MedULA最新文献

{"title":"THE ASSOCIATION BETWEEN MATERNAL CHARACTERISTICS AND COMPLETENESS OF BASIC IMMUNIZATION SERIES AMONG TODDLERS IN KOTA AND JAMBULA PUBLIC HEALTH CENTERS IN TERNATE","authors":"A. Azril, Fera The, Abduljewad Husen","doi":"10.46496/medula.v9i2.24071","DOIUrl":"https://doi.org/10.46496/medula.v9i2.24071","url":null,"abstract":"Background: Immunization is the process of developing immunity towards against infectious diseases through vaccination.  In 2019, the highest and lowest complete basic immunization coverage were achieved in Jambula (100%) and Kota (89%) public health centers, respectively.  Maternal characteristics are considered to play role in basic immunization coverage among toddlers. Purpose: To identify the association between maternal characteristics and completeness of basic immunization among toddlers in the Kota and Jambula public health centers, Ternate. Method: Using purposive sampling, this analytical observational study was conducted in the Kota and Jambula public health centers, Ternate, in 2021. Results: From 192 samples, statistically significant associations were identified between maternal education, knowledge, and attitudes, with the completeness of basic immunizations (p<0,05). No significant associations were detected with maternal age and maternal work. Conclusions: Maternal education, knowledge, and attitudes may affect the completeness of basic immunizations among toddlers. The need for sound programs and parental education regarding complete basic immunizations among toddlers might be crucial.Keywords: immunization, maternal characteristics, Kota Public Health Center, Jambula Public Health Center","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43175513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hesitancy and Acceptance of Covid-19 Vaccine on Pregnant Women in Southeast Sulawesi, 2021","authors":"Juminten Saimin, Lianawati Lianawati, Monovalentino Monovalentino, N. I. Purnamasari, S. Ridwan","doi":"10.46496/medula.v9i2.23925","DOIUrl":"https://doi.org/10.46496/medula.v9i2.23925","url":null,"abstract":"Background: ITAGI has recommended the provision of the COVID-19 vaccine for pregnant women. Women are more hesitant than men on the COVID-19 Vaccine Acceptance Survey in Indonesia. Purpose: To determine the acceptance and doubt about the COVID-19 vaccine in pregnant women. Methods: This was a descriptive study, which was carried out in July-August 2021. The sample was pregnant women in Southeast Sulawesi. Data retrieval using a survey technique with a questionnaire in the google form with informed consent on the first page. Results: Pregnant women who are willing to receive the COVID-19 vaccine voluntarily are 43.6%, undecided 34.1%, and 22.3% are not willing. For pregnant women who are not willing and hesitant to receive the vaccine voluntarily, 29.1% are willing if required and 70.9% are still not willing. If they get privileges, 56.4% are willing and 43.6% are still not. Pregnant women worry about their babies, 84.2% for mothers who are willing to be vaccinated and 77.9% for mothers who are unsure and not willing to be vaccinated. Concerned about their pregnancy, pregnant women who are willing to be vaccinated are 79.7% and those who are doubtful and unwilling are 75%. Those who doubt the safety of the vaccine are 36.6%. Around 51.5% of pregnant women want to consult with doctors and health workers. The most preferred places for vaccination are doctors/midwives/private hospitals (47.2%) and Puskesmas (42.7%).  Most pregnant women widely used (83.6%) and desired (70.2%) social media to get information. Conclusion: Acceptance of the COVID-19 vaccine in pregnant women is low. There are concerns of pregnant women about pregnancy and their fetus, as well as doubts about their safety. Massive information needs to be provided by doctors and health workers through social media and others that can be accessed by pregnant women.Keywords: acceptance, COVID-19, doubt, pregnant women, vaccine","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43661285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Formulation and Antioxidant Activity Test of Binahong (Anredera cordifolia) Leaves Extract Lotion","authors":"Hasty Hamzah, Yuyun Wirasasmita, W. Syafriah","doi":"10.46496/medula.v9i2.24014","DOIUrl":"https://doi.org/10.46496/medula.v9i2.24014","url":null,"abstract":"Background: With current wide range of scientific research regarding the benefits of antioxidants, many has tried to invent new sources of this compound. The use of plant-based source for antioxidants recently become more and more popular, and one of these plants is Binahong (Anredera cordifolia). The leaves of these plant had been analyzed before to contain antioxidant compound. Objective: This research aimed to test, based on previous claim of antioxidant activity of Binahong (Anredera cordifolia) leaves. Methods: The lotion used was formulated using Tween 60 and Span 60 as its emulgator. After test, it was determined that the emulsion type is water in oil (w/o). Before Binahong Leaves extract were incorporated, the lotion was tested for physical stability including organoleptics, emulsion type, pH determination, homogeneity, and viscosity. Results: The analysis for antioxidant activity by DPPH method of Binahong leaves extract with various concentrations of 12,5 μg/mL, 25 μg/mL, 50 μg/mL, 100 μg/mL, 200 μg/mL, 400 μg/mL, yield a value of IC50 822.22 µg/mL (mild antioxidant activity level). This result corroborates previous findings with the same result. Meanwhile, the lotion containing Binahong leaves extract with various concentrations of 25 μg/mL, 50 μg/mL, 100 μg/mL, 200 μg/mL, 400 μg/mL, 800 μg/mL were analyzed with same method and yield a value of IC50 27041.50 µg/mL. Conclusion: The result proved there was a further loss of antioxidant activity after the extract were incorporated into lotion. Keywords: Formulation, Anredera cordifolia, Antioxidant, Antioxidant Lotion, Binahong, ","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44501161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristic Test and Antihyperuricemia Activity of Ethanol Extract Stem of Etlingera rubroloba A.D Poulsen In vitro","authors":"A. Jabbar, I. Sahidin, Khansa Rafida Triaqilah, M. Mubarak, M. Yusuf","doi":"10.46496/medula.v9i2.25290","DOIUrl":"https://doi.org/10.46496/medula.v9i2.25290","url":null,"abstract":"Background: Etlingera rubroloba (E. rubroloba) A.D Poulsen is one of the endemic plants of Southeast Sulawesi, which has the largest species in the world. Local people widely use this plant as traditional medicine. Many of these plant species have been previously reported as antioxidants, antibacterials, and others. However, for E. rubroloba, there are still very few reports from a pharmacological aspect, especially anthiperuricemia. Objective: This study was conducted to determine the characteristics and activity of the ethanol extract of the stem of E. rubroloba A.D Poulsen in vitro. Methods: The stems of E. rubroloba A.D Poulsen were extracted with ethanol solvent by maceration, then the filtrate obtained was evaporated using an evaporator to get an ethanol extract. Furthermore, the extract characterization test was carried out, including water content, ash content, water-soluble extract content, and ethanol-soluble extract content. Then the antihyperuricemia activity test in vitro using the Xanthine Oxidase (XO) kit. Results: The results of the characteristic test showed that the ethanolic extract of E. rubroloba contained 5.15% water content, 5.485% ash content, 55.2% water-soluble extract content, and 56.52% ethanol-soluble extract content. Furthermore, the antihyperuricemic activity of the ethanol extract of E. rubroloba was IC50 48.59 ± 0.03 g/mL and Allopurinol 42.21 ± 0.02 g/mL as positive controls. Conclusion: E. rubroloba stem ethanol extract has characterization results according to the literature, has antihyperuricemia activity, and is a reference for the development of traditional drugs","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47718036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of SQ-FFQ with FR 24 hour for measuring macro nutrient and total flavonoid dietary intake in reproductive age women with obesity","authors":"Nina Indriyani Nasruddin","doi":"10.46496/medula.v9i2.24019","DOIUrl":"https://doi.org/10.46496/medula.v9i2.24019","url":null,"abstract":"Background: Obesity has become a global epidemic with a threefold increase in cases since 1975. Dietary restriction that contains high calories, fat and also dietary interventions with natural bioactive foods such as flavonoids can prevent obesity. Assessment of intake for dietary regulation can use the Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) and 24-hour Food Recall (FR) method Purposes: This study aimed to determine the average intake of macronutrients and total flavonoids using the SQ-FFQ and FR 24 Hr methods in women of childbearing age (WUS) with obesity and to knew the differences and correlations between the methods. Methods: a cross-sectional design was carried out from May to June 2021 in Kendari City. Samples were obtained through the purposive sampling technique as many as 30 WUS aged 18-49 years with a body mass index (BMI) ≥ 25 kg/m2. Data were collected through interviews to obtain information on macronutrient intake and total flavonoids using the SQ-FFQ and 24-hour FR questionnaire instruments. Anthropometric data was performed to assess nutritional status. The data were analyzed using the SPSS program through different tests and correlation tests. Results: The mean intake of macronutrients (energy, protein, fat, and carbohydrates) and total flavonoids using the SQ-FFQ method was higher than the 24-hour FR method. The different tests of the intake of energy, protein, carbohydrates, and total flavonoids using the SQ-FFQ method was significantly different from the 24-hour FR method (p<0.001). Fat intake was not significantly different between the two methods (p=0,267). The intake of energy, protein, fat, carbohydrates, and total flavonoids correlated by the two methods (p<0.05) with a correlation coefficient (r) of energy intake = 0.538, protein = 0.556, fat = 0.395, carbohydrates 0.665, and total flavonoids = 0.723. Conclusion: We conclude that The SQ-FFQ method is a valid tool to measure the intake of energy, protein, carbohydrates, fat and total flavonoids in obese women in women with obesity in the city of Kendari, Southeast Sulawesi, Indonesia.","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42703513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Climate Factors, Population Density, and Larva Free Rate (ABJ) on the Incidence of Dengue Hemorrhagic Fever (DHF) in Kendari City Period 2012-2021","authors":"Fifi Nirmala, Nur S Layaly, La Ode Liaumin Azim","doi":"10.46496/medula.v9i2.25471","DOIUrl":"https://doi.org/10.46496/medula.v9i2.25471","url":null,"abstract":"Background: Dengue Hemorrhagic Fever (DHF) is an infectious disease that is endemic in most tropical areas in the world and around 3.5 billion people live in areas where dengue is endemic. A large number of individuals residing in a certain area will facilitate the spread of dengue disease and accelerate the transmission of dengue virus from vectors. Climate is very important for the survival of the Aedes Aegypti mosquito because mosquito breeding sites will increase along with climate change. ABJ shows the density of larvae in an area. Purpose(s): This study aimed to determine the correlation of climate factors, population density, and larva free rate (ABJ) to the incidence of Dengue Hemorrhagic Fever (DHF) in Kendari City in 2012–2021. Methods: This research method was a cross sectional design and Spearman rank correlation analysis using SPSS application. The data used are secondary data in the form of data on rainfall, humidity, temperature, population density, and the incidence of DHF in a period of 10 years (2012-2021) and ABJ in a period 2016 - 2020. Results: The results of this study indicated that the rainfall variable (p value = 0,000, r = 0,416) and the humidity variable (p value = 0,000, r = 0,446) have a sufficient and unidirectional correlation coefficient to the incidence of DHF in Kendari City in 2012-2021, ABJ variable (p value = 0,014, r = -0,949) has a very strong and non-unidirectional correlation coefficient on the incidence of DHF in Kendari City in 2016-2020, and there is no correlation between the temperature variable (p value = 0,087) and the variable population density (p value = 0,651) with the incidence of DHF in Kendari City in 2012-2021. Conclusion: There was a correlation between rainfall and humidity variables on the incidence of DHF in Kendari City in 2012-2021, there was a correlation between the ABJ variable and the incidence of DHF in Kendari City in 2016-2020, and there wasn’t a correlation between temperature variable and population density variable on the incidence of DHF in Kendari City in 2012-2021.","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48476672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Risk Factor Hypoalbuminemia on the Incidence of Hyponatremia in Children with Nephrotic Syndrome","authors":"Waode Sitti Asfiah Udu","doi":"10.46496/medula.v9i2.25294","DOIUrl":"https://doi.org/10.46496/medula.v9i2.25294","url":null,"abstract":"Background: Nephrotic syndrome is a clinical condition characterized by massive proteinuria, hypoalbuminemia, edema and may be accompanied by hypercholesterolemia. Proteinuria in childhood nephrotic syndrome is mainly in the form of albuminuria. In nephrotic syndrome, electrolyte balance disorders can occur in the form of hyponatremia which can cause complications from asymptomatic clinical manifestations to death. Currently, there are not many studies on hyponatremia in nephrotic syndrome. Objective: To determined hypoalbumin as a risk factor for hyponatremia in children with nephrotic syndrome. Methods: This research was an analytic observational study using a case control design. The subjects consisted of 80 children diagnosed with nephrotic syndrome at the Children's Health Installation at the Dr. Sardjito in Yogyakarta. The data collected included serum albumin levels and sodium levels. Statistical test using Odds Ratio (OR). .Results: The results showed that hypoalbumin (p = 0.000 ; OR 13,5; 95% CI 3,395 – 53,68) was a risk factor for the incidence of hyponatremia in children with nephrotic syndrome at the Children's Health Unit, Dr. Sardjito General Hospital in Yogyakarta. Conclusion: Hypoalbumin is a risk factor for hyponatremia in children with nephrotic syndrome","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49279651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Management Quality During the Covid-19 Pandemic at Inpatient Health Centers in Kendari City","authors":"Sabarudin Sabarudin, Sunandar Ihsan, Fifi Nirmala, Rifa’atul Mahmudah","doi":"10.46496/medula.v9i2.25466","DOIUrl":"https://doi.org/10.46496/medula.v9i2.25466","url":null,"abstract":"Background: WHO has declared Covid-19 a global pandemic after the infection case reached more than 121,000 cases. Puskesmas is the primary service closest to the community, so it has a significant role in dealing with COVID-19. The quality of health services at Puskesmas was influenced by drug management. On the other hand, the COVID-19 pandemic has resulted in changes in health services at Puskesmas. Hence, it is necessary to evaluate the quality of drug management at Puskesmas during the Covid-19 pandemic. Aims: This study aimed to evaluate the quality of drug management during the COVID-19 pandemic in all inpatient Puskesmas in Kendari City. Methods: This research was descriptive non-experimental, with retrospective data collection in all inpatient Puskesmas in Kendari City during the COVID-19 pandemic. Research subjects were indicators used by Satibi, and research objects include drug stock cards, LPLPO, RKO, and several other documents. The instruments used were observation sheets and interview guides. Results: All puskesmas were still active in proposing drugs to Fornas. The percentage of compliance of available drug items with Fornas, planning accuracy, conformity of requests, and the suitability of receipts was not up to standard. Storage according to dosage form, temperature, LASA, and FEFO were per standards, distribution accuracy, empty stock, insufficient stock, safe stock, the excess stock was not meet standards, and there were expired or damaged drugs. The suitability of the physical amount of the drug met the standard, but there were no inpatient health centers that conducted periodic drug management evaluations during 2020. Conclusion: The quality of drug management during the COVID-19 pandemic in all inpatient Puskesmas in Kendari City had not fully met the standards that have been set.","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43532873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis Faktor-Faktor Yang Memengaruhi Tingkat Kecemasan Tenaga Kesehatan Dalam Pelayanan pada Masa Pandemi COVID-19 di Rumah Sakit Umum Daerah Kota Tidore Kepulauan","authors":"Pranita Aritrina Syafri, Nurhasanah Damhar, N. Eddy","doi":"10.46496/medula.v9i1.22770","DOIUrl":"https://doi.org/10.46496/medula.v9i1.22770","url":null,"abstract":"ABSTRAKLatar Belakang. Tenaga kesehatan merupakan kelompok yang sangat rentan terinfeksi COVID-19karena  berada  digarda  terdepan  penanganan  kasus       COVID-19  sehingga  sangat  memungkinkan mengalami kecemasan karena disebabkan oleh beberapa faktor seperti usia, ketersediaan APD dan pengetahuan. Tujuan umum pada penelitian ini adalah untuk mengetahui faktor-faktor yang memengaruhi tingkat kecemasan tenaga kesehatan dalam pelayanan pada masa pandemi COVID-19 di Rumah Sakit Umum Daerah Kota Tidore Kepulauan. Metode. Penelitian ini menggunakan metode analitik obsevasional dengan rancangan cross-sectional di Rumah Sakit Umum Daerah Kota Tidore Kepulauan pada bulan Desember 2020. Penentuan teknik pengambilan sampel pada penelitian ini menggunakan Purposive Sampling  dengan jumlah sampel 165 reponden.  Uji pearson  chi-square dilakukan untuk menilai hubungan antara kecemasan dan usia, status keluarga, ketersediaan Alat Pelindung Diri (APD) dan pengetahuan.  Hasil. Penelitian ini menunjukkan bahwa ada pengaruh yang signifikan pada usia (p=0.035); ketersediaan alat pelindung diri (p=0.006); pengetahuan (p=0.002) terhadap  tingkat  kecemasan   dan  tidak  ada  pengaruh  yang  signifikan  pada  status  berkeluarga (p=0,064)  terhadap  tingkat  kecemasan  tenaga  kesehatan                                               dalam  pelayanan  pada  masa  pandemi COVID-19 di Rumah Sakit Umum Daerah Kota Tidore Kepulauan.   Kesimpulan. Terdapat pengaruh yang signifikan antara usia, ketersediaan alat pelindung diri dan pengetahuan terhadap tingkat kecemasan tenaga kesehatan di Rumah Sakit Umum Daerah Kota Tidore Kepualauan.Kata Kunci : COVID-19, Pandemi, Tenaga kesehatan, Tingkat kecemasan.","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42520433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Usia Lanjut dengan Perubahan Interval QTc Pada Pasien COVID-19 Yang Diterapi dengan Hydroxychloroquine Di RSUD Kota Kendari","authors":"J. Jamaluddin, Arimaswati Arimaswati, Andy Rafdi Al Bagiz","doi":"10.46496/medula.v9i1.22766","DOIUrl":"https://doi.org/10.46496/medula.v9i1.22766","url":null,"abstract":"ABSTRAK Latar Belakang: Hydroxychloroquine adalah obat yang diduga dapat bermanfaat untuk terapi COVID-19. Obat ini diberikan pada berbagai jenis usia sesuai protokol penatalaksanaan COVID-19. Namun, obat ini dapat menghambat kanal kalium dan berpotensi memperpanjang interval QTc. Selain penggunaan hydroxychloroquine, usia juga merupakan salah satu faktor yang  dapat meningkatkan QTc karena proses penuaan yang dapat mengubah miokardium dengan peningkatan fibrosis miokard. Tujuan penelitian ini adalah untuk mengetahui hubungan usia lanjut dengan perubahan interval QTc pada pasien  COVID-19  yang  diterapi  dengan  hydroxychloroquine  di  RSUD  Kota  Kendari.  Metode: Penelitian ini adalah penelitian analitik observasional dengan pendekatan Cross Sectional. Data dalam penelitian bersifat  retrospektif,  dengan  melakukan  observasi terhadap  data  sekunder  berupa rekam medik di RSUD Kota Kendari pada bulan April sampai dengan bulan September tahun 2020. Sampel pada penelitian ini menggunakan Total Sampling. Data diolah menggunakan analisis uji t tidak berpasangan. Hasil: Hasil penelitian ini menunjukkan bahwa dari 106 subjek penelitian yang dibagimenjadi 2 kelompok usia yaitu >45 tahun sebanyak 32 orang (30,2%) dan   ≤45 tahun sebanyak 74 orang (69,8%)  sama-sama  mendapat  terapi hydroxychloroquine, didapatkan bahwa  usia  ≤45 tahunmemiliki median perubahan interval QTc sebesar 12,0 ms dan meningkat hampir dua kali lipat padausia >45 tahun sebesar 22,0 ms dengan menggunakan uji t tidak berpasangan diperoleh signifikansi p <0,001. Simpulan: Terdapat hubungan usia lanjut dengan perubahan interval QTc pada pasien COVID-19 yang diterapi dengan hydroxychloroquine di RSUD Kota Kendari.Kata Kunci: Usia COVID-19, Hydroxychloroquine, Interval QTc","PeriodicalId":40595,"journal":{"name":"MedULA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46687830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}