Expert Review of Ophthalmology最新文献_第7页

How can the safety of antibody therapy for retinopathy of prematurity be improved? 如何提高早产儿视网膜病变抗体疗法的安全性？

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Expert Review of Ophthalmology Pub Date : 2023-01-01 Epub Date: 2023-04-09 DOI: 10.1080/17469899.2023.2200934

M Elizabeth Hartnett

引用次数: 0

Evaluating gap junction variants for a role in pediatric cataract: an overview of the genetic landscape and clinical classification of variants in the GJA3 and GJA8 genes 评估间隙连接变异在儿童白内障中的作用:GJA3和GJA8基因变异的遗传景观和临床分类概述

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Expert Review of Ophthalmology Pub Date : 2022-12-20 DOI: 10.1080/17469899.2023.2160320

Johanna L Jones, K. Burdon

{"title":"Evaluating gap junction variants for a role in pediatric cataract: an overview of the genetic landscape and clinical classification of variants in the GJA3 and GJA8 genes","authors":"Johanna L Jones, K. Burdon","doi":"10.1080/17469899.2023.2160320","DOIUrl":"https://doi.org/10.1080/17469899.2023.2160320","url":null,"abstract":"ABSTRACT Introduction Variants in the two lens-expressed gap junction genes GJA3 and GJA8 are among the most common causes of inherited pediatric cataract. These two genes alone account for up to 18% of the cases, second only to the crystallin gene family. Areas covered All published cataract-associated variants in the GJA3 and GJA8 genes were reviewed for a role in pediatric cataract. Autosomal dominant inheritance was most frequently reported, alongside instances of reduced penetrance and autosomal recessive disease. Variant curation using the ACMG-AMP guidelines identified that many variants do not meet the modern standards for clinical interpretation of pathogenicity. There is broad phenotypic heterogeneity of cataract associated with gap junction gene variants. Pathogenic variants are located throughout both proteins with an enrichment in the N-terminal, first two transmembrane domains, and two extracellular loops. Expert opinion Nearly half the gap junction gene variants observed in cataract patients lack sufficient evidence of pathogenicity to form a useful clinical opinion. For many variants, this may be rectified over time as the variant is observed in additional patients but would be vastly accelerated by the generation of well-characterized and standardized functional data evaluating the specific effect of each variant on protein function.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47285428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Why are soft contact lens wear discontinuation rates still too high? 为什么软性隐形眼镜的停用率仍然过高？

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Expert Review of Ophthalmology Pub Date : 2022-12-20 DOI: 10.1080/17469899.2022.2160321

C. McMonnies

{"title":"Why are soft contact lens wear discontinuation rates still too high?","authors":"C. McMonnies","doi":"10.1080/17469899.2022.2160321","DOIUrl":"https://doi.org/10.1080/17469899.2022.2160321","url":null,"abstract":"ABSTRACT Introduction Notwithstanding continuing improvements in contact lens technology and increasing use of daily disposables, discontinuations from soft contact lens wear remain a significant problem with ‘drop-out’ too often occurring after patients have initially achieved successful routine use. Areas covered This review examines the possibility that the signs and symptoms of discontinuations might, for example be associated with corneal and/or lid wiper neuropathy and/or aqueous, mucin and lipid deficiencies and/or mental health disorders. In addition, this review examines how soft contact lens wear places high demands on tear functions. Expert opinion Limitations in clinically detecting evidence of some adverse responses to soft contact lens wear may explain how discontinuations can sometimes be described as unexplained. Similarly, limitations in clinically determining the significance of different forms of tear dysfunction and their exacerbation by soft contact lens wear may be a barrier to explaining why symptoms of dryness are most commonly associated with discontinuations. The wider experience obtained with cosmetic contact lens fittings that is discussed in this review may be relevant to problems encountered in therapeutic contact lens applications.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45263974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Emerging biosimilars for retinal diseases 新兴的视网膜疾病生物仿制药

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2152005

Ashish Sharma, N. Parachuri, Nilesh Kumar, F. Bandello, B. Kuppermann

引用次数: 1

Endoplasmic reticulum stress as an underlying factor in leading causes of blindness and potential therapeutic effects of 4-phenylbutyric acid: from bench to bedside 内质网应激是导致失明的潜在因素，4-苯基丁酸的潜在治疗效果：从试验台到床边

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2145945

S. Askari, F. Azizi, Pegah Javadpour, N. Karimi, Rasoul Ghasemi

{"title":"Endoplasmic reticulum stress as an underlying factor in leading causes of blindness and potential therapeutic effects of 4-phenylbutyric acid: from bench to bedside","authors":"S. Askari, F. Azizi, Pegah Javadpour, N. Karimi, Rasoul Ghasemi","doi":"10.1080/17469899.2022.2145945","DOIUrl":"https://doi.org/10.1080/17469899.2022.2145945","url":null,"abstract":"ABSTRACT Introduction Mounting evidence has emerged showing that endoplasmic reticulum (ER) stress participates in triggering cell injuries in ocular tissues, manifested as disorders such as cataracts, age-related macular degeneration, glaucoma, and diabetic retinopathy. Areas covered ER stress is a condition in which the ER is perturbed by the accumulation of unfolded and misfolded proteins. In a dynamic signaling cascade, the unfolded protein response (UPR) is triggered by three ER-transmembrane stress sensors to restore homeostasis and cell survival, however, if it fails, the cell will undergo a sustained ER stress condition which deteriorates cell function and promote cell death. Sustained ER stress is shown to contribute in a wide range of diseases including ophthalmologic disorders. Targeting ER stress by inhibitor agents might have promising therapeutic implications in treating eye disorders. The current review summarizes the results of the latest studies in support of the potential therapeutic utility of 4-phenylbutyric acid (4-PBA), an FDA approved ER stress inhibitor, in disorders leading to permanent vision loss. Expert opinion The therapeutic potential of 4-PBA in ophthalmic diseases is strongly supported by many experimental studies. Safety and efficacy studies of intravitreal injection of 4-PBA and other ER stress by inhibitors, are lacking.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42753128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical management of recurrent rhegmatogenous retinal detachment 复发性孔源性视网膜脱离的手术治疗

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2152004

Lucy V. Cobbs, Taku Wakabayashi, Y. Yonekawa

{"title":"Surgical management of recurrent rhegmatogenous retinal detachment","authors":"Lucy V. Cobbs, Taku Wakabayashi, Y. Yonekawa","doi":"10.1080/17469899.2022.2152004","DOIUrl":"https://doi.org/10.1080/17469899.2022.2152004","url":null,"abstract":"ABSTRACT Introduction Primary rhegmatogenous retinal detachment (RRD) repair with modern surgical techniques provides high rates of anatomic success; however, anatomic failure may still occur with any primary surgery, including after pneumatic retinopexy (PR), scleral buckle (SB), and pars plana vitrectomy (PPV), resulting in recurrent RRD. Areas covered This review includes a summary of surgical options and management strategies for eyes with primary failure of PR, SB, and PPV. Expert opinion No standardized protocol is available for determining the optimal secondary surgical options to treat recurrent RRD. However, understanding of the causes and characteristics of the re-detachment, expected anatomic success rates with each surgical option, and potential complications, may improve the outcomes after re-operations. Causes of primary failure include formation of new breaks, re-opening of the original breaks, missed breaks, and most commonly, proliferative vitreoretinopathy (PVR). Rescue PR, revision of SB, and reoperation with PPV with membrane peeling, relaxing retinectomy, and/or long-acting tamponade combined with or without encircling SB, are effective options depending on the cause of primary failure and characteristics and severity of the re-detachment. Further advances in the management of PVR, which is a major cause of primary failure, will help improve treatment outcomes for eyes with complicated recurrent detachments.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47006396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypersonic vitrectomy: a novel approach to vitreous removal 高超声速玻璃体切除术:一种新的玻璃体切除方法

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2148656

Jacob G. Light, H. Anderson, Sunir J. Garg

{"title":"Hypersonic vitrectomy: a novel approach to vitreous removal","authors":"Jacob G. Light, H. Anderson, Sunir J. Garg","doi":"10.1080/17469899.2022.2148656","DOIUrl":"https://doi.org/10.1080/17469899.2022.2148656","url":null,"abstract":"ABSTRACT Introduction Pars plana vitrectomy is the basis of modern retina surgery, and for the last 40 years, has been achieved using the pneumatic guillotine cutter. Recently, a new vitrectomy design has been developed: the hypersonic vitrector. This technology utilizes ultrasound energy to liquefy vitreous in contrast to the mechanical segmentation of vitreous strands that characterizes pneumatic cutters. Areas covered This review provides a history of the development of vitrectomy and summarizes the critical elements of effective and safe vitrectomy systems. The article will describe the novel hypersonic vitrectomy design, discuss what the initial pre-clinical and in-human studies tell us about its performance compared to standard pneumatic cutters, and considers its role in the future of retina surgery. Expert opinion Hypersonic vitrectomy is the first novel way to segment vitreous since the development of pneumatic guillotine cutters. It has the potential to make vitrectomy more efficient both by reducing operating times as well as enabling surgeons to remove silicone oil and retained lens material all with one instrument. With concurrent advancements in guillotine cutters, hypersonic vitrectomy has a high bar to clear to demonstrate advantages that would result in widespread adoption.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45798882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Device-based therapies as a boost of conventional treatment in dry eye disease 基于设备的治疗方法对干眼病的常规治疗有促进作用

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2147928

A. Borgia, R. Raimondi, G. Fossati, Francesco Paolo De Rosa, V. Romano, D. Borroni, L. Vigo, V. Scorcia, G. Giannaccare

引用次数: 5

How could gene therapy change the way we treat age-related macular degeneration? 基因疗法如何改变我们治疗老年性黄斑变性的方式?

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2147927

Huma Khan, Hannah Khan, A. Aziz, Tyler M Ewing, A. Khanani

引用次数: 1

Mechanisms of corneal trauma in response to rubbing and other intraocular pressure elevating activities in keratoconus 圆锥角膜摩擦和其他眼压升高活动引起角膜损伤的机制

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Expert Review of Ophthalmology Pub Date : 2022-11-02 DOI: 10.1080/17469899.2022.2153119

C. McMonnies

{"title":"Mechanisms of corneal trauma in response to rubbing and other intraocular pressure elevating activities in keratoconus","authors":"C. McMonnies","doi":"10.1080/17469899.2022.2153119","DOIUrl":"https://doi.org/10.1080/17469899.2022.2153119","url":null,"abstract":"ABSTRACT Introduction The potential for eye rubbing to contribute to keratoconus development and progression is well established, but the mechanisms of that association have not been fully elucidated. Areas covered This review examines mechanisms for rubbing-related corneal trauma from both anterior and posterior surface responses to elevated intraocular pressure. Apart from rubbing-related intraocular pressure elevation, consideration is given to other sources of elevation which may contribute to corneal bulging and cone formation. Mechanisms whereby intraocular pressure-related increased posterior corneal surface distending stress and stromal hydrostatic pressure may alter keratocyte functions and increase susceptibility to such stress are examined. Expert opinion Elevated intraocular pressure (IOP) that is associated with a chronic habit of abnormal rubbing (CHAR) can be a major contributor of keratoconus (KC) development and progression. Anterior corneal surface protection during rubbing due to Bell’s reflex in most patients, at least for the central and para-central cornea, increases the likelihood that IOP distending stress can be an important source of KC pathogenesis, perhaps even in patients who do not have abnormal rubbing habits. That the earliest pathological changes in KC occur at the posterior corneal surface is consistent with the significance of an IOP-related distending force mechanism for KC pathogenesis.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45516388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2