods. It is endemic in the Mediterranean area and it is caused by species called Rickettsia conorii. Typical diagnosis criteria are based on the triad of high fever, general discomfort and skin rash in a patient living in or back from an endemic region for rickettsiosis. However, this triad is not always present. In fact, atypical forms can be observed with multiorgan involvement including hepatic, renal, neurological and cardiac impairment.1–4","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133280347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}