Expert Review of Ophthalmology最新文献_第7页

Hypersonic vitrectomy: a novel approach to vitreous removal 高超声速玻璃体切除术:一种新的玻璃体切除方法

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2148656

Jacob G. Light, H. Anderson, Sunir J. Garg

{"title":"Hypersonic vitrectomy: a novel approach to vitreous removal","authors":"Jacob G. Light, H. Anderson, Sunir J. Garg","doi":"10.1080/17469899.2022.2148656","DOIUrl":"https://doi.org/10.1080/17469899.2022.2148656","url":null,"abstract":"ABSTRACT Introduction Pars plana vitrectomy is the basis of modern retina surgery, and for the last 40 years, has been achieved using the pneumatic guillotine cutter. Recently, a new vitrectomy design has been developed: the hypersonic vitrector. This technology utilizes ultrasound energy to liquefy vitreous in contrast to the mechanical segmentation of vitreous strands that characterizes pneumatic cutters. Areas covered This review provides a history of the development of vitrectomy and summarizes the critical elements of effective and safe vitrectomy systems. The article will describe the novel hypersonic vitrectomy design, discuss what the initial pre-clinical and in-human studies tell us about its performance compared to standard pneumatic cutters, and considers its role in the future of retina surgery. Expert opinion Hypersonic vitrectomy is the first novel way to segment vitreous since the development of pneumatic guillotine cutters. It has the potential to make vitrectomy more efficient both by reducing operating times as well as enabling surgeons to remove silicone oil and retained lens material all with one instrument. With concurrent advancements in guillotine cutters, hypersonic vitrectomy has a high bar to clear to demonstrate advantages that would result in widespread adoption.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"375 - 382"},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45798882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Device-based therapies as a boost of conventional treatment in dry eye disease 基于设备的治疗方法对干眼病的常规治疗有促进作用

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2147928

A. Borgia, R. Raimondi, G. Fossati, Francesco Paolo De Rosa, V. Romano, D. Borroni, L. Vigo, V. Scorcia, G. Giannaccare

引用次数: 5

How could gene therapy change the way we treat age-related macular degeneration? 基因疗法如何改变我们治疗老年性黄斑变性的方式?

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2147927

Huma Khan, Hannah Khan, A. Aziz, Tyler M Ewing, A. Khanani

引用次数: 1

Mechanisms of corneal trauma in response to rubbing and other intraocular pressure elevating activities in keratoconus 圆锥角膜摩擦和其他眼压升高活动引起角膜损伤的机制

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2153119

C. McMonnies

{"title":"Mechanisms of corneal trauma in response to rubbing and other intraocular pressure elevating activities in keratoconus","authors":"C. McMonnies","doi":"10.1080/17469899.2022.2153119","DOIUrl":"https://doi.org/10.1080/17469899.2022.2153119","url":null,"abstract":"ABSTRACT Introduction The potential for eye rubbing to contribute to keratoconus development and progression is well established, but the mechanisms of that association have not been fully elucidated. Areas covered This review examines mechanisms for rubbing-related corneal trauma from both anterior and posterior surface responses to elevated intraocular pressure. Apart from rubbing-related intraocular pressure elevation, consideration is given to other sources of elevation which may contribute to corneal bulging and cone formation. Mechanisms whereby intraocular pressure-related increased posterior corneal surface distending stress and stromal hydrostatic pressure may alter keratocyte functions and increase susceptibility to such stress are examined. Expert opinion Elevated intraocular pressure (IOP) that is associated with a chronic habit of abnormal rubbing (CHAR) can be a major contributor of keratoconus (KC) development and progression. Anterior corneal surface protection during rubbing due to Bell’s reflex in most patients, at least for the central and para-central cornea, increases the likelihood that IOP distending stress can be an important source of KC pathogenesis, perhaps even in patients who do not have abnormal rubbing habits. That the earliest pathological changes in KC occur at the posterior corneal surface is consistent with the significance of an IOP-related distending force mechanism for KC pathogenesis.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"405 - 414"},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45516388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diagnostic accuracy of machine learning classifiers for cataracts: a systematic review and meta-analysis 机器学习分类器对白内障的诊断准确性:系统回顾和荟萃分析

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Expert Review of Ophthalmology Pub Date : 2022-10-28 DOI: 10.1080/17469899.2022.2142120

Ronald Cheung, Samantha So, Monali S. Malvankar-Mehta

{"title":"Diagnostic accuracy of machine learning classifiers for cataracts: a systematic review and meta-analysis","authors":"Ronald Cheung, Samantha So, Monali S. Malvankar-Mehta","doi":"10.1080/17469899.2022.2142120","DOIUrl":"https://doi.org/10.1080/17469899.2022.2142120","url":null,"abstract":"ABSTRACT Objective The objective of this study was to systematically review and meta-analyze the diagnostic accuracy of current machine learning classifiers for pediatric and adult cataracts. Methods MEDLINE, EMBASE, CINAHL, and ProQuest Dissertations and Theses were searched systematically and thoroughly. Conferences held through Association for Research in Vision and Ophthalmology, American Academy of Ophthalmology, and Canadian Society of Ophthalmology were searched. Studies were screened using Covidence software and data on sensitivity, specificity and area under curve were extracted from the included studies. STATA 15.0 was used to conduct the meta-analysis. Results Our search strategy identified 150 records from databases and 35 records from gray literature. Total of 21 records were used for the qualitative analysis and 11 records (100 134 images) were used for the quantitative analysis. In adult patients with cataracts, the pooled estimate for sensitivity was 0.948 [95% CI: 0.815–0.987] and specificity was 0.960 [95% CI: 0.924–0.980] for cataract screening using machine learning classifiers. For pediatric cataracts, the pooled estimate for sensitivity was 0.882 [95% CI: 0.696–0.960] and specificity was 0.891 [95% CI: 0.807–0.942]. Conclusion The included studies show promising results for the diagnostic accuracy of the machine learning classifiers for cataracts and its potential implementation in clinical settings. Prospero registration CRD42020219316","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"427 - 437"},"PeriodicalIF":0.7,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47318696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The future of biomarkers in neovascular age-related macular degeneration: active disease or degenerative process? 生物标志物在新生血管性年龄相关性黄斑变性中的未来:活动性疾病还是退行性过程?

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Expert Review of Ophthalmology Pub Date : 2022-09-03 DOI: 10.1080/17469899.2022.2139677

Daniel Egger, Reinhard Angermann, S. Waldstein

引用次数: 1

A peek at the window from the eye into the brain: potential use of OCT angiography in dementia 从眼睛窥视大脑的窗户：OCT血管造影术在痴呆症中的潜在应用

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Expert Review of Ophthalmology Pub Date : 2022-09-03 DOI: 10.1080/17469899.2022.2131541

Semih Ceylan, O. Özalp, E. Atalay

{"title":"A peek at the window from the eye into the brain: potential use of OCT angiography in dementia","authors":"Semih Ceylan, O. Özalp, E. Atalay","doi":"10.1080/17469899.2022.2131541","DOIUrl":"https://doi.org/10.1080/17469899.2022.2131541","url":null,"abstract":"Dementia is defined as the irreversible deterioration of acquired cognitive abilities (executive functions, memory, language, visuospatial, and motor) because of progressive neurodegeneration. According to a report by the World Health Organization (WHO) in 2018, dementia ranks as the 7 most common worldwide cause of death. In 2018, the globally estimated number of people afflicted by dementia was 50 million, a figure which is expected to triple by the year 2050 [1]. The worldwide rapidly aging population and the resultant unprecedented rise in the incidence of dementia are anticipated to cause a greater burden in health expenditures both in underdeveloped and developed countries alike. Optical coherence tomography angiography (OCT-A) is a noninvasive and facile method for visualizing retinal and choroidal microcirculation obviating the need for administering a systemic contrast agent. Compared to other brain imaging modalities, such as positron emission tomography imaging, it is more cost-effective and rapidly allows layer-bylayer assessment of retinochoroidal microcirculation. In a routine retina clinic, OCT-A is mainly employed for the diagnosis and monitoring of age-related macular degeneration and diabetic retinopathy. It has also become a popular research tool for assessing peripapillary and macular microcirculation in glaucoma and other optic neuropathies with the hope of finding various vascular cues that may enable earlier disease diagnosis and/or the detection of its progression [2]. In addition to its indispensable role in a busy ophthalmology clinic, studies have shown that OCT-A may potentially be a highly useful ancillary tool in various other non-ophthalmic diseases that directly or indirectly impact retinal and/or choriocapillaris microcirculation, such as multiple sclerosis, Parkinson’s, and Alzheimer’s diseases [3].","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"295 - 297"},"PeriodicalIF":0.7,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43549570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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Expert Review of Ophthalmology Pub Date : 2022-09-03 DOI: 10.1080/17469899.2022.2138345

E. Abu, Odeefour A Ofori, S. Boadi-Kusi, S. Ocansey, Richard K Yankah, Selassie K Dzasimatu, A. Y. Awuku

{"title":"Dry eye-related quality of life among type 2 diabetes patients: a hospital-based cross-sectional study","authors":"E. Abu, Odeefour A Ofori, S. Boadi-Kusi, S. Ocansey, Richard K Yankah, Selassie K Dzasimatu, A. Y. Awuku","doi":"10.1080/17469899.2022.2138345","DOIUrl":"https://doi.org/10.1080/17469899.2022.2138345","url":null,"abstract":"ABSTRACT Background To investigate the impact of dry eye syndrome (DES) on dry eye-related quality of life (QoL) in patients with type 2 diabetes. Research design and methods Evaluation of DES included assessment of meibomian gland function, tear breakup time (TBUT), Schirmer test, fluorescein ocular surface staining, and Ocular Surface Disease Index (OSDI) scores. DES diagnosis was based on OSDI score ≥13, TBUT < 10s, and fluorescein staining. Results After adjusting for age, duration of diabetes, drug usage, and comorbidities, severity of DES symptomatology and signs resulted in poorer QoL of patients when comparing cases and controls. TBUT, meibum quality, and ocular surface staining were the objective clinical tests that significantly correlated with QoL. Poor QoL was also associated with the presence of eyelash and eyelid anomalies (eyelash: aOR = 2.58, CI = 1.49–4.47, p = 0.001; eyelids: aOR = 1.66, CI = 1.01–2.71, p = 0.04). Patients who had been previously diagnosed and treated for DES registered improved QoL measures. Conclusions Symptoms or clinical signs of DES resulted in poorer QoL in a clinical sample of type 2 diabetes patients, stressing the need for clinicians to evaluate such signs and symptoms in order to improve QoL.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"353 - 359"},"PeriodicalIF":0.7,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46823253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Varicella zoster retinal vasculitis without retinitis: a literature review 无视网膜炎的水痘带状疱疹视网膜血管炎：文献综述

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Expert Review of Ophthalmology Pub Date : 2022-09-03 DOI: 10.1080/17469899.2022.2137493

A. Kawali, Aayesha Khanum, P. Mahendradas, S. Sanjay, R. Shetty

{"title":"Varicella zoster retinal vasculitis without retinitis: a literature review","authors":"A. Kawali, Aayesha Khanum, P. Mahendradas, S. Sanjay, R. Shetty","doi":"10.1080/17469899.2022.2137493","DOIUrl":"https://doi.org/10.1080/17469899.2022.2137493","url":null,"abstract":"ABSTRACT Introduction Varicella zoster virus (VZV) uveitis presenting as acute retinal necrosis with vasculitis is well known, but VZV-vasculitis without retinitis is rarely reported. Identification of such presentation can be challenging, especially when other signs of ocular VZV are absent. This is particularly important before considering immunomodulatory therapy for retinal vasculitis without systemic manifestations. Areas covered An online English language literature search for ‘VZV retinal vasculitis presenting without retinitis’ was made and case reports and case series published from 1995 to 2020 were reviewed. The search revealed 26 cases from 21 reports in 25 years. The clinical manifestation, morphology of vasculitis, visual and treatment outcomes were studied. Expert opinion Recent or old history of Herpes Zoster Ophthalmicus or chickenpox especially in young individuals should be elicited in isolated retinal vasculitis. Diagnostic relevance of PCR and serological tests should be investigated further in larger studies. Occlusive nature of vasculitis, including arteriolitis, is common in VZV infection. In chronic cases, end point of antiviral therapy remains unknown. Patients should be warned of grave visual prognosis despite adequate treatment. The importance of adjuvant anti-thrombotic therapy along with anti-viral and immunomodulatory therapy needs to be explored further.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"333 - 341"},"PeriodicalIF":0.7,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46320556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dural venous sinus stenting in patients with idiopathic intracranial hypertension: report of outcomes from a single-center prospective database and literature review 硬脑膜静脉窦支架植入术治疗特发性颅内高压患者:单中心前瞻性数据库和文献综述的结果报告

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Expert Review of Ophthalmology Pub Date : 2022-09-03 DOI: 10.1080/17469899.2022.2139678

M. Kole, J. C. Martinez‐Gutierrez, Francisio Sanchez, Rosa A. Tang, P. Chen

{"title":"Dural venous sinus stenting in patients with idiopathic intracranial hypertension: report of outcomes from a single-center prospective database and literature review","authors":"M. Kole, J. C. Martinez‐Gutierrez, Francisio Sanchez, Rosa A. Tang, P. Chen","doi":"10.1080/17469899.2022.2139678","DOIUrl":"https://doi.org/10.1080/17469899.2022.2139678","url":null,"abstract":"ABSTRACT Introduction Idiopathic intracranial hypertension (IIH) is a disease of excess cerebrospinal fluid (CSF) leading to rising intracranial pressure. Patients most commonly present with headache, tinnitus, papilledema, and vision loss. It most commonly affects young overweight females, a growing population. Traditional management has consisted of weight loss, medical management, surgical CSF diversion, and optic nerve sheath fenestration. In recent years, cerebral venous sinus stenosis has been described as an almost ubiquitously present potentiator of this disease. Venous sinus stenting to normalize cerebral venous outflow has emerged as a highly effective treatment. Areas covered In this review, the authors review the epidemiology and pathophysiology of IIH, as well as its common management strategies. The authors focus on the emergence of venous sinus stenting as a safe, effective, and minimally invasive strategy for managing IIH. Expert opinion IIH caused by venous sinus stenosis can be treated effectively and safely with endovascular stenting of the sinus. Given its low morbidity and failure rate relative to other traditional management strategies, evaluation for venous sinus stenosis should be pursued in this patient population, and referral to a neuro-endovascular specialist made if indicated.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"321 - 331"},"PeriodicalIF":0.7,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42046283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0