肾病综合征患儿低白蛋白血症发生率的危险因素分析

MedULA Pub Date : 2022-05-25 DOI:10.46496/medula.v9i2.25294
Waode Sitti Asfiah Udu
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摘要

背景:肾病综合征是一种以大量蛋白尿、低蛋白血症、水肿为特征的临床疾病,并可能伴有高胆固醇血症。儿童肾病综合征的蛋白尿主要表现为蛋白尿。在肾病综合征中,电解质平衡障碍可以以低钠血症的形式发生,低钠血症可以导致从无症状临床表现到死亡的并发症。目前,关于肾病综合征低钠血症的研究并不多。目的:确定低白蛋白是肾病综合征患儿发生低钠血症的危险因素。方法:本研究采用病例对照设计进行分析性观察研究。受试者包括80名在日惹Sardjito医生的儿童健康设施中被诊断为肾病综合征的儿童。收集的数据包括血清白蛋白水平和钠水平。使用比值比(OR)的统计检验。结果:在日惹Sardjito综合医院儿童保健室,结果显示,低白蛋白(p=0.000;OR 13.5;95%CI 3395–53,68)是肾病综合征儿童发生低钠血症的危险因素。结论:低白蛋白是肾病综合征患儿发生低钠血症的危险因素
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Risk Factor Hypoalbuminemia on the Incidence of Hyponatremia in Children with Nephrotic Syndrome
Background: Nephrotic syndrome is a clinical condition characterized by massive proteinuria, hypoalbuminemia, edema and may be accompanied by hypercholesterolemia. Proteinuria in childhood nephrotic syndrome is mainly in the form of albuminuria. In nephrotic syndrome, electrolyte balance disorders can occur in the form of hyponatremia which can cause complications from asymptomatic clinical manifestations to death. Currently, there are not many studies on hyponatremia in nephrotic syndrome. Objective: To determined hypoalbumin as a risk factor for hyponatremia in children with nephrotic syndrome. Methods: This research was an analytic observational study using a case control design. The subjects consisted of 80 children diagnosed with nephrotic syndrome at the Children's Health Installation at the Dr. Sardjito in Yogyakarta. The data collected included serum albumin levels and sodium levels. Statistical test using Odds Ratio (OR). .Results: The results showed that hypoalbumin (p = 0.000 ; OR 13,5; 95% CI 3,395 – 53,68) was a risk factor for the incidence of hyponatremia in children with nephrotic syndrome at the Children's Health Unit, Dr. Sardjito General Hospital in Yogyakarta. Conclusion: Hypoalbumin is a risk factor for hyponatremia in children with nephrotic syndrome
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MedULA
MedULA MEDICINE, GENERAL & INTERNAL-
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