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Role of selective 5-HT2C ligands on maternal separation induced ultrasonic vocalization and c-fos expression in paternal duplicated mouse pups 选择性5-HT2C配体在母鼠分离诱导的超声发声和父系复制幼鼠c-fos表达中的作用
Journal of Translational Medicine and Research Pub Date : 2018-04-25 DOI: 10.15406/OAJTMR.2018.02.00040
Jha Amrendra, S. Dhungel, T. Takumi
{"title":"Role of selective 5-HT2C ligands on maternal separation induced ultrasonic vocalization and c-fos expression in paternal duplicated mouse pups","authors":"Jha Amrendra, S. Dhungel, T. Takumi","doi":"10.15406/OAJTMR.2018.02.00040","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00040","url":null,"abstract":"Autism and Autism spectrum disorders (ASD) are neurodevelopmental psychiatric disorders characterized by impairments of language, communication, social interaction, stereotype and repetitive behavior.1,2 Twin studies have shown that the narrow as well as broad phenotypes of ASD are strongly associated with genetic component.3 Etiology of the disease is unknown but it is thought to involve an interaction between multiple genes and environment factors. Diagnosis can be made by three years of age based on the presence or absence of specific behaviors that are used as diagnosis criteria. Evidence suggested that language disorder is associated in patient with autism. Knockout studies in mice have shown that mutation of certain type gene may cause the impairment of language in autistic patient but still neural mechanism is not known. In recent years several autistic mice model has been developed to investigate the actual cause of autism and ASD. Alteration of ultrasonic vocalization (USV) is frequently reported by using different model of autistic model mice, suggesting that altered USVs is a reminiscent of language impairment in humans.4–6 Infant mice, like the young of all mammalian species including humans, exhibit distress like reactions when they are separated from their dam and littermates.7,8 Their distress is signaled by the emission of 30-80 kHz USVs that can be heard by the dam and trigger their retrieval.9 Other neonatal rodents including rats, hamster and gerbils also emit maternal separation induced USVs.8,10 Drugs that reduce the anxiety in humans attenuate the emission of USVs in rat pups, leading to the use of these reactions as a screen for potentially anxiolytic compounds.14 Some studies have suggested the involvement of 5-HT2CR in anxiety like behaviour and mood disorder in mice.11–13","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125760302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EGF-like domains with a C-x-D-x(4)-Y-x-C motif 具有C-x-D-x(4)-Y-x-C基序的egf样结构域
Journal of Translational Medicine and Research Pub Date : 2018-04-24 DOI: 10.15406/oajtmr.2018.02.00039
C. Hidai
{"title":"EGF-like domains with a C-x-D-x(4)-Y-x-C motif","authors":"C. Hidai","doi":"10.15406/oajtmr.2018.02.00039","DOIUrl":"https://doi.org/10.15406/oajtmr.2018.02.00039","url":null,"abstract":"The epidermal growth factor (EGF)-like domain was first identified in pro-epidermal growth factor in 1983 and since then many proteins with EGF-like domains have been reported to be involved in pathogenesis.1,2 Pro-EGF is significantly related with oncogenesis.3,4 Mutations of EGF-like domains in fibrillin-1, low-density lipoprotein receptor (LDLR), and coagulation factor IX (FIX) are the causes of Marfan syndrome, the autosomal dominant form of familial hypercholesterolemia (FH), and hemophilia B, respectively.5–8 EGFlike domains are found in numerous secreted extracellular proteins, except for the endoplasmic transmembrane protein prostaglandin G/H synthase.9 Extracellular proteins are easily accessed by drugs and thus are good therapeutic targets, making studies of EGF-like domains medically significant.","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116275423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Prevent BP/diabetes 防止BP /糖尿病
Journal of Translational Medicine and Research Pub Date : 2018-03-29 DOI: 10.15406/OAJTMR.2018.02.00036
G. Grant
{"title":"Prevent BP/diabetes","authors":"G. Grant","doi":"10.15406/OAJTMR.2018.02.00036","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00036","url":null,"abstract":"","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"103 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115732467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic mechanisms in pathogenesis of multiple sclerosis 多发性硬化发病机制的表观遗传机制
Journal of Translational Medicine and Research Pub Date : 2018-03-29 DOI: 10.15406/oajtmr.2018.02.00037
Goldina Ia, Gaĭdul' Kv, V. Kozlov
{"title":"Epigenetic mechanisms in pathogenesis of multiple sclerosis","authors":"Goldina Ia, Gaĭdul' Kv, V. Kozlov","doi":"10.15406/oajtmr.2018.02.00037","DOIUrl":"https://doi.org/10.15406/oajtmr.2018.02.00037","url":null,"abstract":"Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system with immune induced myelin destruction followed by multifocal demyelination of the nervous tissues.1 MS is the most widely spread among the human diseases characterized by myelin destruction .2 Until now both the etiology and pathogenesis of MS have to a large extent remained unclear. Substantial efforts have been made over the last decades to identify biomarkers for MS that can identify disease diagnosis, predict disease progression, and improve clinical outcomes. Degenerative and inflammatory changes in the nervous tissue in MS are characterized by a multiple fibrosis of neuron myelin sheath accompanied by the formation of sclerotic plaques and axon pathology resulting in progressive neurological dysfunction.3,4 Based on the pathomorphological aspects of the disease, French neurologist Dr. Jean-Martin Charcot was the first to recognize MS as a distinct disease in the end of the 19th century. He described the clusters of inflammatory cells in the perivascular space in the brain and spinal cord in patients with intermittent neurological disorders.5","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122943621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Upon the need for a new paradigm for bariatric emergencies and complications 在需要一个新的范例的肥胖紧急情况和并发症
Journal of Translational Medicine and Research Pub Date : 2018-03-22 DOI: 10.15406/OAJTMR.2018.02.00035
Z. Perry, Uri Netz, Y. Glazer, Shahar Atias, Eliezer Avinoh
{"title":"Upon the need for a new paradigm for bariatric emergencies and complications","authors":"Z. Perry, Uri Netz, Y. Glazer, Shahar Atias, Eliezer Avinoh","doi":"10.15406/OAJTMR.2018.02.00035","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00035","url":null,"abstract":"","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"359 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127128090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electro-homeopathy: select numerical aspects 电顺势疗法:选择数值方面
Journal of Translational Medicine and Research Pub Date : 2018-03-20 DOI: 10.15406/OAJTMR.2018.02.00034
S. Padhi, A. Kesari, D. Bhattacharya
{"title":"Electro-homeopathy: select numerical aspects","authors":"S. Padhi, A. Kesari, D. Bhattacharya","doi":"10.15406/OAJTMR.2018.02.00034","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00034","url":null,"abstract":"","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"23 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121276623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insight into pregnant women oral health care 孕妇口腔保健新认识
Journal of Translational Medicine and Research Pub Date : 2018-03-14 DOI: 10.15406/oajtmr.2018.2.00038
Hassan H Koshak
{"title":"New insight into pregnant women oral health care","authors":"Hassan H Koshak","doi":"10.15406/oajtmr.2018.2.00038","DOIUrl":"https://doi.org/10.15406/oajtmr.2018.2.00038","url":null,"abstract":"The human body is comprised of complex systems, which are interconnected with each other. Because of the way, the human body is made; one organ of the body can have an impact on other organs of it. Oral health affects people physically and psychologically and influences how they grow, enjoy life, look, speak, chew, taste food and socialize, as well as their feelings of social well-being. The oral hygiene measures related to professional level, level of education, and periodontal maintenance. Some studies report that oral health has an impact on food choice and on the intake of key nutrients, causing various nutritional problems. Recent researches on oral and general health have shown a link between the two. With more than 90% of systemic diseases having oral symptoms. These symptoms can include swollen gums, sores, ulcers, dry mouth and more, the following diseases are an example of a systemic disease which has symptoms expressed in the mouth like diabetes, leukemia, oral cancer, pancreatic cancer, heart disease and kidney disease.","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130607530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomedical and antifungal application of Cu (II) soaps and its urea complexes derived from various oils Cu (II)皂及其尿素络合物在生物医学和抗真菌方面的应用
Journal of Translational Medicine and Research Pub Date : 2018-03-13 DOI: 10.15406/OAJTMR.2018.02.00033
A. Sharma, M. Saxena, Rashmi Sharma
{"title":"Biomedical and antifungal application of Cu (II) soaps and its urea complexes derived from various oils","authors":"A. Sharma, M. Saxena, Rashmi Sharma","doi":"10.15406/OAJTMR.2018.02.00033","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00033","url":null,"abstract":"The deeper understanding of the role of metal ion in bio-system has led to the awareness that metal complexation is useful in the treatment of bacterial, fungicidal and viral diseases. Most of the antimicrobial agents are obviously organic compounds, which behave as good chelating agent. Their pathogenic activity is enhanced on complexing with various transition and toxic metals. The biological effect of these derivatives depends upon the nature and structure of ligands and their metal complexes and also on the presence of particular element.1–3","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116251479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Acute pulmonary edema and unstable coronary disease 急性肺水肿和不稳定冠状动脉疾病
Journal of Translational Medicine and Research Pub Date : 2018-02-20 DOI: 10.15406/OAJTMR.2018.02.00032
M. Barros, N. O. Neto
{"title":"Acute pulmonary edema and unstable coronary disease","authors":"M. Barros, N. O. Neto","doi":"10.15406/OAJTMR.2018.02.00032","DOIUrl":"https://doi.org/10.15406/OAJTMR.2018.02.00032","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com mortality was 14.1% [2]. Among the modalities of acute cardiac insufficiency, it occupies the second place in hospital cost, the cardiogenic shock is the first one [3]. Breathless is the main symptom of HF and in APE is usually very intense. The differential diagnosis of dyspnea in the emergency room is broad, but the main diseases to be excluded due to the severity and risk of death are HF, acute coronary syndrome (ACS) and pulmonary embolism [4].","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130962929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detoxificating effects of Moringa oleifera leaf and Zingiber officinale root powder on cadmium toxicity in blood and fur of wistar rats 辣木叶和生姜根粉对wistar大鼠血液和皮毛镉毒性的解毒作用
Journal of Translational Medicine and Research Pub Date : 2018-02-07 DOI: 10.15406/oajtmr.2018.02.00030
Jangber Zn, Ekwumemgbo Pa, Okibe Fg, Oladele Sb
{"title":"Detoxificating effects of Moringa oleifera leaf and Zingiber officinale root powder on cadmium toxicity in blood and fur of wistar rats","authors":"Jangber Zn, Ekwumemgbo Pa, Okibe Fg, Oladele Sb","doi":"10.15406/oajtmr.2018.02.00030","DOIUrl":"https://doi.org/10.15406/oajtmr.2018.02.00030","url":null,"abstract":"Heavy metals are hazardous substances that cause serious health risk to ecosystem and organisms due to their high toxicity conferred by nature of their environmental persistence. Heavy metals have been defined based on their specific density (of metals greater than 4 or 5 g/liter), having atomic weight between 63.546 and 200.590 (Sagakachi, Makajima & Atoleiye et al). Unlike organic pollutants, heavy metals are non-biodegradable, so they persist for long in their host organism, constituting long term problem (Atolaiye). Cadmium is a soft, malleable, ductile, bluishwhite divalent metal. It’s average concentration in the earth crust is between 0.1 and 0.5 mg/kg [1,2]. It is an environmental toxicant that adversely affect various organs such as liver, lungs, kidney, pancrease, testis, etc [3-4]. Plants are said to contain some phytochemicals which are good potential chelating agents of heavy metals [5]. Moriga oleifera is a vegetable belonging to the family Moringaceae which is widespread in both tropical and subtropical regions of sub-Saharan Africa [6].","PeriodicalId":410359,"journal":{"name":"Journal of Translational Medicine and Research","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130240026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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