Majalah Kedokteran Bandung-MKB-Bandung Medical Journal最新文献_第5页

Nutmeg Extract Alters Mitochondrial Genes Regulation of Skeletal Muscle Fibers in Aging Rats 肉豆蔻提取物改变衰老大鼠骨骼肌纤维线粒体基因调控

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-12-31 DOI: 10.15395/mkb.v54n4.2930

Setiawan Setiawan, Y. Pratiwi, R. Lesmana, Galuga Sinalusur Sari, A. Ramdan, Aldo Hartono, Fathurachman Fathurachman, U. Supratman

{"title":"Nutmeg Extract Alters Mitochondrial Genes Regulation of Skeletal Muscle Fibers in Aging Rats","authors":"Setiawan Setiawan, Y. Pratiwi, R. Lesmana, Galuga Sinalusur Sari, A. Ramdan, Aldo Hartono, Fathurachman Fathurachman, U. Supratman","doi":"10.15395/mkb.v54n4.2930","DOIUrl":"https://doi.org/10.15395/mkb.v54n4.2930","url":null,"abstract":"Nutmeg as one of Indonesia native plants has already been used widely in herbal treatment. It has been demonstrated that nutmeg presents activities related to mitochondria functions. Nutmeg potentially has the effect of peroxisome proliferator activated receptors Υ (PPAR Υ) which contributes to myogenesis, and may alters mitochondrial homeostasis in respiration and biogenesis. In this study, how nutmeg extract alters oxidative process in skeletal muscle of aging rats was explored. Twenty aging Wistar male rats aged 80 weeks old were divided into two groups (control and nutmeg treatment). Nutmeg extract was administered for 12 weeks using a gavage. After that, the soleus muscles were collected, weighted, frozen, and stored at -800C until used. Nutmeg was observed to increase the COX1 (1.9 folds, p<0.01), COX2 (1.6 folds, p<0.05), and COXIV (2.8 folds, p<0.01) gene expressions, in parallel with increased protein carbonyl levels (1.5 folds, p<0,01). Nutmeg treatment also significantly increased the expressions of antioxidant endogen COQ7 (2 folds, p<0,01) and PDSS2 (2 folds, p<0,01) in the soleus muscle. Taken together, nutmeg extract may improve mitochondrial respiratory oxidative activities in type I aging skeletal muscle.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42835303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with Mortality in COVID-19 Patients Treated at Serui General Hospital, Papua Indonesia 在巴布亚印度尼西亚Serui综合医院接受治疗的新冠肺炎患者死亡率的相关因素

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-12-31 DOI: 10.15395/mkb.v54n4.2864

Fahri Ahmad Baihaqi, Henny Rumaropen

{"title":"Factors Associated with Mortality in COVID-19 Patients Treated at Serui General Hospital, Papua Indonesia","authors":"Fahri Ahmad Baihaqi, Henny Rumaropen","doi":"10.15395/mkb.v54n4.2864","DOIUrl":"https://doi.org/10.15395/mkb.v54n4.2864","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19) has a high fatality rate and has caused around 4,771,408 deaths worldwide as of 30 September 2021. COVID-19 infection presents various severity levels, starting from asymptomatic to severe symptoms that lead to death. Mortality in COVID-19 patients is associated with multiple risk factors. This study aimed to analyze the risk factors associated with COVID-19 mortality in Serui General Hospital, Papua, Indonesia. A cross-sectional analytic observational study was performed in Serui General Hospital from September 2020to September 2021. Subjects were COVID-19 positive inpatients who met the inclusion and exclusion criteria. The independent variables were demographic characteristics, clinical manifestations, comorbidities, and lab findings, while the dependent variable was mortality. Statistical analysis was performed using chi-square test and logistic regression. This study included sixty-nine patients with 21 (30.4%) of them were non-survivors. The multivariate analysis showed that an NLR of >3.13 (OR 7.49; p=0.037; 95% CI 1.63–34.35), hypertension (OR 4.71; p=0.019; 95% CI 1.28–17.29), and age (OR 4.26; p=0.028; 95% CI 1.17–15.52) were associated with mortality in COVID-19 patients. Thus, NLR >3.13, hypertension, and age are considered to be the risk factors associated with the mortality caused by COVID-19 among patients in Serui General Hospital.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43996332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BMI and TLC increase Neoadjuvant Chemotherapy Response in Patients with Locally Advanced Breast Cancer BMI和TLC增加局部晚期癌症患者的新辅助化疗反应

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-12-31 DOI: 10.15395/mkb.v54n4.2797

Sasongko Hadi Priyono, Oscar Tri Joko Putra, A. Yasmina, Hery Poerwosusanta, Eka Yudha Rahman, I. Oktaviyanti

{"title":"BMI and TLC increase Neoadjuvant Chemotherapy Response in Patients with Locally Advanced Breast Cancer","authors":"Sasongko Hadi Priyono, Oscar Tri Joko Putra, A. Yasmina, Hery Poerwosusanta, Eka Yudha Rahman, I. Oktaviyanti","doi":"10.15395/mkb.v54n4.2797","DOIUrl":"https://doi.org/10.15395/mkb.v54n4.2797","url":null,"abstract":"Anthracycline-based neoadjuvant chemotherapy is the recommended therapy for locally advanced breast cancer (LABC) patients. Unfortunately, no study has reported the relationship between body mass index (BMI), total lymphocyte count (TLC), and responses to this type of chemotherapy. This study aimed to determine the relationship between BMI, TLC, and response to doxorubicin/epirubicin neoadjuvant chemotherapy in LABC patients. A retrospective cohort design was applied to medical records of LABC patients undergoing neoadjuvant chemotherapy at Ulin General Hospital Banjarmasin, Indonesia, from July to December 2021. BMI and TLC data were assessed based on the values before chemotherapy, while the chemotherapy response was measured using the RECIST 1.1 criteria after 3 cycles. Multinomial logistic regression test with 95% confidence level was used to analyze these data. The results showed that as many as 71% of patients experienced a Partial Response (PR), while 5% and 23% of the patients demonstrated Stable Disease (SD) and Progressive Disease (PD), respectively. Each increase in BMI of 1 kg/m2 was significantly associated with an increase in the occurrence of PR and PD by 1.26 times and 1.29 times, respectively, when compared to the occurrence of PD. Meanwhile, an increase in TLC of 100 cells/mm3 was associated with an increase in the occurrence of PR by 6.83 times and an increase in the occurrence of SD. of 6.94 when compared to the occurrence of PD. Therefore, there is a significant relationship between BMI, TLC, and response to anthracycline-based neoadjuvant chemotherapy in LABC patients","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43079498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Basil, Lime, Honey, Candlenut, and Tiwai Onion Herbs Combination as Analgesics and Stamina Stimulator 罗勒、酸橙、蜂蜜、花生和蒂瓦伊洋葱草药组合作为镇痛和耐力刺激剂的效果

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-12-31 DOI: 10.15395/mkb.v54n4.2754

Andriyanto Andriyanto, Sharon Aurellia, Silmy Kamila Widyanti, Hamdika Yendri Putra, Leliana Nugrahaning Widi, Rindy Fazni Nengsih, Aulia Andi Mustik, W. Manalu

{"title":"Effectiveness of Basil, Lime, Honey, Candlenut, and Tiwai Onion Herbs Combination as Analgesics and Stamina Stimulator","authors":"Andriyanto Andriyanto, Sharon Aurellia, Silmy Kamila Widyanti, Hamdika Yendri Putra, Leliana Nugrahaning Widi, Rindy Fazni Nengsih, Aulia Andi Mustik, W. Manalu","doi":"10.15395/mkb.v54n4.2754","DOIUrl":"https://doi.org/10.15395/mkb.v54n4.2754","url":null,"abstract":"Traditional medicine is generally considered to be safer than modern medicine because it has lower incidence of side effects and also relatively easy to obtain. The purpose of this study was to examine the analgesic effect of herbs made of basil, lime, honey, candlenut, and Tiwai onions as well as to evaluate the potential of these herbs as a stamina stimulator. This study was conducted at the Laboratory of Animal Management Unit, Faculty of Veterinary Medicine, IPB University, from January–February 2022. Mice were divided into four groups based on the treatment dose with each group consisted of five mice. An analgesic test was conducted using hot water immersion tail-flick test method and the stamina test was performed with swimming endurance test. Data obtained were analyzed using Microsoft Excel 2019 and Minitab 19. Significant differences of the average of each group were shown statistically using the one-way ANOVA and confirmed with Tukey test. Results showed that mice given the combination herbal medicine infusion of with a dose of 4 g/kg body weight had the highest average tail lift time compared to the controls (p<0.05). Mice with a treatment dose of 1 g/kg body weight had the highest analgesic power compared to the other treatment doses. The highest swimming duration was observed in group that received a dose of 1 g/kg body weight. It is concluded that this herbal combination can be used as an analgesic and a stamina stimulator.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43394962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between 25-Hydroxyvitamin D and Mental-Emotional Status in Children during Their First 1000 Days of Life 25-羟基维生素D与儿童前1000天心理情绪状态的关系

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-12-31 DOI: 10.15395/mkb.v54n4.2710

MR Rusli, Susi Susanah, S. Rahayuningsih, N. A. Risan, D. A. Wulandari, Meita Dhamayanti

{"title":"Association between 25-Hydroxyvitamin D and Mental-Emotional Status in Children during Their First 1000 Days of Life","authors":"MR Rusli, Susi Susanah, S. Rahayuningsih, N. A. Risan, D. A. Wulandari, Meita Dhamayanti","doi":"10.15395/mkb.v54n4.2710","DOIUrl":"https://doi.org/10.15395/mkb.v54n4.2710","url":null,"abstract":"Vitamin D receptors are widely expressed in brain tissue, including in the limbic system that plays a role in children's mental and emotional development. This study aimed to analyze the relationship between 25-(OH)-D level and children's mental-emotional development during their first 1000 days of life. A cross-sectional study was conducted on children aged ≤2 years old in Waled and Sukabumi regions using secondary data from previous cohort investigations entitled \"The Role of Vitamin D in Efforts to Reduce Maternal and Infant mortality\". The measurement of 25-(OH)-D concentration and assessment of the mental-emotional development were performed using the Ages and Stages Questionnaires: Social-Emotional (ASQ-SE) questionnaire. Other child and maternal characteristics, and several laboratory results, were also obtained. Statistical analyses were performed using the Spearman rank, Pearson correlation test, and multivariate linear regression analysis. A total of ninety-two children were included, and the median vitamin D level of the population was 20.17 ng/mL (IQR 4.43–49.97). The correlation analysis showed that no significant relationship between children's mental-emotional scores and the parameters tested, including the concentration of 25-(OH)-D (correlation coefficient 0.08; p=0.446). There was no relationship between the vitamin D concentration and mental-emotional development. Based on these results, it is concluded that there is no correlation between 25-(OH)-D concentration and children’s mental-emotional development during the first 1000 days of life. However, further investigations are recommended to eliminate various confounding factors.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48610249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Censorship in Translating Swear Words into Chinese: Using The Catcher in the Rye as an Example 脏话翻译中的审查制度——以《麦田守望者》为例

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-11-07 DOI: 10.1163/21983534-09030006

Yijiao Guo

引用次数: 0

Malaysian Early Childhood Educators’ Use of Web 2.0 for Informal Learning in Professional Development 马来西亚幼儿教育工作者在专业发展中使用Web 2.0进行非正式学习

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-11-07 DOI: 10.1163/21983534-09030005

Rebekah Mui Pei Ern

{"title":"Malaysian Early Childhood Educators’ Use of Web 2.0 for Informal Learning in Professional Development","authors":"Rebekah Mui Pei Ern","doi":"10.1163/21983534-09030005","DOIUrl":"https://doi.org/10.1163/21983534-09030005","url":null,"abstract":"\u0000Early childhood educators’ professional knowledge and skills are often underappreciated (Moloney, 2015; Moss, 2006) even though they significantly impact children’s outcomes (Ackerman, 2004; Bellm and Whitebrook, 2004; Sylva, et al., 2004). In Malaysia, many early childhood educators lack qualifications and the resources to pursue them (Foong, et al., 2018). This study explored the experiences of seven early childhood educators in Malaysia with web-based informal professional development through interviews and media go-alongs, examining participants’ use of and perception towards Web 2.0, particularly for self-directed and interactive learning. Results showed a burgeoning integration of Web 2.0 platforms in participants’ professional learning. Participants emphasised the significant role of personal attitudes and workplace culture in encouraging learning and technology adoption and expressed interest in the development of Web 2.0 communities of practice that support professional discourse and knowledge creation. These have the potential to strengthen professional identities and foster society-wide recognition of early childhood education as a profession.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":"25 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72954771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainability, Development and Biodiversity: Global Theory vs. Brazilian Practice 可持续性、发展和生物多样性:全球理论与巴西实践

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-10-27 DOI: 10.1163/21983534-09030002

Fernanda Monteiro, M. Trombini

引用次数: 0

What is the Problem Represented to be in the Group of Four’s Policy on Reform of the United Nations Security Council? – An Argument for Clarity Towards the Global South 四国集团关于联合国安理会改革的政策所代表的问题是什么?-对全球南方的明确论证

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-10-27 DOI: 10.1163/21983534-09030004

Bjarke Zinck Winther

{"title":"What is the Problem Represented to be in the Group of Four’s Policy on Reform of the United Nations Security Council? – An Argument for Clarity Towards the Global South","authors":"Bjarke Zinck Winther","doi":"10.1163/21983534-09030004","DOIUrl":"https://doi.org/10.1163/21983534-09030004","url":null,"abstract":"\u0000This article applies a critical policy analysis to the United Nations Security Council (unsc) reform policy from the Group of Four (G4), to suggest ways for the G4 to clarify its policy’s impact and opportunities for Global South countries. The coalition comprises Brazil, Germany, India, and Japan. Based on an analysis of a dataset that includes official reform proposals, press statements, meetings statements, meetings notes, and interviews with key actors, the article concludes with five policy directions that can make the G4’s reform policy clear, transparent, and subsequently successful in terms of the necessary appeal and ensuing support from Global South countries. The article relies on a conceptual and methodological differentiation between how the absent unsc reform problem is presented and represented, respectively. A focus on the representation, which mainly refers to the policy’s subtle and implicit strategies and consequences, allows for the following overall contributions to unsc reform studies. First, I point out how the policy promotes and opposes democracy, equality, and increased Global South influence. Second, the analysis guides the G4 strategy and unsc reform strategies, at large, towards emphases on the African Union’s reform position.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":"66 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72502374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Vulnerability, Wildfire Risk, and Ecological Concerns Over the American Wildland-Urban Interface in the San Francisco Bay Area: A Sustainable Development Perspective 社会脆弱性、野火风险和旧金山湾区美国荒地-城市界面的生态关注:可持续发展视角

IF 0.1

Majalah Kedokteran Bandung-MKB-Bandung Medical Journal Pub Date : 2022-10-27 DOI: 10.1163/21983534-09030003

Amm Quamruzzaman, Ava Currie, Emma Centeno, Grace Huang, Joyce Wang, Rohith A. Moolakatt, Scott Hashimoto, A. Sant

{"title":"Social Vulnerability, Wildfire Risk, and Ecological Concerns Over the American Wildland-Urban Interface in the San Francisco Bay Area: A Sustainable Development Perspective","authors":"Amm Quamruzzaman, Ava Currie, Emma Centeno, Grace Huang, Joyce Wang, Rohith A. Moolakatt, Scott Hashimoto, A. Sant","doi":"10.1163/21983534-09030003","DOIUrl":"https://doi.org/10.1163/21983534-09030003","url":null,"abstract":"\u0000Building more homes and amenities in the wildland-urban interface (wui) is not a sustainable practice as it is associated with a greater risk of wildfire, social vulnerability, and ecological damage. Yet, the issue of whether or how to regulate the expansion of the wui remains contentious and largely unresolved in understanding sustainable development. There are fewer studies that explore how wildfire risks are compounded by social vulnerability of people who reside in the fire prone wui. Additionally, much of the extant research is focused on the national or regional level management of ecosystems and forest fires, with a clear lack of focus on local level dynamics. To fill these gaps, our analysis outlines the preliminary steps to identify social vulnerability, ecological damage, and wildfire risk in the wui fire hazard zones of the highest severity type. Utilizing gis mapping, wildfire risk, and census data on social vulnerability, our analysis reveals patterns of the wui expansion in the San Francisco Bay Area from 1990 to 2010 and provides policy recommendations from a sustainable development perspective to address social vulnerability, wildfire risk, and ecological concerns over the wui.","PeriodicalId":40791,"journal":{"name":"Majalah Kedokteran Bandung-MKB-Bandung Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.1,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88383707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0