Expert Review of Ophthalmology最新文献_第6页

Upper blepharoplasty: advanced techniques and adjunctive procedures 上眼睑整形术：先进的技术和辅助程序

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Expert Review of Ophthalmology Pub Date : 2023-01-02 DOI: 10.1080/17469899.2023.2175673

Parya Abdolalizadeh, M. Kashkouli, Vahid Khamesi, N. Karimi, Hossein Ghahvehchian, L. Ghiasian

{"title":"Upper blepharoplasty: advanced techniques and adjunctive procedures","authors":"Parya Abdolalizadeh, M. Kashkouli, Vahid Khamesi, N. Karimi, Hossein Ghahvehchian, L. Ghiasian","doi":"10.1080/17469899.2023.2175673","DOIUrl":"https://doi.org/10.1080/17469899.2023.2175673","url":null,"abstract":"ABSTRACT Introduction Various techniques of upper blepharoplasty are used to correct dermatochalasis as the common sign of aging in periorbital areas. Most patients seeking upper eyelid rejuvenation have other involutional changes in upper face which can be addressed as adjunct to upper blepharoplasty procedure to yield better esthetic and functional outcomes. Areas covered The aim of the present study is to review current concepts in preoperative considerations, surgical techniques, and adjuvant procedures of upper blepharoplasty. The role of social media is also discussed in this arena. A literature search was performed in PubMed database of English-language journals with no restriction on the date of publication using selected keywords. The relevant articles were selected by reviewing the titles and abstracts. Expert opinion Careful preoperative examination of midface and upper face is necessary to assess concomitant ageing deformities besides dermatochalasis. Nowadays, volume preservation approach is the mainstream in upper blepharoplasty. Upper blepharoplasty incisions can be used to address lacrimal gland prolapse, blepharoptosis, Asian medial epicanthoplasty and eyebrow ptosis in selected individuals.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"18 1","pages":"33 - 44"},"PeriodicalIF":0.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44803106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal transplantation in children - when and how? 儿童角膜移植-何时以及如何进行?

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Expert Review of Ophthalmology Pub Date : 2023-01-02 DOI: 10.1080/17469899.2023.2177153

Abha Gour, A. Garg, Shailja Tibrewal, Julie Pegu, Sonal Gupta, Umang Mathur, V. Sangwan

{"title":"Corneal transplantation in children - when and how?","authors":"Abha Gour, A. Garg, Shailja Tibrewal, Julie Pegu, Sonal Gupta, Umang Mathur, V. Sangwan","doi":"10.1080/17469899.2023.2177153","DOIUrl":"https://doi.org/10.1080/17469899.2023.2177153","url":null,"abstract":"ABSTRACT Introduction Advanced surgical techniques, better post-operative protocols, imaging, and better understanding of genetic basis have enhanced outcomes of pediatric keratoplasty. However, results in infants and younger children remain a challenge. Transplants in the pediatric age group are challenging because of the complexity of the indications, the procedure itself, and the problems with respect to follow-up and post-operative care in younger recipients. Areas covered This review presents an overview of challenges faced in the management of pediatric corneal grafts, and problems encountered in long-term survival. We discuss the changing trends in these outcomes of PKP with a current review of the recent literature from PubMed. We also share the results of pediatric keratoplasty done at our center in the last three years and have an in-depth discussion about the management of comorbidities like cataracts and glaucoma Expert opinion Despite several advances in microsurgical techniques for corneal transplantation, pediatric keratoplasty remains challenging due to a variety of factors such as young age, repeated need for anesthesia, immature ocular tissues, and accelerated healing. The advent of component surgeries like DALK, DSEK, and DMEK has improved outcomes and simplified management options. Even after specialized surgeries, long-term follow-ups and management of comorbidities become essential.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"18 1","pages":"57 - 69"},"PeriodicalIF":0.7,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48727120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Factors affecting the prevalence, severity, and characteristics of ocular surface pain. 影响眼表疼痛发生率、严重程度和特征的因素。

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Expert Review of Ophthalmology Pub Date : 2023-01-01 Epub Date: 2022-12-18 DOI: 10.1080/17469899.2023.2157813

Victor Sanchez, Noah K Cohen, Elizabeth Felix, Anat Galor

{"title":"Factors affecting the prevalence, severity, and characteristics of ocular surface pain.","authors":"Victor Sanchez, Noah K Cohen, Elizabeth Felix, Anat Galor","doi":"10.1080/17469899.2023.2157813","DOIUrl":"10.1080/17469899.2023.2157813","url":null,"abstract":"Introduction: Ocular surface pain has been traditionally lumped under the umbrella term \"dry eye\" (DE) but is now understood as its own entity and can occur in the absence or presence of tear dysfunction. Identifying patients at risk for the development of chronic ocular surface pain, and factors contributing to its severity are important in providing precision medicine to patients.Areas covered: In this review, we discuss factors linked to the presence and severity of ocular surface pain, including eye related features, systemic characteristics, and environmental findings. We discuss corneal nerves, whose anatomic and functional integrity can be characterized through in vivo confocal microscopy images and testing of corneal sensitivity. We review systemic diseases that are co-morbid with ocular surface pain, including physical and mental health diagnoses. Finally, we identify environmental contributors, including air pollution, previous surgeries, and medications, associated with ocular surface pain.Expert opinion: Intrinsic and extrinsic factors contribute to ocular surface pain and must be considered when evaluating an individual patient. These factors can inform the suspected etiology of the pain, and guide management decisions such as tear replacement or medications targeting nerve pain.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"18 1","pages":"19-32"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9287616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging glaucoma treatments: are we seeing an improvement in adherence? 新兴的青光眼治疗方法：我们是否看到依从性有所改善？

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Expert Review of Ophthalmology Pub Date : 2023-01-01 Epub Date: 2023-04-12 DOI: 10.1080/17469899.2023.2199981

Andrew P Droste, Paula Anne Newman-Casey

{"title":"Emerging glaucoma treatments: are we seeing an improvement in adherence?","authors":"Andrew P Droste, Paula Anne Newman-Casey","doi":"10.1080/17469899.2023.2199981","DOIUrl":"10.1080/17469899.2023.2199981","url":null,"abstract":"Introduction: Non-adherence to glaucoma medication and poor follow-up is a global health concern.Areas covered: Glaucoma remains one of the largest causes of irreversible blindness worldwide. Traditional treatment guidelines suggest topical eye drop medication as first line therapy followed by addition of supplementary medications before proceeding to more invasive glaucoma surgeries. Unfortunately, poor glaucoma self-management remains high, leading to disease progression and blindness. Recent advancements in the field of pharmacotherapies, surgeries, and behavioral approaches have taken aim at increasing support for glaucoma self-management. We review the current and emerging approaches towards glaucoma management, with the exception of bleb-based surgical approaches, to investigate if they have had an impact on adherence. Literature searches were conducted via MEDLINE (PubMed), Embase (Elsevier), Cochrane Library (Wiley), and Preprints from January 1st, 2018, to January 26th, 2023.Expert opinion: The ability to offer patients a multitude of choices enables patients to tailor their glaucoma treatment to their values and lifestyle. Offering personalized patient education and coaching to support chronic glaucoma self-management would better enable patient engagement in whichever treatment path is chosen. Currently, literature regarding the impact of these new advancements on treatment engagement is lacking; this field is ripe for additional intervention and assessment.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"18 2","pages":"101-111"},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How can the safety of antibody therapy for retinopathy of prematurity be improved? 如何提高早产儿视网膜病变抗体疗法的安全性？

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Expert Review of Ophthalmology Pub Date : 2023-01-01 Epub Date: 2023-04-09 DOI: 10.1080/17469899.2023.2200934

M Elizabeth Hartnett

引用次数: 0

Evaluating gap junction variants for a role in pediatric cataract: an overview of the genetic landscape and clinical classification of variants in the GJA3 and GJA8 genes 评估间隙连接变异在儿童白内障中的作用:GJA3和GJA8基因变异的遗传景观和临床分类概述

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Expert Review of Ophthalmology Pub Date : 2022-12-20 DOI: 10.1080/17469899.2023.2160320

Johanna L Jones, K. Burdon

{"title":"Evaluating gap junction variants for a role in pediatric cataract: an overview of the genetic landscape and clinical classification of variants in the GJA3 and GJA8 genes","authors":"Johanna L Jones, K. Burdon","doi":"10.1080/17469899.2023.2160320","DOIUrl":"https://doi.org/10.1080/17469899.2023.2160320","url":null,"abstract":"ABSTRACT Introduction Variants in the two lens-expressed gap junction genes GJA3 and GJA8 are among the most common causes of inherited pediatric cataract. These two genes alone account for up to 18% of the cases, second only to the crystallin gene family. Areas covered All published cataract-associated variants in the GJA3 and GJA8 genes were reviewed for a role in pediatric cataract. Autosomal dominant inheritance was most frequently reported, alongside instances of reduced penetrance and autosomal recessive disease. Variant curation using the ACMG-AMP guidelines identified that many variants do not meet the modern standards for clinical interpretation of pathogenicity. There is broad phenotypic heterogeneity of cataract associated with gap junction gene variants. Pathogenic variants are located throughout both proteins with an enrichment in the N-terminal, first two transmembrane domains, and two extracellular loops. Expert opinion Nearly half the gap junction gene variants observed in cataract patients lack sufficient evidence of pathogenicity to form a useful clinical opinion. For many variants, this may be rectified over time as the variant is observed in additional patients but would be vastly accelerated by the generation of well-characterized and standardized functional data evaluating the specific effect of each variant on protein function.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"18 1","pages":"71 - 95"},"PeriodicalIF":0.7,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47285428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Why are soft contact lens wear discontinuation rates still too high? 为什么软性隐形眼镜的停用率仍然过高？

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Expert Review of Ophthalmology Pub Date : 2022-12-20 DOI: 10.1080/17469899.2022.2160321

C. McMonnies

{"title":"Why are soft contact lens wear discontinuation rates still too high?","authors":"C. McMonnies","doi":"10.1080/17469899.2022.2160321","DOIUrl":"https://doi.org/10.1080/17469899.2022.2160321","url":null,"abstract":"ABSTRACT Introduction Notwithstanding continuing improvements in contact lens technology and increasing use of daily disposables, discontinuations from soft contact lens wear remain a significant problem with ‘drop-out’ too often occurring after patients have initially achieved successful routine use. Areas covered This review examines the possibility that the signs and symptoms of discontinuations might, for example be associated with corneal and/or lid wiper neuropathy and/or aqueous, mucin and lipid deficiencies and/or mental health disorders. In addition, this review examines how soft contact lens wear places high demands on tear functions. Expert opinion Limitations in clinically detecting evidence of some adverse responses to soft contact lens wear may explain how discontinuations can sometimes be described as unexplained. Similarly, limitations in clinically determining the significance of different forms of tear dysfunction and their exacerbation by soft contact lens wear may be a barrier to explaining why symptoms of dryness are most commonly associated with discontinuations. The wider experience obtained with cosmetic contact lens fittings that is discussed in this review may be relevant to problems encountered in therapeutic contact lens applications.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"18 1","pages":"11 - 18"},"PeriodicalIF":0.7,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45263974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Emerging biosimilars for retinal diseases 新兴的视网膜疾病生物仿制药

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2152005

Ashish Sharma, N. Parachuri, Nilesh Kumar, F. Bandello, B. Kuppermann

引用次数: 1

Endoplasmic reticulum stress as an underlying factor in leading causes of blindness and potential therapeutic effects of 4-phenylbutyric acid: from bench to bedside 内质网应激是导致失明的潜在因素，4-苯基丁酸的潜在治疗效果：从试验台到床边

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2145945

S. Askari, F. Azizi, Pegah Javadpour, N. Karimi, Rasoul Ghasemi

{"title":"Endoplasmic reticulum stress as an underlying factor in leading causes of blindness and potential therapeutic effects of 4-phenylbutyric acid: from bench to bedside","authors":"S. Askari, F. Azizi, Pegah Javadpour, N. Karimi, Rasoul Ghasemi","doi":"10.1080/17469899.2022.2145945","DOIUrl":"https://doi.org/10.1080/17469899.2022.2145945","url":null,"abstract":"ABSTRACT Introduction Mounting evidence has emerged showing that endoplasmic reticulum (ER) stress participates in triggering cell injuries in ocular tissues, manifested as disorders such as cataracts, age-related macular degeneration, glaucoma, and diabetic retinopathy. Areas covered ER stress is a condition in which the ER is perturbed by the accumulation of unfolded and misfolded proteins. In a dynamic signaling cascade, the unfolded protein response (UPR) is triggered by three ER-transmembrane stress sensors to restore homeostasis and cell survival, however, if it fails, the cell will undergo a sustained ER stress condition which deteriorates cell function and promote cell death. Sustained ER stress is shown to contribute in a wide range of diseases including ophthalmologic disorders. Targeting ER stress by inhibitor agents might have promising therapeutic implications in treating eye disorders. The current review summarizes the results of the latest studies in support of the potential therapeutic utility of 4-phenylbutyric acid (4-PBA), an FDA approved ER stress inhibitor, in disorders leading to permanent vision loss. Expert opinion The therapeutic potential of 4-PBA in ophthalmic diseases is strongly supported by many experimental studies. Safety and efficacy studies of intravitreal injection of 4-PBA and other ER stress by inhibitors, are lacking.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"415 - 425"},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42753128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical management of recurrent rhegmatogenous retinal detachment 复发性孔源性视网膜脱离的手术治疗

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2152004

Lucy V. Cobbs, Taku Wakabayashi, Y. Yonekawa

{"title":"Surgical management of recurrent rhegmatogenous retinal detachment","authors":"Lucy V. Cobbs, Taku Wakabayashi, Y. Yonekawa","doi":"10.1080/17469899.2022.2152004","DOIUrl":"https://doi.org/10.1080/17469899.2022.2152004","url":null,"abstract":"ABSTRACT Introduction Primary rhegmatogenous retinal detachment (RRD) repair with modern surgical techniques provides high rates of anatomic success; however, anatomic failure may still occur with any primary surgery, including after pneumatic retinopexy (PR), scleral buckle (SB), and pars plana vitrectomy (PPV), resulting in recurrent RRD. Areas covered This review includes a summary of surgical options and management strategies for eyes with primary failure of PR, SB, and PPV. Expert opinion No standardized protocol is available for determining the optimal secondary surgical options to treat recurrent RRD. However, understanding of the causes and characteristics of the re-detachment, expected anatomic success rates with each surgical option, and potential complications, may improve the outcomes after re-operations. Causes of primary failure include formation of new breaks, re-opening of the original breaks, missed breaks, and most commonly, proliferative vitreoretinopathy (PVR). Rescue PR, revision of SB, and reoperation with PPV with membrane peeling, relaxing retinectomy, and/or long-acting tamponade combined with or without encircling SB, are effective options depending on the cause of primary failure and characteristics and severity of the re-detachment. Further advances in the management of PVR, which is a major cause of primary failure, will help improve treatment outcomes for eyes with complicated recurrent detachments.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"395 - 404"},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47006396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0