Expert Review of Ophthalmology最新文献_第7页

Emerging biosimilars for retinal diseases 新兴的视网膜疾病生物仿制药

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2152005

Ashish Sharma, N. Parachuri, Nilesh Kumar, F. Bandello, B. Kuppermann

引用次数: 1

Endoplasmic reticulum stress as an underlying factor in leading causes of blindness and potential therapeutic effects of 4-phenylbutyric acid: from bench to bedside 内质网应激是导致失明的潜在因素，4-苯基丁酸的潜在治疗效果：从试验台到床边

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2145945

S. Askari, F. Azizi, Pegah Javadpour, N. Karimi, Rasoul Ghasemi

{"title":"Endoplasmic reticulum stress as an underlying factor in leading causes of blindness and potential therapeutic effects of 4-phenylbutyric acid: from bench to bedside","authors":"S. Askari, F. Azizi, Pegah Javadpour, N. Karimi, Rasoul Ghasemi","doi":"10.1080/17469899.2022.2145945","DOIUrl":"https://doi.org/10.1080/17469899.2022.2145945","url":null,"abstract":"ABSTRACT Introduction Mounting evidence has emerged showing that endoplasmic reticulum (ER) stress participates in triggering cell injuries in ocular tissues, manifested as disorders such as cataracts, age-related macular degeneration, glaucoma, and diabetic retinopathy. Areas covered ER stress is a condition in which the ER is perturbed by the accumulation of unfolded and misfolded proteins. In a dynamic signaling cascade, the unfolded protein response (UPR) is triggered by three ER-transmembrane stress sensors to restore homeostasis and cell survival, however, if it fails, the cell will undergo a sustained ER stress condition which deteriorates cell function and promote cell death. Sustained ER stress is shown to contribute in a wide range of diseases including ophthalmologic disorders. Targeting ER stress by inhibitor agents might have promising therapeutic implications in treating eye disorders. The current review summarizes the results of the latest studies in support of the potential therapeutic utility of 4-phenylbutyric acid (4-PBA), an FDA approved ER stress inhibitor, in disorders leading to permanent vision loss. Expert opinion The therapeutic potential of 4-PBA in ophthalmic diseases is strongly supported by many experimental studies. Safety and efficacy studies of intravitreal injection of 4-PBA and other ER stress by inhibitors, are lacking.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"415 - 425"},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42753128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical management of recurrent rhegmatogenous retinal detachment 复发性孔源性视网膜脱离的手术治疗

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2152004

Lucy V. Cobbs, Taku Wakabayashi, Y. Yonekawa

{"title":"Surgical management of recurrent rhegmatogenous retinal detachment","authors":"Lucy V. Cobbs, Taku Wakabayashi, Y. Yonekawa","doi":"10.1080/17469899.2022.2152004","DOIUrl":"https://doi.org/10.1080/17469899.2022.2152004","url":null,"abstract":"ABSTRACT Introduction Primary rhegmatogenous retinal detachment (RRD) repair with modern surgical techniques provides high rates of anatomic success; however, anatomic failure may still occur with any primary surgery, including after pneumatic retinopexy (PR), scleral buckle (SB), and pars plana vitrectomy (PPV), resulting in recurrent RRD. Areas covered This review includes a summary of surgical options and management strategies for eyes with primary failure of PR, SB, and PPV. Expert opinion No standardized protocol is available for determining the optimal secondary surgical options to treat recurrent RRD. However, understanding of the causes and characteristics of the re-detachment, expected anatomic success rates with each surgical option, and potential complications, may improve the outcomes after re-operations. Causes of primary failure include formation of new breaks, re-opening of the original breaks, missed breaks, and most commonly, proliferative vitreoretinopathy (PVR). Rescue PR, revision of SB, and reoperation with PPV with membrane peeling, relaxing retinectomy, and/or long-acting tamponade combined with or without encircling SB, are effective options depending on the cause of primary failure and characteristics and severity of the re-detachment. Further advances in the management of PVR, which is a major cause of primary failure, will help improve treatment outcomes for eyes with complicated recurrent detachments.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"395 - 404"},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47006396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypersonic vitrectomy: a novel approach to vitreous removal 高超声速玻璃体切除术:一种新的玻璃体切除方法

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2148656

Jacob G. Light, H. Anderson, Sunir J. Garg

{"title":"Hypersonic vitrectomy: a novel approach to vitreous removal","authors":"Jacob G. Light, H. Anderson, Sunir J. Garg","doi":"10.1080/17469899.2022.2148656","DOIUrl":"https://doi.org/10.1080/17469899.2022.2148656","url":null,"abstract":"ABSTRACT Introduction Pars plana vitrectomy is the basis of modern retina surgery, and for the last 40 years, has been achieved using the pneumatic guillotine cutter. Recently, a new vitrectomy design has been developed: the hypersonic vitrector. This technology utilizes ultrasound energy to liquefy vitreous in contrast to the mechanical segmentation of vitreous strands that characterizes pneumatic cutters. Areas covered This review provides a history of the development of vitrectomy and summarizes the critical elements of effective and safe vitrectomy systems. The article will describe the novel hypersonic vitrectomy design, discuss what the initial pre-clinical and in-human studies tell us about its performance compared to standard pneumatic cutters, and considers its role in the future of retina surgery. Expert opinion Hypersonic vitrectomy is the first novel way to segment vitreous since the development of pneumatic guillotine cutters. It has the potential to make vitrectomy more efficient both by reducing operating times as well as enabling surgeons to remove silicone oil and retained lens material all with one instrument. With concurrent advancements in guillotine cutters, hypersonic vitrectomy has a high bar to clear to demonstrate advantages that would result in widespread adoption.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"375 - 382"},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45798882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Device-based therapies as a boost of conventional treatment in dry eye disease 基于设备的治疗方法对干眼病的常规治疗有促进作用

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2147928

A. Borgia, R. Raimondi, G. Fossati, Francesco Paolo De Rosa, V. Romano, D. Borroni, L. Vigo, V. Scorcia, G. Giannaccare

引用次数: 5

How could gene therapy change the way we treat age-related macular degeneration? 基因疗法如何改变我们治疗老年性黄斑变性的方式?

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2147927

Huma Khan, Hannah Khan, A. Aziz, Tyler M Ewing, A. Khanani

引用次数: 1

Mechanisms of corneal trauma in response to rubbing and other intraocular pressure elevating activities in keratoconus 圆锥角膜摩擦和其他眼压升高活动引起角膜损伤的机制

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2153119

C. McMonnies

{"title":"Mechanisms of corneal trauma in response to rubbing and other intraocular pressure elevating activities in keratoconus","authors":"C. McMonnies","doi":"10.1080/17469899.2022.2153119","DOIUrl":"https://doi.org/10.1080/17469899.2022.2153119","url":null,"abstract":"ABSTRACT Introduction The potential for eye rubbing to contribute to keratoconus development and progression is well established, but the mechanisms of that association have not been fully elucidated. Areas covered This review examines mechanisms for rubbing-related corneal trauma from both anterior and posterior surface responses to elevated intraocular pressure. Apart from rubbing-related intraocular pressure elevation, consideration is given to other sources of elevation which may contribute to corneal bulging and cone formation. Mechanisms whereby intraocular pressure-related increased posterior corneal surface distending stress and stromal hydrostatic pressure may alter keratocyte functions and increase susceptibility to such stress are examined. Expert opinion Elevated intraocular pressure (IOP) that is associated with a chronic habit of abnormal rubbing (CHAR) can be a major contributor of keratoconus (KC) development and progression. Anterior corneal surface protection during rubbing due to Bell’s reflex in most patients, at least for the central and para-central cornea, increases the likelihood that IOP distending stress can be an important source of KC pathogenesis, perhaps even in patients who do not have abnormal rubbing habits. That the earliest pathological changes in KC occur at the posterior corneal surface is consistent with the significance of an IOP-related distending force mechanism for KC pathogenesis.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"405 - 414"},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45516388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diagnostic accuracy of machine learning classifiers for cataracts: a systematic review and meta-analysis 机器学习分类器对白内障的诊断准确性:系统回顾和荟萃分析

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Expert Review of Ophthalmology Pub Date : 2022-10-28 DOI: 10.1080/17469899.2022.2142120

Ronald Cheung, Samantha So, Monali S. Malvankar-Mehta

{"title":"Diagnostic accuracy of machine learning classifiers for cataracts: a systematic review and meta-analysis","authors":"Ronald Cheung, Samantha So, Monali S. Malvankar-Mehta","doi":"10.1080/17469899.2022.2142120","DOIUrl":"https://doi.org/10.1080/17469899.2022.2142120","url":null,"abstract":"ABSTRACT Objective The objective of this study was to systematically review and meta-analyze the diagnostic accuracy of current machine learning classifiers for pediatric and adult cataracts. Methods MEDLINE, EMBASE, CINAHL, and ProQuest Dissertations and Theses were searched systematically and thoroughly. Conferences held through Association for Research in Vision and Ophthalmology, American Academy of Ophthalmology, and Canadian Society of Ophthalmology were searched. Studies were screened using Covidence software and data on sensitivity, specificity and area under curve were extracted from the included studies. STATA 15.0 was used to conduct the meta-analysis. Results Our search strategy identified 150 records from databases and 35 records from gray literature. Total of 21 records were used for the qualitative analysis and 11 records (100 134 images) were used for the quantitative analysis. In adult patients with cataracts, the pooled estimate for sensitivity was 0.948 [95% CI: 0.815–0.987] and specificity was 0.960 [95% CI: 0.924–0.980] for cataract screening using machine learning classifiers. For pediatric cataracts, the pooled estimate for sensitivity was 0.882 [95% CI: 0.696–0.960] and specificity was 0.891 [95% CI: 0.807–0.942]. Conclusion The included studies show promising results for the diagnostic accuracy of the machine learning classifiers for cataracts and its potential implementation in clinical settings. Prospero registration CRD42020219316","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"427 - 437"},"PeriodicalIF":0.7,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47318696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The future of biomarkers in neovascular age-related macular degeneration: active disease or degenerative process? 生物标志物在新生血管性年龄相关性黄斑变性中的未来:活动性疾病还是退行性过程?

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Expert Review of Ophthalmology Pub Date : 2022-09-03 DOI: 10.1080/17469899.2022.2139677

Daniel Egger, Reinhard Angermann, S. Waldstein

引用次数: 1

A peek at the window from the eye into the brain: potential use of OCT angiography in dementia 从眼睛窥视大脑的窗户：OCT血管造影术在痴呆症中的潜在应用

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Expert Review of Ophthalmology Pub Date : 2022-09-03 DOI: 10.1080/17469899.2022.2131541

Semih Ceylan, O. Özalp, E. Atalay

{"title":"A peek at the window from the eye into the brain: potential use of OCT angiography in dementia","authors":"Semih Ceylan, O. Özalp, E. Atalay","doi":"10.1080/17469899.2022.2131541","DOIUrl":"https://doi.org/10.1080/17469899.2022.2131541","url":null,"abstract":"Dementia is defined as the irreversible deterioration of acquired cognitive abilities (executive functions, memory, language, visuospatial, and motor) because of progressive neurodegeneration. According to a report by the World Health Organization (WHO) in 2018, dementia ranks as the 7 most common worldwide cause of death. In 2018, the globally estimated number of people afflicted by dementia was 50 million, a figure which is expected to triple by the year 2050 [1]. The worldwide rapidly aging population and the resultant unprecedented rise in the incidence of dementia are anticipated to cause a greater burden in health expenditures both in underdeveloped and developed countries alike. Optical coherence tomography angiography (OCT-A) is a noninvasive and facile method for visualizing retinal and choroidal microcirculation obviating the need for administering a systemic contrast agent. Compared to other brain imaging modalities, such as positron emission tomography imaging, it is more cost-effective and rapidly allows layer-bylayer assessment of retinochoroidal microcirculation. In a routine retina clinic, OCT-A is mainly employed for the diagnosis and monitoring of age-related macular degeneration and diabetic retinopathy. It has also become a popular research tool for assessing peripapillary and macular microcirculation in glaucoma and other optic neuropathies with the hope of finding various vascular cues that may enable earlier disease diagnosis and/or the detection of its progression [2]. In addition to its indispensable role in a busy ophthalmology clinic, studies have shown that OCT-A may potentially be a highly useful ancillary tool in various other non-ophthalmic diseases that directly or indirectly impact retinal and/or choriocapillaris microcirculation, such as multiple sclerosis, Parkinson’s, and Alzheimer’s diseases [3].","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":"17 1","pages":"295 - 297"},"PeriodicalIF":0.7,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43549570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0