The Journal of Clinical and Scientific Research最新文献_第3页

Comparison of dexmedetomidine combined with propofol Vs fentanyl combined with propofol for laryngeal mask insertion 右美托咪定联合异丙酚与芬太尼联合异丙酚用于喉罩插入的比较

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.13.032

PJanaki Subhadra, ASowmya Jayaram, M. Rao

{"title":"Comparison of dexmedetomidine combined with propofol Vs fentanyl combined with propofol for laryngeal mask insertion","authors":"PJanaki Subhadra, ASowmya Jayaram, M. Rao","doi":"10.15380/2277-5706.JCSR.13.032","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.13.032","url":null,"abstract":"Background: Few studies have assessed adequacy of anaesthesia provided by propofol in combination with dexmedetomidine and propofol in combination with fentanyl for laryngeal mask airway (LMA) insertion for minor to moderate elective surgical procedures. Methods: Sixty patients admitted for lower abdominal and lower limb surgery were randomized into Group F (n=30) and Group D (n=30). Thirty seconds after the study drug (fentanyl 1 μg/kg in Group F and dexmedetomidine 1 μg/kg in Group D diluted in 10 mL normal saline over 2 min) was administered, induction was done with i.v. propofol 2 mg/ kg in both groups. Ninety seconds after propofol injection, jaw relaxation was assessed and LMA of appropriate size was inserted. If the first attempt failed, another attempt was tried after an additional dose of i.v. propofol (0.5 mg/kg). Haemodynamic parameters, namely, heart rate, systolic blood pressure (SBP), mean blood pressure (MBP), diastolic blood pressure (DBP), arterial oxygen saturation measured with pulse oximeter and respiratory rate were recorded before and at the end of 1st, 2nd, 3rd, 5th and 10th minutes after insertion of LMA. Results: Both the groups were comparable in age weight, sex, age wise distribution and insertion conditions. The reductions in SBP, DBP, MAP were greater in Group F (p < 0.001). More patients developed apnoea in Group F than in Group D (p < 0.05). Conclusions: Dexmedetomidine combined with propofol provides the same conditions for LMA insertion as fentanylpropofol combinations with advantage of better maintainance of haemodynamic parameters.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133428667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Hypokalaemic paralysis due to Sjögren’s syndrome Sjögren综合征引起的低钾血症性麻痹

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.13.069

R. Ram, G. Ramakrishna, P. Sandeep, S. Nageshkumar, N. Rukumangadha, Chowhan Ak, M. Suchitra, B. Vengamma, VSiva Kumar

引用次数: 0

Ebola virus disease: an emerging global threat 埃博拉病毒病:新出现的全球威胁

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.14.060

A. Mohan, Aditya Kumar Pemmaraju Venkata

引用次数: 1

Novel cardiovascular risk markers in hypothyroidism patients 甲状腺功能减退患者新的心血管危险标志物

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.14.057

E. Jayanthi, A. Bitla, A. Sachan, G. Shivakrishna, S. Pvln

引用次数: 1

Mixed infection with with Plasmodium vivax malaria and scrub typhus 间日疟原虫、疟疾和恙虫病混合感染

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.13.063

C. Ravikumar, PVenkata Krishna, Shaik Ahmed

引用次数: 1

An outbreak investigation of suspected Chikungunya fever in Nalgonda District, Telangana state 特伦甘纳邦纳尔贡达区疑似基孔肯雅热暴发调查

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.14.043

Suguna Dumpala, Nagaraj Kondagunta, V. Malhotra, Guru Prasad Venna, K. Jothula

{"title":"An outbreak investigation of suspected Chikungunya fever in Nalgonda District, Telangana state","authors":"Suguna Dumpala, Nagaraj Kondagunta, V. Malhotra, Guru Prasad Venna, K. Jothula","doi":"10.15380/2277-5706.JCSR.14.043","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.043","url":null,"abstract":"Background: An outbreak of fever with joint pains occurred at Proddutur village, Nalgonda District, Telangana state, India. Methods: We investigated the out-break; attempted to identify the agent, source, mode of disease transmission, study clinico-epidemiological factors and recommend control measures during the period 11 th -15 th , February 2014. A rapid fever survey was conducted by using pre-tested, pre-designed epidemiological case sheets. Seventeen serum samples were collected for laboratory analysis. Entomological survey was conducted to identify and study the vectors. Results: The outbreak was observed to be a seasonal disease which started on 12 th January, 2014 and continued till 18 th February, 2014. Out of the total population of 1365 in the village, 259 cases were identified to have chikungunya fever as per case definition. Overall attack rate was 19%. Maximum cases occurred (24.1%) in the age group of 21-30 years and the least (1.9%) in the age group of less than one year and greater than 70 years (2.8%). Proportion of cases of Chikungunya was higher in females (51.9%) compared with males (48.2%). Fever (100%) and Joint pains (92.6%) were the most common clinical manifestations; 61% had severe disability and needed family help to do daily normal activities. Out of seventeen serum samples sent for laboratory confirmation, 5, 2 and 2 were positive for Chikungunya, dengue and both Chikungunya and dengue together respectively. No mortality was reported. Conclusions: The occurrence of this outbreak stresses the need for carrying out continuous surveillance for vector borne diseases so that appropriate remedial measures are initiated.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115848491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Disseminated cryptococcosis in a patient with advanced HIV infection 晚期HIV感染患者的播散性隐球菌病

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.14.015

M. Subbalaxmi, A. Prasad, P. Umabala, TRoshni Paul, M. Shetty

引用次数: 0

Comparison of enzyme linked immunosorbent assay (ELISA) with indirect immunofluorescence for detection of anti-nuclear antibody 酶联免疫吸附法(ELISA)与间接免疫荧光法检测抗核抗体的比较

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.14.056

Abhijit Chaudhury, G.L.S Sumanth Kumar, Anju Verma, U. Kalawat, B. Ramana, B. Kumar

{"title":"Comparison of enzyme linked immunosorbent assay (ELISA) with indirect immunofluorescence for detection of anti-nuclear antibody","authors":"Abhijit Chaudhury, G.L.S Sumanth Kumar, Anju Verma, U. Kalawat, B. Ramana, B. Kumar","doi":"10.15380/2277-5706.JCSR.14.056","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.056","url":null,"abstract":"Background: Detection of antinuclear antibody (ANA) is used as one of the diagnostic criteria for autoimmune rheumatic diseases (ARD). Both indirect immunofluorescence (IIF) and enzyme linked immunosorbant assay (ELISA) methods are used for this purpose. However, there are lack of data comparing these two tests from India. Methods: We prospectively studed 294 patients clinically suspected to be having ARD between April 2012 and September 2013. They were tested for ANA by IIF and ELISA methods. Representative samples positive by both the tests were processed again by a line immunoassay test to detect the specific antinuclear antibodies. Considering the IIF results as the ‘gold standard’, the utility of ELISA for ANA detection was analyzed. Results: Of the 294 samples processed, 181 (61.5%) were from female patients. By IIF 30% of samples in males and 40.3% sample in females tested positive. We found ELISA to have a poor sensitivity (45.8%) but good specificity (99.5%). The positive predictive value for ELISA were 98% and negative predictive value 76.2% respectively. Forty four samples positive by both IIF and ELISA were tested by Western blot to detect individual autoantibodies. Of these, only 24 samples showed the presence of one or more bands, while the remaining 20 (45.4%) were negative by line immunoassay. In our study anti-nuclear ribonucleoprotein/Smith was the most common ANA detected. Conclusions: The poor sensitivity raises concerns regarding the practice of initial screening for ANA by ELISA.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129856337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Potpourri testicular tumour - combination of seminoma, teratoma and yolk sac tumour of testis in a young adult male 混合性睾丸肿瘤:一名年轻成年男性睾丸精原细胞瘤、畸胎瘤和卵黄囊肿瘤的合并

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.13.023

A. Jena, R. Patnayak, N. Kumar, Chowhan Ak, B. Devi, A. Lakshmi

引用次数: 1

Serum magnesium levels in patients with hypertension 高血压患者血清镁水平

The Journal of Clinical and Scientific Research Pub Date : 2014-10-01 DOI: 10.15380/2277-5706.JCSR.14.004

B. Ravi, S. Usha

{"title":"Serum magnesium levels in patients with hypertension","authors":"B. Ravi, S. Usha","doi":"10.15380/2277-5706.JCSR.14.004","DOIUrl":"https://doi.org/10.15380/2277-5706.JCSR.14.004","url":null,"abstract":"Cardiovascular disease is one of the leading causes of death in adults and one of the main reasons for morbidity.1 Hypertension is one of the most important modifiable risk factors for cardiovascular disease.2 Factors implicated in the pathogenesis of hypertension, include changes in intracellular concentrations of calcium, sodium, potassium, and magnesium with an inverse correlation between serum magnesium and incidence of cardiovascular events.3 Experimental studies have shown a relationship between low serum and tissue magnesium levels and hypertension.4 Clinical and experimental studies have also shown a relationship between low dietary intake of magnesium with hypertension indicating a potential role of magnesium in the pathogenesis of hypertension. However, the mechanism is unclear.5,6 Effects of magnesium on smooth muscle cell growth and inflammation have been suggested to play a role.7 The role of serum/ dietary magnesium intake on cardiovascular disease, carot id intima-media thickness (CIMT), hypertension and cholesterol synthesis has been investigated. 8 Lower concentrations of magnesium are known to be associated with oxidat ive stress, proinflammatory state, endothelial dysfunction, platelet aggregation, insulin resistance, and hyperglycemia.7 Thus magnesium appears to play a vital function in cardiovascular stability and health, but an optimal dose and formulation has not been defined. Potentially promising avenues include the combination of magnesium with a statin to reduce cholesterol, C-reactive protein, CIMT, and its early use to reduce stroke morbidity and mortality.8 There are also reports on lack of association between low serum magnesium and risk of hypertension.9 Also, there are conflicting results on the effect of dietary intake of magnesium and risk of hypertension.10,11 Therefore, further studies are needed before advising this mineral supplementation as part of antihypertensive treatment.7 With this background the present study was taken up to assess serum magnesium levels in south Indian population with hypertension.","PeriodicalId":405143,"journal":{"name":"The Journal of Clinical and Scientific Research","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124270488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1