Erythema multiforme: a case series and review of literature

The term erythema multiforme was first coined by Ferdinand von Hebra in 1860. Erythema Multiforme (EM) is an acute mucocutaneous condition caused by a hypersensitivity reaction. Despite being listed with many etiological factors, the exact pathogenic mechanism of EM remains unclear, and as a consequence, there are no evidence-based, reliably effective therapies.1 EM can be triggered by a range of factors, but the best-reported stimulus is with a preceding viral infection with herpes simplex virus (HSV) and other cases are most often triggered by drugs.2 EM has been classified into a number of variants, mainly minor and major forms, as it may involve the mouth alone, or present as a skin eruption with or without oral or other lesions on the mucous membrane.2